16.04.2015
Some researchers have come up with narcolepsy causes as genetics, autoimmunity, and hypocertin deficiency in brain. But, we cannot completely blame genetics for developing narcolepsy, they show such symptoms, when in combination of trauma, viral infection, changes in hormones, stress and autoimmune disorders. Researchers have found out that there is relation between narcoleptic people and HLA-DR15, HLA-DQ6 gene, and particularly HLA-DQB1*0602 gene.
Researchers thought that some factors could work together, which can cause the lack of hypocretin. Still there is much to learn about narcolepsy causes, but it is strongly believe that genes plays a major role and after that low amount of hypocretin, and autoimmune diseases are also a reason behind narcolepsy. It runs in the family for some people, but most of them with narcolepsy, they don’t relate to any of their relatives that suffer from the same disorder. Narcolepsy is a chronic neurological disease which is due to the inability of brain to maintain a sleep-wake cycle in a normal fashion.
Narcolepsy is a sleep disorder due to a neurological condition and is not caused by any mental disorder or psychological illness.
In almost all of the cases, the very first symptom to occur in narcolepsy is excessive daytime sleepiness with other symptoms following in some months or in some cases even years after EDS begins.
The exact cause of narcolepsy could not be found out for quite a few years but scientists have found out about certain conditions that increase the risk of a person having this disorder. The diagnosis of narcolepsy becomes very easy when all the symptoms described above are present in an individual but if the symptoms are very mild and far between then the diagnosis becomes that much more difficult.
Epworth Sleepiness Scale: This is a series of questions that an individual is asked to fill out which determines whether a person has a sleep impairment or not to include narcolepsy.
Apart from using medications, it is important for a person suffering from narcolepsy to take short naps a couple of times to aid in control of EDS.


The influenza vaccine Pandemrix has been associated with an abrupt increase in the incidence of childhood narcolepsy in Finland and Sweden. Great increases in Sweden and FinlandIn Finland and Sweden, an abrupt increase in narcolepsy cases was observed after the flu pandemic in 2009-2010. No cause for alarmFactsThe researchers have isolated two types of genes that are common in children who developed narcolepsy after being vaccinated with Pandemrix. Narcolepsy is a sleep disorder that causes excessive sleepiness during the day and uncontrollable sleep attacks. Narcolepsy is a neurological condition that is made worse by irregular sleep patterns or sleep disorders like insomnia.
Narcolepsy is a lifelong condition that has no cure, but you and your doctor can work together to control the symptoms of narcolepsy and maintain a healthier sleep pattern. The causes are generally linked to genetic abnormalities, which affect certain biological factors in your brain and coupled with some environmental trigger like virus, etc. There is an increased risk of developing narcolepsy with narcolepsy history running in the family. The research conducted in Australia during 2004 said that the autoimmune diseases are also one of the triggers for developing narcolepsy symptoms. Generally, people with narcolepsy have a disturbed sleep at night and will have an abnormal sleep pattern in the day. After a good night's sleep, an individual suffering from narcolepsy falls asleep in the day and feels tired throughout the day. Narcoleptics become so habituated to the tiredness that they do not see anything unusual in their sleeping pattern or tiredness during the day. EDS is generally a lifelong condition whereas other symptoms tend to cease.Many narcoleptics also have lack of sleep for extended periods.


The researchers suggest that this may be the substance that triggers narcolepsy, although this remains inconclusive. People with narcolepsy should not drive or handle any heavy machinery unless they are on medication. Narcoleptics have low levels of a chemical in the brain called hypocretin that promotes wakefulness. The symptoms of narcolepsy are termed as cataplexy, inability to move the body during sleeping or upon awakening also called as sleep paralysis, hypnologic hallucinations, and excessive daytime sleepiness. EDS and cataplexy in narcoleptics become so severe that they start affecting an individual in the personal and professional front.
A factor that predisposes a person to narcolepsy involves an area of Chromosome 6 called the HLA complex. The tests that are most common for the diagnosis of narcolepsy are polysomnogram, MSLT, and finding out the Epworth Sleepiness Score of a person. Narcolepsy is caused by a number of genetic, environmental and biological factors that interact to disrupt the sleep cycle. People suffering from narcolepsy are unable to get the type of deep resting sleep that normal healthy individuals get. Although oral medicines are the first line of treatment for narcolepsy, lifestyle changes also play a key role in the treatment of narcolepsy.
These episodes have severe emotional influence on narcoleptics since it causes severe anxiety and fear and may lead people to avoid situations which may trigger an attack.



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Comments Biological causes of narcolepsy

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