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During normal gut homeostasis, the gut lining expresses mucus molecules decorated at their tips with sialic acids. The active normal gut microbiota (brown mixed cells) cleaves these sialic acids by releasing sialidase to then consume them.

Antibiotic treatment reduces this healthy microbiota population, although sufficient bacteria still exist to liberate sialic acids, making them available to C. FMT replenishes the normal microbiota, thus probably limiting the amounts of sialic acid that can be used by C.

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