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In development for the last 13 years, Invokana employs a “novel mechanism of action” to lower blood sugar in type 2 diabetics, Bloomgarden says. Invokana works by inhibiting sodium glucose co-transporter 2, a carrier that aids in the reabsorption of glucose into the bloodstream through the kidneys, which occurs during the process in which blood is filtered through the kidneys. Because Invokana is such a powerful diuretic, it can help lower a person’s systolic blood pressure, which made some clinical trial subjects feel dizzy and even faint in the first three months while taking the drug.
Additionally, because Invokana blocks absorption of glucose, it could reduce a person’s weight. This method of reducing blood sugar by blocking glucose absorption in the kidneys proved safe and effective through nine clinical trials involving 10,285 participants, according to Janssen Pharmaceuticals. Even though the FDA voted 10 to five to approve Invokana, the jury is still partially out on the drug’s complete safety and the long-term effects of the new class of medication. Even though Invokana is a creative and apparently effective new way of reducing blood sugar, Bloomgarden says that metformin, or Glucophage is, and will most likely remain, the primary drug for treating type 2 diabetes. The FDA said Invokana can be used in conjunction with other drugs, such as metformin, in patients as long as they do not have suffer from any kidney function impairment. Patients won’t have to wait long to get their hands on Invokana if their doctor prescribes it for them. I am taking Invokana alone, as I am allergic to all othet medications for type 2 diabeties it works well keeping my sugars controlled, just have to drink a lot of water, but that is ok. Just started with Invokana about 2 weeks now (taking in addition to other type 2 meds and have seen a considerable drop in blood sugar readings.
After I eat breakfast and take my blood sugar two hours after eating it is actually lower than when I take it first thing in the morning before I take my medications.
I know that the price of this medication is high in cost but I really feel if it works for me which it is my life is more important to me than the money. Have been taking Invokana 100 mg for 4 weeks now and have just started to have cramps and diarrhea every day. I have been on Invokana for 1 week now and have had the best results I have had in 2 years.
I can’t tell how much of my positive result was caused by Invokana and how much to attribute to Weight Watchers.
The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. Despite the epidemic of T2D, leading medical authorities have recently questioned the need for new drugs to treat the disease.
There are still, however, major unmet needs that are not addressed by older antidiabetic agents.
Another incretin mimetic in development, Novo Nordisk’s liraglutide, has also been shown to produce significant weight loss in type 2 diabetics in Phase II clinical trials. After four years, 26 percent fewer people needed to go on diabetes medication in the Mediterranean diet, compared to the low-fat group. So, if you like these foods and think a Mediterranean diet might work for you, that’s great, she said. APPRECIATE IF YOU GIVE A FACEBOOK LIKE or subscribeRSS feed to get new articles in your email. High blood pressure is one of the most common conditions that patients present with in family medical practice.
Recently, new modified guidelines for high blood pressure classification and treatment have been released. 3)  Race is a factor when choosing a type of medication for treatment of high blood pressure in adults under 60 years of age. Also, new guidelines focus on implementing lifestyle interventions such as weight loss, diet and exercise at all times of high blood pressure management regimen. The threshold for normal blood pressure has been increased because there is not enough medical evidence to support that treating mild elevation in blood pressure can significantly reduce risks associated with high blood pressure such as stroke and heart attack. Nevertheless, elevation in the blood pressure increases one’s risk of heart attack, stroke, developing chronic kidney disease, vision loss, as well as, premature death. This morning I was doing my usual search for stories when I came upon this story: Ashley Judd Plastic Surgery? 7.  Because of these side effects, physicians try to use as low a dose, for as short a period of time as possible.
It seems like there is a lesson somewhere in this story: like not jumping to conclusions without having any facts! But Ashley Judd did something very classy when people responded to hearing the correct diagnosis.
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AboutWe are a wife & husband team of physicians who have trained and taught at some of the top medical schools in the country including Harvard, Johns Hopkins and Washington University in St.
Our mission is both a journalistic and educational one: by reporting on common diseases affecting uncommon people, and including the medical facts behind the headlines, we provide a dynamic collection of Teachable Moments in Medicine™ to increase health awareness and medical knowledge. We give you the medical facts behind Hollywood's health headlines plus information that empowers you to achieve your health and wellness goals. Download a printable Immunization Schedule from the CDC and a free Vaccination or Immunization Record template for Microsoft Excel®.
I designed this immunization and vaccination record so that you can keep an electronic record of your immunizations for yourself and each of your children and print it whenever you need to. You should keep a backup copy of your immunization record in paper form in a safe place as well.
Immunization Schedules from cdc.gov - Free printable immunization and vaccination schedules for children of various ages. Printable Immunization Record Cards for Adults, Children, and Lifetime from immunize.org - (Click on the images of the cards to view a printable PDF) You can also order these cards on "rip-proof, smudge-proof, water-proof" paper. You may print and distribute as many paper copies as you want to, as long as you don't make any changes to the form or template.
Disclaimer: The spreadsheet and the information on this page is for general educational use only.
In 2008, the FDA declared that powerful antipsychotics such as AstraZeneca (AZN)’s Seroquel were being over-prescribed and started a monitoring initiative to curb their use. Yet the ISMP found that 47 percent of all adverse events linked to Seroquel since 2004 occurred when the drug was being used for unapproved or “off-label” purposes, such as depression. The report is yet another in a series of publications from a variety of sources that suggest some psychiatric doctors are abusing their patients with Seroquel. Florida’s Department of Juvenile Justice — which houses kids with criminal records — buys twice as much Seroquel as ibuprofen. The military’s spending on Seroquel increased sevenfold since 2001as veterans’ doctors prescribed it for insomnia and post-traumatic stress disorder. Seroquel isn’t approved for children under age 13 but there are plenty of researchers studying it in kids anyway.
Diabetes mellitus, commonly referred to as sugar diabetes, is a growing problem globally largely associated with a more sedentary lifestyle and obesity. Ask a Doctor Online Now!Diabetes mellitus can drastically reduce the quality of life if left untreated and eventually lead to life-threatening complications. Stimulating organs like the liver to convert glucose into its storage form known as glycogen. It is therefore the responsibility of organs like the pancreas to maintain the balance of glucose available in the bloodstream. Complications are the consequences of a disease that is either progressive, left untreated or poorly managed or has existed for a very long period of time.


The complications of diabetes mellitus does not occur overnight – it develops gradually over years and decades. Diabetes mellitus can lead to nerve dysfunction and damage which is known as diabetic neuropathy.. Diabetes mellitus contributes to high blood pressure and hyperlipidemia (increased blood fats) which damages the walls of the blood vessels.
Kidney dysfunction arises as the tiny blood vessels which carries blood to be filtered is damaged and parts of the filtration membranes thicken.
The impaired blood flow and nerve damage associated with diabetes mellitus, as discussed above, impacts the most on the lower limbs. Most cases of gestational diabetes (pregnancy diabetes) are mild and medication is not necessary. The signs and symptoms of untreated diabetes mellitus or poorly managed diabetes mellitus depends on the conditions that arise. Some of the symptoms can be attributed to diabetic complications but cannot be easily differentiated from the clinical presentation of diabetes mellitus itself. Please note that any information or feedback on this website is not intended to replace a consultation with a health care professional and will not constitute a medical diagnosis. Food and Drug Administration means diabetics have a significant new tool for treating the disease, as well as for losing weight and improving their overall health. The excess glucose is then flushed out of the body, which is why Invokana also acts as a “potent diuretic,” Bloomgarden said. It also worked with about the same effectiveness as sitagliptin, or Januvia, which inhibits enzymes and increases pancreatic function, Ren added. For extended periods, however, reducing blood pressure in a population of patients with typically higher than normal blood pressure as a result of their diabetes is a positive side effect. According to Janssen Pharmaceuticals, clinical trials subjects taking the drug experienced a 3 percent weight loss compared to subjects taking a placebo. The most common side effects experienced were vaginal yeast infections and urinary tract infections, according to the company. A drug called dapagliflozin, from Bristol-Myers Squibb and AstraZeneca, that also works as a SGLT2 inhibitor, for instance, was rejected for approval by the FDA in 2012 because of concerns it increased rates of bladder and breast cancers in subjects. However, Invokana can be taken by those already taking metformin and other medications, according to the FDA. According to company spokesperson Christina Holden, Invokana is already being manufactured and field sales agents are already taking order from doctors.
With the prescription she gave me a card to give to the pharmacy, now I get a year for free. I was taking Metformin only, but when it alone wasn’t controlling my glucose level my doctor put me on glimepiride. The worldwide number of diabetics was 30 million in 1985 and is projected to increase to at least 366 million by 2030. In 2006, the ADA and the European Association for the Study of Diabetes (EASD) published a consensus statement on optimal ways to treat T2D using current oral antidiabetics and insulin. Table 1 lists novel and emerging drug classes that may address these needs including several drugs that have been approved since 2005. Despite its related mechanism to incretin mimetics, the DPP-IV inhibitor sitagliptin is only weight neutral and causes no significant weight loss. Dario Giugliano, a professor of endocrinology and metabolic diseases at the Second University of Naples in Italy.
These steroids are similar to hormones that your adrenal glands produce to fight stress associated with illnesses and injuries.
Oral prednisone is spread throughout the body and has the highest potential for side effects. Side effects of inhaled steroids includes coughing, hoarseness, dry mouth, and sore throat.  This can be minimized by gargling with water (and spitting it out) after using an inhaled steroid.
However long term use of inhaled steroids for children with asthma does not prevent them from reaching normal adult height.
After your steroid dose has been decreased or stopped, your adrenal glands may not be functioning at full capacity. I designed the template to allow you to keep an electronic record of immunizations for yourself and your children as well as print a copy whenever you need to.
So, you don't have to worry as much about losing your one-and-only copy of your immunization record. Check with your physician for an exact immunization schedule and to ask any questions related to you or your child's health practices. It hasn’t worked, judging by an analysis of the FDA’s adverse event database by the Institute for Safe Medication Practices. It’s a powerful drug that has serious side effects if taken for a long time: It’s associated with weight gain and diabetes, among other problems. It’s a powerful drug that has serious side effects if taken for a long time: It’s associated with weight gain and diabetes, among other problems. The next largest group was anxiety, and the remainder was divided among many other medical uses including autism, panic attack, headache, restlessness, nervousness, dementia and agitation. The FDA — which has almost no jurisdiction over physicians — and the courts have performed their roles.
Despite it being one of the more common chronic conditions in most populations, there is still widespread ignorance about the serious nature of this disease and the consequences if the condition is left untreated. The presence of diabetes mellitus even when well managed increases the risk of many other serious diseases. The body has several ways of regulating the different levels of various substances in the body. The bloodstream is being constantly monitored throughout the day and should the glucose levels rise too high, the pancreas releases insulin into the bloodstream. The body is in a constant need of energy to fuel all the different process that is constantly occurring including basic life processes like breathing and pumping of blood by the heart. Therefore the effects of untreated diabetes mellitus is actually the complications that arise, usually in the long term. However, severe hyperglycemia (high blood glucose levels) or hypoglycemia (low blood glucose levels) has immediate effects known as diabetic emergencies. The onset of these conditions is largely individualistic meaning that one diabetic may experience certain complications sooner compared to another diabetic.
This may be caused by the narrowing of blood vessels supplying the nerve cells with oxygen and nutrient rich blood. It leads to plaques forming in the blood vessel wall (atherosclerosis) and increases the risk of clots forming in the vessels.
This causes a host of problems in the foot in particular and is therefore known as diabetic foot.
Dietary changes and moderate exercise may be sufficient to manage the diabetes which often resolves after childbirth. Firstly the symptoms of diabetes mellitus itself worsens so it is important to be familiar with these signs and symptoms.
Financial analysts are predicting that the drug will bring in more than $100 million in sales this year and top out at more than $660 million in annual sales by 2016.
I was switched to Invokana after I had a seriously bad reaction with Toujeo ugh it didn’t work for me.
Because I was getting dangerously low readings on the glimepiride, I decided to get a referral to an endocrinologist.
Some researchers believe that weight loss may be an advantage of incretin mimetics over DPP-IV inhibitors, however, it is still too early to definitively make this statement.


This article is based on Diabetes and its Complications: Strategies to Advance Therapy and Optimize R&D, an Insight Pharma report published by Cambridge Healthtech Institute. However, lifestyle changes can help prevent the disease and possibly reverse its course when instigated soon after diagnosis.
Cholesterol levels and blood pressure readings were also more improved in the Mediterranean diet group vs.
Grubb recommended that all people with diabetes work with a dietician to come up with an individualized eating plan that takes into account likes and dislikes.Giugliano said he would recommend the Mediterranean diet for people with type 2 diabetes because in addition to being lower in carbohydrates, the diet seems to have an effect on insulin sensitivity beyond its carbohydrate composition. Therefore, Ashley has been on a heavy dose of medication to overcome it so she could get on a plane and travel to Toronto and New York to fulfill her commitment of completing four consecutive days of press to promote her new show Missing.
If you have a serious illness, surgery or injury, your body may not be able to handle this additional stress, and you may require a short steroid burst.
It’s time for the medical profession to take responsibility for the damage it is causing and cut down on its dispensing of Seroquel. Since diabetes is largely asymptomatic in the early stages and eventually presents with several mild symptoms, there is a misconception that it is not a dangerous condition.
The most severe complications in diabetes is seen in long term cases that are poorly controlled but there are several diabetic emergencies that can suddenly arise which can be equally as dangerous even in a person who has been diabetic for just a short period of time. This is largely controlled by the endocrine system – hormones that are secreted from different glands. This means that pancreas is either not producing enough insulin (insulin deficiency) or that all the cells in the body are not responding as it normally should to insulin (insulin resistance). Even a person who has well managed diabetes mellitus is at risk of developing these complications. The main organs and structures that are affected are the eyes, nerves, kidneys, blood vessels and heart. High quantities of glucose within the nerve cells affects the normal processes responsible for nerve function. This can progress to a stroke or heart attack (myocardial infarction) as the blood supply to the brain and heart is compromised respectively. Injury to the foot is often the trigger event that then progresses to more severe complications as a result of poor wound healing and weakened immune activity.
My doctor put me on Invokana and also gave me a card so I can get a year’s free supply. The latter two drugs were rejected because of their expense, their lesser efficacy in lowering plasma glycosylated hemoglobin (HbA1c, a measure of long-term glycemic control) than the older drugs, and the lack of experience in using the newer drugs in the medical community.
Among the drugs listed in Table 1, pramlintide, an amylin mimetic that is approved for diabetics who use mealtime insulin, promotes satiety and thus reduces average caloric intake and can prevent weight gain. Animal studies indicate that both incretin mimetics and DPP-IV inhibitors may preserve beta-cell function, which addresses the other major unmet need.
Regular exercise and changes in diet are among the most important lifestyle changes that can help manage type 2 diabetes.
Also, all diagnosed patients were initiated on the same medication, without regard to the race, once elevation of blood pressure was noted on three separate occasions. At the physical share the results with the medical provider to determine the necessity of medication.
It damages cells in the body in various ways and by doing so it leads to several other diseases in the long term or increases the risk of developing certain diseases.
Eventually the blood glucose levels are at a higher level than is the norm (hyperglycemia) and damages different parts of the body over months and years. Should medication not be commenced in diabetes mellitus or used as prescribed, and if a person does not undertake dietary changes and start exercising, the blood glucose levels are out of control. However, these emergencies are more likely to arise in a person with poorly managed diabetes mellitus or with incorrect use of diabetes medication. The narrowed arteries and weakened veins especially to the legs leads to sluggish circulation with a host of problems that subsequently develops in the legs and feet.
Increased rates of obesity coupled with an aging population are the major drivers of the T2D epidemic, especially in the U.S. Progression of T2D is mainly due to the loss of pancreatic beta-cell function, which results in increased impairment of patient’s ability to produce insulin in response to increased blood glucose. The recently approved drug exenatide, an incretin mimetic, has been used together with metformin or a sulfonylurea to both meet glycemic goals (HbA1c less than 7%) and to give significant weight loss. However, it is not yet known if these drugs mediate beta-cell protection or regeneration in humans. She was a medical internet pioneer having established one of the first medical practice websites in 1997. While the pancreas produces and secretes digestive enzymes into the gut, it also has a crucial role to play in producing and secreting the hormones that control the blood sugar levels. It tends to remain high most of the time with episodes of very low blood glucose levels (hypoglycemia). Now if I check right after I eat, I might see like 250~300 but if I eat and wait like 2 hours and check, its back down in the 150 range normally.
Incretins such as glucagon-like protein-1 are gut-derived hormones that promote insulin secretion by beta cells in response to intake of food. The Phase III antidiabetic agent, rimonabant, Sanofi-Aventis’ Acomplia, is a cannabinoid-1 (CB1) receptor antagonist. Both hyperglycemia and hypoglycemia have serious consequences and can lead to life-threatening complications in the short and long term.
Looking to to me so far other than I’ve gotten dizzy a few times for a couple seconds and I checked, my sugars were not too low.
Most of the mortality and morbidity as well as the economic costs of diabetes are due to diabetic complications. Of the established drugs for treating type 2 diabetes, insulin, sulfonylureas, and TZDs cause weight gain. Invokana has certainly helped and I will continue to take it until I no longer need it for control. However, the use of rimonabant for treatment of obesity or T2D is under a cloud, due to the incidence of depression and suicides associated with use of the drug.
The Phase II results in obesity with taranabant are encouraging, but the determination of the efficacy and safety profile of this drug must await the completion of the Phase III trial.
As illustrated by Table 2, a major theme of the early-stage drug discovery and development efforts in T2D is developing agents that potentially target both Type 2 diabetes and obesity. They are attempting to address common pathways of both diabetes and obesity, for example, targeting sirtuins and adenosine monophosphate-activated protein kinase, which takes addressing this unmet need one step further than what current agents such as incretin mimetics and DPP-IV inhibitors do.
In addition, at least one type of early-stage program listed in Table 2, development of sirtuin modulators, has the potential for resulting in agents that may slow or reverse declines in beta-cell function in type 2 diabetes.
Thus there are early-stage programs that are designed to address this major unmet need as well. There is a need for novel drugs in T2D, provided that they address major unmet needs in the disease, such as halting disease progression and mediating weight loss. Drug developers have already produced several drugs that may address these needs and they are at work to develop other drugs that are designed to do so.



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