Probiotics and their implications in food safety uk,how much probiotics should i take for diarrhea 8dpo,biotrue vs clear care,what probiotics are in breast milk video - Reviews

Probiota 2014 – the leading conference bridging the interface of academia and industry for cutting edge science about the prebiotics, probiotics and the microbiome – has extended the call for proposals for its poster sessions by one week to Friday 13th December 2013. Probiota 2014The two-day, two-stream event – formerly Probiotech and Microbiota - will be held in Amsterdam on February 4-5 next year. The latest scientific and technical, and market insights from world renowned experts: Top experts, all in one place - whether you are interested in infant nutrition or cosmetics, metagenomics or marketing, we have expert presentations designed with you in mind. Bridging the business-science gap: Coming together helps everybody to maximise potential and reach our goals.
A truly global outlook: Science and business have no boundaries, so why should a conference?
You can find out more about our scientific program and register to attend the conference by clicking here. All posters presented at the conference will be judged by an expert scientific panel, and three winners will be chosen. Get FREE access to authoritative breaking news, videos, podcasts, webinars and white papers.
From botanicals to omega 3s, Millennials want products that include particular ingredients or meet specific requirements. We will be provided with an authorization token (please note: passwords are not shared with us) and will sync your accounts for you. The current widespread use of high-throughput molecular microbiology techniques has enhanced our knowledge about the development of the intestinal microbiota to greater levels than were possible with classical culture techniques (8, 9). It has been suggested that the first contacts with pioneer bacteria could be deterministic for subsequent gut maturation, metabolic and immunologic programing, and consequently for short- and long-term health status (15).
The intrauterine environment and the unborn infant are generally thought to be sterile until delivery.
External factors during pregnancy may also influence the future development and behavior of the infant. The length of the gestational period may also play an important role in initial infant gut microbial colonization. A number of factors (both intrinsic and extrinsic) may influence the process of microbial colonization in infants, which may consequently affect the infant’s health. During the birth process and immediately after birth, microbes from the mother and surrounding environment colonize the gastrointestinal tract of the infant leading to the development of a dense complex microbiota (22).
Children born by cesarean section are also exposed to their mothers’ microbiota, but initial exposure is most likely to non-maternally derived environmental isolates from equipment, air, and other infants, with the nursing staff serving as vectors for transfer (44).
The succession of microbial colonization in the intestinal tract most occurs during the early development stages especially the first year of life. The gut microbiota of children is also influenced by the nature of food (other than formula) they receive, which could also be stratified by income status, mode of upbringing, or geographical location. The influence of the mother on the child’s microbiota is evident during the first year after birth (43). After birth, environmental, oral, and skin microbes from the mother are mechanically transferred to the newborn in different ways, which may influence the diversity of intestinal microbiota in the neonate. Gut microbiota are generally associated with the development and maturation of the immune system (77).
The birth order or family size and the presence or absence of pets have also been implicated in the initial microbial colonization in infants.
Several methods can be used to attempt to modify disturbed gut microbiota and many of them have been implicated in the improvement of gut microbiota in early childhood.
Argentina has had a tampon shortage in recent years based on the country's policies concerning imports and foreign currency, according to reports in January. Most of the nation's tampon imports come from Brazil, Miguel Ponce, head of the Chamber of Importers, told AP.
GM BT corn and cotton had led to a reduction in insecticide use, compared to what is likely to have been applied to conventional crops, of 64 million pounds between 1996-2008.
But the uptake of other GM crops resistant to herbicides in the same period led to an increase in herbicide use of 382 million pounds. In 2014, 96 percent of cotton produced in the United States was genetically modified, according to the US Department of Agriculture.
Writing in the British newspaper The Guardian, Arthur Nelson noted that as many as 31 pesticides with a value running into billions of pounds could have been banned in the EU because of potential health risks, if a blocked EU paper on hormone-mimicking chemicals had been acted upon.
People are not only now unnecessary, they are a serious threat to those who have everything. The more that can be got rid of, palmed off into 'farms' for the sick, the incapable, the better. More than a third of corn grown in the US is a€?stackeda€™ with both herbicide-tolerant and Bt genes. A class action suit against the Monsanto corporation was filed in Los Angeles this week in the Superior Court of California, Los Angeles County. It accuses the company of false advertising for its implied claims that the herbicide, Roundup, is safe for humans.
Into these plants we were putting DNA from various foreign organisms, such as viruses and bacteria.
In South Africa, the African Centre for Biosafety (ACB) filed a complaint because they believed that Monsantoa€™s claims were false. After the complaint was filed, Monsanto was unable to provide sufficient evidence to support their claims, and were thus forced to pull the advertisement. Due to its extensive use in the protection of crops, it is inevitable that it will reach surface and deep waters, especially after rainfalls. A heretofore inexplicable fatal, chronic kidney disease that has affected poor farming regions around the globe may be linked to the use of biochemical giant Monsantoa€™s Roundup herbicide in areas with hard water, a new study has found. Researchers suggest that Roundup, or glyphosate, becomes highly toxic to the kidney once mixed with a€?harda€? water or metals like arsenic and cadmium that often exist naturally in the soil or are added via fertilizer.
The company soon brought glyphosate to market under the name a€?Roundup,a€? which is now the most commonly used herbicide in the world. The hypothesis helps explain a global rash of the mysterious, fatal Chronic Kidney Disease of Unknown etiology (CKDu) that has been found in rice paddy regions of northern Sri Lanka, for example, or in El Salvador, where CKDu is the second leading cause of death among males. The condition has spread quickly since then and now affects 15 percent of working age people in the region, or a total of 400,000 patients, the study says. Basically, the Ministry found that CKDu did not share common risk factors as chronic kidney disease, such as diabetes, high blood pressure and glomerular nephritis, or inflammation of the kidney.
Based on geographical and socioeconomical factors associated with CKDu, it was assumed that environmental and occupational variables would offer clues to the diseasea€™s origins — or in this case, it came from chemicals.
The new study noted that even the World Health Organization had found that CKDu is caused by exposure to arsenic, cadmium, and pesticides, in addition to hard water consumption, low water intake, and exposure to high temperatures. Yet why that certain area of Sri Lanka and why the disease didna€™t show prior to the mid-1990s was left unanswered. Researchers point out that political changes in Sri Lanka in the late 1970s led to the introduction of agrochemicals, especially in rice farming. They believe that 12 to 15 years of exposure to a€?low concentration kidney-damaging compoundsa€? along with their accumulation in the body led to the appearance of CKDu in the mid-90s. The incriminating agent, or Compound a€?X,a€? must have certain characteristics, researchers deduced.
Rice farmers, for example, are at high risk of exposure to GMCs through skin absorption, inhalation, or tainted drinking water. GMCs seem to evade the normal livera€™s detoxification process, thus damaging kidneys, the study found. The study also suggests that glyphosate could be linked to similar epidemics of kidney disease of unknown origin in El Salvador, Nicaragua, Costa Rica, and India.
Recent investigations by the Center for Public Integrity found that, in the last five years, CKDu is responsible for more deaths in El Salvador and Nicaragua than diabetes, AIDS, and leukemia combined. This study reveals that Roundup herbicide (aka glyphosate) and its still-toxic degradation byproduct AMPA were found in over 75% of the air and rain samples tested from Mississippi in 2007. The researchers evaluated a wide range of pesticides currently being used through weekly composite air and rain sampling collected during the 1995 and 2007 growing seasons in the Mississippi Delta agricultural region. Thirty-seven compounds were detected in the air or rain samples in 2007; 20 of these were present in both air and rain. Glyphosate was the predominant new herbicide detected in both air (86%) and rain (77%) in 2007, but were not measured in 1995.
Decreased overall pesticide use in 2007 relative to 1995 generally resulted in decreased detection frequencies in air and rain, but observed concentration ranges were similar between years even though the 1995 sampling site was 500m from active fields while the 2007 sampling site was within 3m of a field. Mean concentration of detections were sometimes greater in 2007 than in 1995 but the median values were often lower.
Seven compounds in 1995 and five in 2007 were detected in ≥ 50% of both air and rain samples.
Atrazine, metolachlor, and propanil were detected in ≥ 50% of the air and rain samples in both years. This estimate, if correct, reveals that there has been an ~ 18 fold increase in glyphosate concentrations in air and water samples in only 12 years (1995-2007). The longer period of exposure adds to growing concern that this ubiquitous toxicant represents an unavoidable body burden and that even small daily environmental exposures may be causing significant harm through their cumulative and synergistic effects with other toxicants.
So, what is the toxicological significance of the discovery of glyphosate in most air samples tested? In the month of August, 2007, if you were breathing in the sampled air you would be inhaling approximately 2.5 nanograms of glyphosate per cubic meter of air. Of course, when one considers the presence of dozons of other agrichemicals found alongside glyphosate in these samples, the interactions between them are incalculably complex and produce far more harm together than glyphosate alone (i.e. Recent cell research has shown that glyphosate may act as an endocrine disrupter exhibiting estrogenic-like carcinogenicity within the part-per-trillion range. More reason to raise the red flag of the precautionary principle — especially since inhaled toxicants evade the elaborate detoxification mechanisms of ingested toxicants which must pass through the microbiome, intestinal lining and liver before entering the blood and only a long time later the lung far downstream. This study brings to the surface the extent to which GM farming has altered our daily exposure to chemicals, such that even the rain and air we now breath contains physiologically relevant levels of glyphosate 'fall out' from the war against any plant not part of the monocultured, genetically engineered system of production.
With a significant body of research now available today showing that glyphosate and its components are far more toxic than believed at the time of its widespread approval, the implications of ubiquitous glyphosate exposure should be carefully considered. Ultimately, unless our food production system moves through its present chemical war-modeled phase of GM monoculturing, even non-GM food will end up being contaminated with these chemicals and transgenes, because nothing 'natural' lives in a vacuum — and if it does, then it really shouldn't be called 'organic,' and maybe shouldn't even be called food.
Please visit to access their vast database of articles and the latest information in natural health. Doctors usually call this metabolic syndrome — people who consume lots of processed corn fructose, not eating fruit, end up developing high blood pressure, suffering from obesity, and developing insulin resistance.
Mike Adams with Sean Stone speaking on Buzzsaw about vaccine mandate GMO and Monsanto and modified seeds.
People hold a sign showing Monsanto as one of the most important producers of Agent Orange used upon Vietnam, as well as its present genetically modified organisms GMO's spread around the world, in front of the White House, May 25, 2013.
Monsanto is trying to take full control of the worlda€™s seed supply for a greater profit, hiding any report of damage GMO does to the ecosystem and human health, Jeffrey M.


Sophie Shevardnadze:A  Do you disagree with the use of GMOs on purely scientific, medical grounds, or do you also have moral qualms as well? But thata€™s a risk that one person will take.A  Right now we cana€™t predictably and safely manipulate the genes in the way we are doing to protect health and the environment. So, to release the products of this infant science, which is prone to side-effects into the food supply and moreover into the environment where the self-propagating pollution of the gene-pool trough pollen drift and seed movement makes it irreversible — thata€™s not responsible at this time. Maybe in 50 to 100 years, maybe at some point in the future when we fully understand the DNA enough to make these manipulations — then it would be responsible to introduce GMOs into the outdoors or food. Sophie Shevardnadze:A  The advocates of GM crops say that they can help us combat poverty, starvation and diseases in the developing world — is there any truth in these claims? The worlda€™s experts at feeding the world and eradicating poverty actually have the report, called 'I-Stat' sponsored by the UN and the World Health Organization — and it concludes that GMOs in their current form have nothing to offer in feeding the world or eradicating poverty.
There has been a promise to get people to try and promote the technology, accept the technology, but it doesna€™t in fact even increase average yield, it reduces yield on average, according to independent science. Sophie Shevardnadze:A  But Jeffrey, from your point of view — are there any tangible benefits at all from GMOs? Ita€™s produced by Monsanto, and they produce roundup herbicides, so the roundup ready crops are able to drink or withstand applications of roundup herbicides, which would normally kill a plant. So from a narrow farmers perspective of weeding — ita€™s easy, because you can spray over the top of the crops, kill all other plant biodiversity, but not the roundup ready crops.
What they dona€™t look at are the health dangers for those who eat the crops that now have the roundup absorbed into the food portion. They dona€™t look at the damage to the soil, the damage to the ecosystem, the promotion of plant diseases — more than 40 of them in the US are the result of the roundup. Their background is quite controversial — they were continually voted the most hated and most unethical company on Earth for years and years, with stiff competition. This is exemplified by the US Food and Drug Administration, where the policy on GMOs was overseen by Monsantoa€™s former attorney, Michael Taylor. And the policy falsely claims that the agency wasna€™t aware of any information showing that GMOs were significantly different — therefore the FDA requires no safety studies and no labeling.
They leave it up to Monsanto to determine if their foods are safe, and Monsanto doesna€™t even have to tell the FDA or consumers if it wants to slip a GMO in our food supply.
By the way the documents made public from a lawsuit revealed that the overwhelming consensus among the scientists working at the FDA was exactly the opposite of that exposed in the policy.
The scientists said GMOs would be dangerous, could create allergies, toxins, and new diseases, and should be tested.
Unfortunately, ita€™s a rubber stamp situation around the world and if you trace it back, it comes down to them doing it, based on Monsantoa€™s own research. Wea€™ve caught them red-handed, rigging their research to avoid finding problems, and covering up problems when they persist nonetheless. They have a very strategic way of infiltrating and influencing, in fact, what the entire biotech industry and Big Agriculture does. Obama nominated Supreme Court Elena Kagan when US solicitor general March 2009 — May 2010 (Obama appointment) sided with Monsanto.
Secretary of Agriculture Tom Willsack was the former Biotech Governor of the Year — he was given the award by Monsanto. The chief negotiator for the US is a former crop-life person, basically the trade group for Monsanto and another biotech groups. The person at the USDA used to give out money for the research — another Monsanto person. So they have insinuated themselves through money, revolving-door and other influence methods. By and large, there are about six countries that do most of the growing, and maybe 90 percent of the growing, and they export the food around the world and so a lot of people are exposed. In February 1991 a gag order was lifted on a [UK] scientist, and the scientist was doing research on the GMOs to figure out how to test for safety.
He accidentally discovered the GMOs were extremely dangerous, and that within 10 days they caused massive health problems for rats.
He went public with his concerns and was a hero for two days at his prestigious institute, but then phone calls from the UK Prime Ministera€™s office to the director ended up causing him to be fired the next day, and silenced with threats of a lawsuit.
But in February 1991 the gag order was lifted by the UK parliament and there was a firestorm in the media about the health dangers of GMOs. Within 10 weeks, the tipping point of consumer objection was achieved in Europe, so Unilever, followed by Nestle, followed by virtually every other food company committed to not feed Europeans derivatives of GMOs. The same companies feed Americans and Canadians and others derivatives of GMOs, because we havena€™t raised a stink, and because the information about the health dangers has not been widely circulated on those continents. Wea€™re talking about Europe — so the problem there is that the EU requires GM products to be labeled as such, but there is a loophole there, when the imported products dona€™t need to be labeled. How did that happen and do you think wea€™ll see more and more GM crops being grown in Europe?
That loophole has allowed millions of tons of genetically modified feed to enter the food supply in Europe. We see gastro-intestinal disorders, immune system problems such as allergies and asthma, and autoimmune disease, leaky gut, diabetes, inflammatory-based diseases and reproductive disorders such as infertility.
And we see a lot of these reversing in humans and livestock and lab animals when they are switching from GM to non-GM feed.
However, in Europe its harder to evaluate, because people are getting exposed to GMOs as animal feed, and it may influencea€¦ it certainly does influence the health of the animals.
Wea€™ve seen damage to virtually every organ and every system in animals, potentially pre-cancerous cell growth, smaller brains, livers and testicles, inflamed immune system organs, damage to the liver and kidney, et cetera.
And also the animals are nutrient-deficient, because roundup binds with nutrients making them unavailable to plantsa€¦ for animals, their most popular dish is roundup ready soy, corn, cotton seed, canola meal, sugar beet pulp and alfalfa — so they are eating nutrient-deficient food.
There is a universal deficiency among the livestock, certainly in the US, that creates more sickness in the animals. So, European consumers are largely unaware that they are still being exposed to GMOs, which may be negatively influencing their health. The president of Whole Foods Market told USA Today that when a product becomes third-party verified as non-GMO, sales increase by 15 percent to 30 percent. We saw the tipping point happen in Europe, and wea€™re seeing stage after stage of the tipping point unfolding in the US. The desire for non-GMO products, because of the concerns about health, especially for children who are most at risk, have driven a movement for labeling, so labeling laws have passed in Connecticut and Maine and are expected to pass in Washington State in the fall.
More than two dozen other states have introduced labeling bills as legislation, they have not yet passed, but many expect them to pass next year as well.
So we are seeing a movement against GMOs and we think this will result in their elimination from the food supply, by the food companies, who will see it as a marketing liability. But, these companies like Monsanto, who produce the GMOs, they are certainly aware of all the repercussions and dangers — what do you think are the motives for them? Similarly, he told me that three of Monsantoa€™s safety study testers for Bovine growth hormone, which is injected in the cows to increase milk supply — they tested the milk and found so much IGF-1, a cancer-promoting hormone in the milk, that the three Monsanto scientists refused to drink milk after that, unless it was organic, and one bought his own cow.
The executives described the world in which 100 percent of all commercial seeds were genetically engineered and patented.
This would give Monsanto and a few biotech industry colleaguesa€™ control of the worlda€™s seed supply. The food is the largest traded commodity, and if you have control of the food and control of the farmers, ita€™s an enormous control and profit motive. So they want all the farmers in the world to be going to the catalogues of Monsanto for its genetically modified, patented seeds. This is an effort to replace the products of the billions of years of evolution with designer genes and designer organisms, designed for greater profit and control. You see, GMOs are in the food supply, so they affect everyone who eats, they are also released outdoors with the genes that can outlast the effects of global warming and nuclear waste as a permanent feature in the gene pool. So, it becomes an irreversible technology that can influence every human being, all living beings and all future generations.
But, similarly to the tobacco industry, they use a€?tobacco sciencea€? with the biotech industry.
They use the wrong detection methods, the wrong controls, the wrong statistics, and when they do find problems, they try to cover it up.
This we have shown time and time again, for example in my book, a€?Genetic Roulette,a€? or in the movie of the same name. Sophie Shevardnadze:A  Talking about the soil, is the penetration of the GM genome in the agricultural ecosystem reversible? The Probiota 2014 program brings top level insights and networking opportunities for business and academia, and encourages conversations that might never happen anywhere else! Our expert presentations offer insights and lessons from emerging and established markets, in addition to looking for business and science lessons from other areas of food and nutrition. This means that you will not need to remember your user name and password in the future and you will be able to login with the account you choose to sync, with the click of a button. This page doesn't support Internet Explorer 6, 7 and 8.Please upgrade your browser or activate Google Chrome Frame to improve your experience. The gastrointestinal tract is the largest source of microbial exposure, as the human gut microbiome contains up to 1014 bacteria, which is 10 times the number of cells in the human body. The largest microbial population of the human microbiome is found in the gastrointestinal tract, and the greatest prevalence is in the colon, which is estimated to harbor 1014 bacterial cells and more than 100 times the number of genes in the human genome (1–3). As a result of comprehensive microbiota analyses over time, insights into fundamental questions about the human microbiome dynamics under different microbial and host conditions are increasing (10).
In addition, although there are discrepancies, metadata analysis over time has suggested an association between the nature of the initial gut microbiota colonization or microbial dysbiosis and a number of disease conditions in infancy and later in life (16, 17). However, some studies have reported the presence of bacteria in the intrauterine environment, which suggest that these bacteria may influence the microbiota of the infant before birth (18–22). For example, infant monkeys born from mothers stressed during pregnancy had significantly lower counts of Bifidobacterium and Lactobacillus (26).
Colonization in preterm infants has been shown to take place slowly, have a low diversity, and several interindividual differences as opposed to that of full-term infants (6, 39).
The following section highlights some of the external factors that affect the initial colonization and establishment of gut microbiota in infants (Table 1). The mode of delivery (vaginally or by cesarean section) has been demonstrated to have a strong influence on early gut colonization (43).
A number of studies have described altered fecal or intestinal microbiota profiles in cesarean section-delivered infants beginning at 1 day after birth and persisting to 6 weeks (7), 6 months, and even 7 years of age (45). The microbiota of children in Burkina Faso was found to be dominated by Bacteroidetes, compared with that of Italians, which was dominated by Firmicutes (64).
This effect is reported to be stronger within the first month of life during which the infant’s intestinal microbiota is both functionally and phylogenetically close to that of the mother.
For example, biodiversity in the homes, in the surrounding environment and in family members who have a close or constant contact with the baby have a direct impact on the diversity of microbes that are transferred to the infant (69–71).
The immune system acquires most of its data from exposure to certain subsets of micro- and macro-organisms (78).


Over two decades ago, Strachan observed that children who had older siblings were less likely to manifest hay fever as adults, as compared to firstborn children, which could be due to a protective effect of infections brought home by the older siblings (89).
Yap and colleagues (93) evaluated the composition of fecal microbiota of infants who developed eczema in the first 5 years of life compared with healthy controls and reported that longitudinal analysis of fecal microbiota composition at 3 days, 1 and 3 months, and 1 year of life showed a higher abundance of Enterobacteriaceae and Clostridium perfringens in children who developed eczema in the first 2 years of life, whereas a lower abundance of Bifidobacterium was observed in those who developed eczema at 5 years of age. A meta-analysis on antibiotic use in infants reported that wheezing and asthma were related to antibiotic use (16). Factors affecting colonization of gut microbiota in neonates and infants or children, specific microbial effect, and the resultant health conditions.
However, an extensive discussion of the methods used to modify gut microbiota is beyond the scope of this review and only brief highlights on probiotics are included. I've stopped using synthetics in favor of organics, but using commonly found organic fertilizers that are chalked full of GMO ingredients seems like the devil in disguise here! It has been estimated the average adult inhales approximately 388 cubic feet or 11 cubic meters of air per day, which would equal to 27.5 nanograms (billionths of a gram) of glyphosate a day. Smith spoke about the dangers posed by GMO products and Monsanto aggressive policies to Sophie Shevardnadze on RTa€™s SophieCo. If you narrow yourself down to one particular attribute, you can sing the praises of this flawed technology.
Smith:A  To clarify, imported products that contain GMOs in Europe do have to be labeled, but the imported animal feed, once ita€™s fed to the animals, the milk and meat in Europe do not have to be labeled as genetically modified. Smith:A  Well, actually the sales of non-GMO labeled products are growing faster than any other category. Smith:A  The tobacco analogy is a good one, but the influence of tobacco will pale in comparison to that which GMOs can and are creating right now. Smith:A  We do know from laboratory studies that genes can transfer from the genetically modified crops into the micro-organisms in the soil, so thata€™s one way. Several studies in recent years have shown differences in the composition of the gut microbiota in children who are exposed to different conditions before, during, and early after birth. The gut bacteria play an important role in human health by promoting intestinal homeostasis, stimulating the development and maturation of the immune system, protecting against pathogens, digesting fibrous food materials through fermentation, and harvesting nutrients (4–6). Longitudinal studies including the Human Microbiome Project have investigated the diversity of the bacterial population associated with the human body, its variability within and between individuals, the impact of internal and external factors, as well as characterizing its key components (8, 11, 12), and there is still much to learn. This review will summarize some of the key factors (pre and postnatal) underlying the establishment of the neonatal gut microbiota and identify its potential impact on some of the immune-, intestinal-, and metabolic-related diseases in childhood or adulthood. For example, Lactobacillus and Bifidobacterium DNA were detected in the placenta of vaginally and cesarean section-delivered infants (23), and Enterococcus faecium strains that were orally inoculated to pregnant mice were later detected in the amniotic fluid and meconium of the pups following delivery (20). Probiotic administration (Lactobacillus rhamnosus) to mothers during late pregnancy also resulted in increased fecal Bifidobacterium longum counts in their infants (27), although, it is not clear whether these microbes were acquired from the mother during pregnancy, during birth, or after birth. A review by Mackie and colleagues (22) showed that, in cases of vaginal delivery, a longer birth process has been associated with the presence of viable microbes in the stomach and mouth of the infant, and the same E.
Infants delivered by cesarean section have a lower total microbial diversity within the first 2 years of life associated with a less abundance and diversity of phylum Bacteroidetes (46).
Dynamic balances exist between the gastrointestinal microbiota, host physiology, and diet that directly influence the initial acquisition, developmental succession, and eventual stability of the gut ecosystem (53).
Similarly, the biodiversity of microbiota from USA was lower than that from Malawians or Venezuelan Amerindians (65). However, at 1 year of age, phylogenetic differences appear while the similarities persist at the functional level (67).
For example, early colonization with Escherichia coli and Bifidobacteria is associated with higher numbers of CD20 + B cells that express the memory marker CD27 at 4 and 18 months of age (79).
The authors suggested that relative abundance of selective microbial targets might contribute to the subsequent development of eczema in childhood. In addition, high-throughput sequencing revealed an incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin (95). A number of maternal factors are responsible for the establishment and colonization of gut microbiota in infants, such as the conditions surrounding the prenatal period, time and mode of delivery, diet, mother’s age, BMI, smoking status, household milieu, socioeconomic status, breastfeeding and antibiotic use, as well as other environmental factors that have profound effects on the microbiota and on immunoregulation during early life. An alteration of the gut microbiota has been associated with an increasing number of diseases including inflammatory bowel disease (IBD), obesity, diabetes, asthma, and allergies (6, 7). The human gut microbiota of a healthy adult is thought to be highly resilient and stable over time, a condition that may differ from one individual to another (13, 14). In addition, a unique placental microbiome niche similar to the human oral microbiome composed of non-pathogenic commensal microbiota from different phyla including Firmicutes, Tenericutes, Proteobacteria, Bacteroidetes, and Fusobacteria were characterized from a population-based cohort of placental specimens (24). Several other variables during pregnancy, including the use of antibiotics in the perinatal period, have been associated with delayed colonization by some microbes especially Bifidobacteria and Lactobacillus species (28, 29).
Moreover, the effect of the natural environment, such as housing conditions, has also been investigated in animals. With respect to fecal microbiota, close similarities were found between the mother and the infant during the first six months after birth of the infant, which was mainly due to the presence of Bifidobacterium bifidum, Bifidobacterium breve, and Staphylococcus aureus (68). In addition, mice exposed to dog-associated house dust were found to be protected against airway allergen challenge, because they exhibited less Th2 cytokine production, fewer activated T cells, and a distinct gut microbiome composition that was highly enriched for Lactobacillus johnsonii, which itself can confer airway protection when orally supplemented as a single species (91). The use of antibiotics in this context has been implicated in the development of IBD and current research has shown that children with IBD are more likely to have received antibiotics in their first year of life as compared to healthy controls (35), suggesting that microbial dysbiosis associated with early antibiotic exposure in neonates may be a predisposing factor to IBD, including other disease conditions, such as wheezing and asthma. Early exposures impacting the intestinal microbiota are associated with the development of childhood diseases that may persist to adulthood such as asthma, allergic disorders (atopic dermatitis, rhinitis), chronic immune-mediated inflammatory diseases, type 1 diabetes, obesity, and eczema.
However, before reaching maturity, the gut microbiota needs to develop and establish a mutual beneficial co-existence with the host. This suggests that the placenta is not actually sterile and that oral microbiota may play a major role in the colonization of the placenta although the mechanism through which oral microbes find their way into the placenta remains to be elucidated. Healthy full-term infants are usually colonized by beneficial microbes, such as Bifidobacterium and Lactobacillus, which are not present or are detected in low levels in preterm infants (41). This implies that the proximity of the birth canal and the anus play an important role in the transmission of microbes from the mother to the infant. However, human milk is known to contain complex polysaccharides that act as selective prebiotics and therefore promote the colonization of the infant gut with beneficial microbiota (60, 61), as opposed to children fed with formula.
In this case, genetically related piglets were housed in either indoor or outdoor environments and sequencing of the 16S rRNA revealed that Lactobacillus strains were dominant in the gut of pigs raised outdoors, compared with hygienic indoor pigs, which had reduced Lactobacillus and more potentially pathogenic phylotypes (66). Molecular microbiology techniques suggest that a high diversity of the gut microbiota in childhood could be more important as opposed to low diversity, which is associated with increased risk of subsequent allergic diseases, since repeated exposure to different bacterial antigens would enhance the development of immune regulation through inhibition of responses to inappropriate targets, such as gut contents and allergens (81, 82). For example, metagenomic analysis revealed that the proportion of Bacteroidetes was increased in children with T1D while the proportion of Firmicutes was increased in normal healthy children (78). Table 2 shows a summary of the factors affecting gut microbiota and their effects in neonates, infants or children, as discussed in this review.
This overview highlights some of the exposures during the pre- and postnatal time periods that are key in the colonization and development of the gastrointestinal microbiota of infants as well as some of the diseases or disorders that occur due to the pattern of initial gut colonization.
It is therefore possible that bacteria in the intrauterine environment could result in prenatal colonization of the meconium (6, 25). The delayed rate of colonization could result from the events surrounding the delivery, because most preterm infants are delivered through emergency or elective cesarean delivery. In addition, bacteria present in the mother’s vagina immediately before birth were reported in the nasopharynxes of over 50% of babies born vaginally (22). It has also been shown that skin microbes including Staphylococcus, Corynebacterium, and Propionibacterium dominate the gut microbiota of cesarean-delivered infants, while vaginally delivered infants have a higher prevalence of vaginal-related microbes such as Lactobacillus, Prevotella, and Sneathia (48–50). Formula feeding has been associated with an increased microbial richness of species in infants at four months of age with overrepresentation of C. There are also observed differences in the composition of the gut microbiota between infants living in countries with a high and a low prevalence of allergy and between healthy and allergic infants, even very early in life before they have developed any clinical symptoms of disease (76). The microbial diversity and composition of 47 infants as analyzed using barcoded 16S rRNA 454 pyrosequencing in stool samples at 1 week, 1 month, and 12 months of age, revealed that low total diversity of the gut microbiota during the first month of life was associated with asthma in the children at 7 years of age (83).
Conversely, the relative proportion of Bacteroidetes is decreased in obese people compared with lean people, while the proportion of Firmicutes is increased in obese people (78).
Jimenez and colleagues showed that the presence of bacterial species in the meconium, such as Escherichia coli, E.
In addition, an increasing number of older siblings are associated with the colonization of Lactobacilli and Bacteroides at 5 weeks of age, all of which are associated with beneficial effects (47). A low gut microbial diversity during the first month of life was also associated with subsequent sensitization and atopic eczema at 2 years of age (82).
In addition, colonization with clostridia, at the age of 5 and 13 weeks is associated with an increased risk of developing atopic dermatitis in the subsequent 6 months of life (47). And in this case, bigger was better.“Almost everything about the fertility of those males is enhanced,” Erdman said, explaining how yogurt-eating males mated faster and produced more offspring.
This could be due to poor development of the immune system since infants born through cesarean section have also been reported to have remarkably lower levels of the Th1-related chemokines CXL10 and CXL11 in their blood, which may translate to less protection (46). In addition, formula feeding induces intestinal hypertrophy and accelerates maturation of hydrolysis capacities; it increases intestinal permeability and bacterial translocation. The mother and family at large, therefore, play a major role in the initial microbial colonization in infants who may have a health impact on the child. In addition, reduced bacterial diversity of the infant’s intestinal microbiota was associated with increased risk of allergic sensitization, allergic rhinitis, and peripheral blood eosinophilia, in the first 6 years of life (81). Breastfeeding and formula feeding play major roles in defining the initial microbial colonization, and a previous meta-analysis showed that breast-fed children have a lower risk of being overweight compared to formula-fed children and that the duration of breastfeeding is inversely and linearly associated with the risk of overweight (94).
Despite these findings, it is not clear whether colonization of the infant’s gut microbiota starts before birth, because the presence of bacteria in the amniotic fluid could also be an indication of undetected infection, which may increase the risk of miscarriages or preterm delivery (20). A meta-analysis of the association between cesarean section and childhood asthma involving studies with different designs, conducted in different countries and using different measures of asthma reported an increased risk of asthma after cesarean section (17), whereas a 20% increase in the risk of childhood onset of T1D was reported in another meta-analysis of children born through cesarean section (51). Early-life exposures, including those known to impact gastrointestinal microbiome composition, such as antibiotic administration have also been associated with increased risk for childhood asthma due to altered microbiota profiles or long-term reduction in microbial diversity (7, 84, 85).
Female mice that ate yogurt were even shinier than the males, and tended to be better moms to their larger litters.“We think it’s the probiotics in the yogurt,” Alm said. In this case, an association of the placental microbiome with a remote history of antenatal infections such as urinary tract infection in the first trimester and preterm birth has been reported (24). An additional meta-analysis investigating the use of antibiotics in infants reported that the use of antibiotics in childhood was associated with asthma and wheezing (16). However, a recent publication observed more than two times increased numbers of bacteria cells in breast-fed infants, compared to formula-fed ones (63). Alterations of the intestinal microbiota in preterm infants characterized by low microbial diversity and abundance of potentially pathogenic bacteria have been highlighted in the development of necrotizing enterocolitis (NEC), although there are discrepancies among different studies (86, 87).
It is therefore clear that breastfeeding may encourage proliferation or colonization by bacteria that may have protective effects on the growing infant, while formula feeding may predispose children to potential pathogens.
These findings may not be exclusively due to a disturbed intestinal microbiota because other confounding factors may also be responsible for NEC; however, further investigation will provide useful information on this topic and further clarify the existing discrepancies.




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Comments to “Probiotics and their implications in food safety uk”

  1. BLADE:
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  2. Tenha_Qaqash_Kayifda:
    Far been done only in mice, so many more.