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First and foremost, there are two types of Diabetes, and they are very different from one another.
Diabetes is a serious health condition that not only affects your lifestyle, but puts you at risk for other health conditions including high blood pressure, stroke, and nerve damage.  Many Americans are at risk for type 2 diabetes, and the numbers are growing yearly.
One change that I always recommend to my clients when we discuss lifestyle-eating, and healthy living options that can be made, is to give up soda. People often look at me, horrified.  They would rather I ask them to nibble on a pigs ear!  Here are some facts for you about regular and diet sodas and what they do to your body and your mind. British-Swedish drugmaker AstraZeneca has been approved by the FDA for its once-a-day Xigduo XR extended-release tablet to treat adults with type 2 diabetes mellitus in the United States. The Xigduo FDA approval gives the two anti-hyperglycaemic agents, dapagliflozin and metformin, a green light to be used as a once-daily oral tablet.
SGLT2 inhibitors are a new class of medicines that remove glucose from the body through the kidneys. However, safety worries have thus far limited uptake for the SGLT2 class, as the treatments have been linked to increased rates of genital and urinary tract infections, plus kidney damage and cardiovascular issues. LGM Pharma provides the two anti-hyperglycaemic agents dapagliflozin and metformin hydrochloride for research and development purposes, and offers clients continued support throughout the R&D process. Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). This entry was posted in Anti-Diabetic, Blood Glucose Regulator, FDA Approved 2014, OTC and Compounding Product, Therapeutic Classification and tagged Australia, type 2 Diabetes by admin. If your body becomes insulin resistant, then you might face different symptoms of diabetes. If you really want to know what causes diabetes type 2, then you need to have thorough consultation with any expert doctor dealing with the concerned disease.
Physical inactivity is also quite important in this case and thus you must consider the same. You also need to change your sleeping habits as bad sleep habits are regarded as one of the greatest causes for the occurrence of this disease.
What are the potential problems of poorly controlled sugar levels in diabetes type 2?Is There A Cure for Diabetes Type 2? The condition of gangrene is a serious one, primarily marked by loss of adequate supply of blood to the tissues of the body, ultimately resulting in its necrosis or death. Injury to the tissues, infection (mostly of bacterial origin) and presence of any underlying health ailment that inflicts damage to the blood carrying vessel structure form the three key underlying mechanisms that are responsible for initiation and development of irreversible tissue damage and life threatening condition of gangrene. As already explained, one of the causes of gangrene in the toes and fingers is linked with damaged blood vessels. High level of blood glucose associated with diabetes mellitus also damages the nerves (known as peripheral neuropathy), especially the nerves in the lower extremities. The dullness or lack of sensation puts diabetic individuals at an increased risk of injuring the skin of their fingers or feet without having any realization (it mostly goes unnoticed in the feet region). The sore or foot ulcer formed takes an extended time to heal because of both, poor circulation of blood through the injured area as well as lesser number of defence cells. Bacterial infection also forms another causative factor that makes the diabetic individual more prone to developing gangrene. Such type of infection is marked by noticeable skin discolouration and dryness along with the formation of skin blisters. The weakened immune system (seen in diabetes) further raises the risk of incurring serious infection, which later develops, into gangrene.
There are several symptoms that you should know so that you will be aware if you are having this chronic skin disease.
Whenever you are experiences most of these symptoms or even just some, it is best to visit a dermatologist.
Aside from the mentioned information above, this skin problem will show like a rash and it will affect the abdomen, legs, back, arms, and chest.
Leg Ulcers are found mainly in people with illnesses and diseases which cause decreased blood supply to the body and lower extremities, most commonly venous insufficiency.
The elderly and obese individuals are the main targets due to their inclination to less activity.
Venous diseases such as venous insufficiency is the main reason for over two thirds of all leg ulcers.
To treat your leg ulcers it is best to see a vascular specialist where a complete diagnosis can be made. The goal of treatment is to provide oxygen to the area, reduce the inflammatory and infectious process and remove dead tissue so healing can take place.
Being among the few vascular and endovascular trained surgeons in Singapore, our doctor can provide comprehensive services from diagnosis to treatment. This is a skin condition which is chronic and inflammatory and normally affects only adults. If left not treated, rosacea typically becomes advanced meaning that it gets worse over time. There is no cure for rosacea, but there are treatments which manage and reduce the symptoms and signs. A flushed face with pimples or bumps on or around the nose, cheeks, forehead as well as mouth a€“ often lasts for days. With no treatment there are some cases of rosacea which cause bumps on the nose and cheeks which are knobby and that will multiply.
Triggers, for instance sun exposure or alcohol, can stimulate increased blood flow, which causes the blood vessels to expand and the redness of the face appears.
In some research it is suggested that there is a link between rosacea and migraine headaches.
Rosacea can begin simply as a tendency to blush or flush easily and to then progress to a tenacious redness in the central part of the face, especially the nose.
As the symptoms and signs grow worse, vascular rosacea can develop a€“ small blood vessels on the cheeks as well as the nose swell and can become visible.
Red, small pustules or bumps can appear as well as persist, and will spread across the cheeks, nose, forehead and chin. Additionally about 1 in 2 individuals with rosacea will also experience ocular rosacea – the symptoms in the eyes are mentioned above.
An actual cause of rosacea is not known but most medical researchers believe it is probably due to some combinations of environmental factors and genetics.
Another theory is that the swelling is caused by the increased blood flow during flushing which leads to an increase in fluid in the tissue and which collects faster than the lymphatic system can eliminate it. There are a number of causes which seem to heighten or trigger rosacea or which make it worse by the increasing of blood flow to the surface of the skin of the face. In rare and very severe cases, the sebaceous glands or oil glands in the nose and often in the cheeks can become enlarged, causing a buildup of tissue around and on the nose. There is no way to eradicate rosacea, but there is effective treatment which can get rid of the symptoms. The physician may mention definite cleansers, moisturizers, sunscreens as well as other products which improve the skin.
An individual with rosacea may need to have a combination of prescription-strength lotions, creams or gels and also oral medications to treat this condition. These medications are applied to the skin once or twice daily and may help to reduce redness and inflammation.
Physicians may prescribe oral antibiotics to treat rosacea more because of their inflammatory properties than to actually kill germs.


Isotretinoin such as Amnesteen and Accutane is another very powerful medication which is oral and used for severe cases of inflammatory rosacea when other treatment options fail to improve the symptoms.
The duration of treatment depends on the severity as well as the type, but normally you will notice an improvement within 1 to 2 months. This website is for informational purposes only and Is not a substitute for medical advice, diagnosis or treatment. Acanthosis nigricans is a skin condition that usually affects the skin folds of the neck, the armpit, and the groin.
The most common symptom of acanthosis nigricans is the presence of the skin discoloration which is dark and velvety.
Aside from the hyperpigmentation, skin tags can also be found in and around the affected areas.
The exact cause of acanthosis nigricans has not been determined yet; however, there are several possibilities that health care professionals believed to have contributed to the development of the condition. This is once known as pseudo acanthosis nigricans and is the most common type among the nine types of acanthosis nigricans. This type of acanthosis nigricans is associated with a syndrome, specifically the type A and the type B syndromes.
Type B syndromes on the other hand is associated with women who have diabetes mellitus, ovarian hyperandrogenism, or autoimmune disorders such as systemic lupus erythematosus, scleroderma, Hashimoto’s thyroiditis, etc. Otherwise known as nevoid acanthosis nigricans, this type is believed to follow an autosomal dominant trait. This type of acanthosis nigricans is rare and is only found in pediatric patients without an underlying pathology. This is again an uncommon type of acanthosis nigricans but may be induced by several medications, including diethylstilbestrol, nicotinic acid, insulin, systemic corticosteroids and pituitary extract. This type is associated with malignancies of the internal organs such as the liver and the stomach or adenocarcinoma of the gastrointestinal area. Mixed type classifies the type of the condition when the patient experiences a combination of the abovementioned classifications. Because the exact cause of acanthosis nigricans is not well determined, for the patient to be given the best treatment possible, it is better to conduct a thorough examination on the patient to determine the type of acanthosis has occurred as well as the underlying cause associated with the condition.
This promotes shedding of hyperkeratotic skin because they modify keratinocyte adhesion, differentiation, and proliferation.
The use of ammonium lactate provides hemuctant effect when applied to the skin as they tend to hydrate the corneal layer of the skin thus decreasing the corneocyte cell cohesion. Complications of acanthosis nigricans may occur; however, it depends on the underlying cause.
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Those who deal with diabetes or heart disease should consume medicines which are suggested by the doctors.
If people who has to drink the medicines is your parents or children, and you can’t be with them every day because you have to go to work, you can assign a nurse to prepare all the medicines, make them drink as being asked, and write it in this form so you can check it after you got back home.
Many people engage in a variety of defenses and excuses when faced with the diagnosis of Type 2 Diabetes.
Whether the patient is diagnosed with Type 1 or Type 2, the health care issues involved are painful and costly.  Peripheral neuropathy is a painful and difficult to treat complication of diabetes.
AstraZeneca’s once-daily tablet is indicated as an adjunct therapy to diet and exercise to improve glycaemic control. Dapagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2) and metformin hydrochloride is a biguanide, which decreases glucose production and improves the body’s response to insulin. As a result, peak sales estimates for the class of drugs have been erratic, with some pegging their potential north of $5 billion and others expecting cumulative revenue more in line with $2 billion a year. Type 2 diabetes is the most common form of diabetes affecting patients globally, and the United States alone has over 23 million people suffering from this condition.
In some cases, pancreas even stops producing insulin and this is quite a dreadful condition and the doctor confirms that you have developed diabetes.
In  this case, glucose directly mixes up with the normal bloodstream rather than getting within body cells and this kind of condition is very much risky and might causes a lot of damages to your body. Increased intake of High-sugar content based foods can be quite riskier and might causes diabetes. You must be physically fit and must leave lethargic habits like watching televisions for hours, sleeping for hours and many more.
Sleeping more than nine hours and less than five hours can be the major reasons that might invite the symptoms of diabetes type 2. It has been found in the medical researches that most of the fellows who are developing this disease after the age of 40.
If you found this useful, please don’t forget to share with your friends and followers at Facebook, Twitter and Google+ etc. Death of cell and tissue may target any part of the body, however, it has been typically observed in the extremities, such as the toes, fingers and hands. In both, type 1 and type 2 diabetes, the raised level of sugar is capable of causing damage to the blood vessels and reducing blood supply.
Owing to the nerve damage, the transmission of sensation, particularly those of pain to the brain gets impaired. A notorious bacterial organism, Clostridium perfringes is often linked with gas gangrene; after it attacks the site of injury or sometimes, surgical wound. You should be aware that whenever you delay the treatment for this skin condition, it becomes severe and symptoms are severe also.
However, there are some individuals who are experiencing this and they age from 10-35 years old.
The only thing is, you need to have it moderately since over doing it will result to sunburn. This provides an entry way for bacteria and other infectious agents into the other layers of tissues below. If you are a diabetic patient, or suffering from hypertension, renal disease, drug addiction, alcoholism, congestive heart failure or rheumatoid arthritis you are at a higher risk to have leg ulcers.
Some leg ulcers that do not heal may require amputation, hence it is necessary to take prevention precautions, especially for diabetic patients. It is a debilitating illness and greatly affects involvement in social activities, therefore their quality of life is often impaired. Local application of ointments mostly of sulfur variety is usually recommended, with large doses of antibiotics for bacterial infection.
Contact us  now if you will like to be informed about the next forum or make an appointment with our doctor for a consultation.
Our clinic always adopts the latest minimally invasive technology to reduce the recovery of our patients. Most often this really needs a blend of drug treatments and some changes in lifestyle changes. They are characterized by dark velvety skin discoloration, which can become thickened and usually smell bad. Also, this skin condition may indicate any malignancies occurring in the internal organs such as stomach or liver cancer. The discoloration is characterized by symmetrical hyperpigmentation commonly found in the armpits, groins, and the posterior neck.


Occasionally, lesions brought about by this skin condition may also occur in the mucous membranes of the oral cavity, nasal and laryngeal mucosa, the esophagus, the areola of the nipple, the eyelids and the conjunctiva, etc.
Its characteristic lesions may appear at any age, but usually it has more effects on the person during adulthood.
The type A syndrome is referred to hyperandrogenemia, insulin resistance, and the syndromic acanthosis nigricans. The skin hyperpigmentation are still commonly seen in dark-skinned individuals such as those who have African descent. They are called unilateral because the lesions are found in unilateral distribution and may become apparent during infancy, childhood, or adulthood. An example would be an obese patient with obesity-related acanthosis nigricans and develops malignant acanthosis at the same time.
The common tests to be done is screening for glycosylated hemoglobin level or glucose tolerance test for diabetes. Retinoids promotes detachment of the hard and cornified cells and thus enhance the shedding of unwanted cells.
Early-onset acanthosis nigricans are considered to be benign in nature, but adult-onset acanthosis nigricans are more serious, especially those cases that are associated with certain malignancies of the gastrointestinal system.
If that’s the case, a medical prescription should be on hand, and perhaps there will be a lot of medication in your medicine chest. Unfortunately, ignoring the information isn’t an answer that will help or resolve anything. Then after a long battle, Eli Lilly and Boehringer Ingelheim finally won approval for empagliflozin.
Continued research and development of new and innovative treatments to combat this ever growing patient population is not only prudent, but also extremely necessary. Low-grade and mild inflation which is being distributed to your body due to fat deposition is the main cause for diabetes. Therefore, diabetic patients are having restrictions in having high-calorie diets, refined beverages and foods and many more.
Keep your body active by doing healthy exercises so that unwanted fat deposition especially at the abdomen area can be prevented. Since genes are automatically transferred from one generation to another therefore you do not have hands in the same and thus you need to take more care and must lead a restricted life. This is because after this age, the immunity power decreases as a result of which the pancreas function is automatically affected. In the absence of a continuous supply of nutrient and oxygen rich blood, the cells within the body begin to fail in carrying out their normal function and finally give up. As a result of restricted blood circulation to the extremities, such as the feet, the area becomes deprived of those cells (white blood cells) which aid in fighting off any infection.
You may have heard of the skin problem rosacea but you are not fully aware what causes it and its symptoms.
This chronic skin problem can cause you to become blind which you definitely don’t want to happen. Ulcers can form in any part of your body where the blood supply is poor and for most people, leg ulcers occur mainly in the lower limb or calf. People in sedentary jobs where they spend long hours in a sitting position are prone to leg ulcers, due to disruption of blood supply.
If you have signs of a deep vein problem, the doctor may do a vascular ultrasound test to examine if there are any evidence of a blood clot.
Should gangrene occur, a stage in which there is greater tissue damage, surgical intervention may be necessary to remove old dead tissues to encourage healing. During the assessment of your deep vein thrombosis, our clinic will conduct a sonography (vascular ultrasound) examination to diagnose for issues in the veins hidden deeper in your legs. Obesity-related acanthosis nigricans is also closely associated with resistance to insulin but not general. The discoloration, however, are present in the dorsal portion of the hands and feet, including the knuckles. In children, malignant acanthosis nigricans is associated with gastric adenocarcinoma, Wilm’s tumor, and osteogenic sarcoma.
In addition, screening for insulin resistance can also be done, and skin biopsy is recommended to examine the affected tissues. Make it a point to educate the patient that prognosis for patients with acanthosis nigricans with malignancies is often poor. If you are having a treatment which requires you to consume a lot of type of medicines routinely, then probably you need to have a medication tracker. Meanwhile, Pfizer and Merck are still working through late-stage trials with the competing ertugliflozin. The level of blood sugar increases as a result of overweight conditions and on the other hand insulation-resistance condition occurs. Swelling and inflammation resulting from the infection causes the local temperature of the area involved to be slightly elevated, and also leads to pain. In most people minor breaks in the skin will heal up without difficulty within a week or two. If your ulcer is due to varicose veins then these may be treated, usually once the ulcer has healed. This can be done onsite during the same consultation as he is able to do the ultrasound personally instead of making another appointment with a technician. In these patients, there is high level of plasma testosterone, thereby leading to hyperandrogenemia.
Although the symptoms of malignant acanthosis nigricans can be similar to the symptoms of other types of acanthosis nigricans, it can still be distinguishable because in malignant type, the lesions appear rapidly, more extensive, symptomatic, and are seen in unusual locations.
Furthermore, patients should be informed that acanthosis nigricans is not a skin disease per se, but it is a sign of an underlying pathology.
Fair skinned people would always complain about this type of skin problem and there are millions of them who are suffering from it. With his ability to do a vascular ultrasound test in the same consultation, our doctor can quickly diagnose and recommend customised procedures to prevent the worsening of the diseases. This allows our doctor to explain the results to you immediately and prescribe a customised treatment for you that is best suited for your body and preferences.
In men, the facial redness normally appears on the nose, although there are symptoms which can appear on other parts of the face. One important example of this is the insulin resistance-associated acanthosis nigricans, which is a sign that the lesions seen outside are just an indication that the patient may be suffering from diabetes. Type medicine names, total dose purchased, consumption period and its frequency in this table.



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