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What is Motilium (Domperidone) used for?Motilium (Domperidone) contains the active ingredient domperidone, which is a type of medicine called a dopamine antagonist. Motilium (Domperidone) works primarily by blocking dopamine receptors found in an area of the brain known as the chemoreceptor trigger zone (CTZ).
Due to its stimulating action on the gut, which speeds up stomach emptying into the intestine, Motilium can also be used to relieve upper abdominal discomfort, a sense of fullness or bloating, and regurgitation of the stomach contents that some people experience following meals. Further Information Motilium can be bought over-the-counter from pharmacies for the relief of after meal symptoms, as the branded product Motilium 10. We sincerely welcome you to our website and we offer our thankfulness to you for visit our site.For the past 04 years, Megasell2014 has been selling variety of consumer goods as per the demand of consumer. Domperidone increases milk supply by blocking dopamine, which results in an increase in prolactin levels. It is also activated directly by agents circulating in the blood, for example anti-cancer medicines.
The non-prescription Motilium 10 product is not suitable for use by children under 16 years old. It does not work in all women and would not be expected to increase milk production in a woman who already has normal (high) prolactin levels.
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Its action on the dopamine-receptors in the chemo-emetic trigger zone produces an anti-emetic effect.

Once activated, it sends messages to another area of the brain, the vomiting centre, which in turn sends messages to the gut, causing the vomiting reflex. We wanted to show by example that a successful business could also be socially responsible. Domperidone does not cross the blood-brain barrier to any appreciable degree and so exerts relatively little effect on cerebral dopaminergic receptors.
Blocking the dopamine receptors in the CTZ prevents nausea messages from being sent to the vomiting centre. Domperidone has been shown to increase the duration of antral and duodenal contractions to increase gastric emptying.
Domperidone does not alter gastric secretions and has no effect on intracranial pressure or on the cardiovascular system.
Motilium (Domperidone) also blocks dopamine receptors found in the upper end of the digestive system. Domperidone is rapidly absorbed, with peak plasma concentrations at approximately 1 hour after oral administration. This results in tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself.
The absolute bio-availability of oral domperidone is low (approximately 15%) due to first-pass hepatic and intestinal metabolism.
These actions speed the passage of food through the stomach into the intestine, which physically helps to prevent vomiting.

Both actions make Motilium useful in treating nausea and vomiting due to many causes, including anti-cancer chemotherapy, emergency hormonal contraception and in migraine.
The plasma half-life after a single oral dose is 7 to 9 hours in healthy subjects but is prolonged in patients with severe renal insufficiency. Motilium is also used to prevent nausea and vomiting that can be caused by medicines for Parkinson's disease, such as levodopa, bromocriptine and apomorphine.
Domperidone undergoes rapid and extensive hepatic metabolism by hydroxylation and N-dealkylation. The proportion of drug excreted unchanged is small (approximately 1% of urinary and 10% of faecal excretion). CONTRA-INDICATIONS MOTILIUM is contra-indicated in patients with known hypersensitivity to domperidone. MOTILIUM should not be used whenever stimulation of gastric motility is to be avoided or could be harmful, eg. MOTILIUM is also contra-indicated in patients with a prolactin-releasing pituitary tumour (prolactinoma).

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