Probiotics help infant colic treatment,digestive enzyme supplements to lose weight xhit,best probiotics for bloating and gas everyday - Step 1

It is important to understand that probiotic supplements contain different strains of bacteria. There is a study that is published in Pediatrics [9] that has shown that the probiotic strain, L.
The study showed that at the 28 day mark of taking the probiotics, the average crying time had decreased from 159 minutes a day to 51 minutes a day and that 95% of the study participants had significant improvement in crying time.
To dispense, tip the bottle at an angle of around 45 degrees and the drops will form slowly.
Information to assist you in making an appointment for your child to see one of our paediatricians, paediatric sub specialists, surgeons or allied health practitioners.
Colic is a diagnosis that can only be made after the baby has been examined and it is felt that the baby’s crying is not due to any medical cause. The most important and serious effects of colic are maternal depression and child abuse, or the Shaken Baby Syndrome. It is thought that they could change the gut flora, reduce gut inflammation, and therefore maybe reduce pain in the gut.
Infant colic (excessive crying of unknown cause) affects up to 20% of infants and is a major burden to families and health services.
Previous small trials suggest that the probiotic Lactobacillus reuteri effectively treats colic in breastfed infants. So researchers based in Australia and Canada set out to determine whether the probiotic Lactobacillus reuteri reduces crying or fussing in 167 breastfed and formula fed infants with colic aged less than three months old. A total of 85 infants were randomised to receive the probiotic and 82 to receive placebo for one month. Levels of gut microbial diversity, faecal calprotectin (a marker of gut inflammation) and E coli colonisation were also examined. The results show that the probiotic group fussed significantly more than the placebo group at all time points from day seven to one month. L reuteri treatment did not lead to changes in infant faecal microbial diversity, E coli colonisation, or calprotectin levels. The researchers point out that this is the largest randomised controlled trial of probiotic intervention in infants with colic to date. Further research is needed to identify which subgroups of infants with colic may benefit from probiotics, they add.
This represents the most definitive and well designed study to date on this controversial topic, writes William E Bennett Jr, Assistant Professor of Paediatrics at Indiana University School of Medicine, in an accompanying editorial. Enter your email address to subscribe to this blog and receive notifications of new posts by email. BioGaia® Probiotic Sugar-Free Chewable Tablets with natural lemon-lime flavour has demonstrated beneficial effects in common digestive upsets such as diarrhea, constipation, gas and bloating.Adults and children may chew at least one tablet a day for good digestive health or until the symptons subside.
Probiotics are beneficial bacteria that, when administered in adequate amounts, confer a health benefit. Children's tummies get bombarded daily by allergens and pathogens mostly through their food and drink .
The goal was to test the hypothesis that oral administration of Lactobacillus reuteri in a prospective randomized study would improve symptoms of infantile colic. Eighty-three infants completed the trial: 41 in the probiotic group and 42 in the simethicone group.
In our cohort, L reuteri improved colicky symptoms in breastfed infants within 1 week of treatment, compared with simethicone, which suggests that probiotics may have a role in the treatment of infantile colic. Mothers with babies with colic are usually sleep deprived, and it can be very stressful and exhausting to look after a baby who cries a lot, especially when it seems that nothing would stop the baby from crying. Although it spontaneously resolves three to four months after birth, its cause remains elusive and no single effective treatment exists.
These studies, however, had limitations as they examined only a highly selective group of infants with colic.
Outcomes included daily duration of crying or fussing at one month, sleep duration, mother’s mental health, family and infant quality of life.
It is the only probiotic licensed by Health Canada with this indication.The recommended dosage for BioGaia® Probiotic Drops is 5 drops daily. The infants were similar regarding gestational age, birth weight, gender, and crying time at baseline.


Some people think it is because of pain originating from the gut.Others think it is because of the baby’s temperament, affected by the mother’s mood.
The drops may be given on a spoon or added to milk, water or any other suitable drink or food. Kansenshogaku Zasshi (Journal of the Japanese Association for Infectious Diseases), 81, 387-93. Many parents try many different kinds of infant formula in the hope that they would find the right one to suit their baby. On day 28, 39 patients (95%) were responders in the probiotic group and 3 patients (7%) were responders in the simethicone group. Only randomized controlled trials enrolling term, healthy infants with colic were included. A meta-analysis of included trials was performed utilizing the Cochrane Collaboration methodology.ResultsThree trials that enrolled 220 breastfed infants met inclusion criteria, of which 209 infants were available for analysis. Lactobacillus reuteri (strains-American Type Culture Collection Strain 55730 and DSM 17 938) was the only species utilized in the therapeutic intervention. The condition has been historically described as irritable or compulsive crying or paroxysmal fussing with a multifactorial etiology [3]. Although it affects 5% -19% of young infants, [2, 4, 5] it remains a frustrating problem for parents and care givers because it is difficult to treat and may result in significant psychosocial consequences. A number of cross sectional studies report significant links between infantile colic and maternal depression and child abuse [6a€“11].Despite forty years of research, the etiology of infantile colic remains elusive.
The current literature suggests several causative mechanisms such as behavioral, food allergy and hypersensitivity, immaturity of gut function and dysmotility [12a€“14]. Recently, the composition of intestinal microbiota has been addressed as an independent risk factor for infantile colic [16a€“18].
Studies indicate that inadequate lactobacilli in the first few months of life may affect intestinal fatty acid profile favoring the development of infantile colic [16, 17]. Coliform bacteria have also been found more abundantly in colicky infants and it is speculated that altering the intestinal microbiota composition may positively influence the management of affected infants [19]. In practice, the only probiotic used for infantile colic is Lactobacillus reuteri (strains-American Type Culture Collection Strain 55730 or DSM 17 938). Other databases were also searched including: EMBASE (January 1980 to September 2012) the Cochrane Central Register of Controlled Trials (CENTRAL, the Cochrane Library, Issue 9, 2012).
Content experts were contacted to identify unpublished and ongoing studies.Study selectionWe included all randomized or quasi-randomized controlled trials that compared probiotics (any dose or composition) to placebo, control or other forms of treatment in healthy full term infants with infantile colic who were less than 4A months of age. We considered articles in any language as long as there was an abstract in English indicating content.Data extractionRetrieved articles were assessed for eligibility, and two reviewers independently abstracted descriptive data on the subjects, type of intervention, infants allocated as control, outcomes and methodological quality of the articles.
Where data were incomplete, the principal investigator of the primary study was contacted for further information and clarification.Methodological quality of the studiesStandard methods of the Cochrane Collaboration [22] were used to assess the methodological quality of included trials.
For each trial, information was sought regarding the method of randomization, allocation concealment, blinding, and completeness of follow up and on reported outcomes of all infants enrolled in the trial.
The secondary outcomes were duration of crying (minutes per day) and adverse events related to probiotic supplementation. For dichotomous outcomes, relative risk (RR) and its associated confidence interval were calculated. For continuous outcomes, treatment effect was expressed as mean difference and its calculated standard deviation. Meta-analysis of pooled data was performed using a fixed effects model with the assumption that L.
A subgroup analysis was planned a priori to investigate the effect of probiotics in subjects with a positive family history of atopy, and additionally on different strains of probiotics utilized. Tests for between-study heterogeneity (including the I2 test) were performed.Since included studies expressed their primary outcome (crying times) as median (range or interquartile range), in order to statistically pool the data and perform a meta-analysis, this outcome was converted into mean (standard deviation) as recommended by Hozo et al.
Seven studies were excluded because the investigators used probiotic based formulae in non-colicky neonates, which undermined the primary objectives of the meta-analysis.
A total of 209 healthy infants were enrolled across the three studies and most of the infants were exclusively breast fed. All of the clinical trials utilized the same probiotic species (Lactobacillus reuteri; strains-American Type Culture Collection Strain 55730 or DSM 17 938) with identical daily doses. Data on crying time were reported by all three trials as a primary outcome and involved 209 infants.


At seven days after initiation of treatment, infants in the probiotic group had a significantly shorter crying time. The crying time at 7A days was significant only in the fixed effects model, but was insignificant in the random effects model. However, the treatment effect was continuous and stabilized at three weeks following the initiation of therapy.
In order to reduce heterogeneity and the potential effect of simethicone, a sensitivity analysis on only the double-blind, placebo-controlled, trials [24, 26] was conducted. Responders (or treatment success) was defined as the percentage of infants achieving a reduction in the daily average crying time of more than fifty percent.
A progressive, statistically significant response was noted starting at 7A days [25] after initiation of therapy (FigureA 3).
A concomitant history of atopy did not alter the efficacy of probiotics in treated infants.DiscussionWe report the first systematic review of randomized trials addressing the efficacy of probiotics in infantile colic.
This positive response was progressive with time and had its peak and plateau at three weeks after initiation of therapy. A similar positive effect was noted in the control group, which could be explained, by the natural history of infantile colic or a placebo effect [22, 23]. However; our overall conclusion is compromised by the small number of enrolled infants despite the common prevalence of infantile colic, and the heterogeneity of included studies that assessed crying time.
This heterogeneity can be explained by the clear imbalance of both groups at baseline, in the study reported by Savino et al. The probiotic group started with significantly longer crying times that quickly moved to a profoundly positive benefit after 7A days of treatment. Most of the included subjects were exclusively breast fed which limits the generalizability of the findings to formula fed infants. However, the incidence of colic in breast and bottle fed infants is similar [30] because the pathogenesis of the disorder is likely multifactorial and the use of probiotics may be influential in the treatment of colic by altering faecal microbiota and gut inflammation irrespective of feeding patterns [16a€“19, 31].The earlier trial by Savino et al. This may have decreased the magnitude of the effect of probiotics unless the effect of simethicone was not indifferent to placebo. The sensitivity analyses confirmed that the inclusion of the simethicone treated patients in this study did not significantly impact heterogeneity or the crying time at 21A days.
One well recognized limitation of all studies on infant colic is the need for a more objective way of measuring duration of crying rather than relying on the parentsa€™ compliance to establish this outcome. Computer recordings of crying episodes comprise a more concrete form of assessment and should be considered for future studies. Two of the included trials were supported by the manufacturer of the probiotic strain under study, which raises the possibility of bias.
However, the likelihood is small since the trials were fully investigator-initiated and data controlled with transparent disclosure of potential conflicts of interest by the respective authors [32, 33].Recently few studies have addressed the role of changing intestinal microbiota in the pathogenesis of colic. Colicky infants were found to have increased colonization by coliforms especially E.coli and decreased and altered colonization patterns by lactobacillus species [17a€“19].
Immune modulation could also play a role in the efficacy of probiotics in infantile colic as it may represent the first sign of food hypersensitivity [37]. Since probiotic supplementation appears to require time to exert an effect in colicky infants, it would be interesting to evaluate its efficacy as a prophylactic treatment after birth.
Ita€™s unclear whether a similar or cumulative effect would be observed if other formulations of probiotic bacteria are utilized either alone or in combination with the same strains of L. However, all three included studies demonstrate a positive outcome which may be a reflection of the relatively small, combined, sample size that overshadows the true effect which may be realized in a single, large-scale, multicenter, randomized trial.
FI: Was involved in the study conception and design, oversaw the protocol development and data interpretation and participated in the manuscript preparation.
BP: Critically reviewed and amended the manuscript and circulated the final version for approval and submission. KA: Played a major role in the study conception, design, protocol development, inclusion selection, quality assessment and statistical analysis and worked collaboratively on the draft of the initial manuscript.



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