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MicroPortA® has always been committed of constantly being at the innovative forefront to deliver best and affordable solutions that save life and improve quality of life. Every 18 seconds, somewhere around the world, MicroPortA® transforms a patient's life by bringing life-saving treatments or quality-improving care, or gives new hope of starting a family. MicroPortA® is contributing to a better world through its life-saving medical therapies and quality-improving care devices being used in patients every 18 seconds.
GnRH Infusion Pump is designed to meet the needs of Chinese physicians and patients for the treatment of Idiopathic Hypogonadotropic Hypogonadism (IHH) which is also known as Kallmann Syndrome. IHH (IndiopathicHypogonadotropicHypogonadism) is characterized by low gonadotropin levels, absence of LH and FSH pulses, low sex steroid hormone levels, delay in or complete failure to undergo puberty, and finally result in infertility. Puberty is initiated by hormonal signals from the brain to the gonads and marked by the pulsatileGnRH, with a 60-90 minutes release cycle which may increase gradually with age until the peak pulses become regular on a daily basis.


Low-frequency GnRH pulses lead to FSH release, whereas high-frequency GnRH pulses stimulate LH release.The function of LH is to stimulate the production of sex hormones, from the ovaries in women and from the testicles, or testes, in men. The LH and FSH levels would rise significantly with pulse waves in the pulse injection three days after the GnRH therapy. After 24 weeks of treatment, thetesticular volume and sperm count would increase with the improvement of sexual desire for male.
The first menstruation (menarche) would occur 100 days after the treatment for female, and the menstrual periods gradually become normal. During the period of 6-9 months, the obvious curative effect would become prominent through the change of secondary sex characters of the patients. Currently, some of our patients who had undergone the treatment have successfullybecome pregnant already. Please see our News section and the Investors section for latest company and industry news made available by MicroPort Scientific Corporation.
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LH and FSH are only released by the pituitary gland if GnRH is released in pulses or short bursts, usually at 90 to 120 minute intervals.


Abnormalities in various genes may cause a defect in the hypothalamus, causing a deficiency of gonadotropin-releasing hormone (GnRH); this in turn causes deficiency in FSH and LH levels. By definition, either anosmia (lack of sense of smell) or severe hyposmia is present in patients with Kallmann syndrome. And the sexual characteristic would appear with regular and steady releasing of LH and FSH.
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LH and FSH then target the gonads, causing the development and maturation egg cells in female or sperm in the male. GnRHpulse infusion have a significant effect on maintaining and increasing in secondary sex characters, a progressive improvement of deficiency of grown-up Growth Hormone (GH)and bone mineral density (BMD), makes a contribution to regain fertility, and reduces the risk of cardiovascular-related adverse events, which is the most ideal treatment for such disease in these days.



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