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How it works: Mucinex used to be available by prescription only, so you know this is some strong stuff. Potential hazards: Monitor the side effects, especially if you have a skin rash or itching, says Binaso.
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By clicking "Sign in", you confirm that you accept our terms of service and have read and understand privacy policy. By clicking "Create Account", you confirm that you accept our terms of service and have read and understand privacy policy. How it works: All the tissues in a warehouse store won't blow out your stuffy nose, because the snotty stuff isn't what's cramming up your nasal passages. Good to know: Although it's an OTC product, pseudoephedrine is stored behind the pharmacist's counter, so you'll have to ask for it. Potential hazards: Increased heart rate, nervousness, or irritability, especially if you require a cup (or four) of Starbucks every morning.

If you manage this site and have a question about why the site is not available, please contact us directly. Pseudoephedrine does the heavy lifting to clear out your stuffy nose and sinus pressure by deactivating those swollen blood vessels. Guaifenesin generally has a wide margin of safety, but it may cause nausea, vomiting, dizziness, headache, skin rash, and itching.
If they become worse and you're suddenly short of breath, stop using the product immediately.
Blame swollen blood vessels for the congestion, says Engle, who recommends turning to a pill packed with pseudoephedrine, a vasoconstrictor that will shrink them in less time than it takes to finish watching an episode of Glee. The Sudafed PE seen on shelves contains phenylephrine—a D-list choice for your cold-and-flu-fighting needs.
Some users also report insomnia, so start with the 12-hour version before you graduate to 24-hour coverage—and take it earlier in the day so it won't interfere with your much-coveted Z's. At the same time, the expectorant will thin any mucus camping out in your lungs and help you cough it up before it becomes a Woodstock-like breeding ground for bacteria, says Binaso.

If you experience major episodes of these side effects, talk to a pharmacist or your doctor for alternatives.
Research published in a 2009 issue of Annals of Allergy, Asthma, and Immunology reported that congested people treated with phenylephrine didn't fare much better than the participants in the placebo group.
Before taking Sudafed, be sure to talk to your doc or pharmacist if you have a heart problem, high blood pressure, or asthma. However, those who popped a single dose of pseudoephedrine felt significantly more at ease within six hours.

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