Glp-1 decrease type 2 diabetes nieuws,jan van gentstraat gent,treatment of gestational diabetes australia,best time to exercise for type 2 diabetes - PDF Review

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Models of human error can be helpful inA determining why errors have occurred in the past, where future vulnerabilities may lie, and how healthcare professionals might take action to make clinical practice safer.
We have mapped many of our learning resources to the RPS Faculty's Advanced Practice Framework and Foundation programme.
Disclosing clinical trial data is a step in the right direction towards transparency, which benefits both the public and the pharmaceutical industry. As a pharmacist working for an international charity, Owen Wood shares his knowledge ofA mass vaccination and medicines procurement. Have your sayFor commenting, please login or register as a user and agree to our Community Guidelines. As blood glucose concentrations decrease, insulin secretion subsides.When exenatide was used in combination with metformin alone, no increase in the incidence of hypoglycaemia was observed over that of placebo in combination with metformin, which may be due to this glucose-dependent insulinotropic mechanism. Exenatide suppresses glucagon secretion, which is known to be inappropriately elevated in type 2 diabetes. Lower glucagon concentrations lead to decreased hepatic glucose output.However, exenatide does not impair the normal glucagon response and other hormone responses to hypoglycaemia.
It should be started at a dose of 5Aµg, administered twice daily, for at least one month to improve tolerability.The dose can then be increased to 10Aµg twice daily to improve glycaemic control further.
Doses higher than 10Aµg twice daily are not recommended.3Original guidance from the National Institute for Health and Clinical Excellence4 did not recommend exenatide for routine use but did allow it as an option if certain criteria were met. Three key large-scale placebo-controlled trials considered the safety and efficacy of long-term (30 weeks) exenatide.


They were conducted in patients with type 2 diabetes who were unable to achieve adequate glycaemic control with maximally effective doses of metformin, sulphonylurea, or metformin and sulphonylurea.2,7,8 A All three studies demonstrated significant improvements from baseline versus placebo in both glycaemic control and body weight. With the 10Aµg dose, a mean reduction in HbA1c of 0.8% was observed across the three studies. In patients treated with 5Aµg or 10Aµg exenatide, generally 40a€“50% reported at least one episode of nausea. With continued therapy, the frequency and severity decreased in most patients who initially experienced nausea.In studies of patients treated with exenatide and a sulphonylurea (with or without metformin), the incidence of hypoglycaemia was increased, compared with placebo, and appeared to be dependent on the doses of both exenatide and the sulphonylurea. To reduce the risk of hypoglycaemia, a reduction in the dose of sulphonylurea should be considered.There have been rare reports of acute pancreatitis.
Therefore, exenatide should not be used for patients who have severe renal impairment.There are no adequate data from the use of exenatide in pregnant women. Studies in animals have shown reproductive toxicity although the potential risk for humans is unknown. A recent trial12 has shown that exenatide in combination with insulin is associated with significant reductions in HbA1c and weight after one year of therapy.
There was also shown to be no increased risk of hypoglycaemia and similar reductions in body weight. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes.
Drug advice: Exenatide, 5 or 10 micrograms, solution for injection, prefilled pen (Byetta). Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.


Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Long-term effects of exenatide therapy over 82-weeks on glycaemic control and eight in over-weight metformin treated patients with type 2 diabetes mellitus.
Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin? Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus.
Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU).
Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study.
Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial.



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    29.03.2015

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    29.03.2015

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    29.03.2015