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Cows' guts (their digestive tracts, or intestines) are packed with microscopic organisms: bacteria, fungi, and single-celled animals called protozoa. To give you an idea of how many there are in total, the rumen may hold up to 95 litres of food & fluid. On the side of the Durham Co-op Grocery building in North Carolina is this faded advertisement for Pepsi Cola.
A new study by Akila de Silva and colleagues from Imperial College London, UK, published in Cell Metabolism, shows that infusion of two gut hormones can reduce food intake and mimic the central effects of a meal in humans. Specifically, the researchers used functional magnetic resonance imaging (fMRI) to examine the effect of infusing the gut hormones PYY(3-36) and GLP-1(7-36 amide) on brain activation with presentation of food-salient images in six brain regions known to be involved in ingestive behaviour (amygdala, caudate, insula, nucleus accumbens, orbitofrontal cortex, and putamen) of 16 young normal-weight volunteers. In addition, the researchers looked at the effect of these gut hormones on hunger and eating behaviour before and after a standardized breakfast and an ad libitum buffet lunch.

Not only does this study provide further insight into how the gut talks to the brain but also provides evidence for the involvement of these hormones in ingestive behaviour.
Whether or not such insights can be harnessed to provide better treatments for obesity remains to be seen. De Silva A, Salem V, Long CJ, Makwana A, Newbould RD, Rabiner EA, Ghatei MA, Bloom SR, Matthews PM, Beaver JD, & Dhillo WS (2011).
There are of course a number of other factors that are hypothesised to be contributing to the increase in obesity e.g. However, targeting energy intake is likely to have the most significant impact on reducing rates of obesity and is and has been the prime focus of the majority of pharmacological interventions. DonationIf you have benefitted from the information on this site, please take a minute to donate to its maintenance.

Absence of glucuronyl transferase or inhibition of the enzyme by steroids block conjugation of bilirubin.
The major route of ethanol oxidation is via alcohol-dehydrogenase an NAD-dependent enzyme (Fig. The Gut Hormones PYY(3-36) and GLP-1(7-36 amide) Reduce Food Intake and Modulate Brain Activity in Appetite Centers in Humans. About 10-15% of the bilirubin arises from the breakdown of immature red cells and cytochrome.

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