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A big credit to rising life expectancy trends goes to pharmaceutical companies for improved treatments options to many of these diseases and disorders. Harris, on behalf of the MetLife Foundation, conducted its survey in September 2010 by asking 1,007 U.S. Diabetes is often brushed aside as a nuisance rather than a serious disease, but prolonged exposure to high blood sugar can cause heart attack, stroke, and kidney failure. Just last week, actor Tom Hanks admitted that he has been dealing with symptoms of type 2 diabetes for the past two decades.
To put heart disease's mortality into scope, the fourth through 10th leading causes of death in 2010 don't combine to account for the number of deaths caused by heart disease. An exciting new treatment to watch here would be Pfizer and Merck's Liptruzet, which is targeted as an LDL-cholesterol lowering drug (the bad type of cholesterol). Perhaps the biggest reason Alzheimer's jumps up the list is because it's one of the most misunderstood and relatively untreatable diseases still out there.
The disease itself is incredibly tricky to treat because of the blood-brain barrier, which makes getting medication from the blood into the brain difficult. When it comes to treating Alzheimer's, I would suggest keeping your eye on Eli Lilly despite its late-stage disappointment with solanezumab. Two more cancer-focused biotechs that could change the gameThe best way to play the biotech space is to find companies that shun the status quo and instead discover revolutionary, groundbreaking technologies. Fool contributor Sean Williams has no material interest in any companies mentioned in this article. According to the World Health Organization's International Classification of Disease, version 10, there are 12,420 different types of diseases in the world. Certain diagnoses have a way of inspiring fear in Americans unlike others, which is why, in 2011, Harris Interactive set out to discover exactly what those were. Rather, they develop diabetes through some mixture of genetics and lifestyle habits such as poor food choices or lack of physical exercise (type 2 diabetes).
It's my personal hope that having a high-profile role model in place will give this disease the acclaim it needs to get high-risk people to eat healthier and exercise more.
The reason SGLT2 inhibitors are so exciting is that they work in the kidneys to block glucose absorption, as opposed to previous generations of diabetes drugs that worked out of the pancreas and kidneys.


4: Stroke (8%) Stroke was the fourth-leading cause of death in 2010, but you'd hardly know it with just 8% of Americans saying they fear it the most. Other factors that increased your chance of a stroke included hereditary factors like ethnicity and age, as well as existing medical conditions like high blood pressure, high cholesterol, and of course, diabetes.
This revolutionary blood thinner was approved by the Food and Drug Administration in late December to prevent stroke in patients with atrial fibrillation. Liptruzet -- which is an oral medication comprised of Pfizer's generic Lipitor and Merck's cholesterol absorption inhibitor Zetia -- demonstrated an LDL reduction of 53%-61% in trials compared to just 37%-54% for Lipitor alone and 20% for Zetia as a monotherapy. 2: Alzheimer's disease (31%) Please note the monstrously large jump between heart disease at No. Harris Interactive's poll notes that 62% of those polled admitted to knowing "nothing" or only "very little" about Alzheimer's.
In 2012, international scientists chose solanezumab -- which attaches to amyloid floating free in the brain before it attaches and become plague -- and LY2886721 -- which blocks a specific enzyme used to make amyloid -- (as well as a drug from Roche) for a long-term (three-year) Alzheimer's study out of 15 possible drugs.
2 leading cause of death behind heart disease likely tops the rankings because of how quickly the disease can strike and the suffering it can cause. This experimental therapy has received the breakthrough therapy designation from the FDA and was recently submitted as a new drug applicant based on some incredible mid-stage study results.
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Approximately 90% of the aforementioned diabetes cases in this country are of the type 2 designation.
This relatively low percentage could have a lot to do with the risk factors for stroke being pretty well-defined. This doesn't make the prospect of having a stroke less scary, but it does help narrow down a person's risk potential dramatically.


When pitted side-by-side against Warfarin, which has been a blood-thinning mainstay for two decades, it outperformed in numerous categories. With a whopping 35.7% of this country considered obese -- and obesity coming with a higher risk of high blood pressure, high cholesterol, and diabetes -- the deck is stacked against a good percentage of the population.
Furthermore, Liptruzet also boosted the production of HDL cholesterol, the good type of cholesterol.
Furthermore, the poll indicates that even though 44% of respondents noted knowing a family member or friend with Alzheimer’s, only 18% of people have developed a plan should they get Alzheimer's, with regard to long-term care options and financial planning. It's far too early to guess whether these compounds will be successful, but you have to like Eli Lilly’s chances with two of its experimental drugs being chosen out of 15 hopefuls. This isn't to say that the aforementioned diseases aren't debilitating, but treatment for many cancer types can involve painful surgeries, radiation and chemotherapy that can lead to unpleasant side effects, and very low success and survival rates depending on the cancer type.
Ibrutinib is designed to treat mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), the most common form of leukemia in adults.
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In addition, previous type 2 diabetes medications either caused weight gain or were weight neutral as in the case of DPP-4 inhibitors, but Invokana was actually shown to induce weight loss in patients! It's hard not to be concerned with heart disease because there are so many variables that act as risk factors, including high blood pressure, high cholesterol, obesity, diabetes, poor diet, your gender, and family history. Some of the more common cancer types like lung cancer and pancreatic cancer carry with them five-year survival rates of just 17% and 6%, respectively.
In MCL trials, ibrutinib delivered an overall response rate (ORR) of 68% with a median response duration of 17.5 months while offering an ORR of 71% in treating CLL.
I'll also add some investing flair by noting an existing or upcoming drug worth keeping an eye on within each disease type that could have an opportunity to significantly change things for the better.
If you have prediabetes, making lifestyle changes may help stop it from progressing to type 2 diabetes.



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