Circadian rhythms with their associated hormonal cycles can explain how some of our daily activities are often at their most optimal at particular times of the day, as shown in the diagram below.
Expose yourself to bright light on a daily basis – particularly in the early morning.
The participants had signed up for a weight-loss program, and the investigators tracked their eating habits. Eat a high carbohydrate (higher GI) meal in the evening, 4 hours before bedtime (reference). In doing so, we became adapted to eat during the daytime, and maladapted for eating at night.

Clock proteins in the colon peak in abundance at dramatically different times during a 24-hour cycle, depending on whether eating is continuous through the day or restricted to daytime. Serotonin is synthesized from tryptophan, and carb intake is known to increase uptake of tryptophan into the brain, where this serotonin synthesis occurs. Many of these are aimed at reducing the negative effects of artificial light on melatonin production. Both groups followed a similar diet, exercised about the same amount, slept the same number of hours, and even produced similar levels of hunger-related hormones. If eating is mistimed, it can create an imbalance between the clock proteins regulating e.g.

People who fall out of sync with their circadian cycles are more likely to suffer from diabetes, obesity, and heart disease.
Melatonin is a critical circadian-controlled hormone secreted by the pineal gland, closely associated with sleep and wakefulness. She found that insulin treatment caused a phase adjustment of the circadian clock of the mice.

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