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WARNING: The Bolus Wizard does NOT account for manual injections, and could prompt delivery of more insulin than needed when used in conjunction with manual injections. Which of these charts shows the patient's glucose levels when the Bolus Wizard® was turned on?
Apart from the Bolus Wizard, all other pump settings were the same for both sets of blood glucose readings.
Is the increased total mortality and sudden death risk associated with the intensive glycemic treatment strategy (ACCORD – VADT) linked to hypoglycemia ? Although metformin is first-line therapy for patients with type 2 diabetes, glycemic control fails with metformin alone in many patients. 4 Relation between PPG control & Achieving A1C Goal Adapted from Monnier L, Lapinski H, Collette C.
Every 1% drop in HbA 1c can reduce long-term diabetes complications 43% Lower extremity amputation or fatal peripheral vascular disease 37% Microvascular disease 19% Cataract extraction 14% Myocardial infarction 16% Heart failure 12% Stroke UKPDS: Stratton et al. Hormone BloodTissue Injection site Carrier Protein Carrier Protein Hormone Receptor Mode of Action Use of Serum Carrier Protein (e.g.


Insulin analogues compared Insulin receptor affinity IGF-1R affinity Insulin receptor off rate Metabolic potency Mitogenic potency Human insulin =100 Insulin aspart 92 ± 681 ± 981 ± 8101 ± 258 ± 22 Insulin detemir 18 ± 316 ± 1204 ± 92711 Kurtzhals P, et al. Insulin analogues compared Insulin receptor affinity IGF-1R affinity Insulin receptor off rate Metabolic potency Mitogenic potency Human insulin =100 Insulin aspart 92 ± 681 ± 981 ± 8101 ± 258 ± 22 Insulin lispro 84 ± 6156 ± 16100 ± 1182 ± 366 ± 10 Insulin glargine 86 ± 3641 ± 51152 ± 1360 ± 3783 ± 13 Insulin detemir 18 ± 316 ± 1204 ± 92711 Kurtzhals P, et al. Summary Treatment with basal analogues enables patients to reach HbA 1c target with low rate of hypoglycaemia HbA 1c improves but some patients need more Levemir® + OD is associated with: –reduced hypoglycemia in comparison to NPH, and –reduced weight gain in comparison to any other basal insulin.
As a registered member, you’ll also be notified of online events that let you hear from distinguished colleagues and participate in important discussions that can help patient outcomes and improve implementation of Medtronic therapies in your practice. Comparison of the effects of continuous subcutaneous insulin infusion (CSII) and NPH-based multiple daily insulin injections (MDI) on glycaemic control and quality of life: results of the 5-nations trial. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. A bolus calculator is an effective means of controlling postprandial glycemia in patients on insulin pump therapy.
Characteristics of basal insulin requirements by age and gender in type-1 diabetes patients using insulin pump therapy.


Bernard Charbonell (University of Nantes, France) discussed new options in diabetes management. An open-label randomized controlled trial was conducted, which compared add-on exenatide with add-on glimepiride in patients who had failed to achieve glycemic control with metformin alone. We recognised that there was underlying moderate-severe insulin resistance affecting muscle and the liver, and this, coupled with beta cell failure, formed the classical triumvirate (1).
Contributions of fasting and postprandial plasnma glucose increments to the overall diurnal hyper glycemia of Type 2 diabetic patients: variations with increasing levels of HBA(1c). The insulin resistance in muscle primarily was responsible for the excessive postprandially rise in plasma glucose concentration, while insulin resistance in the liver, in combination with accelerated gluconeogenesis, resulted in an excessive rate of hepatic glucose production which led to an increase in the fasting plasma glucose concentration (2-4).
Hala Aly Gamal El Din Professor Of internal medicine Faculty of Medicine - Cairo University.



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