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Estrogen hormones are metabolized by the liver through a hydroxylation process in phase I liver detoxification.
The 2-OH metabolite has a very mild estrogenic response and is the preferential estrogen metabolite. Estro-Protect uses a dual-action approach to supporting healthy estrogen-sensitive tissues. These actions may be important for the health of estrogen-sensitive tissues, such as those of the breast, uterus, cervix, and prostate. Broccoli seed extract is renowned for being such a powerful estrogen detoxifier and anti-oxidant amplifier. Research suggests that when SGS is broken down to sulforaphane (its active form), it safely and effectively upregulates the Nrf2 system, activates the antioxidant response element (ARE), enhances the production of important antioxidants, and activates vital phase II detoxification enzymes (7). Neutralizing reactive estrogen metabolites with SGS According to Bolton et al, the oxidation of catechol estrogens (2-OH and 4-OH) via cytochrome P450 enzymes generates reactive electrophilic estrogen quinones and reactive oxygen species (ROS) through redox cycling (8). Formation of quinones is largely minimized via phase II methylation, which produces methoxyestrogens. A promising strategy to address their deleterious effects involves the use of agents to favorably shift the balance between phase I and phase II enzymes (9).

Sulforaphane has been identified as an agent that possesses the ability to potently induce phase II detoxification enzymes—including quinone reductase, HO-1, GST, and glutathione reductase—as well as to inhibit phase I enzymes involved in activation (10, 11, 12) In the case of estrogen quinones, quinone reductase protects cells from oxidative damage by two-electron reduction, thus suppressing oxidative cycling and reactive oxygen species generation (10). As a clinician, I see so many men and women struggling with estrogen dominance and the related symptoms. This supplement is a key for most individuals struggling with menstrual issues, menopausal problems, endometriosis, PCOS, uterine fibroids, estrogen dominant cancers, etc.
The 4-OH and 16-alpha OH are much more powerful and create a persistent estrogenic response. First, it provides diindolylmethane (DIM) to promote healthy estrogen metabolism and create a better balance of estrogen metabolites (2-OH, 4-OH, 16alpha-OH) through phase I cytochrome P450 enzyme induction and promotion of 2-hydroxylation. DIM (diindolylmethane) DIM is an advanced metabolite of indole-3-carbinol (I3C), the indole found in cruciferous vegetables. This science has been validated in animal and human studies wherein supplementation with DIM was shown to increase the ratio of the protective, “good” 2-hydroxyestrone (2-OH) to 16alpha hydroxyestrone (16alpha-OH) (2, 3).
Studies further reveal that DIM may play a critical role in supporting normal cellular proliferation in estrogen-sensitive tissues (3,5,6).
Sulfuraphane Glucosinolate (SGS) is the major component that gives it this extraordinary ability.

However, if methylation is suboptimal, estrogen quinones, which can cause DNA damage in estrogen-sensitive tissues, must be neutralized via other phase II enzymes such as quinone reductase. These include 2-hydroxyestrone (2-OH), 4-hydroxyestrone (4-OH) and 16-alpha-hydroxyestrone (16-alpha-OH).
Compounds that help reduce the 4-OH and 16-alpha OH subtypes and increase 2-OH are desired for good estrogen metabolism. Supplementation with DIM is preferred over I3C due to I3C’s undesirable breakdown products, including the dioxin-like molecule indolo[3,2-b] carbazole (ICZ) (1). The SGS broccoli seed extract used in Estro-Protect is a super vegetable that delivers extended antioxidant support and boasts a very high level of glucoraphanin (13%). If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using these products.

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