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In April 2003, at a cost of $2.7bn, the human genome was announced to great pomp and ceremony. The first problem is that the most common diseases seem more complicated than we had hoped.
One can now do an experiment whereby you measure the genomes of a group of cancer patients and compare them to the genomes of a group of healthy volunteers. Albeit technically difficult, analysing the proteome of patients has the potential to tell you which subset of disease patients may have, it can tell you which faulty genes are the most harmful, and can give you possibilities for new treatments. The Human Genome Project has and will continue to open up new realms of possibility for understanding more about life. The brain bank comprises a group of scientists from the North West of England eager to enthuse and entertain with their scientific banter. Insight from behind the lab bench: Could a period pain treatment be re-purposed to treat Alzheimer’s disease?
This would reveal the deepest secrets of biology, give us the blueprint to create a human and disclose how diseases develop. This was an international collaboration like no other, which would be the shining peak of human endeavour. Instead of being one disease caused by one gene, these diseases seem to be lots of smaller diseases caused by many different genes, conspiring to produce similar results.
Unfortunately, this gives you many, subtle deviations and not one Holy Grail ‘cancer gene’.
Angelina Jolie nobly led the way earlier in the year with the announcement that she had had a preventative double mastectomy.

We hope that what goes on beyond a person’s genes will unlock further understanding of disease and truly bring in the era of personalised medicine. It has given us the basis to build on our knowledge of how we are made and the beginning to personalised medicine. But 10 years on, has the Human Genome Project been a true medical breakthrough and what role does it play in medical treatment today? Being able to look into an individual’s DNA would give us new knowledge about what caused diseases. Jolie had a genetic test which revealed she carried a faulty copy of a gene known to increase women’s chances of breast cancer to 87%.
This fits with the knowledge that these diseases are actually different diseases all showing similar symptoms. It is the proteins that are made from these instructions that are the true machines of the living world. Genes contain the instructions to make proteins via processes known as transcription and translation. By measuring the proteome (all the proteins in a cell) we can now see what the genes are doing. What’s more, this would herald a new era in medicine whereby we could use this to diagnose diseases years before a patient felt any symptoms and tailor their treatment to their own personal needs.
Speaking to the Guardian’s Carole Cadwalladr in her excellent first-hand account of how it feels to get your own genome sequenced, Dr.
People like to group cancers together into one disease but in reality, there are many, varied faulty processes that can cause a cancer to develop.

Having a complete code of the cells in your body can only increase the likelihood of finding similar preventable risks of your own.
By understanding which small subset of disease a patient is showing and how a patient might deal with a drug, we can tailor the treatment accordingly. Proteins are made from genes via processes known as transcription and translation (see picture below). We can see which genes are more active than others by seeing how much of the respective protein is being made. How a protein is made from the instructions in a gene can be impacted by many lifestyle and environmental factors.
The vast complexity of this comes when people can have very similar genes, but widely different combinations of proteins they make from them. Until we understand more about how specific genes make specific proteins and how this is impacted in common diseases, we will only be scratching the surface of the potential personalised medicine has to revolutionise treatment. At this stage, we have increasing numbers of great success stories from rare genetic diseases, but limited success in the most common diseases.
Measuring someone’s genome alone will not tell you exactly what is going on within their bodies.

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