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About Speaking of DiabetesSpeaking of Diabetes is produced by Joslin Diabetes Center for people with diabetes and those who care for them.. Joslin Diabetes Center, a teaching and research affiliate of Harvard Medical School, is a one-of-a-kind institution on the front lines of the world epidemic of diabetes - leading the battle to conquer diabetes in all forms through cutting-edge research and innovative approaches to clinical care and education. This entry was posted in Clinical Research, Diabetes Day2Day, Medications, Research and tagged medications, Type 2 Diabetes.
As we know, diabetes is a progressive disease with glucose control worsening over time due to loss of beta cell function, so figuring out the best way to maintain what beta cell function remains is a key to successfully treating the disease.
The traditional thought has been to add medications in a step-wise fashion when the A1C starts to creep up on the current medication regimen.
The study compared the use of triple therapy treatment to conventional step-wise therapy in 155 participants. Although participants in both treatment arms were able to keep glucose in control, the participants receiving triple therapy did significantly better. The study is small and some researchers found the use of glyburide as one of the drugs in the conventional arm inappropriate (glyburide is associated with more frequent hypoglycemia). Finally, surely our focus should be on 21stC solutions, not just more and more and more of the “diabetes” doom and gloom!
For patients with type 2 diabetes, a new treatment option that's injected just once a week may provide better blood glucose levels as well as other health benefits -- and may actually be easier to remember to take. Bydureon, the brand name of the drug exenatide extended-release for injection, is manufactured by Amylin Pharmaceuticals and the medication received approval from the Food & Drug Administration in January 2012. Bydureon works by helping the body to use insulin more efficiently as well as suppresses appetite. Doing so, he said, helps patients remember to take the medication, rather than forget a dose here and there, which can be common. Bydureon takes six weeks to build up to its full effect in the body, and another six weeks to stop fully working if a patient stops taking it.

According to one study presented in June at the American Diabetes Association's 72nd Scientific Sessions, the annual conference for the professional diabetes community, people who used Bydureon over a period of four years were more likely to have lower A1c readings, fasting blood sugar levels, weight and pulse pressure readings.
Similarly, another study analyzed how effective Bydureon was as compared to taking Levemir insulin once or twice a day. Bydureon's added benefits of weight loss and cardiovascular improvement in addition to better blood sugar control were notable, said Dr. This site complies with the HONcode standard for trustworthy health information: verify here. Canadian diabetic supply store offering discounts on all brands of insulin pump supplies. If you are a Type 1 Diabetic chances are you have heard doctors, nurses, friends and family rave about how fantastic Insulin Pump Therapy would be for you. It’s a question physicians will be pondering as they discuss the results of an ongoing study into how to dose oral medications for people with type 2 diabetes. For example, a person with type 2 diabetes may start by taking metformin, adding a sulfonylureas or a thioglitozone then an incretin such as Victoza® or Bydureon®.
Abdul-Ghani presented were interim (the study has another year to go) but the data looks promising.
They were able to maintain a lower A1C at the two year mark than those using conventional therapy and with less hypoglycemia. And certainly more studies need to be done before doctors throw out a tried-and-true paradigm. Abdul-Ghani, MD, from the University of Texas Health Science Center at San Antonio at the American Diabetes Association 2013 meeting.
Bydureon taken as an injection after the user mixes the medication with a powder and a liquid solution, and should be refrigerated before use.
This was from an analysis of seven clinical studies that included more than 1,700 patients with type 2 diabetes, and researchers were affiliated with both Amylin Pharmaceuticals and Eli Lilly and Company.

That research, conducted over a four-year period, included 176 patients with type 2 diabetes. Type 1 diabetics aren't the only ones using these pumps but type 2 diabetics likewise utilize them to manage their blood glucose levels.
In addition, those on the triple therapy achieved a small amount of weight loss, while participants taking the conventional approach gained weight. However, this study does offer hope that it is possible to slow down the inexorable decline of beta cell function. All materials contained on this site are protected by United States copyright law and may be used for personal, noncommercial use only.
Like other diabetes oral medications, Bydureon is intended to be used along with eating well and regular exercise, as well as other oral diabetes medications as needed, to help manage blood sugar control. They hypothesized that attacking the glucose control problem from more than one angle at once would allow for better, more long-lasting results. Failure of treatment in either arm of the study was an A1C of 6.5 percent on two consecutive clinic visits. The drugs were increased as needed to a maximum of 2000 mg of metformin, 30 mg of pioglitazone , and 10 µg of exenatide.
You may not alter or remove any trademark, copyright or other notice from copies of the content. The conventional group received metformin at 1000 mg increasing to its maximum dose of 2000 per day.

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