29.03.2014
People with sleep apnea stop breathing repeatedly during sleep, waking up partially in order to catch their breath. Sleep apnea is a common disorder in which a person has pauses in breathing or shallow breaths while sleeping. For the study, researchers tested 86 patients with sleep apnea for three months with either CPAP treatment or a "placebo" mask that had tiny holes in it to reduce air flow.
After three months of CPAP therapy, patients with moderate-to-severe obstructive sleep apnea had lower blood pressure, lower cholesterol, and a number of other heart risk factors were reversed.
But the new study only "adds to the growing body of knowledge that obstructive sleep apnea has long-term consequences for your health, and that treatment reverses some of those consequences," Dr.
A new study conducted at Columbia University Medical Center (CUMC) has revealed some of the underlying mechanisms that may increase the risk of heart disease in people with sleep apnea.
More than 18 million adults have obstructive sleep apnea, in which relaxation of muscles in the throat during sleep causes frequent interruptions in breathing.
The study included 128 people who underwent sleep studies at CUMC’s Sleep Disorders Center, including 76 people who were diagnosed with obstructive sleep apnea and 52 people who did not meet the criteria for this condition. The investigators found that people with sleep apnea had higher levels of a protein called CD59, which inhibits the buildup of inflammatory proteins on cell surfaces. Arrows indicate that more CD59 is drawn into the cell in people with sleep apnea who are not taking statins (left); whereas more CD59 remains on the cell surface in those taking statins (right).


The researchers also noticed that CD59 was preserved on the cell surface in a small subset of subjects with sleep apnea who were being treated with statins, similar to those who did not have sleep apnea. Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH) during transient cessation of breathing, triples the risk for cardiovascular diseases. The study included 128 people who underwent sleep studies at CUMC's Sleep Disorders Center, including 76 people who were diagnosed with obstructive sleep apnea and 52 people who did not meet the criteria for this condition. The most common type of sleep apnea is obstructive sleep apnea, which results from airways that are collapsed or blocked during sleep. 15 issue of the New England Journal of Medicine - investigated the connection between obstructive sleep apnea and metabolic syndrome, which is the name for a group of risk factors - including belly fat and insulin resistance - that raise the risk for heart disease, diabetes and stroke.
Sleep apnea effects up to 18 million Americans, but most don't realize they have it because it only occurs during sleep, and doctors generally can't detect the condition during routine office visits.
David Rapoport, an associate professor of medicine and director of the Sleep Disorders Program at NYU Langone Medical Center, told HealthDay.
The condition disrupts sleep and causes fluctuations in oxygen levels, which can lead to excessive daytime sleepiness and difficulty concentrating.
The researchers analyzed cells that line blood vessel walls (obtained from the participants’ arm veins) to look for differences that may explain the increased risk for heart disease in people with sleep apnea. Unexpectedly, however, CD59 was found mainly within the cells of those with sleep apnea, instead of on the cell surface.


6, 2016) -- A new study conducted at Columbia University Medical Center (CUMC) has revealed some of the underlying mechanisms that may increase the risk of heart disease in people with sleep apnea.
The researchers analyzed cells that line blood vessel walls (obtained from the participants' arm veins) to look for differences that may explain the increased risk for heart disease in people with sleep apnea.
Most cases of sleep apnea are caused by the relaxation of soft tissue in the throat, which shuts off the airway.
Previous studies have linked sleep apnea to an increased risk for diabetes, heart disease, stroke, and obesity. In addition, sleep apnea triples the risk for developing heart disease, including hypertension, and ischemic stroke. As a result, the cells of the sleep apnea group had larger deposits of inflammatory proteins. The study also found that statins -- the cholesterol-lowering medications commonly prescribed to combat heart disease -- may help reverse this process. These studies suggest that reduced complement inhibition may mediate endothelial inflammation and increase vascular risk in OSA patients.




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