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Author: admin, 29.05.2016. Category: Garden Soil

Researchers have now shown methanolic (alcoholic) extracts of the whole fruit possess certain active phytochemicals (plant-derived compounds) that can trigger a sequence of orchestrated events in tumour cells leading to their death (a process called apoptosis). The collaborative study was conducted by scientists at the Indian Institute of Science (IISc), Bangalore, and the Institute of Bioinformatics and Applied Biotechnology, Bangalore. One million new cancer cases are reported in India every year and the figure is set to double in 20 years, according to the International Agency for Research on Cancer.
Out of the estimated eight million people globally who died of cancer in 2012, nearly 700,000 deaths were in India. As the disturbing figures rise on one hand, there is also, on the other end, mounting evidences of plant derived dietary substances as "suitable candidates for treating various types of cancers due to their broad chemical diversity".

Raghavan explained: "We have tested its effect on cancer cells derived from different cancers such as leukemia, breast, ovarian and lung carcinomas.
In fact not only did the extract "significantly decrease" the tumour load in mice induced with breast cancer, in 50 percent of the mice examined, Sapota extract also led to a "three-fold increase in the life span compared to untreated tumour mice". The next step, he said, is pinpointing the principal compound or compounds leading to Sapota's anti-cancer effects. A tropical fruit grown and consumed extensively in several countries, including India and Mexico, Sapota (Manilkara zapota) is packed with dietary fibre, minerals, vitamins and high antioxidant properties. Ours is the first study using whole fruit methanolic extracts which explores anti-cancer properties of the same on different cancer cell lines and on animal models.

Raghavan, associate professor at the department of Biochemistry, IISc, told IANS in an email interaction. Clinical trials may follow after identification and optimisation of the purified component(s)," said Srivastava, the first author of the paper. It worked jointly with Bibha Choudhary and Jinsha Koroth at the Institute of Bioinformatics and Applied Biotechnology.

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