There is conflicting information available regarding the safety of long term use of melatonin with studies stating that melatonin is safe to take in small doses for up to 2 years if monitored by a physician while others state that taking melatonin long term will cause the body to stop producing melatonin. After one week of taking 500 mcg of liquid Melatonin just before bed, (placed under the tongue for at least 30 seconds prior to swallowing) I have had phenomenal results in not only falling asleep more quickly, but also staying asleep and am thrilled with the improvement in the quality of sleep I have received each night. According to research published by the Mayo Clinic in October, 2011, taking melatonin daily is considered to be safe, as long as the daily dosage does not exceed 5mg and use does not exceed a two year time frame.
For additional information on the use of melatonin, please seek the advice of your physician. Almost nothing has been recognized about interactions between the melatonin function and other drugs and health problems, but because melatonin is a potent natural hormone, caution should be used regarding the timing, dosage, etc.
High blood pressure: Melatonin can raise blood pressure in people who are taking certain medications to control blood pressure. Melatonin and melatonin-containing supplements should be avoided in people with lupus and other autoimmune disorders because they may stimulate the immune system. Melatonin supplement side effects include; Tolerance, fatigue, nightmares, hypotension, sleep disorders, abdominal pain, among others have been reported. The content provided in Side Effects of Melatonin Supplement is for information purposes only, intended to raise the awareness of different solutions for you or your families sleep problems and should not be considered medical advice.
Melatonin is a powerful antioxidant neurotransmitter produced not only by the pineal gland in the brain but it is also made in the skin and possibly other tissues. The Investor Profile Quiz is designed to help you gain an in-depth understanding of your investment objective, which serves as the foundation of your portfolio.  Your investment objective is based on many factors, including your time horizon, financial goals and risk tolerance. Brent Bauer, an established internist and director of the Mayo Clinic Complementary and Integrative Medicine Program to get first hand commentary from someone with advanced knowledge on the topic of melatonin.

Bauer stated that interest in melatonin continues to grow – not only because Americans are having more problems with sleep, but also because of intriguing studies that suggest, among other things, that it is a powerful antioxidant, may help prevent certain types of headaches, and might also help reduce the risk of cancer.
In addition, people with these conditions should also avoid the prescription sleep aid Rozerem (ramelteon), because it mimics melatonin in the body. Long term administration of a pharmacologic dose (3mg) may disrupt, rather than improve, sleep in some individuals. The pharmacologically effective melatonin dosing has not been established by rigorous studies. Historically, investments with higher return potential have required a higher tolerance for risk. Some possible melatonin interactions with sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. Melatonin might also interfere with ovulation, making it more difficult to become pregnant. Because of its effects on other hormones, melatonin in children might interfere with their development during adolescence. It is important that you understand the necessity of avoiding both melatonin and Rozerem, since sleep aids are often used to help people with fibromylagia and other conditions to attain normal sleep patterns.
Some authorities say melatonin use on consecutive nights should be avoided and only the lowest effective hypnotic dose should be taken. The drug, which delivers melatonin in a prolonged-release formulation, is already available in Europe, Asia and the Middle East. Melatonin is widely known as a natural sleep-promoting compound, but research has shown that melatonin offers other remarkable health promoting benefits.

Therefore, by clearly defining your risk tolerance, we will be better prepared to choose the most appropriate investments for your portfolio. In general, be sure that you speak with your physician before taking any new medications or supplements. Melatonin can accumulate in the liver if used in high does for a long period of time, several months or more. Sleeping pills are not an alternative to taking a look at your life and figuring out why you’re having a sleeping problem. Long-term goals may include saving for your child’s education or planning for your retirement. This can lead to higher than normal melatonin levels in the morning hours when they should be lowest, making it hard to awaken, causing mental fogginess, etc.
Bauer stated, “Researchers have speculated that chronic use might suppress the body's natural melatonin production. High melatonin levels can also suppress normal adrenal function, especially in the early morning hours, leading to fatigue and lethargy.

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