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Harvard researchers used stem cells to create insulin-producing pancreatic cells and hope to transplant them into diabetic humans in the near future. A substitute for the daily drudgery of measuring glucose levels, sticking fingers, and watching insulin pumps may soon be here. Research conducted at Harvard University has successfully treated diabetic mice and other animals by using insulin-producing pancreatic beta cells created from embryonic stem cells. Melton, a Harvard professor, considers this search close to home, as his son was diagnosed with diabetes as a baby. Melton and his colleagues are hoping to eradicate the metabolic swings and possible complications that come with insulin injections and other modes of diabetes treatment by transplanting these beta cells into diabetes patients. Stem cells are basically chameleons—they have the potential to become any other type of cell including tissue and organ cells. Melton and his associates used these newly formed insulin-producing beta cells in three separate glucose challenges in mice and all were successful.
Melton hopes to begin the process of human trials in around three years, but much can happen to alter that timeline. It may take more years of research, but nearly all in the medical community are considerably enthusiastic about this finding. If everything runs smoothly, Melton plans on transplanting the insulin-producing beta cells into the pancreas of diabetes patients and keeping the cells there for a year or more.
And yet, some of Melton’s contemporaries have equated the stem cell findings to antibiotic treatment for bacterial infections, which was a groundbreaking scientific find in its day. As human trials come into play, we are crossing our fingers that the transplant of pancreatic beta cells works and a revolutionized way of treating type 1 diabetes is established. Scientists at Harvard university recently discovered how to make large quantities of insulin producing cells. Type 1 Diabetes (T1D) is an autoimmune disease which prevents a person’s pancreas from producing insulin, which is a hormone that enables people to receive energy from their food. Harvard researchers managed to develop billions of beta cells that (insulin producing cells) would be required for transplantation, which would put an end to the daily injections that millions of people (living with diabetes) all over the world have to take everyday. It’s not 100 percent confirmed yet, the stem cell-derived beta cells are currently undergoing clinical trials in animal models, which include non-human primates. This new discovery comes approximately one year after researchers at the Harvard Stem Cell Institute (HSCI) discovered the hormone and thought (then) it could be used to treat type two diabetes (see video below). Despite cell transplantation for people with type 1 diabetes being strictly experimental, this new research is clearly providing promising results and inches us closer to a real cure. Research shows that in terms of health, meat eaters have 4 times more breast cancer, 3.6 times more prostate cancer, 4 times more diabetes, and much more in general chronic disease. If you’re ready to take the first step, begin your transformation by clicking the transformations below!
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Harvard University and Massachusetts Institute of Technology scientists have indicated in a study, published in the journals Nature Medicine and Nature Biotechnology, that they are getting closer through research to a possible type 1 diabetes cure. Last year the Harvard Stem Cell Institute were able to create beta cells which are able to store and release insulin. A lifelong condition, diabetes, causes the glucose (blood sugar) in a person to get too high.
Type 2 diabetes is different than type 1 diabetes and more that 29.1 million people in America suffer from type 2. Researchers next step in the new developments for a cure for diabetes is looking forward to preliminary clinical trials.
Doctors from Boston University and Harvard Medical School are developing a potentially game-changing technology for people with type 1 diabetes. Harnessing the power of collaboration and patient engagement, T1D Exchange speeds the search for treatments and a cure.
How an innovative tele-mentoring model is reaching patients who are often unable to get the specialized care they need.
The Helmsley Type 1 Diabetes Program was launched in 2008 with the goal of having a positive impact on people living with type 1 diabetes (T1D).

Understanding the DiseaseType 1 diabetes develops because of genetic and environmental factors.
Developing Better TreatmentsWhile our ultimate goal is to prevent T1D, we recognize that this is not likely to happen for many years. As part of our work to spur breakthrough therapies and technologies, we seek to support efforts to optimize the clinical development process.
Improving Care and AccessT1D is an unrelenting disease that requires constant management, and accessing quality specialized health care can be challenging, particularly for economically disadvantaged and rural populations. What Is Type 1 Diabetes?Type 1 diabetes (T1D) is a life-altering autoimmune disease that afflicts nearly two million people in the U.S. Advancing Biomedicine From Classroom to Clinic The Harvard Stem Cell Institute and Harvard Department of Stem Cell and Regenerative Biology advance the understanding of human development and disease, support the discovery of stem cell-based therapies and cures for diseases, create collaborations across traditional institutional and disciplinary boundaries, and teach and train the next generation of leading stem cell scientists.
In what’s being called one of the most important advances to date in the field, researchers at Harvard have used stem cells to create insulin-producing beta cells in large quantities.
By using human embryonic stem cells, a research team led by Doug Melton created human insulin-producing beta cells that are virtually equivalent to normally functional beta cells in the kind of large quantities required for cell transplantation and pharmaceutical purposes.
Currently, the cell-derived beta cells are undergoing trials in animal models, including non-human primates.
People with this condition often develop serious complications such as as heart disease, stroke, kidney failure, blindness, and premature death. Ultimately, these new lab-grown cells could be transplanted into diabetes patients, allowing them to create insulin naturally. The cells share key traits and markers characteristic of beta cells with those from healthy individuals, including the packaging of the insulin they secrete in granules.
The result was a scalable differentiation protocol that will be usable in industrial production of beta cells.
Melton cautions that the work is still years from being tested in patients and many challenges, scientific and practical, remain.
A new study published on October 9, 2014 in the scientific journal Cell illustrates a new way to help diabetes patients: using stem cells. These cells can then repair the damaged pancreatic cells at the very source using the very source. In the past, the process to convert stem cells into other types of cells, such as pancreatic beta cells, was very slow and could only be done in small quantities. In immunocompromised mice, the beta cells didn’t just control diabetes, but cured it altogether.
These cells will produce insulin in the body and eliminate most other mechanisms of diabetes management. While they are happy about the findings, they warn that this is not yet a cure, as certain media outlets have gone off telling everyone a diabetes cure is here.
They are claiming that this breakthrough is just as big as the development of antibiotics, which (although successful) have not come without severe and damaging health consequences. This occurs when the body’s immune system attacks and destroys the insulin producing cells in the pancreas, which are called beta cells. These results have been successful so far, as the beta cells are still producing insulin after several months. Over 20 years ago his son was diagnosed with type 1 diabetes, since then he has dedicated his life to find a cure, he’s now extremely close. Even though diabetics can can keep their glucose metabolism largely under control by injecting insulin multiple times a day, it still doesn’t do the trick entirely when it comes to controlling metabolism. As the founder and CEO of Fitlife.TV, he is committed to sharing educational, inspirational and entertaining videos and articles about health, fitness, healing and longevity.
That's why I signed up for the protocol, but the most exciting result is that I found ME in the process. The American Diabetes Association reports that approximately 1.25 million Americans are affected by type 1 diabetes. The beta cells where the first step, and now with the new development they can implant a device that can possibly prevent the beta cells from being compromised by an attack on the immune system for upto six months. The pancreas kills off the beta cells when a person has type 1 diabetes, because it is an autoimmune disease.
Type 2 diabetes can be controlled by proper diet and exercise, where type 1 can not because it is an autoimmune disease. We look to foster novel collaborations that leverage the best minds and efforts across disciplines and institutions. To date, the majority of research around T1D has focused on the development of treatments that mitigate the effects of the disease or slow its progression and, of course, on an elusive cure. As such, our program invests heavily in the development of new treatments and technologies that will ease the burden of living with T1D.

To that end, the Trust supported the creation of the T1D Exchange, a nonprofit organization with a groundbreaking patient engagement platform designed to accelerate all aspects of drug and device development.
Our program supports the development of innovative models of service delivery and efforts to make these models broadly accessible to people with T1D. In the study, Melton describes a step-by-step procedure that starts with stem cells and results in hundreds of millions of the vital pancreatic cells that secrete the hormone insulin, which keeps blood sugar levels in balance. But he is gratified to have reached this point and even more motivated to continue, so as not to disappoint the millions of people who suffer from type 1 diabetes, which is usually diagnosed in children and young adults.
Already, cells are being transplanted into primates through a collaboration with a researcher in Chicago. It arrived through the hard work of 50 graduate students and postdoctoral researchers who have worked on the project over the last 15 years. Through Melton’s research, they can now grow beta cells much faster and in the hundreds of millions, eventually even billions. Apparently, the cause is not well understood, but scientists believe that genetic and environmental factors play a role. He is also a best selling author and the founder of Organifi, an organic, incredibly delicious greens powder, chock-full of superfoods to make juicing easy no matter your busy schedule.
To date, the program, which has rapidly become the largest private foundation funder in T1D, has made in excess of 350 grants totaling more than $300 million in pursuit of this goal.
We make meaningful investments, not only of capital but also of our deep staff knowledge and expertise that can be marshalled on behalf of our grantees and their efforts. However, despite significant investments, a cure is still far off in the future, the causes of the disease remain unknown and there are no viable prevention strategies. We support many of the most prominent and innovative academic and scientific research institutions across the nation.
Elevated glucose levels can be immediately life-threatening in severe cases, but more commonly they can result in a range of serious long-term health complications, including blindness, amputations, heart disease and kidney disease. The new challenge is then to replicate this cure in healthy animals with stable immune systems and eventually in humans. FitLife changed my life and I knew I had to share it with others.-Lynne, Longwood FL I started with Fitlife back in 2011-2012…I wrote into Fitlife asking for an extreme amount of help.
Researchers are looking at ways to keep the beta cells from being attacked by it’s own immune system. As such, a key priority of our program is supporting research that seeks to illuminate how T1D develops and identify ways to prevent it. Given the relatively small market opportunity that T1D offers to for-profit medical device makers as compared to many more prevalent diseases, the Trust also actively partners with leading and up-and-coming players from industry to de-risk and speed the development of new technologies that will help manage the disease. Data generated by the Exchange are helping to improve standards of care and accelerating projects of academic and industry researchers worldwide. On a global level, the Trust is funding an initiative to chart the worldwide insulin market and identify barriers to access and areas of need.
It is perhaps the only disease in which patients are required to monitor their condition constantly and make their own dosing decisions with a drug that, if improperly administered, can kill them.
T1D is managed today by a rigorous regimen of monitoring glucose levels – either by pricking one’s skin multiple times per day or wearing a subcutaneous continuous glucose monitor – and then administering insulin via injection or an insulin pump. Testing is currently being done in non-human primates to see how the beta cells react when transplanted into the pancreas of animals more genetically similar to humans. Our grants toward this strategic goal fund new and existing efforts in primary prevention research – that is, science that explores approaches to thwarting the disease before it starts – and the development of infrastructure for primary prevention clinical trials. A primary focus of our funding in this area has been supporting early-stage research toward commercial development of automated insulin delivery systems that can lessen the burden of disease management and, most critically, improve health outcomes for people with T1D. Another globally-focused grant seeks to develop scalable pediatric diabetes detection models in Haiti and Rwanda that can be replicated in under-resourced countries around the world.
Just try 1 juice per day along with the rest of your nutrition and see how your body responds.
Though this strategy, we also fund efforts to collect, store and make widely available human tissue samples in order to facilitate more precise and relevant research into avenues of prevention. These healthy, nutrient-dense juices can replace that coffee you reach for in the morning or that soda in the afternoon.

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