MUSE is short for "medicated urethral system for erection." It consists of a tiny medicated pellet that is inserted into the urethra, the opening at the end of the penis, to produce erections. Administration of the drug alprostadil through the urethra using the MUSE system is an effective alternative treatment for many men, and provides a less invasive alternative to intrapenile injection. Alprostadil is a prostaglandin E preparation in a pellet form that is inserted with a plunger-like mechanism into the urethral opening. The plunger device is pre-filled to deliver a pellet about an inch deep into the urethra at the tip of the penis. Alprostadil is a form of a natural substance, prostaglandin E1, which serves to open blood vessels. Prostaglandin E1 raises the intracellular concentration of the cyclic AMP, which leads to relaxation of the cavernosal smooth muscle, increase of arterial blood flow, dilation of sinusoids and veno-occlusion, thanks to the compression of sub-tunica albuginea venules against the tunica albuginea. Men should be advised to urinate before insertion, because lubricants should not be used and a moist urethra will allow for easier insertion of the plunger device. This illustration shows how the applicator is inserted into the opening at the end of the penis to leave the small pellet. Patients also find that it works better with a ring-type device to prevent the drug from getting absorbed into the systemic circulation. The first application (usually a 500-µg dose) should be undertaken in the physician's office because of the potential complications of urethral bleeding, vasovagal reflex, hypotension, and priapism. The side effects of the drug itself are the same whether the drug is administered by injection or through the urethra, although each method has other side effects that are specific to it. About 10% to 17% of MUSE administrations result in a burning sensation in the urethra that can last five to fifteen minutes, but this moderate pain does not appear to be a main reason for discontinuing treatment. Men with or at risk for blood clots or who are using blood thinners, such as heparin or warfarin, should not use it.
One of the more unusual side effects involved a case where the MUSE pellet became caught in a female partner's mouth during oral sex and created an allergic reaction which necessitated a trip to the emergency room.
Contraindications include usage with a pregnant partner or a partner who is likely to get pregnant, hypersensitivity to prostaglandin, and sickle cell anemia, or a patient who is prone to developing priapism. In another study, the efficacy of intraurethral alprostadil was evaluated in a double-blind, placebo-controlled trial in 1511 men with chronic erectile dysfunction from a variety of organic causes. In one study, 65% of men achieved erection using MUSE, and these men achieved intercourse in an average of 7 out of 10 administrations. This is the world-leading Taiwan Mahjong game and all the stars voices are performed by themselves. BBM brings you together in the moment with friends and family through instant chats and more. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
Clipping is a handy way to collect and organize the most important slides from a presentation. In the 14 years or so since Viagra was introduced in 1998, the number of men diagnosed with erectile dysfunction (ED) has increased by a whopping 250 percent.
Alprostadil is an FDA-approved erectile dysfunction drug that can be injected directly into the penis to trigger an automatic erection. If you have a neurological disorder or spinal cord injury and other erectile dysfunction treatments aren’t effective, two types of surgical implants could offer solutions to your ED.
Herbal supplements such as ginkgo biloba, saw palmetto, and yohimbe have been touted as sexual enhancers, and some men have been tempted to try them to treat erectile dysfunction. The idea of using low-energy shock waves to treat erectile dysfunction comes from studies that show that these types of shocks help heart blood vessels regrow, a process called revascularization.


The next new treatments for erectile dysfunction will probably be improvements in some ED drugs already being used. From our SponsorsEveryday Solutions are created by Everyday Health on behalf of our sponsors. Read the package leaflet for more information about risks and side effects, or ask your doctor or pharmacist for advice. Muse sticks are administered directly into the opening at the end of the penis (urethra) using a special applicator. Muse is available in three dosage strengths: 250 mcg, 500 mcg and 1000 mcg, with a choice of one or six vials.
Furthermore, Muse is not to be used in conditions such as leukaemia, sickle cell disease, multiple myeloma (Kahler's disease), thrombocytopenia and polycythaemia. It is effective in men with a wide range of medical disorders, including diabetes, surgery, and injury. Evidently, the attempt to use this drug transurethrally with no need for a penile injection is very appealing. Depending on the erectile response, you may then be instructed to increase or decrease the dose (up to 1000 µg or down to 250 µg).
Priapism (prolonged erection) is a potential side effect for both forms of administration although there is less chance for it using the MUSE system. Up to 50% of patients have a measurable drop in blood pressure, although only about 3% are aware of it.
Two-third of these men responded to intraurethral alprostadil with an erection sufficient for intercourse in the clinic; these men were then randomly assigned to therapy with either alprostadil or placebo.
A more recent study, however, reported disappointing results, with only 27% achieving erections and only 18% requesting additional refills. The vacuum pump method is the next most common choice among men with erectile dysfunction who pass on pills, says Dr.
Bennett warns, however, that none has been approved by the FDA or even shown by any reliable studies to prevent, treat, or improve erectile dysfunction. Shock wave therapy may also work on the penis, and there have been some promising results, but it’s not currently an approved ED treatment. View all.ConnectDon't miss out on breaking news, live chats, lively debates, and inspiring stories. The substance is absorbed and relaxes the blood vessels in the corpus cavernosum, thus allowing more blood to enter the penis to cause an erection.
Despite the existence of submucous veins that communicates the corpus spongiosum and the corpora cavernosa, therefore creating a possible absorption means, this procedure is considered erratic, meaning there is no constant correlation between given drug dose and absorbed dose. After insertion, the pellet within the urethra should be dissolved by massaging or "kneading" the penis for about a minute. If this occurs, applying ice for ten-minute periods to the inner thigh may help reduce blood flow.
Some patients have significant symptoms of hypotension Symptoms include dizziness, lightheadedness, and fainting. More recently, Porst reported that 43% of patients treated with 1000mcg of transurethral alprostadil were able to have a sexual intercourse, but only 10% mentioned rigid erection.
Successful intercourse on at least one occasion was much more likely with alprostadil (65 versus 19 percent with placebo).
Aside from pills like Viagra, Levitra, and Cialis, for example, there are surgical, therapeutic, even do-it-yourself treatments that can bring back that lovin’ feeling. MUSE, with an inspiring name that actually stands for medicated urethral system for erection, will trigger an erection in about 10 minutes that may last as long as an hour.


Moreover, supplements are unregulated and can have many side effects or interfere with prescribed medications you’re already taking.
A new form of alprostadil may make it possible for you to rub it directly on the penis instead of inserting or injecting it. Join the conversation!Free NewslettersPersonalized tips and information to get and stay healthier every day. ED occurs when there is insufficient blood flow to the penis to achieve or maintain an erection. Similarly, Werthmam and Rajfer obtained 30% of erections that enabled vaginal penetration, but only 7% of 100 patients using up to 1000mcg of alprostadil mentioned rigid erections. Among the men who responded to alprostadil, 7 of 10 applications were followed by successful intercourse. Possible side effects include a burning sensation and priapism, an erection that lasts more than four hours and requires medical treatment.
Using MUSE to treat ED can result in somewhat unpleasant side effects, however — including an aching sensation, burning, redness, and minor bleeding. To create an erection, you place a plastic cylinder over the penis and pump the air out of the cylinder to force blood to flow into the penis. Hormone therapy with injections, patches, or gels applied to the skin may improve mood and sex drive, but it likely won’t fix any mechanical issues. Don’t jeopardize your health by taking a supplement to treat erectile dysfunction without first talking with your doctor. And newer phosphodiesterase inhibitors that last even longer and cause fewer side effects are being developed.
Alprostadil is the same as a naturally occurring chemical called prostaglandin E1 (PGE1), which works by widening the blood vessels and thus increasing blood to flow into the penis. It is therefore advisable to reduce or stop alcohol consumption while taking this medicine. Scarring of the penis (Peyronie's disease) is also possible with both treatments, although the chances are far less with the MUSE system. The drug may have toxic effects if it reaches the fetus in pregnant women; men should not use alprostadil, then, for intercourse with pregnant women without the use of a condom or other barrier contraceptive device. Read on to find out about nine common remedies for ED, plus the truth about which ones live up to the hype and which fall flat. MUSE provides an effective solution to ED because it widens the blood vessels and supplements the deficiency of PGE1, increasing blood flow to the penis and producing an erection suitable for intercourse. It does not involve syringes, it is easier than injections and a good alternative when erection pills do not have the desired effect. If you lie on your back too soon after administration, blood flow to the penis may decrease and the erection may be lost. Side effects include numbness, bruising, and weak ejaculation — and the ring must be removed after 30 minutes. You should be upright, either sitting, standing or walking for about 10 minutes after administration.



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