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ProBioCare is a line of premium probiotic supplements; each formula is designed to help replenish beneficial bacteria in the intestinal tract and to support digestive and immune health. Disclaimer Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease.
Disclaimer: Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Consult a health care practitioner prior to use if you are having coagulopathy problems or taking anticoagulants or other medications, or if you are pregnant or breastfeeding. January 28, 2015BIMUNO PRe-bioticAnxiety, Bifidobacteria, Bimuno, Bimuno Feeds Good Gut Bacteria, C diff & Anxiety, C. I was looking for a non-pharmaceutical way to help my anxious and OCD patients so asked my supplements guru, David Miller, MD at LifeThyme (a health food store in NYC).
It comes as sachets of tasteless powder to sprinkle over food or add to drinks and also as soft chewable pastilles. Bimuno® is a new PREbiotic product that feeds the good, PRObiotic bacteria living in our guts (such as Lactobacilli and Bifidobacteria) to the detriment of the bad bacteria (pathogens). PREBIOTICS are specialized plant fibers containing complex sugars (such as inulin,  fructo-ogliosaccharides and galacto-oligosaccharides) that are indigestible by humans but promote the growth of beneficial bacteria (PROBIOTICS) living in our gut microbiomes by serving as food for them. PROBIOTICS are helpful, live bacteria and yeasts our bodies need to function and maintain good health. Sometimes PREBIOTICS and PROBIOTICS are combined in the same supplements, called SYNBIOTICS. See my earlier posts Prebiotics and Probiotics and  PREbiotics and PREbiotics for more information. It selectively boosts Bifidobacteria which play a key role in immune function and maintaining and building a healthy digestive system.
Bimuno is the result of many years of intensive research by a team of international digestive health experts and the University of Reading. Bimuno® original powder is the natural way to increase and energise your good gut bacteria helping you to manage your gut health.  Bimuno works in a similar way to prebiotics naturally found in human breast milk which promote a healthy bacterial balance within the gut.
Scientific studies indicate that the unique second generation Galacto-oligosaccharide formulation of Bimuno powder, can help to encourage and sustain a healthy level of your friendly gut bacteria(Bifidobacteria). Published scientific studies have shown that, with daily use, the majority of Bimuno users experience a significant increase in their gut Bifidobacterium within just 7 days. This in itself is impressive but by a unique anti-adhesive action it also helps flush ‘bad’ bacteria from your gut at the same time for a healthy microflora balance. Christian John Lillis, of the Peggy Lillis Foundation, reports noticing an uptick in the number of people on Clostridium difficile Facebook groups who mention that they’re also struggling with anxiety.
Animal studies have previously shown a link between mood and brain function and probiotics in the gut microbiota. Now new research on healthy human adults conducted by a group of neurobiologists at Oxford University demonstrated that supplementation with PREbiotics (Bimuno® galacto-oligosaccharides, B-GOS) lowered the subjects’ neuro-endocrine stress responses and increased their ability to  process positive versus negative attentional vigilance. The researchers assessed how subjects processed emotional information, such as positively and negatively charged words, after they’d been taking the prebiotic supplement.
A similar effect has been observed in people taking anti-depressants and anti-anxiety pharmaceutical medication. The galacto-oligosaccharides in Bimuno® are a mixture of disaccharides, trisaccharides, a tetrasaccharide and a pentasaccharide.
DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment.
In general I am wary of websites that present research about their specific product as being helpful without presenting other studies comparing to other companies products or to levels in known other sources of the stuff.
The article you site mentions three types of prebiotics occurring naturally in foods: Inulins, Fructo-oligosaccharides (FOS), and Galacto-oligosaccharides (GOS).
Here’s a list of research studies that led to the development of Bimuno with the particular type of galacto-oligosaccharides found in it. Our results have provided the necessary ‘proof-of-principle’ for the central actions of prebiotic consumption. BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels? Sorry, but eating prebiotic foods, while the intention is good, the results don’t equate. Enter your email address to subscribe to this blog and receive notifications of new posts by email. Subdivided into two groups, grains are rice, bran, wheat, cornmeal, oatmeal, or other cereals. Examples of whole grain products include brown rice, bulgur, cornmeal, oatmeal, quinoa, and whole wheat flour. Doctors and nutrition experts recommend consuming more whole grain foods than refined grains. Studies indicate that the American diet is severely lacking in whole grain consumption with the average person consuming less than one whole grain item per day. Salt influenced the establishment of trade routes and cities, provoked and financed wars, secured empires and inspired revolutions. The English word salary derived from sal, the word for salt: Roman soldiers were paid in salt rations.
The word salad also originated from sal:  Early Romans salted their leafy greens and vegetables. Salt crystals growing on the walls of a tunnel at the Salina Turda Salt Mine in the town of Turda, Transylvania, Romania, now turned into a museum.  This mine dates from the 17th century.
In 2,200 BC, the Chinese emperor Hsia Yu levied one of the first known taxes – on salt. In colonial India during the Raj, only the British government was permitted to make and profit from the salt production conducted by Indian workers living on the coast. In the American colonies under British rule, salt production also played a significant role.
If your interest in the history of salt has been piqued, see History of Salt for more information. I also highly recommend a New York Times bestseller by Mark Kurlansky called  Salt: A World History.
Kurlansky is a winner of the James Beard Award for Excellence in Food Writing for Cod: A Biography of the Fish that Changed the World.
Throughout history, salt was indeed divine – full of trace minerals, unlike the processed table salt generally in use today. Table salt is mined from the earth with bulldozers and other machinery and then heavily refined. It’s soaked in a solution which may contain sulfuric acid or chlorine and various  bleaches.
Unrefined salts contain trace minerals that support the proper functioning of all our bodily systems, including the immune system, glandular system and nervous system.
Salt has increasingly been blamed for a number of  health problems, such as high blood pressure, heart disease and stroke. Most of what we’re told about salt these days is that its consumption needs to be reduced. When salt is chemically cleaned and processed, the trace minerals and electrolytes that naturally occur in unrefined salt are removed as if they were impurities.
Chemically processed table salt is inorganic, which means that the chemical bonds are so strong they can’t easily be broken down or metabolized by our bodies.
Processed table salt provides virtually NO benefits for the body and causes numerous health problems. Refined, adulterated salt (a byproduct of the chemical industry) contains only two elements: sodium (Na) and chlorine (Cl).
Most statistics on salt intake lump refined table salt with unrefined, unprocessed sea salt – leading salt to be seen as harmful.
The ONLY salts the body is able to digest, assimilate, and utilize properly are unrefined, unprocessed sea salt or rock salt.
The addition of iodine to table salt is a real problem, turning the salt our bodies need daily into little more than a poison. We get iodine from eating fish and shellfish, eggs, cereal grains, legumes, dairy products from cows fed with iodized salt, and some food additives. Our blood is a 1% sole (water and salt) solution – the same concentration as ocean water. Making sole:Add one one teaspoon of unrefined sea salt to a glass of artesian or spring water and drink before eating or drinking anything.


Salt can neutralize acids in our bodies and it can also cancel out harmful electromagnetic vibrations in our environment.
It is water and salt that regulates all metabolic functions of the body, including functions of the solid matter itself.
Without potassium (which is stripped from processed table salt) and sodium, we could not think or act. Cells suffering from a dietary deficiency of trace elements lose their ability to control their ions – causing dire consequences on the human body. Ingesting natural sea salt (reconstituted seawater) allows liquids to freely cross body membranes, blood vessels walls, and glomeruli (filter units) of the kidneys. In addition, healthy kidneys are easily able to remove these natural saline fluids, which is essential for keeping the fluid concentration in the body balanced. Refined salt, in contrast, may pose a great risk to the body by preventing this free crossing of liquids and minerals thereby causing fluids to accumulate and stagnate in the joints, lymphatic ducts, lymph nodes, and kidneys.
The dehydrating effect of commercial salt can lead to gallstone formation, weight increase, high blood pressure, and other serious health problems. The Celts, who lived throughout Europe about 1,200 BC to 61 AD, used unrefined sea salt to treat major physical and mental disturbances, severe burns, and other ailments. Research has shown that sea water removes hydro-electrolytic imbalance, a disorder that causes a loss of the immune response, allergies, and numerous other health problems.
In recent years, salt has received a bad reputation and people have learned to fear it – in the same mistaken way they fear cholesterol and sunlight.
While it is true that consuming processed table sale is likely to have serious health consequences, eating unrefined salt fulfills the body’s need for salt without upsetting the hydro-electrolytic balance. If your diet contains an adequate amount of potassium in natural form, there’s no cause for concern about being harmed by the relatively small amount of sodium in real sea salt. Foods that are  high in potassium are bananas, apricots, avocados, pumpkin seeds, beans, potatoes, winter squash, and many other vegetables. However, if potassium levels in the body drop below normal, sodium (even in natural salt) can become a source of imbalance. Dissolving a pinch of sea salt in a small amount of water and adding that to fruit or other foods that are usually eaten raw will aid in their digestion while also helping to de-acidify the body.
Adding a pinch of sea salt to drinking water generates desirable alkaline properties and provides you with important minerals and trace elements. Himalayan Pink Salt was formed from marine fossil deposits over 250 million years ago, during the Jurassic Era. Himalayan sea salt’s high mineral and iron content causes its crystals to range in color from sheer white, varying shades of pink, to deep reds.
It is used to stimulate circulation, relax the body, lower blood pressure, soothe sore muscles, and remove toxins from the body. Regular consumption of Himalayan Pink Salt provides essential minerals and other trace elements, balances electrolytes, supports proper nutrient absorption, eliminates toxins, balances the body’s pH, normalizes blood pressure, and increases circulation and conductivity. Balances blood sugars. Celtic sea salt helps balance blood sugars so is especially helpful for diabetics. Increases energy. Salt and water are the key elements for the generation of hydro-electric energy in the cells. Builds immunity. Regular intake of natural sea salt and its highly absorptive minerals can provide a higher resistance to illness, infections, and disease. Promotes restful sleep. The abundance of trace minerals in natural sea salt will have a calming effect on the entire nervous system. Prevents muscle cramps. Muscle cramps are often caused by an electrolyte imbalance, especially a lack of sodium.
Maldon sea salt is produced by evaporating the salty waters of the Blackwater River that winds through southeast England, in Essex County. Salt has been harvested in Essex for over 2,000 years, when seawater was partially evaporated and then heated in clay pots over open fires. According to the Domesday Book completed in 1086 on orders of William the Conqueror, there were 45 salt pans operating in the Maldon area and 100’s more across the county.
All the other salt makers were taxed out of existence, leaving Maldon as the last survivor of this long history of high quality salt making. Unrefined Maldon salt crystals are mild tasting, crunchy, and retain high levels of the trace minerals and elements the human body needs to function properly. Fleur de Sel is also  very high in mineral content, due to the well-controlled evaporation process of the paludiers (salt rakers) who harvest it from the pans where the sea water is evaporated. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. I just ordered some (the pastilles) to try myself – especially to use during travels outside the country, which often lead to upsets in my gut microbiome. They are found in fermented foods such as kefir, live-culture yogurt, real sauerkraut and pickles (not ones made with vinegar), kimchi, kombucha and other naturally fermented foods.
In fact Bimuno has the most potent bifidogenic (Bifidobacteria promoting) effect of any available prebiotic. Ingestion of Lactobacillus rhamnosus (a strain of PRObiotic) has been demonstrated to modulate information processing strongly linked to anxiety and depression and to improve the neuro-endocrine stress response in lab animals – in plain English, this probiotic turned anxious, fearful mice into mellow ones. In other words, PREbiotic supplementation with Bimuno REDUCED THEIR ANXIETY LEVELS AND OCD THINKING. Results showed that the supplemented group paid less attention to negative information and more attention to positive information than either a group given another type of prebiotic (fructooligosaccharides, FOS) or a group given a placebo.
Taking a prebiotic supplement may relieve their life-impinging symptoms while also improving their overall physical health – without the adverse effects of pharmaceuticals. The research that led to the development of Bimuno demonstrated only Galacto-oligosaccharides (GOS) to be useful in reducing anxiety levels and OCD thinking in the study’s subjects. The increase of hippocampal BDNF after prebiotic intake is consistent with a probiotic effect, and may have been a direct consequence of elevated gut Bifidobacteria numbers. In order to post comments, please make sure JavaScript and Cookies are enabled, and reload the page. Foods that are made from whole grains are generally healthier than their refined grain counterparts.
Whole grains are an excellent source of dietary fiber in addition to antioxidants, and trace minerals zinc, iron, and copper.
Many consumers may have difficulty distinguishing between refined and whole grain products in the grocery store. Here's a very quick crumb-less alternative I cooked up which was pretty low-calorie but still passed the husband and son taste test!
The Peng-Tzao-Kan-Mu, the earliest known treatise on pharmacology, was published in China about 4,700 years ago. It was a valuable trade commodity between the Phoenicians and the lands of their Mediterranean empire.
The plentiful salt deposit was a decisive factor in the development of the prosperous town of Turda in ancient Roman times.
The Chinese government, like many others over time, made salt taxes a major revenue source. In 13th century Tibet, Marco Polo observed that tiny cakes of salt were pressed with images of the Grand Khan and used as coins.
In March 1930, Gandhi protested the British monopoly and marched to the coast  with his followers.
The first patent to produce salt in the colonies was held by the  Massachusetts Bay Colony, which continued to produce it for the next 200 years. To make this salt resistant to the re-absorption of moisture, increasing its shelf-life and making it more convenient for consumers to use in salt shakers, processors add desiccants (anti-caking agents).
Then it’s heated to a temperature that removes all the minerals and other trace elements that our bodies need to function. It no longer has the ability to combine with our body fluids, so undermines necessary, basic chemical and metabolic processes. It’s added to almost all manufactured foods and most food eaten in or purchased from restaurant chains and other restaurants.
For optimal health, 25% of our food intake must digest as acidic and 75% of our food intake must digest as alkaline. If your body does not have enough alkaline reserves to neutralize excess acid, your bones come to your rescue. For salt to be useful to the body, it needs to penetrate foods – that is, dissolve in the moisture of our food. The other 93% is used by industry, which requires chemically pure sodium chloride for the manufacture of explosives, chlorine gas, baking soda, fertilizers and plastics. When the natural salt concentration rises in the blood, the salt will readily combine with the fluids in the neighboring tissues.


Natural salt, saliva and gastric secretions combine to break down the fibrous parts of carbohydrate foods. Too little can cause spasms, irregular heart rhythms, sudden death and even increase the risk of heart attack in hypertensive patients.
It contains over 84 minerals and trace elements – such as calcium, magnesium, potassium, copper and iron. Himalayan Salt can be used for cooking, in bath salt recipes, body scrubs, aromatherapy, and handmade soaps.
It’s helpful for arthritis, skin rashes, psoriasis, herpes, and flue and fever symptoms.
It supplies, in bio-available form, all 82 trace minerals needed by the human body for optimal health. Celtic salt helps eliminate existing mucus buildup and also helps prevent it – making it very helpful for people with allergies, asthma, sinus issues, or bronchial congestion. For problems with water retention, gradual sea salt intake can help to release the excess water stored in body tissue. It can also help your body to heal faster after an injury or surgery and aids in relieving skin conditions. In addition, the proper ratio of water and salt consumption can help to prevent the need to urinate during the night. These vital trace minerals are needed to promote optimum biological function and cellular maintenance.
The water is filtered and carefully evaporated to create pyramid-shaped crystals that have a large surface area but are very thin and light in texture. When all the water was gone, the pots were broken open to reveal the resulting salt crystals.
The Guild of Salt Makers was founded in 1394 and its sign, the three cups, is still seen in Essex. A small amount of harvested reddish Hawaiian clay (Alae) enriches the salt with iron oxide.
Good for roasting or grilling meats, it’s the traditional seasoning for native Hawaiian dishes such as Kalua Pig, Hawaiian Jerky, and Poke. If our gut flora has already become seriously out of balance, we can also benefit from taking high quality probiotics as supplements to populate the necessary array of friendly bacteria in our gut microbiomes. An out of balance (dysbiotic) gut microbiome produces a wide variety of symptoms – including anxiety, depression, and OCD. The people who had taken Bimuno® also had lower levels of cortisol (a stress hormone linked with anxiety and depression) in their morning saliva. Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Whole grain foods are made from the bran, endosperm, and germ while refined grains have been milled, which strips the kernel of the bran and germ and results in a loss of iron, B vitamins, and dietary fiber.
As Americans become more conscious of the nutritional content of their foods, more and more whole grain products are becoming available in everyday grocery stores. Because whole grains contain more protein, these foods may be beneficial for weight loss as they provide a fuller feeling in the stomach for a longer period of time.
A large portion of it was devoted to a discussion of the medicinal uses for more than 40 kinds of salt. Water retention, kidney and blood pressure problems, gall stones, and many other serious health problems can result from refined salt consumption.
In this case, when you take in table salt your body sees it as a poison and tries to get rid of it as quickly as possible.
If salt is used in its dry state, it enters the body in a non-ionized form and creates thirst – a sign of being poisoned. As much as 75% of the body’s iodine is stored in the thyroid glad and used to produce hormones regulating metabolism.
This can lead to nervous disorders, brain damage, or muscle spasms, as well as a breakdown of the cell-regenerating process.
This, in turn, will allow the cells to derive more nourishment from the enriched intracellular fluid. In its dissolved and ionized form, salt facilitates the digestive process and sanitizes the GI tract. However, to live a salt-free life means suffering from an increased risk of mineral and trace mineral deficiencies, as well as from numerous related complications. This salt is recognized for its beautiful pink color, high mineral content, and its therapeutic properties. Natural salt with adequate water intake can help to stabilize irregular heartbeats and normalize blood pressure. It supports the health of nerve cells and their ability to communicate and process information. Your body will take what it needs and get rid of the rest, as long as you are drinking enough water.
Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity ofBifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. PYY) or other mediators, such as the immune system resulting from direct oligosaccharide-gut interactions, cannot be ruled out. Nevertheless, refined grains have a finer texture and longer shelf life, which is preferable for some food makers such as bread and pasta companies. Studies also indicate that a diet rich in whole grains may reduce the risk of developing heart disease, diabetes, and obesity. Consumers should read ingredient lists to verify whether products are indeed made of whole grains to ensure they are reaping the full nutritional value of the grain products they include in their diet.
This Salt March to Dandi, or the Salt Satyagraha, encouraged people across India to begin making their own salt in protest, and the march became an important milestone in the struggle for Indian independence from British rule. And during the American in 1812 Civil War, the Union Army captured significant Confederate salt works, creating a serious salt shortage in the southern states.
Because the body’s concern is with what it need in the present, not what it will need in the future, it takes calcium from your bones to neutralize the acid. In other words, if you have low blood pressure, taking Celtic sea salt can help to raise it. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. The elevation of NMDAR subunits after prebiotics is intuitive given their reduction in the brains of germ-free animals. B vitamins and iron are often added back into refined grains, or enriched, while fiber is generally not added to these products. When we eat a meal that is overly acidic, the body must neutralize the acid and regulate the alkalinity of the blood – which it accomplishes by taking organic sodium from its alkaline reserves. I would have no less requirements of proof of scientific results for reportedly natural stuff that I would for other stuff. Furthermore, the strong correlation between Bifidobacteria numbers and cortical NR1 levels presented in this report, further supports a link between the microbiota and central glutamate neurotransmission. Ancient Greek slave traders bartered salt for slaves – giving rise to the expression that someone was not worth his salt. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Mechanistic investigations beyond the scope of the present study, are now required to ascertain the systems underlying the observed changes, and will also reveal if vagal nerve modulation is involved.
Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Moreover, behavioural analysis in rats will ascertain if the changes in BDNF after prebiotics impart an anxiolytic action, or that increased NMDAR subunits translate to improved cognitive performance.
Importantly, our study has provided sufficient cause to warrant further exploration into the utility of prebiotics in therapies of neuropsychiatric illness and which, by virtue of their ability to proliferate gut bacteria and stimulate neuroendocrine (and other) responses, may even prove to be more potent than probiotics. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner.



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