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31.01.2016
1.1 Students learn to identify the role of enzymes in metabolism, describe their chemical composition and use a simple model to describe their specificity on substrates.
Most people would know that some animals (like frogs, snakes and lizards) are a€?cold-bloodeda€? and that when the weather is cold, these animals are less active than when ita€™s warm. Each enzyme has a unique shape - it is this shape that means it will make just one reaction go. Enzymes are not usually used up in chemical reactions - they can be used over and over, so they can be present in tiny amounts.
Enzymes are difficult to study in high school but there is one in saliva that we can study. Explain why our bodies need to make large amounts of digestive enzymes (like pepsin) but only tiny amounts of other enzymes (like hexokinase, which is present in every cell and catalyses the breakdown of glucose to glucose 6-phosphate). This experiment is important to addressing the skills outcome H11 (a€?A student justifies the appropriateness of a particular investigation plana€?). I hope you have a picture of many chemical reactions occurring in your own body right now, each one occurring because of the presence of tiny amounts of enzymes. So, it is important that the temperature and acidity in your body has to be kept at the right level.
Maybe you can think of some changes that occur in your body when the temperature gets too low! The first step to prevent your death is for your body to recognise the change in your body temperature. I have only considered what happens when there is a danger of you over-heating but there are many aspects of your body that have to be kept constant - for example, oxygen, sugar and water levels in the blood.
Nerve impulses travel very quickly, and travel from one small part of the body to another small part.
Hormones travel relatively slowly in blood, from an endocrine gland to a number of target organs. An example might be the hormone adrenalin, travelling from the adrenal glands above the kidneys to skin (constricting blood vessels), the pacemaker in the brain (increasing heart rate), the liver (increasing the level of glucose in the blood) and many other organs. At the Mid-Atlantic ridge, a€?black smokersa€? raise the temperature of the ocean above 100oC without the water boiling (because of the very high pressure). There are other organisms that thrive in temperatures close to the freezing point of water. The temperatures at which organisms are found and the range over which they can survive is because of the enzymes in their bodies.
A Grylloblattid - (Grylloblatta bifratrilecta) an insect related to crickets and cockroaches that lives in snow. Leta€™s make our ectotherm the impressive but relatively harmless (if left alone) Red-bellied Black Snake (Pseudechis porphyriacus). Comparing our ectoderm (Black Snake) and endoderm (Wombat) it is clear that both have behaviours and bodies that help them to survive extremes.
Your textbook does not give any examples of plants responding to temperature change - only adaptations to temperature extremes -so Eucalypts have drooping leaves which helps them to avoid overheating when the Sun is high; deciduous trees drop their leaves which helps them to avoid frost damage.
Responses of plants to temperature change are not common but there has been great interest from horticulturalists over several hundreds of years in the ability of Rhododendron spp to curl their leaves in response to temperature change. Most people would know that some animals (like frogs, snakes and lizards) are a€?cold-bloodeda€? and that when the weather is cold, these animals are less active than when ita€™s warm.A  Why is this? Enzymes are not usually used up in chemical reactions - they can be used over and over, so they can be present in tiny amounts.A  But most importantly, they only work under special conditions - a narrow temperature range and a narrow pH (acidity) range. That usually doesna€™t happen because things happen in your body to cool your body.A  You sweat, surface veins open up so that blood flows closer to the cooling air, and you breathe more often releasing warm our from your lungs. This is a practical investigation involving second-hand research.A  Before you start it, you should read these notes. I have only considered what happens when there is a danger of you over-heating but there are many aspects of your body that have to be kept constant - for example, oxygen, sugar and water levels in the blood.A  For each, there are receptors that detect the changes and a control centre (usually in the brain) that counteracts the change.
Nerve impulses travel very quickly, and travel from one small part of the body to another small part.A  An example might be from a fingertip to a very small part of the brain when we touch something. There are other organisms that thrive in temperatures close to the freezing point of water.A  For example, there are bacteria-like cells that grow on snow turning it red (to produce a€?watermelon snowa€?). On the other hand, individual organisms can generally survive in a fairly narrow range.A  For example, tropical fish die in cold water, yet antarctic fish would die in tropical waters. Choose an ectothermic animal species, an endothermic animal species and a plant species.A  Dona€™t forget the advice about second-hand research, especially to acknowledge your sources.
Your textbook does not give any examples of plants responding to temperature change - only adaptations to temperature extremes -so Eucalypts have drooping leaves which helps them to avoid overheating when the Sun is high;A  deciduous trees drop their leaves which helps them to avoid frost damage. Most likely, you will not experience the thrill of having different hot women fall heads over heels in love with you until you learn the secret meanings behind girla€™s text messages and you know how to react properly to every text message that she sends. Tease her, but do not make her feel uncomfortable or offend her, always look out for her boundaries. Hook her into something funny and interesting, cook up ridiculous stories and she will send longer responses. Consider the time it takes you to reply a text from a close friend, most probably a male friend. In the 80s, BSE became the poster-TSE, although naturally under its more dramatic moniker Mad Cow Disease.
Before I leap into a discussion of how prions cause disease, I first need to tell you a little bit about how proteins are made in the cell. One of the most heavily studied areas of prion biology is the mechanism of transmission (indeed a recent paper on the topic from a group here at Brown University appeared in Science last year).
As with any infectious disease, global health initiatives generally focus first on containment. ADDENDUM: It would appear I missed a report this week of the first blood test for CJD (see comment below). On Thursday last agroup of family members of victims of nvCJD were threatened with arrest when the peacefully went into the Ministry of Justice demanding answers about what the UK government really knew about how BSE in cattle becomes nvCJD in human beings. G M Trevelyon of Brockenhurst a former head of the Rural Payments Agency knows the truth as does MR Alan Hood of the Agency and David Bennett promoted for services to the crime of concealing this information who lives in Gorse Road South Finchhampsted was prepared under official instruction to perjure himself to protect the real truth behind nvCJD. We could so easily move rapidly to a better understanding of this terrible disease possibly a cure but certainly a test if the government were forced to come clean on what they know.
I will attempt to describe briefly The Serotonin Connection as asequence of psychological and biochemical events in the development of emotional disorders.
1) An extended period of physical or psychological stress, will produce stress hormones such as cortisol and adrenaline, that can interfere with the synthesis of the brain neurotransmitter, Serotonin. 2) A neurotransmitter is any one of numerous chemicals that occupy the gap (synapse) between two or more nerve cells (neurons) and thereby allows the triggering of a tiny electrical currents in adjacent cells. 3) Serotonin is a neurotransmitter that conveys the positive sensations of satiety, satisfaction and relaxation. 4) A deficiency of Serotonin in the brain can cause endogenous depression, upsets the appetite mechanism and may lead to obesity or other eating disorders such as anorexia and bulimia nervosa and may be responsible for insomnia. 5) Serotonin is produced from an essential amino acid (protein unit), called tryptophan, obtained from food and then converted to Serotonin under the influence of vitamin B6 (Pyridoxine) and magnesium. 6) If there is a deficiency of vitamin B3 (niacin),the body will use dietary tryptophan to synthesize niacin.
7) The absorption of tryptophan competes with the absorption of other amino acids in the digestive process. 8) The absorption of tryptophan can be accelerated by consuming refined carbohydrates, such as sugar. 9) Sugar consumption stimulates the body to produce insulin, a hormone which transports glucose, fatty acids and amino acids (except tryptophan) into body cells. 10) This leaves tryptophan available for absorption and conversion to Serotonin (via 5-hydroxytryptophan, 5-HTP) in the presence of vitamin B6 and magnesium, and presto we feel happy.
11) A person low in Serotonin will be inclined to consume greater amounts of sugar in an attempt to increase Serotonin production and this may lead to sugar addiction. 13) Insulin resistance starts first as mild insulin resistance leading to hypoglycemia (low blood sugar level also called ‘hyperinsulinism’), then reactive hypoglycemia, more severe insulin resistance which causes unstable concentrations of blood glucose, and finally more complete insulin resistance, causing diabetes over time. 15) The brain requires an inordinate amount of biological energy (about 70-80% at any time), mainly derived from carbohydrates, to synthesize the feel-good neurotransmitters, such as serotonin. 16) In hypoglycemia wild fluctuations in blood sugar levels causes the body to produce excess adrenaline, which functions to convert glycogen (stored sugar) into glucose in an attempt to stabilize the supply of glucose to the brain. 17) Treatment of hypoglycemia is achieved by adopting a hypoglycemic diet accompanied with vitamin and mineral supplements (Vitamin C, Zinc, Chromium picolinate, Thiamine (B1) and other B-complex vitamins, see “The Hypoglycemic Diet” ). 19) Depressant drugs, such as alcohol, tranquilizers, benzodiazepines, sleeping pills may temporarily counteract the effects of adrenaline, these are however very addictive and this helps to explain how hypoglycemia may lead to alcohol or drug addiction.


20) It is suggested that insulin resistance may also interfere with the absorption of other essential amino acids such as phenylalanine and tyrosine, which are forerunners of important brain neurotransmitters, such as dopamine and norepinephrine. 21) Norepinephrine (closely associated with dopamine) is believed to be a neurotransmitter that blocks out any irrelevant information from the brain and helps a person (usually young children) to concentrate on the task at hand. 23) The presence of excess dopamine in the brain causes the down-regulation of dopamine receptors as a defence against superfluous dopamine. 24) Treatment aims at reversing the Serotonin Connection by correcting the chemical imbalance of the various neurotransmitters. 25) Considering exposure to emotional STRESS as being a possible factor of the Serotonin Connection, it is important that the person undergoes a course of  psychotherapy to help him deal with stress situations more effectively by learning new social skills.
Are there any case studies to substantiate the proof of the relationship between Insulin resistance and serotonin? Serotonin is the most commonly dysregulated neurotransmitter in the etiology of MDD and this system is the primary focus of most medications used in the treatment of illness. Make certain that the Num Lock key has been pressed to activate the numeric key section of the keyboard. While the Alt key is depressed, type the proper sequence of numbers (on the numeric keypad) of the ALT code from the table above. For terms of use, conventions used in this table, access to additional charts and ways to access the code charts, see Character Code Chart Help and Links. Here you'll find bits and pieces of wisdom learned from cycling 17,000 miles from Alaska to Argentina together as a family. He has been criticized for being a misanthrope, a subvert, a cynic and a pessimist, but I think these assessments are off the mark. This self-confidence, sometimes mistaken for simple arrogance by the less decisive, is actually of a very specific rather than a general nature; its source lies in the specialized knowledge systems that most INTJs start building at an early age. Advancements in technology have transformed the way that we correspond with others in the modern world. These chemical react to make new chemicals and to absorb, release or turn one kind of energy into another. Many more chemical reactions than usual are happening and so much more heat than usual is being generated.
If the car is not fitted with cruise control, we maintain a constant speed by watching the speedometer and adjusting the pressure on the accelerator pedal. For example, if we play a hard game, a temperature sensor detects an increase and adjustments are made to lower the temperature.
There are temperature sensors (a€?thermoreceptorsa€?) in the hypothalamus of the brain that recognise the dangerous temperature rise. The brain sends nerve messages to many parts of the body to counteract the rise in temperature.
You may remember from your Year 10 Science studies, that messages are sent around the body in 2 ways: nerves or hormones. Warm water fish have enzymes that work best at warm temperatures; cold water fish have enzymes that work best in cold temperatures.
In cooler weather or at night, when it is less active and therefore more vulnerable to predators, it hides. However, because it can maintain its body temperature within a narrow range, wombats can remain active over a much wider temperature range.
If she sends shorter messages, you can send shorter ones too and if she sends longer ones, you can do the same. The rule of thumb is that you should not wait too long before texting her back neither should you send an instant reply. It also makes you to appear as thou you do not have something else to do but waiting to receive a text from a girl.
Respond to the text from a girl who texts you first, in the same amount of time as would have been the case when responding to a text from a close friend. When a girl does use a punctuation mark, there is definitely a secret message she is trying to communicate. However, when she uses a question mark in a scenario where there is no question, it means she is not sure or she is confused.
The key behind learning how to decode her messages is always having a messaging seduction handbook such as magnetic massaging pdf, at your side.
As always, there was a variety of questions to be answered, one of which was “would you like to be an organ donor?” to which I replied: “I’d love to, but I can’t”. Included in the TSE familiy are BSE in cows, Scrapie in sheep and CJD in humans, among others. BSE’s infamous rise to fame began in 1984, when the first confirmed case was documented in the UK. In my last post I discussed viruses as a cause of serious infection, and similarly bacteria and fungi can take up residence in a suitable host, but in the case of the TSEs something completely different is going on. Prion proteins however are capable of folding into more than one biologically stable structure, and this is where the problems begin. Unlike bacteria or viruses, a prion has no genome to store biological information or direct replication. It was characterized by Gerhard Creutzfeldt and Alfons Maria Jakob in the early twentieth century (pictured below), hence the name. It was only in 2006 that British beef farmers were allowed to resume export after major changes in animal husbandry practices, and there remain tight restrictions on the handling and use of British human blood products. Indeed the only way of diagnosing a patient irrefutably is through brain biopsy, which for safety reasons is usually performed post mortem.
Atarashi and colleagues have refined a protocol previously shown to work in hamsters and sheep for the detection of prion form PrP in human cerebrospinal fluid.
Early detection could however rule out the potential that a patient has the disease and allow the exploration of alternate diagnoses. Spending 3 months or more in the UK after 1980 precludes donation, whereas for the rest of Europe it’s 5 years. The government knows that the route from BSE in cattle to nvCJD in human is not via the common beef burger and are not only with holding that information but threatening scientist with withdrawal of research funds if they fail to toe the UK line. I met a young lad Paul from Romford Essex who suffered brain surgery asa result of an accident . An entire herd of cattle was rustled in Leicester and the diligent farmer found them all geared up for transport to the abattoir not far away.
Most of the statements below can be verified by scientific studies, but some are still controversial, especially the relationship between insulin resistance and absorption of amino acids. Doctors usually prescribe Selective Serotonin Reuptake Inhibitors (SSRIs) which have the effects of increasing the amount Serotonin and thereby medically treat the above conditions. High levels of insulin cause receptors for insulin to shut down by means of ‘down-regulation’.
Thus there is a range of insulin resistance from low to severe which causes erratic and unpredictable sugar levels in the blood and to the brain. It also causes to dump magnesium into the urine, upsetting the delicate balance of intracellular magnesium and calcium ions that regulate blood pressure, thereby contributing to hypertension. In the absence of energy the brain is energy starved, cannot synthesize neurotramsmitters and will trigger the release of stress hormones. This helps to stabilize the blood sugar, insulin and stress hormone levels, even out mood swings, rebalance the appetite mechanism, equalize energy intake and expenditure; and halt if not reverse obesity. An error in norepinephrine synthesis has been associated with Attention Deficit and Hyperactivity Disorder (ADHD), because the person is bombarded with irrelevant information and cannot concentrate. Dopamine conveys the sensation of pleasure and many addictive drugs such as heroin and cocaine increase the amount of dopamine, by blocking (inhibiting) the reabsorption (reuptake) of dopamine by brain cells.
Receptors for dopamine are reduced and the person becomes dependent on the heroin, cocaine or any other addictive drug to artificially obtain ‘normal’ levels of dopamine. It is essential that the patient adopt the hypoglycemic diet together with nutrient supplements, vitamins and minerals, omega-3 fatty acids, neurotransmitter precursors, exercises and so on as explained in the article Treatment of Drug Addiction. But it is important to realize that psychotherapy can only be effective AFTER treatment of the biochmical factors. To type a special character, using an Alt keyboard sequence: Ensure that the Num Lock key has been pressed, to activate the numeric key section of the keyboard.
While the Alt key is pressed, type the sequence of numbers (on the numeric keypad) from the Alt code in the above table. If you enjoyed these inspirational quotes and feel they would be beneficial for others, we would appreciate it if you would take a moment to share it with your friends via Twitter, Facebook, Pinterest or email.
Because of the constant buzz in our technological world, it's easy to forget how important communicating face-to-face is.


There are lots of keys (substrate molecules) but they can only open one lock - only one enzyme will act on it.
Your body temperature could rise too far, enzymes could easily be destroyed and you would die. If the cara€™s speed increases, by going downhill for example, we notice that the speed has increased by looking at the accelerator then adjust the speed by taking some pressure off the accelerator. Your body temperature is rising, there is a danger of your enzymes being destroyed and the vital chemical reactions stopping.
There are also temperature sensors in the skin that send nerve signals to the hypothalamus. Sweat glands are stimulated, veins in the skin dilate (open up), your breathing rate increases and you may feel like you have to leave the field to rest. Luckily, key lock sequence pdf, gets behind the complexities and lays the female mind bare. However, it can be aggravating if you are constantly getting back short responses such as ok, great, awesome, from a girl.
This can be something like, a€?A zombie has just run into my room but I have taken care of it. When you communicate in the same style as her, she will see you as a person who is just like her. On the other hand, a€?playing it coola€? by taking too long to text her back, may make her lose interest and forget the great experience you had with her.
An example: a€?We will meet up later?a€? In this example there is no question being asked so it maybe that the girl is not sure whether the meeting will take place. Most men are struggling with more than just understanding text from women and are basically struggling to get a better understanding of the female species. As a British citizen who lived in the UK between 1980 (well, I wasn’t born until 1983, cheeky!) and 1996, I am not allowed to donate my organs to an American.
They cause progressive and irreversible neurodegeneration in which brain tissue develops a “spongy” consistency as nerve cells die.
Members of the Fore tribe of Papua New Guinea, who eat their relatives in an act of mourning, have developed Kuru since the mid 20th century, but it appears that all incidences of the disease stem from one individual in the tribe who developed CJD and was subsequently eaten (I’ll return to why this is important later).
Prion proteins have normal functions within our cells, but they can only perform their function if they are folded correctly. Naturally, much research time and money has been spent on developing a reliable diagnostic test that can be performed on a live individual without poking a needle into their brain.
Their assay builds on two principals discussed above; that prions can induce structural changes in non-prion PrP, and that once in this prion state the proteins then form aggregates.
Similarly, given the reliability of the test, it could be used to screen potential donors, like me, for the disease. I considered incorporating the Sup35 story into my post, but I already had my hands pretty full talking about the disease-causing prions, never mind going into the nitty-gritty of translation, termination and stop-codon readthrough! Given the similar population of GB and F the documented prevalence rate in GB vs F is only about 20x higer.
With the funds so far invested at the very least a test for nvCJD should by now have been available but neither a test r cure is likely until we have the facts that are being concealed by the governments where civil servants are prepared to perjure themselves to conceal the truth. Some considerable time later it was discovered that the instruments used in his operation had previously been used on an nvCJD patient. One in ten animals that were supposed to have been slaughtered never went near a rendering plant but after claiming compensation they were put into the food chain on re-cycled passports.
Unfortunately, SSRIs may have side effects in some patients, and generally do not address the underlying biochemical causes of depression. This causes increased levels of dopamine which is felt by the addict as a high and as a feeling of great pleasure. Treatment aims at rebuilding natural dopamine receptors through abstinence from drugs and with nutritional aids, such as omega-3 essential fatty acids (fish oil) which is thought to help restore brain cell membranes. If therea€™s one thing Friedrich Nietzsche did well, ita€™s obliterate feel-good beliefs people have about themselves.
When conversing old-school style, it's not only speech we verbalize that matters, but what our nonverbal gestures articulate as well.
They occur on a tiny scale, they happen dissolved in water and they only happen when another kind of chemical - an enzyme is present.
For most parts of most living things, it is close to 7.) Notice that the scale is the opposite to what you might expect - low pH is acid and high pH is base.
You will need to get creative and deploy the right seduction weapons as explained in the key lock sequence, if you hope to ever take her on a date and eventually unlock her legs. If you are struggling to understand women, struggle no more, there is a tried and tested technique that lets you hack the female brain, decode her messages, win her over, win her loyalty and gain her approval among other benefits. The symptoms of TSEs are dramatic and debilitating: In humans, dementia rapidly progresses, and patients display memory loss, erratic movements, hallucinations and seizures. At the time, it was common agricultural practice in Europe to supplement cattle feed with meat and bone meal in order to increase the amount of protein in their diet. Each bead is unique, and therefore the type of necklace made depends on the beads that are used. When it turns into an aggregate, translation termination efficiency goes down, stop codons get read through, and a whole bunch of different proteins are produced. He must now live with the real prospect of either being a carrier or suffering full blown nvCJD without at present any test to determine his status. Such a course is available free of charge at the web Hypoglycemic site at: Psychotherapy Course. There are some gaps in the numerical sequence of Alt character codes, because either those elements do not exist, or they are duplicates of elements listed elsewhere. This assumes we reach the same speeds while carrying enough fuel to last 7 million years, which we can't. In winter, they often feed in the snow (see photo) but can return to the burrow and warm up.
This animal meal was manufactured from byproducts of the food industry, as well as sheep and cows that had died from illness rather than at the slaughterhouse. Our cells determine the sequence of amino acids in each protein using the genetic code (see part of my previous post on the central dogma of molecular biology). It can communicate its shape to normally folded proteins and make them adopt the same conformation. The key take home message from this brief report is that the new assay is 100% specific to CJD; it can discriminate between the prion disease and other neurological disorders in which aggregate formation is a feature. Their shape gives them a small surface area to volume ratio, helping them to retain body warmth. Unfortunately, BSE has the ability to cause vCJD (variant Creutzfeldt-Jakob Disease) in humans, a severe and ultimately fatal neurodegenerative disease. In their mis-folded state they stick to each other and form exceptionally stable clumps, or aggregates. This therefore allows the prion to propagate, and is at the root of why cannibalism causes TSEs; if you ingest a prion it can corrupt your normal PrP and cause disease. It is not known exactly what causes all cases of so-called sporadic CJD, as only a small percentage of patients harbor a mutation in the PrP gene. It is also extremely sensitive, and if employed clinically would allow for the early diagnosis of CJD. There is currently no test for the condition or means of removing it from organs or blood products, so it’s an understandable restriction I suppose. Because of the chemical and physical differences in each amino acid, just like the differences in the beads on the necklace (imagine big ones, small ones, textured ones etc.), this primary structure then influences how the protein can fold. These clumps accumulate inside, and on the surface of, cells and seriously compromise the tissue in which they reside, for example by “spongifying” the brain in CJD. In addition, brain biopsy is unnecessary, with material being acquired through a relatively non-invasive lumbar puncture. This protein is a prion, and its name derives from the fact that it is a proteinaceous and infectious particle. These secondary structures can then influence how the protein finally assumes its functional, three-dimensional tertiary structure.



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