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Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder affecting approximately 7 per cent of women of reproductive age. In the majority of cases PCOS is diagnosed because amenorrhea, obesity or overweight, acne or hirsutism occur. The most common characteristic is the menstrual abnormality: menstrual intervals can be longer than 35 days and there are fewer than eight menstrual cycles a year. The elevated levels of male hormones result in excess facial and body hair (hirsutism) and adult or severe adolescent acne. In these women the ovaries appear polycystic so characterized by an increase in antral follicles and ovarian stroma as well as by theca cell hyperplasia and ovarian cortical thickening.
Therefore, expecially if the obesity (or the overweight) increases the condition, PCOS becomes a factor and a part of an heterogeneous disorder called "metabolic syndrome", in which the metabolism of carbohydrates and the pathway of insulin play a very significant role. Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal obesity, elevated blood pressure, elevated plasma glucose, high serum triglycerides, and low high-density cholesterol (HDL) levels. Insulin resistance is defined clinically as the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization in an individual as much as it does in a normal population. Insuline resistance is very common and plays a central pathogenic role in PCOS, it is present in approximately 50-70 per cent of these women. The studies about insulin signaling pathways in different responsive tissues - such as adipose tissues, skeletal muscles, adipose tissues, fibroblasts as well as ovaries - suggest a post receptor signaling defect: metabolic action of insulin is compromised but not the steroidogenic and mitogenic actions.
For these reasons in the women affected by PCOS high androgen levels lead to menstrual disturbances, development of ovarian cysts and hirsutism, all clear symtomps typical of the disorder. IR also increases the risk for development of glucose intolerance, type 2 diabetes mellitus, hypertension, dyslipidaemia and cardiovascular abnormalities in these women. Adipocytes are not simply a storage depot: they are also endocrine organs, with multiple metabolic roles. The adipocyte hormones leptin and adiponectin activate the AMP-activated protein kinase (AMPK) in muscle and other tissues, a pathway that increases fat oxidation and glucose transport. Also physical exercise activates the AMPK and, importantly, the same pathway is activated by the antidiabetic agents such as thiazolidinediones and metformin, used in the therapy of PCOS. When fat mass increases, leptin blood level increases, suppressing appetite until weight is lost.
However obese individuals generally exhibit an unusually high circulating concentration of leptin : they are resistant to the effects of leptin.
Also adiponectin is synthetised by adipocytes and its plasma concentration falls with increasing obesity. Finally adipose tissue in obese persons shows higher expression of pro-inflammatory proteins, including TNF-? and IL-6.
TNF-? increases systemic insulin resistance by promoting the release of fatty acids from adipose tissue. In the same condition IL-6(whose concentration correlates with insulin resistance) increases lipolysis and fat oxidation. Moreover, there is a relationship between iron deficiency and obesity: in fact the chronic low-grade inflammation that characterizes obesity enhances hepcidin production, the principal regulator of iron availability. Then, hepcidin inhibits iron transport across the gut mucosa reducing iron absorption and also inhibits transport of iron out of macrophages (site of iron storage and transport). A considerable iron deficiency ends up paralysing mechanisms and pathways that need iron, first of all the mitochondrial elecron transport chain that drives ATP synthesis. About the last two points it is funded by now that the two major pharmacological approaches to the treatment of diabetes are also an efficient therapy of PCOS. These are the insulin sensitizers: the biguanide metformin and the thiazolidinediones troglitazone, pioglitazone, and rosiglitazone. Metformin modestly increases menstrual regularity and ovulation and decreases weight and hyperandrogenism.
If drugs are not enough to avoid a pregnancy, gonadotropins so follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are administered by injection.
However, the safest and cheapest therapy that has shown benefit both in diabetes and PCOS is weight loss by lifestyle modification.
Several studies have revealed that even modest weight loss (10–20%) improves all symptoms of PCOS in obese patients: acne, hirsutism, and menstrual irregularities. The improvements are likely a result of the reductions in insulin levels, insulin resistance, dyslipidaemia and hypertension (all factors of the metabolic syndrome). It is useful to pay attention to dietary composition: increasing fiber intake (because fiber slows nutrient absorption after meals and reduces insulin secretion), reducing both carbohydrates and the total calories intake. Finally, as a lifestyle modification, physical exercise helps sustain weight loss, but it also has other benefits. Exercise as the primary intervention without attendant weight loss (< 5% weight loss) improved insulin sensitivity and testosterone index and induced ovulation in 9 of 18 obese PCOS patients.
The key enzyme of all the therapies is certainly the 5' AMP-activated protein kinase or AMPK that plays a central role in cellular energy homeostasis.
It is expressed in various tissues, including the liver, the brain, and the skeletal muscle. Then, clearly the AMPK pathway involves all the targets implied in the more difficult complications of PCOS, so the metabolic syndrome and the insuline resistance. Both the drug therapy, first of all the metformin, and the muscle contraction close in the activation of this enzyme, that is also the target of leptin and adiponectin. The PCOS is a very heterogeneous disorder that needs an early diagnosis to avoid the regression in the worse manifestations, such as the diseases related with the carbohydrates metabolism and the insulin resistance.
Either way there are valid solutions and treatments for both women who want to plan a pregnancy, and not. Anyway, the most prudent and natural approach to this disorder corresponds to adjust the lifestyle with a correct and adapt diet and above all an healthy and moderate physical exercise. There is little scientific evidence to support the claim that HGH slows or reverses the effects of aging. HGH testing has been around a long time but it is not very successful and can be “fooled” in many ways.
HGH is a natural hormone produced in the pituitary gland and its production decreases as the human body ages.
Aiding in the synthesis of new protein cells that can lead to more muscle mass or lean body mass.
One thing is for certain: the patient must work out aggressively and “overload” their musculoskeletal system if they are going to get positive strength gains regardless of the use of HGH.
Hyperthyroidism, which main cause is Graves' disease, is a condition when there is an inappropriate functioning of the thyroid gland (also called thyroid), leading to an overproduction of hormones. The thyroid produces two hormones called thyroxine and triiodothyronine, better known as T3 and T4. The pituitary gland or pituitary gland is an organ that is located at the base of the brain and controls the degree of thyroid function through a hormone called TSH (Thyroid Stimulating Hormone). When there is little circulating of thyroid hormone, the pituitary detects this drop and immediately increases TSH secretion, stimulating greater production of T3 and T4 by the thyroid. Hyperthyroidism occurs, when there is an excess of T3 and T4 in circulation that cannot be corrected by normal mechanisms. 1 - A problem in the pituitary causing uncontrolled production of TSH, which in turn stimulates the thyroid to produce T4 and T3 indefinitely. 2 - The thyroid becomes an independent body to produce T3 and T4 at their pleasure, ignoring the blood levels of TSH. Note: in clinical practice there is free T4 (FT4) which is the fraction of chemically active hormone.

Regardless of the cause, the symptoms of hyperthyroidism are always caused by excessive circulating of FT4, which is a common consequence, either by itself or in central problem thyroid.
The goiter, last sign described above, occurs when there is increase in size of the thyroid gland. A serious disease is 8 times more common in women and usually occurs at the age between 20 and 40 years old.
In addition to all the signs and symptoms described above, by Graves' hyperthyroidism may present the so called Graves' ophthalmopathy. The antibodies attack not only the thyroid, but also the muscles and fatty tissue in the area around the eyes. The patient with Graves' ophthalmopathy may also have double vision, constant eye irritation, eye pain, blurred vision and, in severe cases, blindness. A rare manifestation of Graves' disease is the dermopathy, called myxedema, which occurs by infiltration of the skin by autoantibodies. Plummer's disease or toxic multinodular goiter: the formation of adenomas, benign tumors in the thyroid. Toxic Adenoma: the same situation as above, except that there is only one solitary adenoma producing excess hormones. Excess thyroid hormone: patients with hypothyroidism who make excessive replacement of hormones may provide a framework for hyperthyroidism. TSH-secreting adenomas: less than 1% of cases of hyperthyroidism occur due to inappropriate TSH secretion.
There are three different modalities of treatment for hyperthyroidism: drugs, radiation or surgery.
The two main drugs used in the treatment of hyperthyroidism are propylthiouracil and methimazole. For a quick control of symptoms, beta-blocking drugs such as propranolol or atenolol may be used. About 30% of patients can, after 2 years, definitely stop medication without presenting return of hyperthyroidism.
Because side effects are common and sometimes serious, other therapeutic modalities are needed. The destruction of the thyroid by radiation is a definitive treatment option for hyperthyroidism. Both surgery and radioactive iodine cure hyperthyroidism, but destroy the thyroid, leading to hypothyroidism. Most lifters spend plenty of time hammering their front and side delts through heavy chest pressing, shoulder pressing, front raises and side lateral raises, but end up heavily neglecting their rear deltoids in the process. 1) You end up limiting the total amount of shoulder size and strength you can develop, since you’re under-training one of the three heads that make up this complete muscle group. In a nutshell, this creates instability in the joint which can set you up for a whole host of issues over the long run, from rotator cuff injuries to shoulder impingement to elbow problems. If you want to develop a rounder, more muscular set of shoulders while improving your posture and decreasing injury risk at the same time, some direct rear deltoid exercises should definitely be included as part of your training plan.
Although the rear delts will receive some decent stimulation during rowing exercises for your back, you’ll still want to include some additional rear delt isolation exercises for optimal size and strength development.
Well, keep in mind that we’re actually dealing with a pretty small muscle group here, so there’s no need to perform an endless number of different exercises and variations in order to get an effective rear delt workout. Face pulls are a very uncommon, but hugely effective exercise that should be included as a staple in any well rounded training routine.
These are basically a horizontal row, but instead of pulling to the chest or waist like you would on most back exercises, the resistance is pulled toward the face.
3) With your chest up, shoulders down and back, scapula retracted and head stationary, pull the rope towards your face while at the same time imagining that you’re trying to pull the rope apart. This is a direct isolation exercise that will train the rear delts effectively with minimal involvement from other muscle groups.
Although it can be performed using dumbbells, I would suggest going with the cable variation if possible since it places the rear deltoids under constant tension throughout the entire exercise, whereas dumbbells provide minimal to no resistance in the lower half of the range.
Either version will still be effective, but for the very best results you’ll want to use cables here.
1) Start off in a bent over position with your upper body just above parallel to the ground. 2) Next, allow your shoulder to hang forward slightly and keep your scapula flat rather than retracted. 3) From there, while focusing on pulling through your elbow rather than your hand, and while emphasizing control rather than just heaving up the weight, raise the cable out to your side until you feel a strong contraction in the rear delt. Although a bent over rear lateral raise and face pull are my top two picks and will usually be sufficient on their own, you can also incorporate a third exercise into your plan if really want to hone in on that rear deltoid and upper back area even further. 1) Setup a flat bench and place one knee up on the bench with the other foot planted firmly on the ground. 2) Using the opposite arm for support, grab a dumbbell using an overhand grip and, instead of tucking your arm in toward your side as you would for a traditional dumbbell row, flare it outward so that your upper arm is perpendicular to your body. 3) With your torso parallel to the ground or just slightly higher, row the dumbbell up toward your chest while focusing on squeezing your rear delt in the process.
Or, if you have a machine row available that allows you to perform the exercise with your upper arm perpendicular to your body and row the weight up to your chest, that can optionally be used as well. Again, there are many different exercises and variations out there can be used to get in an effective rear delt workout, but these 3 are my top recommended choices. Structuring a complete rear delt routine using these lifts is very straightforward, and my suggestion is to just select two exercises and perform 3 sets of 8-10 reps for each, 1-2 times per week. Rear delt training works well when included as part of a complete shoulder workout, or it can be performed at the end of a back workout. Although most lifters in the gym over-look this muscle group as part of their programs, including some focused rear deltoid exercises is a great way to build up a rounder, thicker set of shoulders while also improving shoulder joint health at the same time.
Sean Nalewanyj is a best-selling fitness author, natural bodybuilder and success coach who has been publishing science-based, no B.S muscle building and fat loss information online since 2005. An episiotomy is a surgical incision made at the time of child birth in the muscle between the woman’s vagina and rectum to increase the size of the opening through which a baby emerges.
Women who have not received an epidural are typically given a local anesthetic prior to performing an episiotomy. An episiotomy has been a controversial subject and in recent times, the incidences of this surgical procedure have gone down since earlier times when episiotomies were often performed without any real requirement. There are several benefits to having an episiotomy in that it makes it easier for the mother to deliver her baby since there is less pushing for her to do. The often made argument in favor of episiotomies is that it can trauma to the vaginal tissue and is easier to recover from that spontaneous or accidental tearing of the tissue there, with fewer chances of complications. If there is any kind of fetal distress or if the baby is in an awkward position, an episiotomy is indicated for a speedier delivery.
Earlier it was also believed that episiotomies could prevent incontinence and prevent displacement of the bladder and rectum however it has later been found that routine episiotomies do not prevent this.
There are also several complications that can occur as a result of an episiotomy – there is the danger of infection and delayed or improper healing, since there are chances of improper closure of the wound given the location of the incision.
There also exist possibilities of swelling and bleeding from the area and which can create problems.
So the bottom line is that episiotomies are not to be performed routinely, they should only be done when there exists an actual medical requirement. Metabolic syndrome increases the risk of developing cardiovascular disease, particularly heart failure, and diabetes.

IR progresses towards the development of compensatory hyperinsulinemia, and hyperinsulinemia implies hyperandrogenemia.
The enlarged adipocytes of obese individuals recruit macrophages and promote inflammation and the release of a range of factors that predispose toward insulin resistance. This hormone circulates in blood and acts on receptors in the hypothalamus of the brain, where it inhibits appetite counteracting the effects of neuropeptide Y (that on the contrary stimulates the appetite) and supporting the synthesis of ?-MSH, an appetite suppressant. The high concentrations of leptin from the enlarged adipocytes drives leptin desensitization, so the body does not adequately receive the satiety feeling subsequent to eating. Reduced adiponectin concentrations correlate with insulin resistance, hyperinsulinemia and hypertrophy of the adipocytes.
So, in states of high hepcidin levels (including inflammatory states such as the obesity), serum iron levels fall.
In particular is known that the cytochrome complex, or cyt c is a small heme protein associated with the inner mithocondrial membrane that transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase) through the passage from the ferric iron (oxidized form) to ferrous iron (reduced form).
These agents improve not only glucose control, but also the reproductive abnormalities associated with PCOS. It improves insulin resistance, increases peripheral glucose uptake and decreases hepatic glucose production.
Pramlintide is an analog of amylin, a ?-cell hormone that is normally co-secreted with insulin; it complements the effects of insulin in postprandial glucose control, in part by suppressing glucagon secretion.
Moreover an outpatient surgery called “laparoscopic ovarian drilling” is an option for few candidate women with PCOS. In PCOS, women who self-reported 8 hours of sports activities per week had improvement in acne and menstrual irregularities. The functions of AMPK are: stimulation of hepatic fatty acid oxidation, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. Several famous athletes are accused of using HGH as a part of the rehabilitation process when they were recovering from a potentially career-ending injury.  The implicated athletes are threatening reporting agencies with a lawsuit, and no one can prove that these athletes used or did not use the hormone. The philosophy in healthcare and rehabilitation does not include the use of performance enhancement substances.  It will not change in the near future, therefore Physical Therapists must rely on standard training principles to get the desired results for their patients. These hormones control our metabolism and are responsible, among others, for our caloric expenditure, body temperature, for our weight gain, etc.
When there is too much circulating of the hormone, it decreases the secretion of TSH, discouraging the thyroid to produce T3 and T4.
When the cause of hyperthyroidism is central, that is, one pituitary poorly functioning we will have a very high TSH also associated with a very high T4. When the problem is in the thyroid itself, the first thing our body does when the pituitary detects high levels of hormones is suspending production of TSH. This growth is common when there is a constant stimulus for production of T3 and T4, which can be noticed clinically as a bulge in the neck. This disease is an autoimmune process when the body starts producing antibodies inappropriately against their thyroid.
This aggression causes injury and edema of the extraocular muscles, leading to a protrusion of the eye, besides swelling and inflammation around it (periorbital edema). These adenomas are chemically active and produce T4 and T3 thyroid independently as well as circulating of TSH.
It may be due to viral infections, autoimmune causes other than Graves' disease, postpartum etc. The choice of the most appropriate is made individually for every patient due to some data such as age, severity and cause of hyperthyroidism.
When you place a larger amount of focus on building up the pecs and front delts in comparison to the upper back and rear delts (as nearly everyone in the gym trying to build muscle does without even realizing it) you end up creating an imbalance in the shoulder joint as it begins to “roll forward” and out of proper positioning. Most people perform this exercise by gripping the rope from the top with the palms facing down, but the variation I outline here allows for a larger range of motion and greater external rotation of the shoulders as you pull the rope backward. Through the comprehensive free content found in his Articles, YouTube Channel, Facebook Page and online newsletters, Sean has helped hundreds of thousands of average, everyday people from all over the world build muscle, lose fat and completely transform their bodies and lives. I give out real, science-based, no B.S training, nutrition and supplementation advice to help you build muscle and lose fat in the most productive yet practical way possible. An episiotomy usually takes between 4 and 6 weeks to heal, depending upon the size of the incision and the kind of suturing done. The argument against routine episiotomies is strong – firstly there is the fact that recovery can be long and uncomfortable; and could mean painful sex for a long time. Short term sexual dysfunction may be noted and many women report that they are unable to have pain free sex for many months after the delivery. If the iron level is very low the cyt c and all the chain may not to operate well and the muscle prefer not to oxidize energetic substrates, principally the glucose.
Anti-androgen therapy, such as spironolactone (that blocks the effects of androgens on the skin) can be added for further treatment of hirsutism. D-chiro-inositol is an insulin sensitizer that has preliminarily been shown to increase ovulation in PCOS. The surgeon makes a small incision in the abdomen, inserts a tube attached to a camera (laparoscope) and uses electrical or laser energy to burn holes in follicles on the surface of the ovaries. This raises a more fundamental question: What are the capabilities of HGH and how it might help these athletes or anyone during the rehabilitation process? Studies would have to be performed to discover the amount of HGH that is needed to stimulate muscle development.  It could help the patient rehabilitate musculoskeletal injuries more quickly and enable the Physical Therapist to be more aggressive with the rehabilitation prescription. These antibodies attack TSH receptors, causing the thyroid think there is too much TSH in the bloodstream. However, in Graves' ophthalmopathy the protrusion is so important that you can see the whites of the eyes (sclera), above and below the iris, as exemplified below. Although they are benign tumors, their growth can compress brain structures and cause neurological and vision loss.
Its effect takes on average three weeks since these drugs only prevent the synthesis of new hormones, having no effect on those already produced and circulating. As the thyroid uses iodine feed to produce T3 and T4, it starts to focus all radiation ingested, the same being destroyed over 6 to 18 weeks. It may be indicated when the thyroid is greatly enlarged, with great risk of goiter and airway obstruction. There’s nothing wrong with involving the muscles of the upper back, but with this particular exercise we want to focus on pure rear deltoid isolation. In an industry that has become completely overrun with gimmicks, false information and outright scams, you can trust this site as an honest, reliable resource to help you reach your fitness goals. According to many experts the risk of developing fecal incontinence is also said to rise with this surgical procedure.
In this way it may become not responsive to insuline (because it doesn’t manage to use glucose) and aids the condition of insuline resistance. If the patient was able to recover more quickly from a strenuous strength training session and experienced alleged results similar to some athletes they would be able to return to their pre-injury status more quickly. The radiation of this treatment is very small and practically restricted to thyroid, not being able to cause cancer elsewhere in the body. However, distance from pregnant women is recommended during the first 7 days of treatment, since there is always a chance of exposure to radiation.

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