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Pagina inicial - Complicacoes Cronicas do Diabetes - Ulcera isquemica no MIE. The pancreas has many islets that contain insulin-producing beta cells and glucagon-producing alpha cells. Since diabetes is a disease that affects your body's ability to use glucose, let's start by looking at what glucose is and how your body controls it. When you eat food, glucose gets absorbed from your intestines and distributed by the bloodstream to all of the cells in your body. To maintain a constant blood-glucose level, your body relies on two hormones produced in the pancreas that have opposite actions: insulin and glucagon.

Insulin is made and secreted by the beta cells of the pancreatic islets, small islands of endocrine cells in the pancreas.
As such, insulin stores nutrients right after a meal by reducing the concentrations of glucose, fatty acids and amino acids in the bloodstream. Your body tries to keep a constant supply of glucose for your cells by maintaining a constant glucose concentration in your blood -- otherwise, your cells would have more than enough glucose right after a meal and starve in between meals and overnight. The cells take in glucose from the blood and break it down for energy (some cells, like brain cells and red blood cells, rely solely on glucose for fuel). So, when you have an oversupply of glucose, your body stores the excess in the liver and muscles by making glycogen, long chains of glucose.

Insulin is required by almost all of the body's cells, but its major targets are liver cells, fat cells and muscle cells.

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