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The term probiotic means “for life” and is currently used to name friendly bacteria associated with beneficial effects for humans and animals.
A prebiotic is generally a long-chain, non-digested carbohydrate classified as a fiber that ferments in the digestive tract and preferentially or selectively feeds friendly bacteria.2 Examples of prebiotics include inulin, fructooligosaccharides, mannan oligosaccharides and arabinogalactans. The question has often been posed as to whether there is a difference in obtaining probiotics from supplements or from food products such as yogurt.
Foods that contain probiotics, including yogurt, sour cream, kefir, sauerkraut, kombucha (fermented) tea and fermented soy (miso, tempeh) generally focus on one or two strains. Since most brands do not indicate the probiotic dosage on the product, it is generally not a simple task to make that determination. By contrast, probiotic supplements are available as single strain products, as well as products with multiple species and strains. In addition, some research suggests that the consumption of certain probiotic strains commonly found in supplements may have more of a therapeutic effect than consuming a yogurt drink that does not contain that same strain.6 Unfortunately, some brands of probiotics tested did not contain what their labels claim,7-8 so it is always important to choose probiotic products from trustworthy companies. Probiotic supplements are available as liquids, freeze-dried powders, capsules (containing freeze-dried powder) and beads. Powders consist of probiotics that have been freeze-dried under low temperature and pressure in order to remove water without damaging the delicate structure of the cell or organism itself.
Once moisture becomes available again to the bacteria (such as when they are ingested) they rehydrate.
Since probiotics are not nutrients, they are often not thought of in regard to being deficient in the human body. The result is an increase in chronic diarrhea, as well as more bacteria and toxins finding their way from the intestine to the blood, as well as intestinal absorption disorders causing vitamin B12-deficiency anemia, low levels of various vitamins and protein deficiency.
The bifidobacteria genus normally colonizes in the human colon23-24 and, like lactobacillus species, also produces lactic acid. In addition to the prevention and treatment of probiotics deficiency, probiotics have also been used in treating a wide range of disorders, and there is strong evidence for their efficacy in some clinical scenarios. A significant amount of research has been conducted regarding the different probiotics strains, and the value that these individual strains have for human health. It is inevitable that a certain percentage of probiotic bacteria will be destroyed by gastric acids.
For purposes of maintaining a healthy level of friendly intestinal bacteria, a higher dose of probiotics is not necessarily better. Similarly, it can actually be more beneficial if a single strain of probiotic is used rather than multiple strains because this will limit the effects of possible interactions of multiple strains. Depending on the clinical benefits one is looking to achieve, it is possible that certain strains may counteract the benefits of others in a multi-species mixture, resulting in an ineffective product. A probiotic isolated from switchgrass is one of the newest competitors in the robustness claims sweepstakes. Get FREE access to authoritative breaking news, videos, podcasts, webinars and white papers. We are constantly being assaulted by environmental pollutants and toxins such as UV rays, diesel exhaust and cigarette smoke. Conducting a clinical trial in the health nutrition industry can be an intimidating process.


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INNOBIO is a leading manufacturer of functional nutritional ingredients and an expert in meeting customer specific requirements. GoodBelly, a line of probiotic drinks formulated for daily digestive health, has unveiled GoodBelly Protein Shakes, a line of multi-functional beverages.
An estimates 10% of breastfeeding women are affected by mastitis, whereby the breast tissue becomes painful and inflamed.
The Spanish firm Biosearch Life has filed for a health claim linking a probiotic strain with the reduced risk of painful inflammation of the breast during breastfeeding.
The article 14 claim reads: “Lactobacillus fermentum CECT5716 decreases the Staphylococcus load in breast milk.
In fact, the Food and Agriculture Organization of the United Nations and the World Health Organization define probiotics as “live microorganisms which when administered in adequate amounts confer a health benefit on the host.”1 Several probiotic species, mainly those of the lactobacilli and bifidobacteria genus, are used singly or in combination in dietary supplements and functional foods. However, before addressing the health applications, it’s important to describe the definitions of additional key terms associated with the category of probiotics. This puts the probiotic bacteria in a state of suspended animation well suited to long-term storage. Subsequently, a proportion of the bacteria will go on to function and divide again as they did before being freeze-dried. The claim to fame for these products is that enclosure in the softgel beads is supposed to protect the probiotic bacteria from the acidic environment of the stomach.
Nevertheless, some inflammatory conditions of the gut are thought to be caused, at least in part, by “a relative deficiency of bifidobacteria.”13 Furthermore, there are a range of adverse effects when probiotics are present in insufficient quantities. Lactobacilli refer to a genus of lactic acid- producing, friendly bacteria17-18 that make up many of the 400 normal probiotic species in the human body.19-22, 17 The most important of these are probably L. These probiotics appear to be the most important organisms in the intestine in helping to create a microbial barrier to infection. Many marketers claim that a relatively high dose is necessary (5 to 10 billion cells or colony forming units, CFUs) to assure that an adequate quantity of these microorganisms will make it through to the intestinal tract intact to provide their benefits.
Higher doses may be indicated for shorter periods, however, if a specific medical need is being addressed. It’s wise, therefore, to always choose strains that have been studied for a particular effect and, if a combination is considered, to be aware that potential interactions may occur between different bacterial species. This is kind of like recreating the paleo diet with the organisms present on the food they would have been consuming,” he said.
The drinks help maintain digestive health on-the-go and tout the same well-researched probiotic strain used in the brand’s existing lineup, Lactobacillus plantarum 299v (LP299V), which can withstand the stomach’s acidic environment allowing it to reach the digestive system and positively support digestive health when consumed daily, say company officials. Packed with 15-grams of plant-based protein to nourish the body and 40 billion live and active probiotic cultures to support digestive health, GoodBelly Protein Shakes are available in three juicy flavors: Tropical Coconut, Green Power and Triple Berry.
Plus, the food may or may not provide a clinically relevant dose of the strain(s) it does contain. Once this happens, research has also demonstrated the rehydrated probiotics are able to effectively provide their respective benefits.10-11 Whether or not refrigeration is required for probiotics is dependent upon the actual strains, some of which are heat and shelf stable and some of which are not.
Microencapsulation is a technology of packaging active materials in miniature sealed capsules that can release their contents at controlled rates under the influences of specific conditions.


While the softgels may or may not do this, there is a serious question as to whether or not the probiotic will survive the softgel encapsulation process, due to the high temperature used to keep the gelatin in a liquid state prior to forming the actual softgel. One example of this is small intestine bacterial growth syndrome, a condition associated with the increase in pathogens.
However, the bottom line is that it’s more advantageous to ensure the good bacteria survive to begin with rather than rely on taking high doses in the hopes they will survive. Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria.
If you have any concerns about your digestive system, please consult your healthcare professional. Consequently, there is a built-in issue of storage and shelf-life that can be short for some live products.
With regard to probiotics, the purpose is to enhance their viability during processing, and also for their targeted delivery in the gastrointestinal tract.12 While microencapsulation certainly has value, this process is probably unnecessary where hardy, stable probiotic strains are concerned. In conversations with a softgel manufacturer, I was informed that, in their experience, analytical testing found that probiotic bacteria did not remain viable after softgel encapsulation. This occurs, in part, due to the fact that there are insufficient numbers of friendly, probiotic organisms to inhibit the spread of the harmful, pathogenic organisms.
The problem with the approach has been that many of these organisms proved delicate.“There were quite a few challenges,” Bakal said. The marketers of spore-forming probiotics that also target foods and supplements, such as Ganeden Biotech, Sabinsa Corp.
Refunds will be processed net of coupons, in-store discounts and any other discounts, for only the actual amount spent on GoodBelly.
Furthermore, competition for nutrition between bacterial strains within the same live product is another important consideration. But that stability can be a two-edged sword, Bakal said.“Most food plants are trying to get rid of spores because they are the thing that is so difficult to kill. Green Power offers a blend of good-for-you greens, including spinach, alfalfa grass and spirulina, this healthy shake is balanced by the sweetness of apples, pears and bananas.
The new strain is part of the development of the probiotic space from a shotgun approach (just get a lot of CFUs in there) to a method of drilling down to the specific strain level to prove benefits, he said.“Originally it was you just call it a probiotic and that was enough. GoodBelly Protein Shakes contain 40 billion live and active cultures per bottle, in addition to chickpea protein. Then there was sort of a cold war in the probiotic space with everyone claiming higher and higher colony forming unit figures. Like all other GoodBelly products, GoodBelly Protein Shakes are Non-GMO Project Verified, dairy-free, soy-free, vegan and kosher.
These studies can be quite expensive, and you hope get lucky to get into an NIH study or a university study,” Bakal said.“If you look at the science claimed by some other companies, a lot of those are studies they didn’t do themselves.
We have data on immune response and on general gut health, and one of things we are trying to do is to excite interest on the part of potential research partners,” he said.



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Category: Probiotics Immune System


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