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The amino acid called GABA (Gamma Aminobutyric Acid) is the principal INHIBITORY neurotransmitter in the mammalian central nervous system,   sending chemical messages through the brain and nervous system and helping regulate communication between brain cells. Pharmaceuticals called benzodiazepines bind to the same receptors as GABA, mimicking GABA’s natural calming effects. Glutamate (also called L-glutamate or glutamic acid)) is another important amino acid neurotransmitter released by nerve cells in the brain. An earlier experiment, in 2011, demonstrated that a different type of gut bacteria, Lactobacillus rhamnosus, dramatically altered GABA activity in the brains of mice as well as affected how well they responded to stress. When the researchers surgically removed the vagus nerve, the communication pathway between the gut and the brain, the effect on the mice disappeared – more evidence on how gut bacteria influence the brain. The research team, led by Philip Strandwitz at Northeastern University in Boston, is now searching for other gut bacteria that consume or even produce GABA.
Researchers are just at the beginning of looking into the many ways the gut microbiome influences, if not regulates, many bodily processes and how unbalance in the gut microbiome eventually leads to poor health. DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment. July 4, 2015Gut Microbiome and MoodAdrenal Insufficiency, Anti-inflammatory Action of Probiotics, Anxiety, Bacteroides fragilis, Bifidobacterium infantis, Bifidobacterium longum, C.
Scientists are discovering that some probiotic micro-organisms living in our guts are also psychoactive. I’d say that the field of psychobiotics in the not so distant future will be understood more broadly to include all of us, not just those with diagnosable mental illnesses. It runs from the brain stem down each side of the neck, across the chest, down through the abdomen allowing the brain, lungs, heart, spleen, liver, pancreas, kidneys, stomach and intestines to communicate bi-directionally along its network. Did you notice the mention of the anti-inflammatory actions of probiotics in the quote above? These signaling irregularities affect our emotions, mental abilities, behaviors, and perception of and reactions to pain (nociception). Our gut microbiome, the 100 trillion micro-organisms (500-1,000 species of bacteria, fungi, viruses, and other tiny life forms) living in our intestinal linings, is so important to the proper functioning of the entire body that many scientists now regard it as an organ in and of itself. In 2013, microbiology researchers Mazmanian and Hsiao published research results that linked a specific variety of probiotic bacteria with anxious behaviors in mice.
A recent study found that a combination of the probiotics Lactobacillus helveticus and Bifidobacterium longum (probiotic bacteria found in healthy human gut microbiomes) reduced anxiety, depression, and stress levels and improved coping strategies.
Our psychological and physiological reactions to fear and stress play a large role in depression. What often happens now is that we live in a state of chronic cortisol overproduction, over stimulated, afraid, unable to calm down, wearing out our adrenals.
GABA (gamma-Aminobutyric acid) is our central nervous system’s chief inhibitory neurotransmitter, playing a central role in reducing neuronal excitability throughout the body and regulating muscle tone. Many physiological and psychological processes associated with depression, including negative ruminations, can be traced to a deficiency in the neurotransmitter GABA. Bifodobacterium longum is found in unprocessed yogurts, various types of fermented dairy foods (kefir’s a good choice), and fermented vegetables such as sauerkraut.
A team of biologists at MIT found that another probiotic strain, Lactobacillus reuteri, improved mood, restored a youthful appearance to the skin, and promoted general health by increasing levels of oxytocin, the love hormone.
Lactobacillus rhamnosus is a bacterial strain that has been shown to reduce anxiety and depression in anxious mice. GABA, the central nervous system’s principal inhibitory neurotransmitter, regulates many physiological and psychological processes in the body.
When the vagus nerve was severed, GABA receptor levels and the animals’ behavior remained unchanged after treatment with L.
The researchers allow that the vagus nerve is the obvious communication route but perhaps not the only one, that messaging may also occur via other nerves or chemicals in the blood. If you doubt there’s a direct connection between the health of the gut microbiome and mental health, keep in mind that functional bowel disorders and mood disorders such as anxiety and depression are generally comorbid (they generally occur together). Lactobacillus acidophilus improves the functioning of canabinoid receptors in the spinal cord that are important for regulating pain perception.
A number of microbes can produce other neurotransmitters, such as norepinephrine, serotonin, and dopamine. Bifidobacterium infantis has been clinically demonstrated to be very good at reducing the symptoms caused by chronic immune activation in the gut, autoimmune diseases, and excessive cortisol release. Years ago, when I was living in Cambridge, MA, my neighborhood grocery store was Savenor’s.

This is also true of genetic predispositions for heart disease, diabetes, Alzheimer’s, cancer,  and pretty much every other illness.
Research has shown that probiotic bacteria produce positive changes in the mucosal lining of the small intestines which affect gene activity and cellular reactions.
If you pay attention to any of the commercials on TV promoting Probiotic supplements, they bring up another important benefit to taking a Probiotic supplement; immune support. It is involved in most aspects of normal brain functioning, including cognition, memory and learning. They found that a type of recently discovered gut bacteria, called KLE1738, can survive and reproduce only if it has GABA molecules to feed on. That is, they deliver neuroactive substances such as gamma-aminobutyric acid (GABA) and serotonin that influence the brain via the gut-brain axis.
And they all begin with the health of the several pounds of miniscule critters living in our gut microbiomes.
The theory is that these micro-organisms  communicate with the nervous system using some of the same neurochemicals the body uses to relay messages in the brain. The mice were known to have alterations in their gut microbiota and GI barrier defects  (increased gut permeability, AKA leaky gut) and also exhibited anxious, obsessive behaviors (such as obsessively burying marbles). People suffering from major depression also have elevated levels of cortisol, the stress hormone our adrenals release to get us ready to fight for our lives or flee from the danger. Chronically elevated cortisol production interferes with learning and memory, lowers immune functioning, decreases bone density, increases weight gain,  raises blood pressure and cholesterol levels, leads to heart disease, increases risk for depression and anxiety, decreases resilience – and is generally exhausting.
Alterations in GABA receptor expression are linked to the the development of anxiety and depression. For example, Bifidobacterium infantis, taken as an probotic, alters serotonin levels – just like Prozac but without the undesirable side effects.
So it, along with some other probiotic bacteria, is a good choice for people with leaky gut, IBS, IBD, celiac disease, and Crohn’s disease. Mrs Savenor kept a huge, wooden pickle barrel next to the checkout counter.  The top of the barrel was open. The Childs lived in the neighborhood of beautiful big houses on the north side of Kirkland Street. Any of these forms may be effective for digestive problems as long as they contain the right kind of beneficial organisms in adequate numbers. Inflammation is associated with immune system imbalance and disruption of hormone activity. More than 90 percent of the body’s serotonin, a feel good neurotransmitter, lies within the gut. The other 75% is environmental (both internal and external) and therefore largely up to you. We are now promoting a “Supplement of the Month.” We are doing this to gradually introduce the importance of nutritional supplementation. I often wonder how much people actually know about Probiotics outside of what these commercials say. Now before anyone gets scared of the word bacteria, you need to understand that there are good bacteria as well as some bad ones.
It has shown incredible results with the majority of our patients with health issues, but I still recommend it whether you think you have a problem or not. Research suggests that GABA helps control fear and anxiety when neurons become overexcited. The researchers tried providing KLE1738 with other types of neurotransmitters but the bacteria couldn’t survive on anything but GABA. Such work may eventually lead to new treatments for mood disorders like depression or anxiety.
Neurotransmitters and specific microbes may become the treatment of choice for mood disorders – or, even better, for preventing mood disorders in the first place. Unbalance in the composition of microbes there creates inflammation inside the intestinal linings, increasing gut permeability, leading to chronic inflammation elsewhere in the body – and disease. If something interferes with signaling somewhere in the system, a circuit can malfunction and perhaps cause the entire switchboard to break down.
When they were given oral doses of  one of two strains of the bacterium Bacteroides fragilis (probiotic bacteria found in normal gut flora), both their GI problems and maladaptive behaviors improved.
Back when we frequently encountered predatory animals and were often in a fight or flight situation, this elevated release of cortisol was a very useful thing.

A combination of the probiotics, Lactobacillus helveticus and Bifidobacterium longum, was found to reduce cortisol levels. This is a good thing – colonizing probiotic strains of bacteria in your gut can restore your health. When the researchers supplemented chronic fatigue syndrome sufferers with a live casie strain of L. Many scientists and doctors therefore recommend that pregnant women take it as a supplement.
The brine may be cloudy – full of lactic acid bacterial growth (the desirable probiotics) created during fermentation.
The brine was cloudy, sometimes scummy looking, and every once in a while the barrel emitted a big belch of gas.
I was in the neighborhood of old apartment buildings on the south side of Kirkland, where students and other people with little money lived. Reputedly, she’d smuggled her young boys out of Lithuania by walking across the border with them under her voluminous, floor length skirt when the Nazis set about exterminating all the Jews there.
Two antidepressants, mirtazapine (Remeron) and fluoxetine (Prozac), are linked to a nearly 50 percent increased risk for Clostridium difficile infection. Now we have good research and more than enough clinical evidence that specialized probiotic bacteria are essential for health, and also profoundly influence mood. Epigenetics is the study of factors that turn genes on and off and affect how cells read genes.
Probiotics influence activity in our genes, allowing them to express their contents in a positive, disease-fighting manner. These little strains of bacteria play a key role is supporting and strengthening your immune system. Below normal GABA levels in the brain have been linked to depression, anxiety, sleep disorders, and schizophrenia. It accomplishes all this by producing large amounts of acid to make our digestive tracts and vaginas inhospitable to pathogenic bacteria and parasites.
Psychobiotics could target genes responsible influencing neurotransmitters like GABA that have a strong connection to mood and behavior.
Provide it with lots of good microbes (probiotics and psychobiotics) to keep a good balance in there and avoid the bad ones (bacterial pathogens and other toxins) as much as possible.
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects.
A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Think of them as little soldiers in your body that are there to fight anything bad that gets in. The company is so precise in their quality, they guarantee those numbers make it past your stomach and into your intestinal tract. The number one reason someone seeks out the use of a Probiotic is typically for gastrointestinal issues. Antibiotics are prescribed to patients on a regular basis today, and many times it’s the exact opposite of what the patient needs. When they switched the gut bacteria of the rats, the docile rats became aggressive and vice versa.
If the patient is sick, then why would you prescribe a medicine that goes in and kills everything? Now Probiotics are being shown as very beneficial with brain disorders ranging from ADHD in kids to Alzheimer’s in the geriatric population. I have seen research showing that the states with the highest consumption of antibiotics also have a correlation with the highest cancer rates in the country. Whenever I have a patient that tells me they are on an antibiotic, I ALWAYS recommend that they take a Probiotic supplement after the antibiotics are done.

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