08.02.2014

Ivf success at 40 years old

When couples are trying on their own to get pregnant the fertility issue that reduces chances for success is related to the quality of the eggs.
Although these age and fertility statistics are specifically about IVF success, there is a similar loss in fertility potential with aging in the general "normal fertile" population. The graphs below are from the 2012 ART Success Rates report published by the CDC, Centers for Disease Control and Prevention, a US government agency. Another point shown here is that there not a substantial decline in success by age of the recipient woman with donor egg IVF.
The national summary (as well as clinic specific results) of IVF success rates for cycles done in years 1995 through 2012 are posted on the CDC website.
Antral follicle counts (along with female age) are by far the best tool that we currently have for estimating ovarian reserve, the expected response to ovarian stimulating drugs, and the chance for successful pregnancy with in vitro fertilization. The level of response of the ovaries when the woman takes injectable FSH for stimulation is often predictive of the egg quantity and quality - and therefore, also the relative chances for success with infertility treatment.


To some extent, the more eggs we have to work with, the greater the chance that IVF will be successful.
Women under 38 in our IVF program have acceptable live birth rates even with only 3 - 6 eggs, do better with more than 6 eggs, and do best with more than 10 eggs.
They also have substantially lower success rates with fertility treatments including in vitro fertilization (IVF). With treatments such as IVF, the issue that holds back success potential is both egg quality and egg quantity. With IVF treatment we hope to get multiple embryos so we can choose the best ones from a group for transfer back to the uterus. However, when going through a fertility treatment such as IVF, the quantity of eggs remaining influences response to ovarian stimulating medications.
This report was generated from national data from hundreds of clinics and well over 100,000 IVF cycles.


Most of the decline with advancing age is due to increasing rates of chromosomal abnormalities in older eggs.
As women age, we need more eggs to be able to make IVF work - because of the lower quality of the eggs. This is because success rates are very low when less than 3 mature follicles are present on ultrasound.



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