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Drug-induced liver disease: Drug-induced liver diseases are diseases of the liver that are caused by physician-prescribed medications, over-the-counter medications, vitamins, hormones, herbs, illicit ("recreational") drugs, and environmental toxins. Sun-Sensitive Drugs (Photosensitivity to Drugs) Symptoms, Treatment, Causes - What is ultraviolet light?
View pictures of the most prevalent adult skin diseases such as eczema, shingles, psoriasis, rosacea and more.
What types of treatment, including other medications, did you receive after experiencing a sun-sensitive drug reaction? The Surgeon General's report on oral health highlights the relationship between oral and overall health, emphasizing that oral health involves more than dentition.1 Physicians regularly encounter oral health issues in practice.
Fluconazole mouth-rinses for oral candidiasis in postirradiation, transplant, and other patients.
A systematic review of the effectiveness of antifungal drugs for the prevention and treatment of oropharyngeal candidiasis in HIV-positive patients.
High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials. A double-blind study of topically applied 5% amlexanox in the treatment of aphthous ulcers. Thalidomide as therapy for human immunodeficiency virus-related oral ulcers: a double-blind placebo-controlled clinical trial. Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program. Comparison of fluconazole and nystatin oral suspensions for treatments of oral candidiasis in infants. Treatment of oropharyngeal candidiasis and candidal diaper dermatitis in neonates and infants: review and reappraisal. A double-blind, placebo-controlled trial of continuous acyclovir therapy in recurrent erythema multiforme.
A controlled clinical trial of the efficacy of topically applied fluocinonide in the treatment of recurrent aphthous ulceration.
The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients.


Learn about each skin condition, its diagnosis, symptoms, and treatment through doctor reviewed medical images of the most common skin problems.
Recognition and diagnosis require taking a thorough history and performing a complete oral examination. A minority of persons develop a symptomatic primary infection, presenting with an acute outbreak of oral vesicles that rapidly collapse to form zones of erythema and ulceration. A common oral inflammatory condition of unknown etiology, it has an estimated prevalence of 1 to 3 percent. This condition results from inadequate desquamation or increased keratinization of the papillae. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Examples include pain-relievers such as acetaminophen and nonsteroidal antiinflammatory drugs (NSAIDs), certain antibiotics, antidepressants, anti-cancer agents, and drugs used in controlling high blood pressure, high cholesterol , diabetes, and irregular heart rhythms. Drug-induced liver diseases vary widely in severity. Knowledge of clinical characteristics such as size, location, surface morphology, color, pain, and duration is helpful in establishing a diagnosis. In all cases, the gingiva is involved; in addition, other oral mucosal sites and the perioral skin may be affected.
The reticular form can appear as bilateral asymptomatic, white, lacy striations (Wickham's striae) or papules on the posterior buccal mucosa (Figure 8). This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.
The spectrum of diseases include 1) abnormal blood levels of liver enzymes without symptoms, 2) hepatitis (inflammation of liver cells), 3) necrosis (death of liver cells), 4) steatosis (accumulation of fat in the liver), 5) cirrhosis (advanced scarring of the liver), 6) fulminant hepatitis (severe, life-threatening liver failure), and 7) blood clots of the veins within the liver. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. Oral candidiasis may present as pseudomembranous candidiasis, glossitis, or perlA?che (angular cheilitis). Tongue lesions exhibit central erythema caused by atrophy of the filiform papillae and usually are surrounded by slightly elevated, curving, white-to-yellow borders (Figure 6). The erosive form manifests as zones of tender erythema and painful ulcers surrounded by peripheral white, radiating striae (Figure 9A).
Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO.


She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Oral candidiasis is common in infants, but in adults it may signify immune deficiency or other illness. Patients with more serious disease (such as hepatitis and necrosis) develop symptoms and signs such as fatigue, weakness, vague abdominal pain, loss of appetite, yellowing of the skin or jaundice due to the accumulation of bilirubin in the blood, itching, and easy bruising due to decreased production of blood clotting factors by the diseased liver. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey. Commonly used therapies include topical corticosteroids, such as fluocinonide gel (Lidex) and triamcinolone acetonide with carboxymethylcellulose paste (Kenalog in Orabase). Patients with advanced cirrhosis can develop fluid accumulation in the legs (edema) and abdomen (ascites), mental confusion or coma, kidney failure, vulnerability to bacterial infections, and gastrointestinal bleeding. Recurrent aphthous stomatitis most often is a mild condition; however, severe cases may be caused by nutritional deficiencies, autoimmune disorders, or human immunodeficiency virus infection. However, most individuals are asymptomatic and do not require treatment for this benign condition. Most cases improve with avoidance of predisposing factors and regular tongue brushing using a soft toothbrush or tongue scraper.
Commonly used topical regimens include nystatin (Mycostatin; not absorbed), clotrimazole (Mycelex troche), and systemic fluconazole (Diflucan).
For symptomatic cases, several treatments have been proposed, including topical steroids, zinc supplements, and topical anesthetic rinses. Hairy tongue represents elongation and hypertrophy of the filiform papillae and most often occurs in persons who smoke heavily. Certain risk factors have been associated with each of these lesions, such as poor oral hygiene, age, tobacco use, and alcohol consumption, and some systemic conditions may have oral manifestations. Use of systemic antivirals for herpes labialis generally should be reserved for immunocompromised patients. Many recommended therapies for oral lesions are unsupported by randomized controlled trials.



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