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Arnab De, an Indian scientist in UShas developed a potential non-insulin drug candidate for diabetic patients.
A young Indian scientist has developed a potential non-insulin drug candidate for diabetic patients that can help eliminate the risk of low-blood glucose shock in case of an insulin overdose.
Distractions are a part of daily living, but when they happen with a medication like insulin (and it will), the stakes are high.
Mistakes happen, just as you will likely lock your keys in the car at some point — you will also take your insulin twice or give yourself or your child the wrong kind of insulin.
Miscalculations - These can occur with faulty carbohydrate ratios, math errors or simply entering the wrong data into a pump. Giving the wrong insulin - Check your bottles more than once before you give it; nurses have a three-check system in the hospital. Visual issues - Syringes are small and difficult to see, using assistive devices can prevent errors. Because we are all prone to mistakes as human beings, no one is exempt — including doctors, nurse practitioners, physician assistants, pharmacists, nurses and anyone that is involved in your care.
According to Diabetes Health, a study of state hospitals by the Pennsylvania Patient Safety Authority revealed that 20 percent of patients are actually dispensed the wrong kind of insulin — shocking, but true. Insulin is labeled as a "high-risk" medication in which many hospitals have standards that two nurses are required to check the dose prior to its administration. A company called Common Sensing has one of the best products I've seen for tracking insulin doses via an insulin pen: the GoCap. If you're taking pills to manage Type 2 diabetes, technology called a "smart pill bottle" by Adhere Tech may stop double pill dosing issues.
Utilize 911 or consult your healthcare team immediately for immediate assistance or guidance through the recovery period that follows an insulin or pill overdose. Picture of Insulin pen, compact case, disposable needles, close-up stock photo, images and stock photography.. Insulin is a hormone produced by your pancreas whose primary function is to lower blood sugar. Der GeschA¤ftsbereich Digital Pen wurde durch eine eigene entwickelte Software erweitert.
Hollywood actor stars in documentary for online design site to remodel his childhood home as a gift for his mother. Ashton Kutcher has upped his role from an investor in online home design website, Houzz, to being the new face of the Israeli-created company.
The 37-year-old Kutcher can now be seen in short video clips all over social media, talking about his decision to use Houzz to remodel his childhood home. Kutcher explains how he helped build his childhood home in Iowa with his stepfather, Mark Portwood, when he was just 13.
Kutcher, with the help of Portwood, created an ideabook on Houzz, found a local interior designer in Iowa to implement the ideas, and bought nearly all the new furnisher through the Houzz shop.
Viva Sarah Press reports on the creativity, innovation and ingenuity taking place in Israel. Type 1 diabetes mellitus All people with Type 1 diabetes should receive signs of hyperglycemia in type 2 diabetes lowell massachusetts professional lifestyle advice. We are going to pick up our series on depression symptoms with a discussion about feeling emotionally numb.
Given the increased focus on disability in type 2 diabetes evident in the recent literature more treatment trials 2009. Care guide for Diabetic Ketoacidosis In Children possible causes signs and symptoms standard treatment options and means of care and support.
Is natural stevia better than controversial artificial sweeteners, which have been linked to serious health concerns?
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Errors such as giving insulin twice, giving 10 units instead of 1.0 units, or selecting and giving the wrong kind of insulin occur — and with some regularity.
Insulin pens are similar to syringes but definitely have a learning curve and require more education for the user. A replacement cap transmits dose information via Bluetooth technology to a mobile device for self tracking. Always be sure to have glucagon on hand for severe low blood sugars and be sure to train important people in your life on administering it. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Insulin is necessary for the body to function, and often people put off using it because of the fear and myths associated with insulin use. Some with type 2 also depend on this hormone to regulate their skyrocketing blood sugar levels. It does this by binding to insulin receptors on the cell wall which open glucose transporters. He says his mother had long wanted to convert the basement into a lighter, airier space and as such he decided to do it for her as a surprise thank you gift.


Her work has been published by international media outlets including Israel Television, CNN, Reuters, Time Out and The Jerusalem Post.
According to the American Diabetes Association (ADA) about complications high blood sugar surgery north dakota fargo 90-95 percent of all diabetes cases are type 2. For about 15 years I have In ype 1 diabetes in which insulin must be injected many of the complications of the blood sugar highs and lows can be minimized and lower doses of insulin can be used if the proper diabetic diet is followed and blood sugar control is maintained. It seems that while there are studies supporting the effectiveness of stevia in weight management and diabetic diet, there is also research available to negate its safety. It's incredibly easy to check yourself on insulin doses given in the pump history, something old-school syringes lack. The beauty of this product is found in the information flow — it requires little patient engagement.
Putting off insulin use because of fear or misinformation can be detrimental to diabetes control. Once the glucose transporters are opened by the action of insulin, glucose can flow freely from the blood into the cell. Type 1 1 2 Diabetes Diagnosis California Long Beach management of diabetic retinopathy: a systematic review.
Insulin treatment has also been reported to cause weight-gain that may exacerbate a diabetic condition, De said.
There are great safety mechanisms to activate on insulin pumps — be sure you are using them. MODEL Clinical Research located on the campus of Greater Baltimore Medical Center conducts clinical trials in type 1 and type 2 diabetes hypertension osteoporosis lipids cardiovascular diseases neurology renal diseases and diabetes treatment ppt slides saint paul minnesota obesity. My six-year-old son ran a fever for two days with no other symptoms except for a very mild headache and a little fatigue.
Insulin injections were inconvenient and the hypoglycemia induced by insulin-overdose could be fatal. Or, it can be delivered utilizing an insulin pen which is actually a cartridge pre-filled with the medication. Randomized Basal Bolus versus Sliding Scale Regular Insulin in patients with type 2 Diabetes Mellitus(RABBIT-2 Trial). Sulfonylurea drugs were administered orally, however, do not typically provide satisfactory control of blood glucose as a starting treatment in 25% - 30% patients.
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Therefore, it was imperative to develop a method for the control of human and animal diabetes mellitus. Recently, insulin gene transferred and expressed in non-pancreatic cells as a means for the treatment of diabetes was developed rapidly in the expanding gene therapy. Retrovirus, lentivirus, adenovirus, adenoassociated virus and herpes simplex had been used as viral vectors, and the constructed viral-insulin gene was successfully transferred into diabetic rat cells. If you are concerned about pre diabetes you can change your eating habits now to cut your risk. A gene, containing promoter, enhancer and rat type I insulin gene (a-chain, b-chain and signal peptide), was constructed into a retrovirus vector in the study.
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The insulin concentration for the viral vector containing enhancer and promoter of rat insulin gene was higher than the vector containing only insulin gene by a 61% increase in the cultured mouse fibroblast cells. The enhancer and promoter activity of rat insulin gene would be an important determinant for the expression of insulin gene. There is a huge market for such a therapeutic in India given the growing number of patients," Mozumdar said.
Blood glouse decreased sig- nificantly for at last 10 days demonstrated that transfection, direction injection of viral-insulin gene into pancreas of diabetic rat, was successful. These studies suggest that the retrovirus vector might be used to transfer the insulin gene in vitro and in vivo. These individuals are three times more prone to heart attacks or stroke and five times more likely to develop adult-onset of diabetes vis-a-vis individuals without the syndrome. INTRODUCTIONHuman type I diabetes mellitus caused by the lack of insulin secretion secondary to the autoimmune destruction of pancreatic cells was usually treated by multiple injections of insulin [1,2].
Evidence also existed for a genetic basis and altered immune response in the pathogenesis of canine diabetes. In addition, at least 50% of diabetic dogs were type ? diabetes based on the present evidence of immune destruction in beta-cells [3]. As a consequence, diabetic patients (including human and animal) experienced profound metabolic derangements (hyperglycemia, ketosis, and hyperlipemia) and developed vascular and neurological chronic complications. In type II diabetes mellitus, patients have functional cells, but these cells respond poorly to the stimulation of glucose.
Therefore, the patients were treated with a dietary treatment supplemented with either a sulfonylurea drug or insulin injection to control type II diabetes mellitus.


However, the insulin injections were inconvenient and the hypoglycemia induced by insulin-overdose would be fatal. Sulfonylurea drugs were administered orally; however, sulfonylurea drugs typically did not provide satisfactory control of blood glucose as a starting treatment in 25% - 30% patients [4]. Therefore, it is imperative to develop a new method for the control of human and animal diabetes mellitus. The use of rat in diabetes study is the most common mode as well as the one of the most feasible way. In addition, the molecular structure of the rat insulin is very similar to human and dog insulin molecular structure, both posed by the a-chain and b-chain.
However, the thirtieth amino acid of the b chain in human, rat and dog are serine, threonine and alanine, respectively [5]. Recently, gene therapy has been rapidly expanding; insulin gene was transferred and expressed in non-pancreatic cells as a means for treating diabetes. Retrovirus, lentivirus, adenovirus, adenoassociated virus and herpes simplex had been used as a viral vector [6-9], the constructed viral-insulin gene was successfully transferred into diabetic rat cells [10-12], and the treatment temporarily decreased blood glucose concentration.2. Isolation of Pancreatic IsletFive male Sprague-Dawley (SD) rats were anesthetized with pentobarbital sodium. Following a midline incision, the bile duct was cannulated with a polyvinyl tubing (0.625 mm, id) and injected with 15 - 20 ml of KrebsRinger bicarbonate (KRB) buffer. The pancreas tissues were cut into fine pieces, approximately 1 - 2 mm, and then digested with collagenase.
Transferring Retrovirus VectorPackaging cells (mouse fibroblast cells), Packaging cells, mouse fibroblast cells, were cultured on a 60 mm plate for 12 - 24 hours, and then transferred with 10 ?g plasmid DNA. After 24 hours, the culture medium was discarded and the transferred cells were washed with PBS. The Determination of Insulin ConcentrationThe expressed insulin concentrations were determined by using radioimmunoassay (RIA) as previously described by Hale and Randle in 1963.
The samplings had been made from the tail vein and measurements of the blood glucose were made with Accu-Chek Go (Roche). Data Statistical AnalysisData were analyzed by using analysis of variance (ANOVA) to determine the significance of treatment and time.3. RESULTSIn this study, we constructed a gene containing rat type I insulin gene promoter, enhancer and insulin gene (achain, b-chain and signal peptide) into a retrovirus vector (Figures 1-3).
The 3-day cultured mouse fibroblast cells were homogenized, and then the insulin concentration was determined by using RIA. The insulin concentration for the viral vector containing enhancer and promoter of rat insulin gene was 61% higher than the vector containing only insulin gene. The activity of rat insulin enhancer and promoter gene would be an important determinant for the expression of insulin gene.The constructed viral-insulin gene was transferred into rat pancreas, and the blood glucose concentrations were monitored to determine the effect of gene therapy in diabetic rats induced by STZ.
The rat insulin gene a-chain, b-chain and signal peptide gene were inserted into pLNCI2 plasmid.Figure 2.
The rat insulin gene enhancer, promoter, a-chain, b-chain and signal peptide gene were inserted into pLNCP2 plasmid.was producing physiologically significant levels of insulin. The blood glucose concentration in pLNCP2 transferred rats had fallen to within the normal range by 9 days after transfection. One to ten days transfection, blood glucose in the pLNCP2 injected diabetic rats lower than that in the pLNCI2 injected diabetic rats (Figure 4).4. DISCUSSIONDiabetes was one of the important and serious human diseases, and was the fifth of the ten leading causes of death in Taiwan. In addition, diabetes was also closely related to the cerebrovascular disease, cardiovascular disease, and hypertension [13]. Blood glucose concentration in diabetic rats, assessed as a function of time (1 to 10 days) after transfection with pLNCP2 and pLNCI2 (transferred in mouse fibroblast cells) injected diabetic rat pancreas.
Values were expressed as mean ± SE (n = 5).hypoglycemic agents have been mainly used for the treatments of diabetes. However, the injections of insulin are inconvenient and insulin overdose-induced hypoglycemia could be fatal, and the oral of sulfonylurea treatment typically do not provide satisfactory control of blood glucose.Recently, due to the development in molecular biology, there are more in-depth understanding of the etiology and pathogenesis of diabetes, and new therapeutic method developed for the treatment of diabetes. Therefore, there are more researches trying to get through biotechnology to treat diabetes by using the viral vectors performance of insulin genetic in eukaryotic cells to proliferate insulin out in vivo [4,10,14]. Hopefully, there is no longer need the long-term insulin injections and also achieve the therapeutic effect. It should be emphasized that, the release of insulin by the insulin gene transferred did not regulate by glucose in the present study. In addition, the pancreas of diabetic rat transferred with insulin gene will be perfused with glucose and determine the insulin concentrations to evaluate the effect of insulin gene therapy. Proceedings of the National Academy of Sciences of the United States of America, 92, 3293-3297.



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