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Recent breakthroughs in type 2 diabetes treatments promise new treatment options for type 1 diabetics.
Less than 20 years ago, the only thing type 1 and type 2 diabetes seemed to have in common was a shared name; they were related conditions but only as distant cousins, and once removed, at that. Doctors and researchers discovered the last decade that, for a variety of reasons, many type 2 diabetics could benefit from taking insulin.
There are numerous causes for this, according to Andrea Penney, RN, CDE, with the Joslin Diabetes Center. That change in thinking about the ways type 2 diabetes evolves indirectly opened the door to considering new ways of thinking about how type 1 diabetes behaves. There is only one treatment besides 54 varieties of insulin approved by the Federal Drug Administration for use by type 1 diabetics, according to the University of Maryland Medical Center, and that drug is pramlintide acetate, which is marketed under the name Symlin. Pramlintide is a small peptide hormone produced in the pancreas and, in people without diabetes, is released alongside insulin after meals or food ingestion, to help reduce high blood sugar.
According to the FDA, which approved Symlin for use in treating type 1 diabetes in 2005, “Symlim is an injectable medicine for adults with type 2 and type 1 diabetes to control blood sugar.
Symlin’s manufacturer, Amylin Pharmaceuticals, Inc., says that Symlin works to reduce blood sugar by generating a feeling of fullness after meals, slowing the rate that the stomach empties after meals, and reduces the release of glucagon from the liver after meals.
Some doctors are also prescribing metformin, which is the most prescribed oral type 2 diabetes treatment in the United States, off label as an adjunct to insulin for type 1 diabetics. Other drugs used to treat type 2 diabetics are being studied to see if they should be submitted to the FDA for approval to treat type 1 diabetics. GLP-1 is a naturally occurring hormone released in the intestine that stimulates the release of insulin from pancreatic beta cells when carbohydrates are absorbed in the intestine.
Some limited research suggests that GLP-1 treatments might be effective in helping type 1 diabetics better control their blood sugar. A full-scale clinical trial of Victoza on type 1 diabetics is potentially in the works from the maker of Victoza.
Then, this January Novo Nordisk started recruiting more than 1,400 subjects for a 52-week trial on the effects of Victoza on type 1 diabetics. Until that trial is completed and the FDA acts, however, Byetta, Victoza, and Bydureon are explicitly not approved for use by type 1 diabetics, according to the product warnings on each drug. If any type 1 diabetic wishes to try the drugs off label (which is the medical jargon for when patients receive a prescription to use a drug for a purpose for which it has not been FDA approved) researchers and doctors suggest consulting with a qualified endocrinologist experienced both in prescribing GLP-1 drugs and treating type 1 diabetics. Anyway, if this sounds interesting to anyone, they’re currently enrolling people in a year-long study to see if regular treatment with Bydureon (the once-a-week version) is helpful to people with Type 1. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. But there are structured diabetes education programs that your doctor must enable you to attend such a course.
Linaglyptin works in a similar way to Sitagliptin above, but is is safe in reduced renal function. If you compliance is not good and you only want twice daily injections and don't want to test much, and new ultralongacting insulin degludec may help. Site rotation is a system of changing injection sites in a pattern that will help you choose different sites each time you inject. March 17, 2012 by Dr Chetali Samant World Health Organization has listed 21,000 plants from all over the world, which possess medicinal properties. Ayurvedic plant remediesare revered as potent adjuvant therapies in many diseases ranging from cancer, cardiovascular diseases, and Obesity to Alzheimer’s for their rejuvenating, anti-oxidant qualities and lack of side-effects. Gurmar or Madhuvinashini (Gymnema sylvestre)-  ‘Gurmar’  in Hindi (National Language of India) or ‘Madhuvinashini’ in Sanskrit literally means ‘one that vanquishes sugar’. Fenugreek (Trigonella foenum graecum)-The seeds and leaves of Fenugreek, commonly known as ‘Methi’ in Hindi and ‘Methika’ in Sanskrit are an integral part of Indian cooking. Turmeric (Curcuma longa)-Turmeric or ‘Haridra’ (Sanskrit) or ‘Haldi’ as it is commonly known in India, is the most preeminent Indian spice, an integral part of Indian cuisine and an auspicious component of Hindu Religious ceremonies. The Nature of Type II Diabetes does vary from person to person, hence Ayurveda advises that any supplement; diet or lifestyle changes should be customized to meet your specific health requirements. Burke et al, Rapid Rise in the Incidence of Type 2 Diabetes From 1987 to 1996 Results from the San Antonio Heart Study, Arch Intern Med.
Krawinkel et al, Bitter Gourd (Momordica charantia): A Dietary Approach to Hyperglycemia, Nutrition Reviews Volume 64.
Gupta A, Gupta R, Lal B, Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. Lekshmi PC, Arimboor R, Raghu KG, Menon AN., Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects. Shehzad A, Ha T, Subhan F, Lee YS., New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Having practiced Ayurveda in entirely diverse cultures like India and United States, Dr Chetali Samant has experienced the myriad facets and the true meaning of Ayurvedic Health Care.
Novo Nordisk is well-known in the diabetes community for its insulins, Novolog and Levemir, used to treat mainly type 1 diabetes.
This content is created for Diabetes Mine, a consumer health blog focused on the diabetes community. The content is not medically reviewed and doesn't adhere to Healthline's editorial guidelines. Please note that we are unable to respond back directly to your questions or provide medical advice.
Please say howdy once again to Dana Howe, a recent graduate student in Health Communication from Tufts University who's had type 1 since age 8. He is the voice of Darth Vader, and the guy who delivered one of the best-known modern monologues in "If You Build It, They Will Come" from the movie Field of Dreams.
If we had a dollar for every time "What the heck??" was uttered in managing diabetes, we'd probably have enough funds to find the cure ourselves!
Byetta, Victoza and the weekly candidate in the pipeline mainly restore the incretine effect.


I have just started using this and it is very odd.I am glad that I have the same issues as some of the cases. I started Victoza 13 april and had some green apple quick step the first few days taking .6 mg. Navigating this world of new, and apparently improved drugs, however, is anything but simple or straightforward. The paradigm at the time was that type 1 and type 2 diabetes required different treatments because they were, in fact, very different conditions. The recently realized realities regarding the ways each condition evolves and behaves has led to new ways of treating each type of diabetes and a sharing of therapies between the two. That shift led to considering whether that door swung both ways and if type 1 diabetics might benefit from treatments designed to treat type 2 diabetes.
Symlin is recommended for type 1 diabetics who have not achieved good blood sugar control, which is decided on a case-by-cases basis by a person’s physician. These drugs, once-daily injectable Victoza, Byetta, and once-weekly injectable Bydureon, are all GLP-1 agonists. Additionally, GLP-1 (which stands for “glucagon like peptide”) is also present in the brain, where it acts as an appetite suppressant and produces one of the same effects of taking Symlin.
I want to add to Kelly’s experience by saying I was in a tiny, preliminary trial using Byetta, and was astounded by the result. This is the tissue between the fat layer just under the skin and the muscles that are under the fat.
Type II Diabetes also known as Non-Insulin Dependent Diabetes Mellitus (NIDDM) or ‘Prameha’ in Sanskrit, is a metabolic disorder. It is so called because it temporarily abolishes sweet taste by anesthetizing our taste buds. However, despite of its bitter disposition, it is still one of the tastiest vegetables in Indian cuisine.
Understanding you Ayurvedic Body Type or Prakriti, your age, digestion, nature and chronicity of your diseases are the key factors for deciding which Ayurvedic dietary supplement or herb suits you the best. Devasagayam, Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes, J Clin Biochem Nutr. She has received her master’s degree in Ayurveda (M.D Ayurveda) from Gujarat Ayurveda University- one of the most prestigious universities of Ayurveda in India and the only Ayurveda University in the world. But in the last year, Novo launched a new kind of injectable, a "first line of defense for people with type 2 diabetes" called Victoza (generic: liraglutide). That means that they restore the colone hormones' capability to order insulin just in time as new glucose is passed on into the portal vein.
I started on 0.6 for a few weeks, taking it at night to overcome the nausea my endo warned me about. In type 1 diabetes the pancreas stops making insulin so type 1 diabetics injected insulin to replace what the body was no longer producing. Type 2 is progressive: the pancreas produces less insulin each year, more treatment and eventually insulin is often needed.
Giving injections in the same place each day may cause your skin to become sunken (atrophy) or lumpy (hypertrophy). The incidence of diabetes is increasing globally at an alarming rate.2 Many Ayurvedic herbs and classical blends are beneficial in managing the high blood sugar levels, underlying insulin resistance and side effects that tag along with Type II Diabetes. It helps in keeping blood sugar levels in check and improves insulin resistance in Type II diabetes. Research studies have found that turmeric lowers blood sugar levels and works at many levels in improving insulin sensitivity and inhibiting certain enzymes that have been linked with type II diabetes.9 Turmeric reduces inflammation of body tissues caused due to damaging free radicals.
This not only brings the disease under control; it leads to true manifestation of health and well-being! Shanmugasundaram, Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients, Journal of Ethnopharmacology. She has been honored with a gold medal for her academic achievements during her postgraduate studies. It's a glucagon-like peptide-1 (GLP-1) drug designed to stimulate insulin secretion when hyperglycemia (high blood sugar) is present.Victoza is still the new kid on the block here in the US, having just been approved by the FDA on January 25. And depending on the amount of beta cells left to answer the call postprandial spikes may rise lower. I eat very well, work out with a trainer 3 times a week and cook most of my meals and so with my sugar pretty controlled I was put on this. Type 2 diabetes, however, was a condition in which a person’s pancreas was producing insulin, but their body was not metabolizing and using the hormone efficiently. People can also become insulin resistant due to weight gain or chronic emotional or physical stress. However, this process is a lot slower with regular exercise, a healthy diet, and keeping thin. Below given are 5 potent Ayurvedic herbs that have been found to be highly effective as adjuvant therapies in Type II Diabetes. A popular way of taking fenugreek seeds is to soak 1 tablespoon of fenugreek seeds in water at night and eat them early next morning on empty stomach. Such chronic low grade inflammation is now being considered as the root cause of many metabolic diseases including Diabetes, cancer, obesity and cardiovascular diseases.
After specializing in the field of mother and child care, she realized that the health of one family member indeed depends on the health status of every member of the family.
It was approved in Europe last July, and has already been used by a fair number of patients there.The big question on the market, and among doctors and patients now is, how will Victoza stack up against Byetta, the most well-known injectable drug for type 2 diabetes? I will say though that despite the horrendous nausea and splitting headaches, my blood sugar is the best it's been in ten years. I have just a slight nagging nausea that I think I will be able to tolerate even it it never goes away.
Type 2 diabetics took oral medications to help improve their ability to metabolize the insulin their bodies were producing.


What’s more, normally, Byetta is thought to work by boosting insulin production (in people with Type 2). Best way to take turmeric is to include it your daily diet.10 Also, whole turmeric is more effective than using its individual active constituents like curcumin. Byetta has been very successful as a weight-loss aid, but the nausea it causes makes it intolerable for some people.One big difference is that Victoza has a longer half-life, so it can be injected just once a day, at any time. In the info sheet, it says that side effect occurred in less than .2% of trials, somehow I am always the exception. The main reason I'm Type II is because I am about 75lbs overweight, so whatever weight loss I experience will be a blessing.
But when they analyzed my blood, they found that I was producing LESS insulin on the Byetta day than I was during the regular glucose tolerance tests. On the 100-unit syringe, each line equals 2 units.Opened vials of insulin, cartridges or pens in current use do not need to be refrigerated if used within 30 days of their first use.
Refrigerated and unopened vials or pens can last up to the expiration date on the box or vial. I have been able to reduce my insulin from 160 units per day to 100."The side effects, he says, were some nausea and stomach pains which lasted only about a week. Before, due to lack of energy, all I did was lie around and wait for something to drag me off the bed.
The injection hurts less if the insulin is allowed to come to room temperature before injecting. We are really excited by these results so far and are anxious to see if her A1C has gone down! You may warm the insulin syringe by rolling the syringe between your hands before injecting.
When all of the previous sites are used, move to a new area of the body and choose a new site in that area for each injection. Most mornings I have to force myself to eat breakfast but I know I must keep a regular eating pattern. Byetta worked for a while, but eventually I wasn't getting the results I started out getting and the injection sites turned into itchy welts that would last for days.
The Victoza I believe has really helped me as I was fast becoming insulin-intolerant."So what happens when patients combine Victoza with their usual oral anti-diabetes drugs?A  Funny you should ask. The bottle or pen must be thrown away once it has been opened for 30 days (whether it has been refrigerated or is at room temperature).
It has been tricking timing that medication so it doesn't cause me severe nausea or vomiting with the Victoza. Still, the only way to find out is to continue ongoing cancer monitoring for the next 15 years (!)There have also been discussions that drugs like Byetta and Victoza can cause an increased risk of pancreatitis. In response, the drugmakers state: "There is no clear association between this class of drugs with pancreatitis. Make sure that the expiration date has not passed and that the top of the bottle is not damaged.
Do not mix either of these insulins with any other insulin without first discussing this with your doctor.
Those issues are some of the reasons why Novo Nordisk decided to pursue this therapeutic area."So Novo believes that Victoza is a fix for all those problems?A  Mr. Moses admits that the company also became interested in working on VictozaA  because their insulin products are predominately used by people with type 2 diabetes later in the course of the disease.
Clean the top of the insulin bottle with an alcohol swab or a cotton ball dipped in alcohol. If you are unable to inject the needle, ask your physician, pharmacist or nurse educator about devices to help you. Victoza gives Novo an opportunity to start at the diagnosis of type 2 diabetes, hopefully to extend the ability of a person to use their own insulin. Draw air into the syringe by pulling back on the plunger to the amount of insulin to be given.
How have you found it?A  Please take a moment to share your thoughts in the comments section here. If there are no air bubbles, push the top of the plunger tip up to the line, which marks your exact dose. DO NOT bring the container with the used syringes to the hospital or to your physician’s office. If there are air bubbles in your syringe, flick or tap the syringe at the bubble with your finger (see Picture C). If you are using a sharps container from a medical company or from a pharmacy, DO NOT return it to the hospital or your physician’s office. When the air bubble goes to the top of the syringe, push the plunger tip up to your exact dose.
Disclaimer: This information is not intended to substitute or replace the professional medical advice you receive from your child's physician.
The content provided on this page is for informational purposes only, and was not designed to diagnose or treat a health problem or disease. Draw air into the syringe by pulling out on the plunger to the amount of cloudy insulin to be given. With the bottle standing upright, insert the needle into the rubber stopper of the cloudy insulin and push in the plunger (Picture D). Insert the needle into the rubber stopper of the clear insulin bottle and push air into the bottle (Picture E).



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