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Digestion is needed to breakdown large insoluble molecules found in the bolus into smaller soluble molecules.  These molecules can then absorbed through the walls of the small intestine and onto the blood stream by diffusion. The muscle before the bolus of food contract and the muscles after the bolus relax resulting in a wave of muscular contractions which pushes the bolus through the oesophagus.

In the duodenum, the bile produced by the liver as well as the enzymes produced by the pancreas are released in the alimentary canal and they will mix with the food. The acid lowers the pH of the gastric juices to a value close to the pH optimum for pepsin.

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