22.02.2014
Light tests have shown that patients frequently on react to a certain part of the light range, i.e.
It is interesting to note that some patients, whose urticaria is only triggered by the light of the sun, can tolerate artificial light without any problems. Another option of symptomatic treatment is the administration of antihistamines which block the effects of histamine. An alternative therapy that may be successful, but hardly feasible in reality, is a light desensitisation treatment.
Phase-1 Studie zur Prufung der Vertraglichkeit und Wirksamkeit eines Antikorpers zur Behandlung der systemischen Mastozytose.
The Dermatology Center at University of Charite Berlin is looking for adult patients with chronic spontaneous urticaria.
The Dermatology Center at University of Charite Berlin is currently looking for patients with cold urticaria who is interested in testing the drug Rilonacept. A cholinergic urticaria causes itchy wheals, which oftentimes cannot be controlled sufficiently with antihistamines. Several research groups examine the connection between the vitamin D level in the blood and chronic spontaneous urticaria (CSU). Solar urticaria (an inducible type of urticaria) leads to wheals, redness and itching on the skin after the exposure to light – especially sunlight. UV-8 Series are advanced double beam design consisting of 3 models: UV-8000, UV-8000A, UV-8000S. In the case of solar urticaria, the appearance of wheals and itchiness occurs after exposure to light, particularly sunlight. For some 70 % of the patients with solar urticaria there is a specific wavelength range, beside the action spectrum, that actually suppresses the formation of wheals.


Sometime skin changes may also be due to the so-called polymorphous light dermatitis which resembles those of solar urticaria. Apart from antihistamines all the drugs can be used for treatment which are currently also recommended for spontaneous chronic urticaria. For this therapy initially only parts of the body, later the whole body, are exposed to light of the triggering wavelengths (phototherapy). Immer wenn sie Sport machen oder aus anderen Grunden ins Schwitzen kommen, bekommen sie kleine juckende Quaddeln?
In common language light urticaria is (wrongly) sometimes called “sun allergy”.Solar urticaria can occur at any age. Usually the wavelengths of the inhibition spectrum are longer than those of the action spectrum: If, for instance, the action spectrum is in the UVA range of wavelengths around 320-400 nm, the inhibition spectrum would potential be in visible light (400-780 nm). The intensive exposure leads to the desensitisation of the skin to light and wheals do not occur so easily.
Possible women are more frequently affected than men, however, little is yet known about the ratio among the sexes and the duration of solar urticaria. Some patients with solar urticaria are intolerant to visible light, other only react to, for us invisible, UVA radiation (340–400 nm wavelength) or to UVB radiation (280-320 nm) (Ill.
The same applies to photoallergic and phototoxic contact eczema and more rare diseases like lupus erythematosus and porphyria.CausesContrary to the case of spontaneous chronic urticaria, little is known about the possible connection between solar urticaria and infections, food additives, allergies or other causes. The symptoms of light urticaria can be triggered by visible light but also by UVA or UVB rays.Solar urticaria typically begins suddenly in spring or summer. In the case of solar urticaria, as a rule only such areas of the skin are involved which have been exposed to the sun, whereas in the case of heat urticaria the wheals occur more on skin under clothing (heat generation). The patient reacted clearly to UV rays with wheal formationA light test should be carried out to diagnose solar urticaria.


A few seconds or minutes after exposure to light (UVA, UVB or visible light), itchy wheals form on the skin in the areas exposed to the light.
This involves exposing the skin (or parts of the skin) to light of various wavelengths to establish the triggering wavelength range.
The test is made with a so-called “photo patch” on patches of the skin not usually exposed to the sun, e.g. Lightweight clothing does not completely ward off UVA rays and visible light, this means that solar urticaria can also appear on “covered” areas of the body. Once the sun exposure is discontinued, the symptoms often disappear again in one or two hours.
Exposure to lower intensity rays may only cause redness or small wheals, therefor it is not always easy to differentiate solar urticaria from other skin reactions triggered by light.
If the entire body is exposed to the triggering rays, then serious symptoms like respiratory distress, dizziness or an anaphylactic shock may occur. However, it is typical for solar urticaria that the wheals appear within a few minutes after radiation on the test areas. TreatmentBecause it is not exactly known yet how and why solar urticaria occurs, there is currently no known approved effective therapy, which combats the cause of the disease. An attempt is therefore being made to either prevent the urticarial outbreak by protection against light or to alleviate the symptoms.One relatively simple way to provide protection against exposure to the sun is to use sunscreens with a high light protection factor which filter out a wide range of light, as well to wear appropriate clothing and hats and to primarily stay in the shade. Unfortunately these measures are only effective for patients who react to ultraviolet light, but are of little benefit for urticaria triggered by visible light.



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