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Tanzeum (albiglutide), developed by GlaxoSmithKline (GSK), is a GLP-1 receptor agonist indicated for treatment of type 2 diabetes.
Tanzeum's mechanism of actionTanzeum contains Glucagon-like peptide-1 (GLP-1) receptor agonist, which is a recombinant protein made by combining two tandem copies of modified human GLP-1 genetically merged in tandem with human albumin. The symptoms of type 2 diabetes include frequent urination, constant appetite and excess thirst.
In recognition of November as Diabetes Month and the rising costs of diabetes medications around the globe, we’ve put a report together on type 2 diabetes drug treatments.
Drugs such as Januvia and Onglyza belong to the newest class of diabetes pills called DDP-4 inhibitors, aka gliptins. The downside of gliptins is that studies on their side effects are still vague and inconclusive. Glucotrol, glipizide, Amaryl, Diabeta and glimepiride are all diabetes pills belonging to a class of drugs called sulfonylureas.
Get your Prescription Discount Card and automatically SAVE on over 50,000 drugs nationwide. We negotiate lower prices on prescription medications, that we pass on to our members for free. Trulicity (dulaglutide) is a once-weekly glucagon-like peptide-1 (GLP-1) agonist for the management of type II diabetes. Trulicity is licensed for the treatment of type II diabetes when diet and exercise provide inadequate glycaemic control.
The safety and efficacy of dulaglutide were evaluated in six randomised, controlled, phase III trials involving 5,171 patients with type II diabetes. Another study compared dulaglutide 1.5mg and 750 microgram with sitagliptin 100mg daily in metformin-treated patients with inadequate glycaemic control.
Dulaglutide was compared with insulin glargine in patients receiving metformin and a sulfonylurea. Patients were randomised to dulaglutide once weekly or insulin glargine once daily, both in combination with prandial insulin lispro three times daily, with or without metformin.
Higher rates of symptomatic hypoglycaemia were observed when dulaglutide was given in combination with a sulfonylurea plus metformin or prandial insulin.
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Basal, or background insulin, is typically taken once daily to cover the liver’s secretion of glucose into the bloodstream.

This medicine should not be used in people under 18 or to treat diabetic ketoacidosis (a potentially life-threatening condition marked by a chemical imbalance in the body).
Toujeo is expected to debut in the United States in April 2015 and will be available in the Toujeo SoloSTAR, a prefilled, disposable pen containing 450 units of the medicine. For more information about Toujeo, see the press release on Sanofi’s website or visit the official Toujeo website. Disclaimer of Medical Advice: You understand that the blog posts and comments to such blog posts (whether posted by us, our agents or bloggers, or by users) do not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs. My insurance covers it, shockingly, and because my deductible is met it doesn’t cost me anything… Thank heavens!! GSK received approval for Tanzeum from the US Food and Drug Administration (FDA) as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in April 2014.Albiglutide received marketing authorisation from the European Medicines Agency (EMA) for treatment of type 2 diabetes in adult patients in March 2014. Ninety percent of diabetes cases are classified as type 2 diabetes, and over 370 million people worldwide are diagnosed with this illness.
It improves glycaemic control by lowering fasting, pre-meal and postprandial glucose concentrations. Dulaglutide 1.5mg was superior to insulin glargine in lowering HbA1c at week 52 and the benefit was maintained until trial end (78 weeks).
Toujeo has the same active ingredient as Lantus, but it is three times the concentration and is designed to release more gradually. The most common side effects of Toujeo (apart from hypoglycemia) are nasopharyngitis (inflammation of the nose and pharynx) and upper respiratory tract infection. The opinions and other information contained in the blog posts and comments do not reflect the opinions or positions of the Site Proprietor. Even though patient could eat pork without problem the longer they used porcine insulin the more sensitive they got.
It is available in 50mg dose that can be administered through injection for subcutaneous (SC) use.Clinical trials of TanzeumFDA approval for Tanzeum was based on results obtained from comprehensive Phase III study known as Harmony programme that consisted of eight clinical trials, which enrolled more than 5,000 patients and treated more than 2,000 of them with Tanzeum. When it comes to diabetes medications, reports and studies suggest that a higher price does NOT equate with a safer, more effective drug. Not all functions of the enzyme are understood, but it appears to be a suppressor of cancer cells and tumors. First-generation sulfonylureas have been used as a type 2 diabetes treatment since the 1950s.
In a series of international studies involving more than 3,500 adults with Type 1 and Type 2 diabetes, Toujeo produced similar blood glucose control to Lantus, but with lower rates of hypoglycemia (low blood glucose).

The symptoms of the disease include frequent urination, constant appetite and excess thirst. In fact, generic diabetes drugs that have been around for many years are proven to be more effective in controlling blood sugar levels.
Studies are still being done to determine if cancer or tumor growth is a side effect from long-term use of DDP-4 inhibitors. The main side effects from taking biguanides include gastrointestinal problems such as diarrhea, nausea and flatulence. The patients were randomised to receive Tanzeum 30mg SC once weekly, Tanzeum 30mg SC once weekly uptitrated to 50mg once weekly at Week 12, or placebo.The study results demonstrated that the patients who were treated with Tanzeum 30mg or 50mg showed statistically significant reductions in HbA1c from baseline at Week 52.
By inhibiting DDP-4, incretins are allowed to increase insulin production while secretion of glucagon is simultaneously decreased in the pancreas. Medications like Januvia and Onglyza are also expensive compared to older drugs, and can cost around $300 for a month’s supply. They are also not recommended for patients with kidney problems or heart failure due to lactic acid build up. Side effects include upset stomach, weight gain on average between 5 and 10 pounds as well as an increased risk for hypoglycemia. When referencing information that is not based on personal experience, please provide links to your sources. Other medications available for the treatment of type 2 diabetes include Forxiga (dapagliflozin) developed by AstraZeneca and Bristol-Myers Squibb, and Invokana (canagliflozin) manufactured by Janssen Pharmaceuticals and Mitsubishi Tanabe Pharma Corporation. Sulfonylureas may not work for everyone and are sometimes combined with biguanides like metformin for greater efficacy. All commenters are considered to be nonmedical professionals unless explicitly stated otherwise.
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