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A yearlong clinical trial in more than a dozen countries reveals that once-a-week-Trulicity, used in conjunction with short acting insulin, not only improved blood sugar control for subjects with type 2 diabetes, but also curbed hypoglycemia compared to a standard treatment and reduced weight in trial subjects.
Trulicity is in a class of treatments known as GLP-1 receptor agonists—short for glucagon-like peptide-1 receptor agonists.
By hypoglycemia he meant a blood sugar reading of 70 or less, or signs and symptoms of low blood sugar, or both. Milicevic estimated that 20 to 30 percent of all type 2 diabetics are currently being treated with insulin, while the other 70 to 80 percent take oral medications to stabilize their blood sugar. Subjects using Trulicity reported they experienced some gastrointestinal side effects more commonly than those using Lantus.
While the results from the study were mostly positive for Trulicity, there is one major obstacle to more widespread use of GLP-1s that is affecting all such treatments, whether they are administered daily or weekly. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. Total Cholesterol is a soft, fat-like, waxy substance found in the bloodstreamand in all of your body’s cells. Glucose is a type of sugar that travels through the bloodstream and is the primary source of energy for your cells. Cortisol, a glucocorticoid (steroid hormone), is produced from cholesterol in the two adrenal glands located on top of each kidney. Creatinine is a chemical waste product in the blood that passes through the kidneys to be filtered and eliminated in urine.
TSH is produced by the pituitary gland, and is part of the body’s feedback system to maintain stable amounts of thyroid hormones. GLP-1 is a hormone in the body that gets released in the intestine during the stage of digestion when carbohydrates are absorbed, stimulating the release of insulin from pancreatic beta cells.
For the trial, Trulicity was compared to insulin glargine, a once-daily injectable treatment, the most popular of which is Sanofi’s Lantus.
Basal-bolus therapy is when a diabetic takes long acting insulin once a day to stabilize glucose levels while fasting, while also taking short-acting insulin before main meals to counteract increases in blood glucose levels from eating.
Between 16 and 17 percent of subjects on Trulicity (depending on the dose) experienced diarrhea, while between 18 and 26 percent suffered from nausea. Cholesterol is an important part of a healthybody because it’s used for producing cell membranes, some hormones andserves other needed bodily functions. Medical experts believe HDL carries LDL cholesterolaway from the arteries and removes excess cholesterol from arterial plaque, slowingits buildup. Nicotine is a chemical found in tobacco products, including cigarettes and chewing tobacco.


It is normally released in response to events and circumstances such as waking up in the morning, exercising and acute stress. It is a major source of energy and is used by every living organism.When you eat food, your digestive system breaks it down into glucose in the blood so your cells can extract energy from it and recharge themselves. Ninety percent of the adults suffering from diabetes have Type 2 diabetes.Type 2 diabetes occurs when your pancreas produces the insulin, but your cells are unable to use it properly.
Basal-bolus therapy is thought by many to approximate the way in which a person without diabetes produces insulin. Most of the trial’s 884 patients were from the United States, while others were from Europe, South America, and Asia. By contrast, 6 percent of subjects on Lantus experienced diarrhea and 3 percent of subjects reported nausea. Measuring cotinine in people's blood is the most reliable way to determine exposure to nicotine for both smokers and nonsmokers exposed to environmental tobacco smoke (ETS).
In medical terminology, this is called insulin resistance.Initially, the pancreas responds by making more insulin to try to get the cells to use it properly.
Type 1 diabetes is where the body stops making insulin and the blood glucose level goes very high.
The A1C complex is formed when the glucose in the blood binds irreversibly to hemoglobin (glycates).
Some people who have type 2 diabetes may also need to have insulin injections to help control blood sugar levels. This may ultimately cause excess blood sugar.Excess blood sugar due to either type of diabetes is a major cause for concern. There are different types of insulin available which are classified according to how quickly and for how long they work.
Your doctor or diabetes nurse will discuss the various preparations and devices available and help you choose a regimen that is right for you.
Treatment with insulin is usually lifelong.  What is insulin and how does it work? Since the kidneys’ filters are so minuscule in size, they do not filter these useful substances and they remain in the blood and benefit the body.However, diabetes damages the filters over time, causing a complete failure of the filtration process. This, in turn, allows the proteins in the blood to escape to the urine.Albumin is one such protein that passes through to the urine. A dangerous excess of the same is called microalbuminuria.Microalbuminuria could indicate an early stage of kidney failure. Diabetic nephropathy (diabetes-induced kidney disease) is the most prevalent cause of end stage kidney disease, according to a 2001 study published in the Journal of the Royal Society of Medicine.


This is when your kidneys fail completely and are no longer able to support you.It could take years for kidney damage to occur in diabetic patients. Eventually, this starves the nerves of oxygen and nutrients, and damages them severely.Because nerves run throughout the body, nerve damage can have a variety of symptoms depending on the area of the body that has been affected. So, when your blood glucose level begins to rise (after you eat), the level of insulin should also rise. Insulin works on the cells of your body and makes them take in glucose from the bloodstream. Some of the glucose is used by the cells for energy, and some is converted into glycogen or fat (which are stores of energy). Some glycogen or fat is then converted back into glucose which is released from the cells into the bloodstream.
If the blood glucose level remains high despite these measures then tablets to reduce the blood glucose level are usually advised. Insulin cannot be taken by mouth, as it is destroyed by the digestive juices in your digestive system. Insulin may come in a vial to be injected with a separate syringe, in a cartridge to be used with an injection device (pen), in a pre-filled injection device, or it can be given continuously by a pump. They are available as vials to be injected with a separate syringe, as a cartridge to be used with an injection device (pen), or in pre-filled injection devices. Before you start treatment your doctor or diabetes nurse will give a lot of advice and instruction on how and when to take the insulin.
An insulin pump may be suitable for people who have lots of 'hypos' (blood sugar becomes very low) or very high blood sugar in the morning, even when on a suitable insulin regimen. This part can be measured and gives a good indication of your blood glucose control over the previous 1-3 months. But if you have a lot of hypos or you are unable to tell when you are going to have a hypo then you are not allowed to drive. You will need to inform the Driver and Vehicle Licensing Agency (DVLA) that your have diabetes and are taking insulin.



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