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As the parent of a child with type 1 diabetes, I avidly follow news about advances in treatment of the disease. When Bisi was diagnosed, several people tried to encourage us by saying how fast research is moving on the disease. Susan Bonner-Weir, a senior investigator at the Joslin Diabetes Center, is one of those researchers looking for a cure, though her research looks only at the beta cell aspect of the type 1 diabetes conundrum. Earlier this year, Bonner-Weir  gave a talk at a Joslin symposium on cutting-edge research into type 1 diabetes.
Based partly on Joslin’s ongoing 50-year medalist study, in which every pancreas examined so far has still had scattered beta cells (despite at least five decades of diabetes), Bonner-Weir and other scientists have argued that either the beta cells in the pancreas continue to make copies of themselves, or that the pancreatic ducts, through a process called budding or neurogenesis, continue producing new cells. Right now, Bonner-Weir is trying to understand exactly how the progenitor cells change into beta cells, and how those cells then function. Even if Bonner-Weir’s lab is able to figure out how to grow the duct cells into mature beta cells, these new cells would then face sustained autoimmune attack. A researcher looking to solve even just one aspect of type 1 diabetes needs to have tremendous patience. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes.
Enter your email address and we'll send you our weekly newsletter chock-full of useful advice for all aspects of diabetes care and the latest in the field. Recent research demonstrates some exciting results in the dementia risk reduction for people taking a medication that targets diabetes. The American Diabetes Association published the 2016 Standards of Medical Care for Diabetes. Learn the key differences between the DexCom 4 and DexCom 5 systems and reviews the pros and cons of continuous glucose monitoring. Although experts have known for some time that bariatric or metabolic surgery improves diabesity, new guidance suggests surgery as treatment.
Trulicity - a new Glucagon like peptide agonist, non-insulin injectable,Type 2 diabetes medicine by Eli Lily and Company has been approved by the FDA. The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) has issued a clinical appraisal of insulin pump safety standards.
The introduction of insulin pumps has been one of the greatest advances in type 1 diabetes treatment history. Whilst insulin pump manufacturers have taken care to ensure a strong level of safety, problems that can and do occur in a home usage setting include adverse events such as insufficient or excessive insulin delivery which can occasionally lead to dangerous short terms complications such as ketoacidosis and severe hypoglycemia.
Within the clinical appraisal, the ADA and EASD note a number of recommendations towards improving insulin pump safety.
Bringing together American and European standards to be met by insulin pump manufacturers both before and after insulin pumps are launched. The European and US regulators should maintain a single publicly accessible database for reporting of adverse events.
Pump manufacturers should provide more transparency in terms of data including how many people use their pumps, how durable and precise the pumps are and data related to product recalls. National and international societies should set guidelines on indications for insulin pump usage, education for insulin pump usage and standards for healthcare professionals that are responsible for overseeing care of patients on insulin pump therapy. Research funding bodies should facilitate funding of independent trials to determine insulin pump effectiveness and safety within a real-world setting. Healthcare teams responsible for patients on insulin pumps should provide regular structured training for patients and should encourage patients to report all adverse events related to insulin pump usage.
The Animas Vibe insulin pump, which incorporates the Dexcom 4 Platinum continuous glucose monitoring (CGM) sensor, has finally received FDA approval for use in adults within the Unites States. The artificial pancreas has reached another important step towards becoming a reality for the public after success in a clinical trial which compared two different types of artificial pancreas against conventional insulin pump therapy. Insulin pump manufacturer Medtronic has started to enrol patients with type 1 diabetes for a clinical trial which will test out its latest technology.


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Despite the fact that not all doctors are mindful of the experimental advances that demonstrate it, most diabetics can now dodge insulin infusions and avert or reverse the fatal complications of this disease.
Assume responsibility of Your Diabetes showcases the extraordinary arrangement, Centers for Disease Control and Prevention have has grown in treating a huge number of instances of Type 1 and Type 2 effectively.
Q: TRY— Asked on April 16, 2014This question has not been responded to yet.Have a Question? How To Make the quality CHOCOLATE CAKE and also BEAUTIFY IT LIKE A PRO – Step-by-Steps Guide! As I’ve written, Bisi loves her new Omnipod pump; I have heard great things about the new Dexcom G4 Platinum CGM and suspect that Bisi will start using it in the not too distant future. Maybe, in a decade or so, the problem will be solved, they told us.  But I’m someone who was born the year Nixon declared war on cancer and I’ve since lost my aunt and then my father to that disease, so I’m skeptical whenever I hear talk of cures, especially for a problem as complicated as type 1 diabetes.
Any potential cure for type 1 diabetes will have to solve two large problems.  How do you regenerate an adequate supply of insulin-producing beta cells? She began her talk with a quote from an early study of diabetes, written less than two decades after insulin was discovered. Bonner-Weir’s work focuses on this latter process, which she believes holds more hope for creating an adequate supply of beta cells.
Yet Bonner-Weir is optimistic about the promise of duct cells as a home-grown factory for new beta cells. Bonner-Weir has been investigating the question of how to produce new beta cells for years, and first published a study showing the promise of pancreatic ducts for producing new islet tissue almost 15 years ago. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Insulin pumps are now commonly used in the treatment of type 1 diabetes and are also being considered and used in some people with gestational diabetes and type 2 diabetes. The key is treating the root issue of diabetes as opposed to concentrating on controlling blood sugar levels, an old fashioned practice that puts patients at more serious danger for heart assault and stroke. Drastically not the same as customary treatment conventions, the project incorporates a simple to-take after eating methodology, a moderate practice and anxiety diminishment plan, vitamin and supplement proposals, and a physician endorsed prescription regimen that lessens the quantity of solutions over the long haul rather than the conventional treatment model: venturing up measurements as diabetes advances. I am excited about the potential of a closed-loop system that would presumably take much of the meal-to-meal management out of type 1 diabetes while also protecting against scary lows and highs. Doug Melton, the co-director of the Harvard Stem Cell Institute who devoted his career to curing type 1 diabetes after both his children were diagnosed with it, told me before a recent talk he gave that type 1 diabetes is a much thornier problem to solve than cancer. Weir, are looking into ways to protect beta cells through protective capsules made of algenate—a form of seaweed—or some sort of polymer.
Despite being commonly used, however, there are areas related to safety which could and should be improved according to the joint statement.
The current funding landscape for type 1 diabetes makes it even less likely that a cure will be discovered anytime soon. It does not submit without a struggle to injury, but endeavors to regenerate.” Can this effort be exploited? But what I and others have suggested is that the duct population of the pancreas remains sort of a pool of potential progenitors,” Bonner-Weir explains. Yet work like this gives me hope that someday, maybe when my daughter is a parent herself, type 1 diabetes will no longer be something she needs to contend with every meal, every day. In order to determine the better urine sample for detecting ACR, we estimated ACR in three modes of urine sample. Two hundred patients of uncontrolled diabetes mellitus with proteinuria irrespective of age and sex were studied for urinary ACR in all the three types of samples over a period of 2 years.
INTRODUCTIONDiabetic nephropathy (DN) is the most frequent single cause of end-stage renal disease in many countries [1].
Increased levels of albumin in the urine have been clearly established as an important determinant for renal complication of diabetes [3-5].


Screening for increased albumin excretion has therefore been advocated to identify individual at risk for renal disease progression in a timely manner.
However, there is still continuing uncertainty as to how urine should be collected and which urinary proteins should be specifically measured for prediction of renal events [6]. So, the present study therefore is to investigate which urine sample such as 24 hour, first morning void or spot urine sample is to detect actual value of microalbuminuria for DN.
But measuring only urinary albumin excretion (UAE) is not sufficient as it is influenced by intra-individual variations in urinary volume. That can be overcome by using albumincreatinine ratio (ACR) that is dividing UAE with urinary creatinine excretion as creatinine excretion in urine has relative constancy over time [7]. Selection of SubjectsThe present study was conducted in the department of Biochemistry of Burdwan Medical College, Burdwan, West Bengal. Collection of Samples After noting the age and sex, three types of urine samples (24 hour, first morning voided and random) were collected from all subjects. Parameters AssayAlbuminuria was measured by immunoturbidimetric method [8,9] using semiautoanalyser (Chem 5v2 plus). Urinary creatinine concentration was assayed by Jaffe’ method [10] using auto analyser (Transasia, XL- 600). Using comercially available Hemoglobin A1C kit supplied by Siemens Company did Hemoglobin A1C test. This company also supplied total Hb kit for estimation total Hb by alkaline hematin method. Another observation is that spot urine ACR value has higher mean, SD and has wider confidence interval than other two samples as shown in Table 2.Table 1. Pearson’s correlation of 24 hour urinary ACR with early morning and spot urine ACR.(a)(b)Figure 2. Receiver Operative Characteristic (ROC) curves of ACR (a) between 24 hours and early morning sample (b) between 24 hours and spot urine sample.Table 4.
DISCUSSIONACR has been proposed as both a screening and diagnostic test for kidney disease [11].
Screening for microalbuminuria is essential as it allows interventions aimed at preventing diabetic nephropathy [12,13] and part of the everyday treatment of diabetic patients [14-16] for detecting kidney disease progression and also evaluation of treatment effect [17] therefore, samples providing immediate and reliable results are highly desirable. With the respect to urine collection procedure 24 hour collection were initially advocated gold standard [18-20] because of circadian rhythm of urinary protein excretion [21] and has found to be the least variable parameter for the measurement of microalbuminuria [22,23]. But 24 hour urine collection is a cumbersome procedure and subject to collection errors [24-27].
More practical and easier alternatives are collection of a first morning void or a spot (random) urine sample [28-32].
Numerous recent studies have been shown that early morning urinary ACR for screening purpose is also a predictor of overt DN and is useful to identify patient at risk [33] as it is less influenced by the factors such as hydration status, physical activity and concentration bias [34,27]. In present study, when cut-off values are used that are advocated in reagent manual, the value of ACR of first void sample are closed to the value 24 hours than spot urine. Various previous studies also give support towards this factor due to easy collection, low cost and high sensitivity [2,35-37].5.
CONCLUSION The study concluded that early morning sample not the spot urine sample could replace the 24 hour sample for estimation of urinary ACR.6. Karthik Roy, Naba Kumar Das and Chandi Charan Das of Burdwan Medical College and Hospital for technical support.



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