07.07.2015

Pregnant over 40 with ivf

People were sympathetic but at no point was it even suggested that, were I to meet a man, I had anything more than an outside chance of conceiving — and only then with the help of IVF. Despite a trouble-free pregnancy, I could sense a feeling of caution whenever I went for a scan or a check-up, as if my pregnancy were a freak accident that was bound to end in tears.
Almost three-quarters of people do not think women should receive IVF to help them conceive beyond their natural childbearing years, a poll has found.
The Shameless actress travelled to Cyprus for IVF treatment and conceived her daughter, Flame, with donor eggs, giving birth aged 50.Two-thirds of those surveyed said they thought children born to women aged 50 to 55 were negatively affected by having an older mother. We are willing to take on the most difficult cases with lower prognosis, so long as we feel there is a chance for pregnancy. Of course, one option for such women is donor eggs, but many women would prefer getting pregnant with their own eggs.
A 43 year old woman who married relatively late in life was told by numerous doctors and infertility clinics that she could only get pregnant if she used donor eggs, and some also recommended donor sperm because of the husband’s age (which was silly).
Another example: A 41 year old nurse married to a 39 year old physician had already gone through three conventional IVF cycles elsewhere with PGD and no success. A great example of the superiority of mini-IVF for older women is a 43 year old who had gone through 5 previous conventional high dose stimulation IVF cycles since she was 40 years old.
A very determined 45 year old woman underwent four cycles of mini-IVF stimulation for IVF resulting on a total of 14 frozen stored embryos, because she knew how low her chance was for pregnancy per embryo with her own 45 year old eggs.
Suzanne Gastineau got pregnant with her first baby so easily, it never occurred to her that a few years later, she would be trying to conceive her second for a year-and-a-half with no results. A dramatic example of mini-IVF for women over 40 is a typical case of what we call secondary infertility, where the couple was able to conceive and deliver a healthy baby when they were younger, but now find themselves infertile in their attempt to have another child a few years later.
For example, a physician patient with a zero sperm count because of pituitary deficiency (a rare condition in males), had his sperm count return with the proper hormone treatment, but because the count was still low, they needed ICSI-IVF. A 45 year old single woman had to go through 4 cycles of mini-IVF with embryo banking, and was thereby able to store up 6 good quality embryos derived from her own eggs. An interesting 38 year old couple saw us in whom the husband was deemed to be azoospermic (no sperm) and the wife’s testing revealed premature ovarian failure with only a few antral follicles and a high day 3 FSH. In fact the remarkable successes with some of these older women resulting from the mini-IVF protocol are causing us to be cautious about how many embryos we transfer at one time even when older eggs are involved.
We can sometimes even achieve pregnancies in women 46 years of age and older with this approach (although donor eggs is a much more sure technique for achieving a successful result for such cases). A striking example of how mini-IVF with back-to-back cycles to store up vitrified embryos can allow older women to get pregnant and have babies with their own eggs is a couple from the north central area of the U.S.
Another beautiful example is a 47 year old woman who went so far as to store up 14 embryos with mini-IVF. We recently took care of such a case, a young woman I had known since she was a little girl, who had undergone multiple surgeries at various clinics for other health problems, but the result of her cure was just one remaining ovary with hardly any eggs left. There are many more such examples where persistence and mini-IVF can be successful with older couples or women with very few eggs. If a woman absolutely cannot get pregnant with her own eggs, then donor eggs is her only remaining option. Various experts had told her that her eggs would be too old or that IVF would represent her only chance of conceiving, but despite that she fell pregnant naturally — twice — once, with twins, that she sadly miscarried, and subsequently with an ectopic pregnancy that resulted in the removal of one of her Fallopian tubes.
Women over 38 years of age often have very few eggs, respond poorly to conventional ovarian stimulation, and because of lower pregnancy rates, are often just cancelled by IVF clinics for fear that such cases will lower their reportable statistics. For them the news is even harsher when an IVF clinic tells them they will need to use donor eggs. Finally, we transferred 4 embryos (because her eggs were so old, and as expected, she did not become pregnant.
Now at age 43, with such a low ovarian reserve, three years later, they wanted to try for another child. But she was obviously not certain that even this would result in a pregnancy because of her age, and so she decided in her 5th cycle to use donor eggs as well.


One 44 year old woman who was turned down by many IVF centers unless she agreed to use donor eggs, underwent two mini-IVF cycles at our center in which we were able to retrieve 4 eggs each time, resulting remarkably in 4 embryos each time, which were frozen by vitrification and stored for eventual transfer.
We celebrated with our amazing two-month-old twin baby girls and we wanted to extend our sincerest gratitude for helping us realize our dream to become parents. Firstly, it is hard to overstate how crucial is the purity of air quality in the lab as well as in the operating room. She already now has two babies (with her own eggs) and still has four more frozen embryos with which she can try for a third baby despite now being almost 50 years old.
But with this mini-IVF approach of storing up vitrified embryos month by month in older women, we have a remarkable pregnancy rate even in women over 42 years of age of over 50%, and this year thus far 67%. Most IVF centers will turn these women down if they do not agree to donor eggs, or else string them along with tests and meager treatments that are doomed to fail, until they finally agree to donor eggs.
The advantage of mini-IVF is that we can get better quality embryos at a much lower cost per cycle, store them up safely with vitrification, and spend less than the conventional IVF cycles would cost.
Many IVF programs just have a small local pool of egg donors, which we feel is not a favorable approach. And it seems my experience certainly isn’t unusual.Jan Andersen, a freelance writer and editor, discovered she was pregnant at 40. Also, such patients usually require huge doses of expensive drugs that can add another $6,000 or $7,000 to the already high cost of conventional IVF, bringing total costs to as much as $18,000 or more per cycle. Louis, is just the right approach for older women or women with low ovarian reserve who still want to use their own rather than donor eggs. We placed her on a program of mini-IVF back to back cycles to store up embryos by vitrification over the next year. Her first embryo transfer here resulted in no pregnancy, but with her second single blastocyst transfer she became pregnant and delivered a healthy baby boy, with her own eggs, never having to resort to donor eggs. Now at age 43, we put her through one cycle of mini-IVF, and she produced 5 high quality embryos and is pregnant. However, six months later we thawed and transferred 4 more embryos, but this time she became pregnant and delivered a healthy baby with her own eggs at the age of 46. With mini-IVF and ICSI we managed to get 3 eggs, all good quality, inject them with his few sperm, obtain 3 good quality embryos resulting in a healthy baby boy nine months later.
Indeed we found a few sperm in him with TESE that were quite good quality, and with mini-IVF, obtained 3 eggs from her very deficient ovaries.
So at age 44, we thawed and transferred just two embryos (to be safe) and she did not get pregnant.
These cases of women over 46 getting pregnant with their own eggs are unusual, but it is nonetheless quite possible if donor eggs are not an option for them.
We have been offering donor egg IVF for over 24 years, and therefore have had a chance to follow these children and their parents for a almost a quarter century. Assuming I had reached the menopause, I carried on with daily life, irritated that I was putting on weight. But a month later she was pregnant again — and in January this year Deborah gave birth to her son, Oliver. It takes advantage of your own natural FSH elevation with an ingeniously simple protocol that strives for smaller numbers of better quality eggs. She still has 6 more frozen embryos remaining, and so it is possible she could even have a second child in a few years, before she is 50, to be a sibling for this miracle baby she had from mini-IVF with her own eggs at age 46.
Their local IVF center laughed at them; but because they were physicians, they knew not to give up hope.
It is just that most people would prefer their own DNA, and for that goal, properly administered mini-IVF with embryo banking is the best alternative for the older woman or for even for the younger woman who suffers from low ovarian reserve. Two months later we thawed and transferred two more embryos, and again she did not get pregnant.
I was treated like any other ‘normal’ high-risk pregnancy because of my ‘advanced maternal age’ of 43 and carrying twins.


I told them we could easily restore his fertility with a vasectomy reversal or just retrieve his sperm microsurgically, but the problem was her age. She went through a total of 6 cycles of IVF just to store up embryos, retrieving only a few eggs at a time, and eventually storing up 10 embryos.
Both the children and the parents are well adjusted and completely happy with their lives as a result of the donor egg IVF.
It wasn’t until someone commented on my new cleavage that it occurred to me to take a pregnancy test.
Instead of massive doses of expensive hormones to try to blast out a few poor quality eggs, it more naturally teases out of the older ovaries their best quality eggs with a carefully devised protocol of minimal stimulation. Both were physicians, only 34 years old, and had been told by several IVF centers they had visited that she had only a few follicles left, was about to go into early premature menopause, and was not a candidate for IVF with her own eggs. So this time, again with mini-IVF, we actually got 6 eggs and 5 good quality embryos, giving them two more children, even at age 43, when every other center would automatically turn them down because the results are normally so poor with conventional IVF in women over 40. This case exemplifies dramatically that if you can get good quality embryos using mini-IVF from your own eggs, even for patients in their mid-forties, pregnancy is still possible without the need necessarily of donor eggs.
After saving up several more embryos, with another cycle of mini-IVF, and another TESE for him, they now had 5 good quality embryos frozen using our advanced vitrification technique. So five months later, at almost 46 years of age, she asked to thaw and transfer all four of her remaining frozen embryos, thinking that from such old eggs, there was very little risk of multiple pregnancy. I had a very healthy pregnancy and made it to 39 weeks with what my OB described as a pregnancy better than most of her moms carrying ‘singletons’. Although I brought up donor eggs as the surest solution, they insisted on trying with her own eggs.
A half a year later, at age 48, and completely devoid of eggs, we transferred these three beautiful frozen embryos, and she has a healthy pregnancy at age 48. This resulted in a healthy pregnancy and enough frozen embryos to eventually have the big family she always dreamed about. She became pregnant and delivered a healthy baby at age 44 without having to resort to donor eggs. As though this was not enough of a family, they decided at 45 to try once again with her remaining 3 frozen embryos to enlarge her family further and now again has a healthy pregnancy due to deliver when she is 46 years old, all from her own few remaining eggs, and his near zero sperm count. Finally, the ability to freeze the embryos with impunity and then transfer in a later cycle where the uterine lining is more perfectly synchronized to the stage of embryo development than during a stimulated cycle, all adds up to better success rates in challenging cases. I took four home pregnancy tests — all positive — before I made an appointment to see my GP. When she didn’t conceive, she was given the fertility drug Clomid and, a year later, had IVF.
The reason it is so often misunderstood is that what appears to be ingrained character in a child is in truth, a subtle result of early interaction with parents in the first two or three years of life.
By the time Nicole was 42, she had been through IVF six times and describes herself as ‘emotionally and financially exhausted’.  Then she read about CARE Fertility in Nottingham, offering fertility treatment for women over 40. Fortunately, and as expected, her triplet pregnancy spontaneously reduced to twins, and she delivered healthy term twins, with her own eggs.
The character, personality, intelligence, and even coordination motor skills of the child are dependent on that emotional bonding and complex interaction with parents in the first few months and years. Thus, with our new mini-IVF technology, we have to still be cautious not to transfer too many embryos at one time, even with older eggs. In fact Nicole was diagnosed with a condition where the body’s immune system goes into overdrive, producing killer cells which enter the placenta and attack the embryo.



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Comments to «Pregnant over 40 with ivf»

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