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A scientific breakthrough from MIT, Harvard, Boston Children’s Hospital, Joslin Diabetes Center, and UMass Medical School could put a cure for type 1 diabetes within reach. Type 1 diabetics’ immune systems mistakenly attack insulin-producing cells, making it impossible for the body to naturally make enough insulin to properly process energy derived from food. The researchers developed a capsule that surrounds HSCI-developed stem cells, effectively making the foreign bodies invisible to the immune system. Daniel Anderson, senior author of the study and a Koch researcher, said in a statement that the discovery suggests that an injection-free future could be a reality for type 1 diabetes patients.
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Lab tests done on mice with Type 2 diabetes revealed that glucose metabolism improved after transplanting stem cells from the pancreas combined with drugs that sensitize insulin. The scientists conducted several tests to check which insulin-sensitizing drug could maximize the effect of stem cells on diabetes and obesity. It means a cure for Type 1 diabetes - which affects 400,000 people in the UK - could be much closer.
A cure for Type 1 diabetes is a step closer after scientists managed to halt the condition for at least six months thanks to insulin-producing cells.
In individuals with Type 1 diabetes, the immune system assaults the pancreas, leaving patients without the ability to naturally manage blood sugar. According to two new studies, published in Nature Medicine and Nature Biotechnology, researchers have developed a way to transplant pancreatic cells, replacing those lost to Type 1 diabetes, and were able to use the technique to temporarily cure the disease in mice. Individuals with type 1 diabetes currently cope with their condition by carefully keeping track of the sugar in their blood, measuring it many times per day and then injecting themselves with insulin to maintain proper blood sugar amounts.
Doctors have been experimenting with ways to transplant health pancreatic cells since the 1980s, but the alginate gels used to encapsulate cells had been causing scarring – rendering the treatment ineffective. After developing a library of almost 800 alginate derivatives, the scientists conducted a number of tests in mice and primates.

A stealth material surface, shown here, has been engineered to provide an “invisibility cloak” against the body’s immune system cells. After implantation, the cells instantly started generating insulin as dictated by blood sugar amounts and were able to kept blood sugar in check for the length of the study, more than 170 days. The scientists said they now plan to test their new materials in primates, with the purpose of ultimately holding clinical trials in diabetic patients. A CURE for diabetes is within reach after scientists proved the debilitating condition can be stopped for six months. Scientists are hoping a cure for Type 1 diabetes is getting closer after they managed to halt the condition for six months in an experiment involving insulin-producing cells. A team of experts from hospitals and institutions in the US, including Harvard University, have succeeded in transplanting cells into mice which immediately began producing insulin.
Within the experiment, the team showed they had found a way to prevent the body’s own immune system from knocking out the cells, meaning they continued to be effective.
Type 1 diabetes affects 400,000 in the UK and the scientists hope this latest work will bring a cure a step closer.
The findings follow on from news revealed at the end of 2014 that experts had found a way to make huge quantities of insulin-producing cells. The findings, published in the journals Nature Medicine and Nature Biotechnology, were funded by the Juvenile Diabetes Research Foundation (JDRF).
Now because something works in mice does NOT mean it works in humans.  But, the hope is that by blocking excess glucagon, blood sugar regulation in humans will occur and insulin won’t even be required.
The multi-institution research team, however, may have found a way to prevent the immune system from destroying insulin-producing cells made from stem cells. They implanted the encapsulated insulin-producing stem cells into mouse models, where they successfully regulated blood sugar and functioned without immune system attack for at least six months.
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This time, a new research sheds light into the possibility of doing the same for Type 2 diabetes. The tests were also conducted to assess the impact of stem cells on obesity, which yielded promising results.
In order to post comments, please make sure JavaScript and Cookies are enabled, and reload the page. Experts from US hospitals and institutions including Harvard University managed to transplant cells into mice, which immediately began producing insulin. However, precise control of blood sugar is challenging to achieve, and patients face a range of long-term medical complications consequently. One of the most promising was a derivative referred to as triazole-thiomorpholine dioxide (TMTD). If successful, this method could mean long-term blood sugar control for individuals with diabetes.
Doing so could pave the way to a diabetes treatment more effective and less invasive than manual insulin injections.
Based on that promising result, they’ll move next to testing the method in non-human primates, then, hopefully, to human clinical trials.
The findings build on the news at the end of 2014 that experts had discovered how to make huge quantities of insulin-producing cells. The study team decided on a species of mice with a strong immune system and inserted human islet cells encapsulated in TMTD into a area of the abdominal cavity referred to as the intraperitoneal space.

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