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Please help improve this article by adding citations to reliable sources. It has been associated with groups such as rockers, punk rockers, bikers and metalheads. Given the small number of NAION events with PDE5 use (less than 1 in 1 million), the large number of users of PDE5 inhibitors (millions) and the fact that this event occurs in a similar population to those who do not take these medicines, the FDA concluded that they were not able to draw a cause and effect relationship, given these patients underlying vascular risk factors or anatomical defects Colorado, Clifton
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