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Type 1 Diabetes is when the body stops producing insulin and then the body builds up high levels of glucose (sugar).
Type 2 Diabetes is either when the body produces some insulin, but not enough or when the insulin produced does not work properly. Diabetes UK are a leading charity that drive awareness campaigns, give advice and also fund Diabetes research. Their website is packed with information about how to spot potential Diabetes and what foods are suitable for those who suffer with Diabetes.
Diabetes can put you at risk for suffering from many skin conditions, some wanting medications while others not engaging in any specific treatment measures. Skin complications can range from the mild ones as itching to the more serious and troubling ones like vitiligo and Necrobiosis Lipoidica Diabeticorum (NLD). The first thing you need to do is to consult your doctor when you note any abnormality or change in skin. Diabetics can also have an allergic reaction to several things including medications, insulin and anti-hyperglycemic medications.
Digital sclerosis affects mostly the type 1 diabetes which is not controlled appropriately. Brining blood glucose levels back to a normal level is the main treatment measure to be adopted. Blood sugar control apparently does not play a role here, both before and after diagnosis of the condition. Prompt diagnosis can ensure timely treatment of a skin condition, before it can actually become a problem.
It is important for diabetics to keep their skin clean and dry.  Even minor injuries and abrasions should be attended cautiously and monitored for infection or any other sign of deterioration.
The symptoms of diabetes, on skin are mostly curable, especially, if they are detected early.
Due to diabetes, the smaller blood vessels supplying blood and oxygen to the skin get damaged. The diabetes leads to damaging of the blood vessels and this damage is visible in the form of different skin conditions. Other than diabetic dermopathy, damage in blood vessels can also cause Necrobiosis lipoidica diabeticorum or NLD, where large and shiny scaly patches develop over the skin. The diabetics have high sugar level in their blood, providing a perfect medium for the growth of fungus and other pathogens. This fungus mostly develops in moist and warm areas regions of the skin, like, around the fingernails, between toes, in armpits, in groin area, under foreskin of male genitalia, and also in corners of the mouth. Other fungal infections that may be found in the skin of diabetic patients, include, athlete’s foot, jock itch and ring worm. Bacterial infections are also very prominent, on the skin of diabetic patients, due to high blood sugar levels. The most common bacterial infections found in the skin of diabetic patients, include, boils, infection of glands present in the eyelids, inflammation of a certain region of skin and tissues below it also called as carbuncles, folliculitis (infection in the hair follicles) and inflammation around the nails. Blisters are not a regular sight in the diabetic patients, but, some patients may develop blisters in their forearms, feet, toes, hands and fingers. This condition is mainly found in the patients suffering from type 1 diabetes and can be controlled by normalizing blood sugar levels. This condition of the skin is mainly found, in the males of younger age group, suffering from type 1 diabetes.
Due to high glucose levels, the fluid from the skin cells evaporates, leaving the skin dry.
Diabetic patients need to take special care of their skin, and keep on sanitizing and moisturizing it, to prevent it from drying. Atherosclerosis is the thickening of arteries, and a common occurrence in diabetic patients. Bringing your blood sugar level close to the normal range is considered the best option for treating your diabetic skin problems. People with poorly controlled diabetes are susceptible to bacterial infections of the skin.
As most Staphylococci infections are becoming resistant to penicillin, doctors usually recommend penicillin-like antibiotics flucloxacillin and methicillin for treating the infections. Itching of the skin in diabetics is a symptom of skin dryness, fungal infection or poor blood circulation. When the cells that form the skin pigments are destroyed by diabetes, the skin loses its natural color. When topical steroids cannot produce the desired result, your doctor may recommend psoralen photochemotherapy for treating the condition. For people with extensive vitiligo that covers more than half of the body, micropigmentation or depigmentation is recommended. This is a rare skin disorder related to diabetes that causes thickening of the skin on the upper back and back of the neck.
Shiny circular or oval lesions that usually appear on the front of the legs are called diabetic dermopathy.
Medications that studies suggest can be used for treating NLD include tretinoin and hydroxychloroquine.
The skin on the hands, fingers and toes of people with digital sclerosis is thick and waxy. Drugs commonly used for treating this skin condition include statins, bile acid binding resins, fibrates, nicotinic acid and probucol. Ron: If you don’t mind, very briefly, when you say your diet fluctuates, can you elaborate?
Sam: I tend to start my day with some almond butter or cottage cheese, to get myself a little protein.
Shelley Schlender: And if I can add one thing, it’s that when Sam went to get his heart scan, he said that he is so afraid that his heart scan means he will have to give up butter. Ron: But some of the other things that you’re eating are extremely detrimental, and I will tell you why and how they are very, very relevant to your heart scan. Shelley: Sam, you said that you actually had muscle pains when you took statins once before.
Ron: That same enzyme, as is very typical in biology, is not used for just one purpose, however. Ron: Not only that, but because, perhaps, and this is somewhat speculation, it is known that when you reduce cholesterol, you increase risk of death. Sam: As a lay person, I’m thinking, the mortality rate has been linked to the statin use, but they’ve been able to isolate other risk factors and say that statins increase your chance of dying of something? Ron: Most of the data indicating dangers from statins is not done on statins particularly, because the people who are doing research on statins are the drug companies. Shelley: I think that if a drug company person is listening right now, you might be hurting their feelings. Ron: Ejection fraction is a measure of how strongly your heart beats, how much blood it pumps out. Ron: I was involved in some of the early studies on using statin drugs for arterial calcification, and they don’t work.
Ron:  Heart Disease, however, there’s lots of science to show that other hormones are very much involved that do involve your diet. Ron: Leptin also controls the immune system via influencing on macrophages and white blood cells. Ron: You can measure it, just as easily as you can measure cholesterol, and about just as cheaply.
Sam: So next time I go to my doctor and he gives me the sheet to take to the lab and he ticks off the different things the lab is supposed to look for, could he just be ticking off leptin as well?
Shelley: Before you get into that, when we were at the calcium scan place and they were explaining what things make a difference, the data that they have say that diet and exercise make almost no difference, that the only lifestyle that makes a difference is whether you feel stressed.
Ron: One of the events that occurs in this fight-or-flight response is to increase glucose, meaning sugar, in the blood.
Sam: To get that extra burst of energy in a fight-or-flight situation, it’s adrenalin that starts pumping. Sam: So I could do all manner of things, yoga, meditation, exercise, to reduce stress, but if I have a diet that has a lot of sugars, that’ll be just as bad or worse?
Ron: Why is your body going to such pains to first make sure that it manufactures cholesterol in the liver and create proteins to transport it?
Sam: So can I be eating that stuff that’s supposed to be full of “bad” cholesterol, like eggs? Sam: I’m having a disconnect between what we’re talking about and the recommendation to strictly limit your egg consumption. Shelley: When we had a conversation with some doctors here in the Boulder area, one was a cardiologist who actually was very open to higher-fat lower-carb diets and paleo kinds of diets. Ron: Under the question, then, which fat to eat, if you had to eat one or the other, which was the second half of your question, the saturated fats are among the least problematic.
Ron: All that being said, if you’re not really good at burning fat, eating omega-6 fatty acids, which are high in widely used vegetable oils, such as corn oil and soy oil, will be more detrimental to your health by fat than eating saturated fats, as far as causing cardiovascular disease and other diseases of aging itself. Ron: When you’re told to take a statin drug, to lower cholesterol, to lower cardiovascular risk and to lower calcification in your arteries, that is scientifically nonsensical, number one, and number two will actually promote the diseases that they’re espousing it’ll reduce. Ron: That was shown by the ACCORD [Action to Control Cardiovascular Risk in Diabetes] study, where everybody’s still scratching their heads about what went wrong. Shelley: Ron Rosedale, after you eat a meal, do you like to have a walk with your loved ones?
Ron: I do want to mention, though, that it’s been shown since the 1970s or maybe earlier, if you infuse insulin into the artery of a dog, which is where it was first done, and then it was done in chickens and other animals, the arteries will fill up with plaque in the artery that you’re infusing. Ron: But almost more immediately, you will widen your arteries to increase blood flow, reduce risk of unwanted clotting of your blood, so you reduce your risk of heart attack almost immediately. I’d never heard of the connection between insulin and arterial plaque or leptin and calcification of the arteries. The action of reliever inhlaers usually involves a selective beta2 adrenoreceptor agonist (or short-acting beta2-agonist for short).These drugs are known as bronchodilators, as they dilate (widen) the bronchi (airways) by relaxing the airway muscles. This inhaler is sometimes prescribed to asthma patients where symptoms are not controlled by short-acting bronchodilators and regular inhaled corticosteroids. These inhalers take longer to open the airways up (1-3 minutes) but can keep them open for up to 12 hours (instead of 4 hours). Side effects = shaking (usually of the hands), headache, cough, muscles cramps, anxiety, Low blood potassium level (hypokalaemia), nausea, abnormal heartbeats. This can be easily treated with insulin injections and normally takes effect in childhood, but can also develop in early adulthood.
Type 2 Diabetes normally affects people over 40. The ages of onset for Diabetes can vary depending on ethnic origin.
When it comes to avoiding skin complications and unfavorable outcomes of diabetes, the most crucial thing is blood sugar control.
Sty (infection of the eyelids), boil (infections of the hair follicles), carbuncles and nail infections are some of the infections diabetics are likely to experience. Fungal infections, as those mentioned here, are generally caused by a yeast-like fungus (Candida albicans). Atherosclerosis affects vessels that cause cardiovascular disease; vessels supplying blood to the skin can also be affected. They are similar to burn blister and usually found on fingers, toes, hands, feet and forearms. Symptoms of this skin condition appear as thick, waxy (but tight) skin on hands, fingers and toes. Medications may be used; it is difficult to arrive at a conclusive treatment measure fro NLD due to lack of knowledge about what causes this condition. Many diabetic skin problems can be prevented through tight blood sugar control and routine examinations of the skin. This increase in blood glucose can be either because of inefficiency of the body to produce insulin, or due to inefficiency of the body cells to respond to insulin. In fact, it has been observed in studies that as much as 33% of the total population, in the world, suffering from diabetes, has to suffer from different types of skin disorders.
So, anyone having a diabetic condition should take these symptoms seriously and get them cured, as early as possible. This is caused due to hyper pigmentation and occurs mainly in the places, where the skins meet, like, neck, armpits, groin, and under the breasts. This results into the formation of small scaly patches of reddish to brown or light brown color, over the skin. Poor circulation of blood due to damage of blood vessels also leads to itchiness and numbness of skin. These fungal infections are characterized by the present of sore spots and rashes, which are surrounded by small blisters on all sides. Patients having any of these symptoms of fungal infection, need to immediately rush to the doctor and get proper medications. These infections are mostly characterized by inflammation of the affected tissue, which is red in color and very painful.
These blister resemble those blisters that are developed due to burns and can be of any size, from small to large. This condition is known as digital sclerosis, and it makes the joints of affected body parts (mostly fingers) stiff and incapable of normal movement.

This dryness is also caused due to infection of pathogens, like, fungus, bacteria and virus. These factors include different types of infections, dryness of the skin, and also allergies. This condition affects the legs of the patients and results into hairless, shiny, thin and cold skin. But, thankfully, you can control these skin conditions, by using proper medication and remedies. Patients with a history of penicillin allergy are usually treated with erythromycin, vancomycin, rifampicin or clindamycin. Using a mild soap while bathing and applying moisturizing lotion to the skin after bath help to moisten the dry skin and reduce itching.
This condition known as vitiligo is characterized by discolored patches on the face, abdomen and chest. Treatment includes applying topical psoralen on the vitiligo patches and exposing the skin to artificial ultraviolet A light for about 30 minutes. Treatment for scleredema diabeticorum involves applying moisturizing lotion to soften the thickened areas of the skin. Ticlopidine, clofazimine, nicotinamide and perilesional heparin injections can reduce complications of NLD. When eruptive xanthomatosis does not respond to lipid lowering drugs, the bumps on the skin can be destroyed with laser therapy, excision, topical trichloroacetic acid or electrodesiccation.
It’s not a Snickers, it’s something I might get at Whole Foods that’s promoted as protein and nutrition, although it tastes pretty sweet. So yeah, I would say that the diet I just described has been more or less similar for the four years since the first scan.
It’s, I’m sure, quite different than what is normally being proposed and promoted to deal with increased arterial calcification. My primary care doctor, who I really feel we have a good relationship and I appreciate the care, but that was one point where we disagreed. You’re not going to find an independent person spending upwards of $50 million or $100 to do a big study on a statin drug to show a negative effect.
The actual ejection fraction is a percentage of the blood that goes out with each beat versus the blood that goes into the heart. I’ve done it on my patients and just by taking people off of cholesterol-lowering drugs, I’ve saved numerous surgeries, because I look at ejection fraction and say, “That’s not so good.” I’ve saved people from heart transplants, because they had ejection fractions really low.
This place this did the scan said there’s water-soluble statins that might not lead to the muscle soreness I had with the Lipitor version. I haven’t really looked into the research as to why they feel it would reduce pain or if it would even reduce the inhibition, for instance, of coenzyme Q10 manufacture.
Leptin, through the hypothalamus, we know, helps control the sympathetic nervous system, which is very relevant in that it helps dictate the narrowing and widening of arteries.
And that to me is an absolute sin and really should be malpractice, because high leptin is why you’ve got cardiovascular calcification, and they don’t even measure it.
So forget about worrying about your diet, forget about exercising, and just work on stress.
When you have high levels of glucose in the blood, we also know that the sympathetic nervous system is stimulated, both through increasing insulin levels and through rising leptin.
As far as you’re concerned, as far as your vascular physiology and calcification, and we could talk for weeks, maybe months, on the cardiovascular physiology of insulin and leptin, but let’s just talk about the calcification. All of those nutrients that will allow that egg to most successfully turn into life and give that life a good running start to be successful and make it in this world, the nutrients in an egg were hand-picked by evolution to be those that are most vital to life. Despite all this great medical advice that we’ve had, where are we headed as far as cardiovascular disease?
He said these alternative diets are actually very beneficial for some people, and he observed that the kinds of medications that he can offer people are there waiting for if they don’t want to change their lifestyle, and most people don’t.
If you undergo tests to measure osteoporosis, bone scans, you’ll see yes, the thickness and density of the bones improved. That study showed that the more doctors controlled their patients’ blood sugars with blood sugar lowering medications, when they threw more drugs on these patients to lower their blood sugar levels, there was a very significant increase of death.
Leptin is really powerful, working in concert with insulin to affect virtually every physiologic process from a very deep, fundamental level, and also controlling cholesterol manufacture and the size of cholesterol particles, which is extremely important. They do this by mimicking the effects of adrenaline and noradrenaline, which are molecules usually produced by the adrenal glands and are involved in the “fight or flight” reaction. It not only helps in preventing a complication (including skin complication) but also treating the same in case of its occurrence. This fungus is usually found in warm and moist skin areas like fingers and toes, corners of the mouth and vagina. Antihistamines and decongestants are generally used to hinder the effect of chemicals involved in an allergic reaction. Necrobiosis Lipoidica Diabeticorum has association with diabetes mellitus, predominantly in the insulin dependants.
Your legs are mostly affected if you have poor blood flow. Skin lotions can relieve itching to certain extent. High blood glucose can reduce your strength to fight invasions, including those on the skin. Attune with your doctor for becoming more aware of diabetic consequences and have regular checkups to get timely treatment.
The skin related symptoms of diabetes may also act as warning signals, to help patients become aware of their fluctuating blood sugar levels.
These blisters are mostly painless and develop, when major fluctuations occur in the blood sugar levels of the patient. Allergies surface in the form of itching, in diabetic patients, and other skin conditions also normally lead to itching. Also, as you may have noticed, many skin conditions are result of temporary sugar imbalance, so, if you are diabetic and want to avoid such uncomfortable conditions, try to keep your sugar in control. Exposure to too much sugar circulating in the blood makes the skin vulnerable to infections and several other disorders.
It works by fading the color of the unaffected areas of the skin, so that the entire body has a uniform light color. Applying bovine collagen to the affected areas can provide relief from this skin complication.
Laser treatment is sometimes recommended for improving the condition of the skin affected by NLD. However, reducing the blood sugar level is the best treatment for this diabetic skin complication. This skin condition is treated with lipid lowering drugs and cholesterol and fat restricted diet. Losing weight and applying skin-lightening creams to the affected areas are currently the only treatment for this skin disorder. I might skip lunch, I might just have some kind of nutrition bar, or I might have a sandwich. I don’t know if you remember, but I did a pilot group with you several years ago that Shelley had set up. I did finally break down, he was recommending statins because my bad cholesterol had gotten over 200 and stayed there, and after resisting it for a few years, I finally did say, “OK, I’ll try it.” I was on a low dose of Lipitor, and I did have some muscle cramping. It’s not a side effect, it’s a secondary effect—actually, it’s a primary effect of statin drugs, not even a secondary, not even a side effect.
One of the other purposes of HMG coenzyme A reductase is to manufacture something called coenzyme Q10, which is involved in the so-called mitochondrial respiratory chain. What they try to tell you is that taking cholesterol-lowering medications reduces risk of cardiovascular disease.
If your heart were 100% with each beat, it would pump every drop of blood out that came in. Lo and behold, you take them off statin drugs and their ejection fraction goes up at least 10 points.
You can get a good measure of ejection fraction just by doing an echocardiogram, where you bounce sound waves. It originates from the hypothalamus, and one of the events that occurs when adrenalin and other hormones are pumped out and the sympathetic nervous system is stimulated like that, is the body on its own puts more glucose in the blood, either from reserves it keeps or by burning the body’s own muscles to make sugars for the blood. Basically, it’s a reverse process – higher blood sugar becomes a sign to your body that you’ve got stress around.
It actually has very little to do with the causation of coronary artery disease, even, or plaque formation. That’s telling you one of two things: we’re not getting a whole lot of bang for our buck, or it could be telling you something else—that we are getting bang for our buck, we’re just going in the wrong direction. It was interesting talking with him and with the other local doctors, because one of the things they were debating was things like saturated fat versus vegetable oils. What causes that one-way valve is, initially, elevations in insulin and later on disruptions in insulin and leptin signaling, so your brain doesn’t even know how much fat you’ve got. It’s good in that is causes less lipid peroxidation, it causes less damage in some membranes. So the institutional public policy of banning full-fat butter and instead using high Omega-6, poly-unsaturated margarines, which is what we’ve been told to do since the 1950s, has very much adversely affected our health.
I wanted to be sure to ask you the other part of my diet that I’ve always been concerned about is my tendency to eat late at night. The reason for this is because your digestive system is a big part of you, and it needs to sleep, too. There’s a big connection between the endothelium, which is the cells that line the arteries, and bone. If it’s a cause of disease, it’s only because it’s being given signals to do the wrong thing, it’s not being orchestrated properly.
I have your book on my shelf, and I think it’s time to read it again and get the diet into shape. If you have any questions on the diet or on the relationship between leptin and your condition of arterial calcification, please let me know. However, these have side effects and should be implemented with precaution.  Immunotherapy is another alternative treatment option. They neither itch, not cause irritation, and therefore, they do not demand medical treatment also. These bumps cause itching, and mostly appear on skin of the feet, back of the hand, arms, buttocks and legs. Diabetics have to know accurate measurements on their blood sugar levels or risk having to high blood sugar and damage their body. Making knowing what is the normal blood sugar level and absolute need for the survival of the diabetic.
This is a small unit that measures the amount of glucose in a person’s blood and displays it. Most of these skin infections are caused by the colonization of the bacteria Staphylococci (staph).
This process involves applying monobenzene to the unaffected areas of the skin until these areas match the discolored patches.
My doctor said, “It’s been four years,” and he recommended another one.” That scan showed significantly increased plaque and calcification build-up. I’m drinking a little every day, not to excess, but I’ll typically have a glass of red wine or two or a glass of whiskey or two. I lost a considerable amount of weight and tried to stick to the recommended diet and was pretty successful for a while, but gradually dropped away from that, not for any particular reason I can think of, other than, it just fell away. Actually, as we speak, on my kitchen counter right now, I have an open stick of butter on a plate that I periodically take a pat of and just stick it in my mouth, just because I love butter. The primary effect of statin drugs like Lipitor is to reduce an enzyme called HMG coenzyme A reductase.
Co-Q10 is very critical in transferring energy from food into usable little batteries within the mitochondria of our cells – batteries that all of life uses called ATP.
It’s now been known since at least 2002, and perhaps earlier, that leptin is very, very much not only involved in arterial calcification, but perhaps even might control it.
I lost a lot of weight and I’ve kept most of it off, and it did improve my diet, even though I backslid. Leptin is the major way that your body speaks to the brain to tell your brain how much energy is available within your body, and what to do with it.
This mental picture that medicine paints to delude people into thinking that your arteries are like copper pipes in the kitchen and if you eat fat they will plug up and you’ll die of a heart attack could not be further from the truth.
And we know that cardiovascular disease is a disease of inflammation, where the lining becomes inflamed and therefore swells, and you get plaque as a result of that inflammation. A high glucose, then, is put there for an emergency fuel supply, because it can be burned without your having to breathe beyond your capacity in supplying oxygen.
When you have high levels of glucose, we know that it causes stimulation of the cells in the pancreas to put out insulin. Despite that country spending 10 times more on medical care than any other country, where do we rank as far as health? In other words, it could be that the medical care is not just not doing enough in this country, it could be that it is doing something: that it’s killing people.

It’s not so good in that it’s a little bit harder to burn because it doesn’t oxidize as readily. If you put endothelial cells, the inner lining of your arteries, in a Petri dish and expose them to leptin, they will build bone. Osteoclastic cells are those cells that tear down bone, on purpose, because your body wants you to remodel bone. The way to treat it is to treat the signals that orchestrate the way cholesterol is being transported in your body to save your life, not to kill you. There are a couple of references in my book, The Rosedale Diet, on leptin and bone, but since I wrote it a decade ago, there’s been a ton of information linking leptin to other hormones, to serotonin and bone formation and arterial calcification.
One effect of these molecules is to stimulate the airway muscles to relax, and therefore open them up (dilate) so more air can enter the lungs. A bacterial infection can be successfully treated with antibiotics implemented as cream or pill, as directed by your doctor. There are other ways to treat an allergic reaction depending on the severity and symptoms of the condition.
The blood is placed in a small plastic strip that is then scanned and the results are displayed on a small window on the side. Antifungal medications commonly used for treatment include imidazoles, polyenes, allylamine, thiocarbamates, undecylenic alkanolamide, benzoic acid and ciclopirox olamine. When your blood sugar level returns to the normal range, the blisters heal naturally within a few weeks. He said, “OK, if you don’t want to take them.” The blood work that we did right after I stopped taking the statins did show that that cholesterol number had dropped.
When you diminish coenzyme Q10, you diminish the ability of all your cells to produce energy. But a lot of data can be gathered without having to spend $50 million or $100 million, and this other data  shows that if you just check cholesterol levels, and lower your cholesterol level, below somewhere in the neighborhood of 250, your risk of dying accelerates. However, they could have measured ejection fraction, and you can do a stress echo that will measure ejection fraction. To tell you the truth, I’m not an expert on the water-soluble that they have just come out with. But there’s no drugs to control leptin, and if there are no drugs to control something, in other words, if there’s no money to be made, they do not care about it. Inflammation is there to help heal, but if it’s overdone and goes on too long, it can cause death also.
It’s been known for 10 years now, and there’s probably hundreds of articles that show the control of leptin on cardiovascular calcification. Some of our ancient evolution somehow in development, the same progenitor cells that make bone also make arteries. It’s a reserve fuel supply for anaerobic emergencies, for very stressful, high-exertion activities where you cannot breathe fast enough to supply enough oxygen to burn fat,. You can burn, you can get energy from glucose, even though you’re not able to breathe fast enough to be able to burn fat. What’s less appreciated is that there is also a stimulus to put up higher levels of leptin.
Occasionally, maybe, but I would certainly not want to kill the firemen as a means to put out the fire.
If he’s having a bagel, should he put butter on it or a vegetable oil spread that doesn’t have so much saturated fat on it?
So you could be 200 pounds overweight, you could have all sorts of extra fat that would be very detrimental to your life, but ultimately what happens is that there’s a disregulation in the signals that tell your brain that you’ve got this much fat, and your brain doesn’t have any idea. It’s far less important than it’s given credit for as far as causing aging and age-related disease. However, you can change that by going into a physiology of burning fat more continuously, and then your body gets good at burning fat, and then it burns saturated fat, and then the type of fat you eat becomes less relevant because you’ll just burn it.
In other words, almost every health recommendation given for long-term health—take calcium for strong bones, eat a low-fat diet, take statins to lower cholesterol, cholesterol is the prime cause of heart disease—all of these things couldn’t be further from the truth. All bones end up with little tiny cracks and fractures, because they undergo damage, just like all of us do on a day-to-day basis.
And the jelly, of course, has fructose and other sugars which have all sorts of adverse effects. If you have too much leptin, which is influenced by what you eat, just the high leptin circulating, some people think it might actually get caught in plaque to increase its concentration, it will stimulate cells in the lining of the arteries to make bone.
There’s a huge connection and interest in the connection between bone and arterial calcification.
Insulin is a chemical created by the pancreas; the job that does is in turning the glucose (sugar) in the body into fuel that the body can use. They had me in late 2008 as a 3 on that scale, and now, in early 2013, I had gone to an 18. I might have one of those in the middle of the day, and then I’m very hungry when I get home at night and tend to overeat. But what they fail to tell you is that despite—perhaps—reducing cardiovascular deaths, taking statins increases total mortality. Pharmaceutical companies will spend a lot of money to do a study, not to find an ultimate truth that would better your health or even care about your health, but to look after their financial interests and the financial interests of their stakeholders, to which they are beholden.
And in fact, your risk of dying with low cholesterol is considerably more than your risk of dying with cholesterol above 250.
It talks with the brain by signaling the hypothalamus, which is a sort of information switching center within the brain. Your arteries can dilate and constrict, and the dilatation and constriction largely determine your circulation, over and above if you have blockages. If you take the lining of your artery, the endothelium, and even just expose it to leptin, it will classify. When you get scared in our evolutionary history, all of a sudden you’re attacked by a lion or a bear or a saber-toothed tiger, you’ll do things that previously perhaps were super-human.
Both of these things cause an increase in the sympathetic nervous system response, which is the stress response that causes vasoconstriction – meaning narrowed blood vessels. It has gotten the gold star from evolution, and to be the most nutritious food that life can have to initiate life and sustain life in its early stages, what food has the most cholesterol?
It thinks you’ll be too skinny to survive a famine, and it’ll continue to have you be hungry, eat more, and store more fat until it finally gets the signal from leptin that you’ve got too much fat and you’d better burn some off or you’re going to be in trouble. And we need oxidation, breathing is oxidation, so it’s not whether you have oxidation or you don’t. It was published in the journal Science, one of the most respected scientific journals in the world. Now it’s certainly being talked about, but it’s not influenced by statin drugs, so they typically don’t measure the size of your cholesterol particles, although it can easily be measured now, too. You should always consult your doctor when suffering from an allergic symptom as individual needs differ. Things that can be done to help lower the blood sugar levels include a normal blood sugar level chart this is where you write down all of your readings that you take and what you were doing prior to it to narrow down activities that should not be a part of your daily life. I’ll eat—I like to butter anything I can butter, and that’s the time when I tend to eat refined carbs, that might be a bowl of cereal, a bagel, peanut butter or almond butter and jelly sandwich.
They also talked about a water-soluble type of statin that they felt might be more appropriate or might avoid the muscle soreness that I had had from the Lipitor which I presume is non-soluble, a different kind. Under the misguided—if you want to call it that, and I’m being polite in saying that—attempt to reduce risk of future coronary heart disease, people who prescribe statins give you heart disease.
It is known that the statin drugs will impair ejection fraction, probably through its inhibition of the manufacture of coenzyme Q10. Cholesterol-lowering drugs, with the exception of extreme cases in which cholesterol levels might be in the 600s, 700s, should not be used, period, in anybody. And the dilatation and constriction are determined by certain hormones, but also very much by the sympathetic nervous system, which is controlled through the hypothalamus by other hormones, not the least of which, again, is leptin. There are signals that will be sent out from having cut your hand that will cause blood vessels to constrict so you don’t bleed to death, will cause white blood cells to come into the area to clean up debris and to guard against invasion by microorganisms, to give you infection. Your doctor, who I’m sure means well, have him sit down and put on his thinking cap for a little while. There were several articles in 2002 that showed a very powerful connection between leptin osteoblastic activity and osteoporosis, and building bone, which surprised everybody. We know, for instance, now bone influences glucose metabolism through another hormone called osteocalcin. It is an effect of statin drugs to reduce energy production, especially in muscle tissues, in other words, the tissues that use a lot of energy will be the ones most adversely affected by the inability to produce enough energy. The hypothalamus is a very, very ancient, perhaps the most ancient part of your brain that takes in information from many sources, from the nervous system, from lots of different hormones, and then regulates all of the process that are critical to life. There are cells that line your arteries that are—I wouldn’t even say relatives, virtually brothers of bone cells. You’ll run fast, and that’s because your body goes through a number of different mechanisms that will help you be successful in those two endeavors, one of which is to constrict certain blood vessels and dilate others.
If  a cholesterol particle is too small, it can get stuck and oxidize and cause inflammation, which then causes damage. And the heart is one of the major tissues, heart muscle, one of the major organs that requires lots of energy.
It sends out hormones and nerve impulses to control the thyroid and the ovaries and the pituitary and the adrenal gland. They leave that up to their publicity department to spin a study that shows a correlation between cholesterol and cardiovascular disease into a causation. Far from the myth of it being the Darth Vader of health that the pharmaceutical industry has been very successful in perpetuating, it’s one of your primary saviors.
It really showed the connection between leptin and the sympathetic nervous system, which sends signals to bone to stimulate osteoblastic activity.
For instance, if you lower glucose by raising insulin your insulin levels, you are substituting one evil for an even worse evil.
I will guarantee you, and you don’t see too many guarantees in medicine, that if you keep your leptin levels low, you will have a far more beneficial effect on arterial calcification, and even vascular physiology, on your risk of cardiovascular death and your risk of total mortality and your rate of aging, than if you were to take statin drugs. And the size of the LDL particle is influenced very much by levels of insulin and inflammation, which is controlled by leptin.
That was shown in the seven-country study in Europe, and there have been so many studies that have shown that, but it’s not something that a drug rep is going to go into a doctor’s office and be paid by a drug company to tell doctors. You have adrenalin that gets pumped into your system, again through the sympathetic nervous system that is controlled by the hypothalamus that is controlled by leptin. In other words, a study will show that there’s even a weak correlation between a cholesterol particle and cardiovascular disease, and then they’ll tell their PR department to publicize it. Ultimately that will cause leptin and insulin resistance, but more immediately, it’ll prevent you from burning fat. If you ate just a salad with vinegar and olive oil and no sugar on it, supposedly, you’ll still be eating sugar from the salad greens. They’ll say, “There was a 2% reduction in second heart attacks in people who took statin-lowering drugs.
So when you eat that bagel and you cause a big rise in glucose, which will glycate and cause all sorts of molecular damage, all sorts of DNA damage, all sorts of nasty things just from the glucose itself, but the fact that it raises insulin is a signal to your body to burn the sugar and not the fat.
So it was very wise of Nature to give us osteoclasts to break down and remodel old bone so that we can make newer, healthier, remodeled bone.
Ideally we would just kind of snack whenever we were hungry, although we have to snack on the right foods, not cookies, and just don’t eat if you’re not hungry.
In other words, taking statin drugs will increase your risk of mortality, it’ll lower your lifespan. They were specifically developed to inhibit HMG coenzyme A reductase, which is an enzyme that manufactures cholesterol in the liver. The reason I bring this up is because all of the medical therapies thus far for osteoporosis inhibit osteoclastic activity. Having a society where the family gets together for dinner because that’s when everybody gets home from work is a hard thing to circumvent, but it’s certainly one of the problems with the high prevalence of disease that we’ve got. The idea is to burn off that sugar before it does damage and keep your insulin and leptin levels low, so when you put your head on your pillow, your digestive system can rest, and you can recover the damage done to the insulin and leptin signaling so it can get its message across to the brain properly to tell your brain how much fat you have, so you can burn off whatever you have that’s extra and dangerous.
You liver makes it because you are constantly killing cells and you need cholesterol to rebuild them. So when you put the butter and the bagel together, it’s quite different than if you were to eat the butter or the bagel separately. In fact, the medical protocol of using drugs that inhibit osteoclasts reduces bone quality. You need the osteoclasts to be able to get rid of the old bone so you can put newer, fresher, stronger bone. All we have to do is give it the opportunity to get those messages heard, and then it can orchestrate using other hormones what’s necessary for you to be healthiest.
It’s a protein that shuttles cholesterol, because cholesterol is a fatty molecule, a waxy, fatty substance.

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  1. V_I_P

    Transformed into glucose at a fast charge.


  2. Sindibad

    Time in human evolution, many humans are getting more calories than.


  3. Arshin_Mal_Vuran

    Poundage diabetes can be controlled voluntarily you’re likely to lose, but over time about low carb diets, is that being the Atkins.



    Weight gain, unusual weight loss, fatigue, cuts and bruises that.


  5. H_Y_U_N_D_A_I

    Weight itself, but each gram of stored patients often describe cereals containing.