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Workshops, conferences & eventsThis resource highlights upcoming workshops, events and conferences run by the HTMR Network and our colleagues in clinical trials. For more training courses, including short courses, Masters degrees, and training resources from our colleagues see here.
To receive our fortnightly newsletter highlighting upcoming events in trials methodology, or if you'd like to promote your event on our site, email us. The HTMR Network has provided funding to support a workshop focussed on new Chief Investigators.
This one day introductory course aims to provide an overview of the practical considerations associated with collecting Patient-Reported Outcome Measures (PROMs) in clinical trials and is aimed at Research Nurses, Data Managers & Study Co-ordinators. This one day course aims to provide an overview of the design, data collection, analysis and reporting considerations associated with successful incorporation of Patient-Reported Outcome Measures (PROMs) in clinical trials and is aimed at Chief and Principal Investigators, trial managers, clinical researchers and academics.
The effective scientific evaluation of modern surgery and other invasive therapeutic interventions based on technology has become an increasingly important issue. This intensive course will comprise lectures, workshops and interactive sessions, delivered by a faculty of highly experienced clinical trialists, senior trial administrators and statisticians from CTSU. This course is designed primarily for senior investigators from any discipline and experienced trial administrators who want to conduct successful randomized trials.
The number of clinical trials being conducted has increased, and the need for greater efficiency in design, conduct, analysis and reporting has been recognised in both the public and industry sector. Trial design, trial conduct, recruitment of trial participants, public and patient involvement, analysis and reporting, health economics. The course assumes an understanding of core medical statistics topics, such as regression methods (such as linear, logistic, and Cox) and parameter estimation.
The Randomised Clinical Trial (RCT) is widely regarded as the principal method for obtaining a reliable evaluation of treatment effectiveness of healthcare interventions. The conference will examine how to create a pathway for the effective scientific evaluation of modern surgical treatments, with a focus on the potential of the IDEAL Framework and Recommendations as an evaluation template. The London School of Hygiene and Tropical Medicine (LSHTM) is pleased to host the UK-CIM 2016, which will take place from Wednesday 13th to Friday 15th April 2016, with a selection of pre-conference workshops held on Tuesday 12th April . The Annual Meeting of the Society for Clinical Trials is a multidisciplinary program with broad participation. PSI are pleased to announce that theme of the 2016 Conference is “Promoting Statistical Insight and Collaboration in Drug Development”. The conference will consist of a variety of plenary sessions, parallel sessions, breakout discussion sessions, a poster session and the annual general meeting.
The ISCB 2016 conference will provide a scientific forum for international exchange of theory, methods and applications of clinical biostatistics among biostatisticians, epidemiologists and other medical researchers. Jointly supported by the ICTMC and the Society for Clinical Trials, the 2017 conference will be hosted in Liverpool from 7-10 2017. However, the problem of identifying the cis-regulatory modules controlling these networks is still a major challenge.
Several other interesting aspects of fish in general have spurred the sequencing of a number of other teleosts. Teleosts are a highly diverse group, making up half of all extant vertebrate species (Nelson, 1994).
Some teleosts are used as experimental developmental models, in particular zebrafish and medaka. Such studies have identified enhancers responsible for the regulation of PAX6 (Miles et al. ?-galactosidase expression in a manner that recapitulated several aspects of DACH1 endogenous expression.
Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes. A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts.
Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional.
Evaluation of the RET regulatory landscape reveals the biological relevance of a HSCR-implicated enhancer. Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genes. Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6. A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1.
Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13. Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate.
Arrays of ultraconserved noncoding regions span the loci of key developmental genes in vertebrate genomes. Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, andpufferfish genomes. 2013 is the MRC Centenary year and we’ll be taking the opportunity, here on the blog and elsewhere, to celebrate past discoveries and look to the future of medical research. When the Medical Research Council’s forerunner, the Medical Research Committee, was established in 1913 to combat tuberculosis, its members may have thought the disease would be conquered within a few years. This example from the first half of the MRC’s existence illustrates just how long it can take for medical research to come to fruition and change people’s lives. That’s why efforts to support the translation of research from the UK’s laboratories into people’s hands are so important. The MRC doesn’t focus just on laboratory-based science; the organisation’s longevity has had benefits in other types of medical research. Finding the answers to these questions needs the foresight and commitment to study people from birth into adulthood and old age, something the UK and the MRC have been undertaking for more than 60 years by studying groups of people, or ‘cohorts’ drawn from across the social spectrum. The National Survey of Health and Development, for example, which began in 1946, was one of the first to reveal the life-long health impacts of low birth weight, and the influence of early life circumstances on school attainment.
The relative roles of genetics and our lifestyle and environment in whether we develop a disease are subtle and complex, and only long-term studies of large numbers of people that pull this diverse information together will provide answers. Scientists can use this information to unpick the mechanisms of cancer, heart disease, diabetes and many other conditions which touch our lives. MRC 1301 - AC Throttlepack - Discount Train: A huge variety of model trains and accessories at deep discounts! A central theme of my previous postdoctoral research has been to combine protein biochemistry with functional and behavioural assays, to elucidate the role of protein interactions in influencing the function of ion channels, in both mammals and C. The focus of my research since I joined Bill’s lab has been to better understand the mechanisms of mechanosensation, using the (gentle) touch receptor neurons and the multifunctional nociceptor neurons of C. I completed my undergraduate degree at the University of Queensland (Australia), and am now a graduate student in the Schafer Lab.
My interest is to investigate the molecular mechanisms underlying mechanotransduction in C. Ron’s research has established conjugation with the Small Ubiquitin-like Modifier (SUMO) as an important regulatory mechanism in eukaryotes.
A familiarity with traditional aggregate data (non-IPD) meta-analysis methods would be advantageous, though not essential. The Clinical Trials Unit at Keele University is committed to undertaking high quality RCTs of complex interventions and we are offering a course dedicated to running RCTs.
The Meeting brings together the clinical trials community from academia, the pharmaceutical and device industries, government agencies, medical groups and centers and clinical research entities. Looping model of direct long-range enhancer action in control of transcriptional regulation. To kick things off, Minister for Universities and Science David Willetts reflects on 100 years of publicly funded medical research, and why we must play the ‘long game’. Yet it wasn’t until the late 1940s that MRC researchers carried out the first randomised controlled trial of streptomycin, the first TB drug. But this long journey from the laboratory bench — or increasingly the computer screen — to a patient’s bedside isn’t consigned to the past. There are some key questions about human health that can’t be answered with traditional lab experiments: will exercise help my memory as I get older? The insights gained through this study have influenced many areas of Government policy, from education and family support to healthcare and public health. We have a large and diverse population, a historic strength in genetic and cohort research and a unified healthcare system. This leads to better diagnosis and more effective treatments, benefitting patients, driving growth and keeping the UK at the very forefront of medical innovation. She is using genetics, calcium imaging, and pharmacology to understand the roles of particular neurons and neurotransmitters in the function of this motor circuit.
I am investigating sensory transduction using calcium imaging and cell culture techniques, trying to identify receptors responsible for responding to stimuli including salt, osmolarity and mechanical touch.

He recently uncovered a key role for SUMO and ubiquitin in mediating the therapeutic effects of arsenic for the treatment of Acute Promyelocytic Leukaemia. And it was the 1960s before Professor Wallace Fox showed that drug treatment at home was just as effective as that in sanatoria, leading to their closure and huge savings for health services.
The UK Biobank, set up in 2006 and part-funded by the MRC, is a cohort of half a million adults in middle age. I am using a combination of calcium imaging, behavioural assays, optogenetics and protein interaction studies to identify novel components of the mechanostransduction machinery, and to understand the molecular and cellular basis for the distinct localisation and functional properties of the different mechanotransducers. I am currently using computer vision, calcium imaging, genetics and in vitro assays in order to map this circuit. I am also interested in developing new methodologies for identification of novel sensory receptors in C.
He obtained his PhD in 1979 from the Medical Research Council Virology Unit in Glasgow under the supervision of Dr John Hay for studies on the replication of herpes simplex virus DNA.
Mapping cisregulatory domains in the human genome using multi-species conservation of synteny. Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome. Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions. New 3' elements control Pax6 expression in the developing pretectum, neural retina and olfactory region. Long human-mouse sequence alignments reveal novel regulatory elements: a reason to sequence the mouse genome. Dynamics of enhancer-promoter communication during differentiation-induced gene activation.
Phylogenetic timing of the fishspecific genome duplication correlates with the diversification of teleost fish.
Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells. Differences between pair-wise and multi-sequence alignment methods affect vertebrate genome comparisons. Rounding up active cis-elements in the triple C corral: combining conservation, cleavage and conformation capture for the analysis of regulatory gene domains.
Computational identification of protein coding potential of conserved sequence tags through cross-species evolutionary analysis. Search for enhancers: teleost models in comparative genomic and transgenic analysis of cis regulatory elements. ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Analysis of intronic conserved elements indicates that functional complexity might represent a major source of negative selection on non-coding sequences.
A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Participants have provided a range of information about their lifestyles, physical characteristics and health, and they will be followed for at least 25 years. In addition, I’m developing bioinformatic techniques to identify novel sensory molecules that are conserved in all animals with a nervous system. A Damon Runyon-Walter Winchell Cancer Fund postdoctoral fellowship award led him to work in the laboratory of Dr Mel DePamphilis at Harvard Medical School, Boston where he determined the location and structure of RNA primers that initiate DNA replication at the Simian Virus 40 origin of replication. General organization of the locus and sequence comparisons of genes s15 and s19 in evolutionary distant species. The centralised infrastructure of the NHS means we have the ability to track the health of participants through their health records and prescriptions. Returning to the MRC Virology Unit in 1982, he established an independent laboratory working on the initiation of adenovirus DNA replication. The MRC is also assessing a plan to spend ?10m on analysing the genomes of a subset of UK Biobank participants. Andrews where he held Lecturer and Reader positions before taking up the Chair in Molecular Biology and becoming Deputy Director of the new Centre for Biomolecular Sciences.
In 2005 he joined the Wellcome Trust Centre for Gene Regulation and Expression in the College of Life Sciences at the University of Dundee as Professor of Molecular Biology.

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