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The European Prebiotics Market to Reach $1.17 Billion by 2015, According to New Report by Global Industry Analysts, Inc.
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I've taken various probiotics for several years and really likes the idea of the chewables. September 5, 2013 by Lara Swanson The beneficial effects rendered by the probiotics are now beyond doubt and most of the people around the world believe in their effectiveness and efficacy. The commercially available probiotic strains are used by the individuals simply as lyophilized powdered products, chewable tablets and so on.
In addition, the dosage and the actual number of the bacteria administered are also under control unlike the intake through the traditional food products. The beneficial effects of the administration of viable or non-viable probiotic cells through oral or subcutaneous routes were also analyzed in some studies. Recent research shows that the oral intake of probiotics could alleviate problems of Salmonella infections.
The Influenza viruses have been associated with increasing cases of mortality and morbidity through their ability to interfere with our immune responses and make us immuno-compromised.
In a very recent publication in the International journal, Antiviral Research the Scientists tried to find out the efficiency of nasal administration of the probiotic bacteria lactobacilli and their effect in providing protection against health complications like common cold in human beings. They found that the intranasal administration of the Lactobacillus strains could bring about better efficiency in providing protection against common cold as compared to the oral administration thereby acting as the mode of choice for the quicker relief. However, the strains taken in and the specific dosage formulation determination are prerequisites for the effective beneficial effects upon the cases applied for.
There a number of ways through which the probiotics can be taken by the hosts to get the health related benefits unlike the yester years when it was taken only orally. Vikas Punia 1 , Sandhya Kapoor Punia 2 , Meenakshi Khandelwal 3 , Vivek Sharma 4 , Vivek Lath 5 1 Sr. Science is providing us the tools to diagnose and treat the infection before it causes damage. At that time Henry Tissier (1906), a French paediatrician, observed that children with diarrhea had in their stools a low number of bacteria characterized by a peculiar, Y shaped morphology.
Metchnikoff worked at the Pasteur Institute in Paris and had discovered Lactobacillus bulgaricus, a strain he later introduced into commercial production of sour-milk products in France and throughout Europe.
As concentrated and dried cells packaged as dietary supplements (non-dairy products such as powder, capsule, gelatin tablets). The mechanisms by which probiotics exert their effects are largely unknown, but may involve modifying gut pH (normalization of intestinal microbiota), antagonizing pathogens through production of antimicrobial compounds (organic acids, hydrogen peroxide, and bateriocins), competing for pathogen binding and receptor sites as well as for available nutrients and growth factors, stimulating immune modulatory cells, and producing lactase. As the bacterial resistance to antibiotics is emerging wide spreadly, the concept of probiotic therapy has been considered for application in oral health.
To have a beneficial effect in limiting or preventing dental caries, a probiotic must be able to adhere to dental surfaces and integrate into the bacterial communities making up the dental biofilm. Nikawa et al.[18] reported that consumption of yoghurt containing Lactobacillus reuteri (L.
The first studies of the use of probiotics for enhancing oral health were for the treatment of periodontal inflammation.[21] The main pathogenic organisms associated with periodontitis include Provitellagingivalis, Treponemadenticola, Tannerella forsythia etc. A recent study has shown that patients with genuine physiologic or pathologic halitosis benefited significantly from two-week therapy with tablets containing L. Candida species constitute part of the commensal oral flora in about 50% of healthy subjects, but able to cause a clinically apparent lesion if the immune defenses were breached either on the local or systemic level.[31] One study has shown that the subjects who consumed cheese containing the probiotic L. Different strains of same species may possess different characteristics, necessitating rigorous strain selection before being labeled as probiotic. Potential future uses of probiotics include inflammatory disease control, the treatment, and prevention of allergies, cancer prevention, immune stimulation, and a reduction in respiratory disease. The concept casts new light on the connections between diet and health, including oral health.
Rescue Remedy can be used daily in chronic situations of nervousness, tension, panic, and trembling especially if resulting from accidents, shock and traumas. Traditional dosage of Rescue Remedy Drops: Add ten drops of Rescue Remedy to a glass of water. Patients taking any other medication should consult their health care professional before taking any complementary medicine.
Drops – contain alcohol and should not be used by people with an Intolerance or sensitivity to alcohol. Consult your healthcare professional if your symptoms are severe or persist for longer than 24 hours in the case of shock induced effects and between 3 to 4 weeks in the case of stress, nervous tension and mild depression or anxiety. Avoid taking Rescue remedy within half an hour of chocolate, coffee or any other aromatic substances.
If for any reason you need to dispose of this medication, please return it to your pharmacist who will dispose of it responsibly. No medicinal claims are made for this product and all data is supplied for information only. The form of the probiotics also vary from live to heat inactivated dead cells with even the DNA or the protein parts of the strains being capable of rendering their beneficial effects.
Infact the number of bacteria taken in and their viability is a matter of great concern with regard to the probiotic biology and their positive influence on the health of the host.

In one such study carried out by the group of Cesolari, it was found that in either of the cases and the forms administered, the probiotics could prevent gastrointestinal problems.
Till now the oral route has been followed as the best preferred route for the administration of using probiotic strains in the treatment modalities against various health compromised conditions, recent advances has shown that under such circumstances even sub-cutaneous intake can be quite beneficial. The probiotics are increasingly being used in protection against Influenza virus related infections.
The levels of secretory IgA through this mode of administration as well as those of cytokine production were better as compared to the other modes. In as study published in the Journal of Nutrition, it was demonstrated that the administration of L. The success of the administration of the probiotics through a specific route depends upon the context under which it is to be used. For some decades now, bacteria known as probiotics have been added to various foods because of their beneficial effects for human health. Oral infections constitute some of the most common and costly forms of infections in humans.
Prebiotics are dietary carbohydrates that escape digestion in the upper gastrointestinal tract, alter the bacterial composition of the gut, by changing the type of the substrate provided to the existing microbial population in the gut e.g.
Probiotic bacteria have been shown to influence the immune system through several molecular mechanisms.[11],[12] The mechanisms of probiotic action in the oral cavity could be analogous to those described for the intestine. Prevention of respiratory tract infections (common cold, influenza) and other infectious diseases as well as treatment of urogenital infections.
Dental caries, periodontal disease, halitosis, and oral candidosis are among the oral disorders that have been targeted.
Various studies have reported the capacity of lactobacilli to inhibit the growth of periodontal pathogens, including P. It regularly affects about one in four adults and frequently is caused by anaerobic bacteria that degrade salivary and food proteins to generate amino acids, producing volatile sulfur compounds (VSCs).[27] Halitosis is considered to be an aesthetic problem, with multiple local and systemic etiological factors. Some probiotic strains have been in use for many years and have excellent safety records.[37] Probiotics are live micro-organisms and hence, it is possible that they may result in infection in the host. Their main thrush is on reducing the harmful properties of pathogenic strains naturally colonizing the oral cavity. Such effects could justify the addition of not one but potentially several probiotics to commonly consumed foods, which could achieve population-wide health benefits. Probiotics are, nevertheless, a new and interesting field of research in oral microbiology and oral medicine. Can also be used before any stressful events to help calm down and reduce anticipatory anxiety, e,g, before exams or going to the dentist. A large number of our traditional foods are based on the fermentative capability of these probiotic bacterial strains and our forefathers were also in the habit of taking fermented milk and other foods although with little knowledge about the probiotic bacteria. The commercially available probiotic products are more effective from the point of view that they have been produced keeping in mind all the safety guidelines.
But with all the recent developments in this field of using probiotics as beneficial modulators of our health, there is an important question doing the rounds for their further betterment as our ‘friendly’ biota; which is the best route of their administration into our body? The systemic intake of the organism was able to induce anti-inflammatory responses within the host thereby suggesting that the oral route is not the ultimate necessity for the beneficial effects. Anti-inflammatory responses were also noticeable with the intake of oral or sub-cutaneous live or dead cells. In a recent study, the sub-lingual route of probiotic delivery was carried out in influenza infected individuals. Therefore, each of the ways of administration of the probiotics into the individuals has their own potential which has to be weighed properly according to the need and the choice be made. The use of antibiotics, immunosuppressive therapy and irradiation, amongst other means of treatment, may cause alterations in the composition and have an effect on the Gastro-intestinal (GI) Tract flora. The concept of microbial ecological change as a mechanism for preventing dental disease is an important concept while altered microbial ecology may lead to dental disease.
He suggested that these bacteria could be administered to patients with diarrhea to help restore a healthy gut flora. In oral cavity, probiotics tend to create a biofilm, acting as a protective lining for oral tissues against oral diseases. An essential condition for a microorganism to represent a probiotic of interest for oral health is its capacity to adhere to and colonize various surfaces of the oral cavity.[12] Lactobacilli constitutes about 1% of the cultivable oral microflora in humans. The main local etiologies include periodontitis, poor oral hygiene, deep dental caries, tongue coating, and faulty restorations. Although probiotic therapy is generally considered safe, the concept of willingly ingesting live bacteria remains somewhat counter intuitive.
In field of oral immunology, probiotics are being used as passive local immunization vehicles against dental caries (C3). Most of the studies have been conducted with probiotic strains originally suggested for gut health. Probiotics and their fermented food products are beneficial for health Journal compilation 2006 The Society for Applied Microbiology.
Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro. Effects of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli. Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children.

Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity. Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid.
Probiotic effects of orally administered Lactobacillus salivarius WB21- containing tablets on periodontopathic bacteria: a double-blinded, placebo controlled, randomized clinical trial.
Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial. Effect of oral Lactobacillus salivarius TI 2711 (LS1) administration on periodontopathic bacteria in subgingival plaque. Inhibitory effect of Weissellacibaria isolates on the production of volatile sulphur compounds.
Probiotics reduce the prevalence of oral Candida in the elderly--a randomized controlled trial.
Growth inhibition of oral mutans streptococci and Candida by commercial probiotic lactobacilli-an in vitro study. Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus. Intestinal colonization with Enterobacteriaceae in Pakistani and Swedish hospital-delivered infants. Effects of probiotic Lactobacillus salivarius W24 on the compositional stability of oral microbial communities.
Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials. The beneficial strains helped them maintain good health away from frequent encounters with disease manifestations.
Since, no significant difference could be observed between the two routes of administration and their stimulation of effects within the hosts either of the routes could be followed. Although in depth studies are required to find out the exact mechanistic behind the quicker response in providing protection against the pathogen affecting the respiratory system by the application of probiotics through the nasal mode, it can be definitely said that it holds high potential in fighting against the disease under such circumstances. Therefore, the introduction of beneficial bacterial species to GI tract may be a very attractive option to re-establish the microbial equilibrium and prevent disease. Lactobacilli are extremely aciduric and can withstand a pH as low as 3.5, which is a prerequisite to survive the low-pH transition into the intestines. In a study by Nase et al.[19] they found that children consuming milk containing probiotic, particularly those 3-4 years of age, had significantly fewer dental caries and lower salivary counts of S. Systemic infection has rarely been reported with Bifidobacterium , although many cases of sepsis secondary to Lactobacillus rhamnosus GG or Lactobacillus casei have been reported [38], [39] The risk and morbidity of sepsis due to probiotic bacteria should be weighed against the potential for sepsis due to more pathological bacteria and the morbidity of the diseases for which probiotic bacteria are being used as therapeutic agents. Bacteriophages, viruses that kill bacteria, have been detected in oral pathogens, such as Actinobacillus actinomycetemcomitans, and they may play a role in the pathogenicity. A literature reviews shows that probiotics use in associated to an improvement in oral health, which is mainly due to significantly reduced levels of cariogenic as well as periodontal pathogens. Remember that as homeopathic medications are normally absorbed through the mucous membranes of the mouth, it is better to hold the medication in your mouth for a short period of time.
There are also suggestions that the effects of probiotics are not solely based on the local administration and the systemic intake is a genuine possibility. Traditionally, probiotics have been associated with gut health, and most clinical interest has been focused on their use for prevention or treatment of gastrointestinal infections and diseases; however, during the last decade several investigators have also suggested the use of probiotics in oral health care. Together, these observations suggest that lactobacilli residing in the oral cavity could play a role in the oral ecological balance.[22] Patients with various periodontal diseases, gingivitis, periodontitis, and pregnancy gingivitis, were locally treated with a culture supernatant of a L.
Cibaria) has ability to decrease the production of volatile sulphur compounds (hydrogen sulphide and methanethiol) by Fusobacterium nucleatum (F. Subsequently, future studies should be conducted to investigate if phage therapy might be applied for oral and dental diseases in the same way as has been attempted for systemic infections. However, the ease of intake of the probiotic strains is another matter which should be taken into account while selecting the preferred mode of administration.
Limited research is available showing that some probiotic cultures may help dental improvement. These promising results suggest a potentially beneficial application of probiotics for the prevention of dental caries.
The selection of the best probiotic for oral health is also an issue that calls for further study. With these pieces of evidences, the sub-lingual mode of probiotic administration can definitely be used as a promising alternative to the already existing methods of probiotic intake in the treatment against influenza.
It has been suggested that the operative approach in caries treatment might be challenged by probiotic implementation with subsequent less invasive intervention in clinical dentistry. The application of probiotic strategies may, in near future provide an end to many infections occurring in oral cavity. There has been significant interest in using probiotics in treatment of periodontal disease recently, too.
This article describes on the mechanism of action, benefits, safety issues and future aspects of probiotics for oral health. Furthermore, in some studies the observed differences were quite small, though statistically significant.

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