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Probiotics c diff zoonotic,best time to take live probiotics cultures,are probiotics good for ringworm look - 2016 Feature

Consuming supplements and food containing probiotics may reduce the risk of antibiotic-associated diarrhea, according to a systematic review from the prestigious Cochrane Collaboration.
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We know this because of a randomized study just published in the New England Journal of Medicine. The study was stopped after an interim analysis. Of 16 patients in the infusion group, 13 (81%) had resolution of C. But many of us in the ID world knew that fecal transplant was going to work great for C diff even before this study. The published uncontrolled studies on use of fecal transplant were extraordinarily favorable. Enemas do not typically reach the transverse or the right colons, so in theory would be inferior to colonoscopic deliveries. However, fecal transplant through ND tubes should be just as effective as colonoscopies, and much less expensive. I recall hearing of this in medical school from our ID attending some years ago, in the context of using a chocolate milkshake with fecal matter mixed in. I learned this thing in the first year of my residency (2005) but somehow it never became a standard therapy…hope this study will make us finally accept what might be the best way to go! Regardless of all of this, the procedure remains the only transplant where it is much better to be the donor than the recipient.
Enter your email address to subscribe to this blog and receive notifications of new posts by email. NEJM Journal Watch is a publication of NEJM Group, a division of the Massachusetts Medical Society. Taking antibiotics can destroy your natural gut flora unless you take preventative measures.
My mother was healthy, even as she got older, until a hospital-based infection destroyed her.
In my mother’s case, I immediately made copies of research studies on the use of probiotics for the treatment of C.
I wanted to know why medical doctors did not know about FloraStor, and why it wasn’t part of first-line treatment when there was good scientific and clinical evidence that it helped.
Since my mother’s tragic iatrogenic infection and the disappointing mismanagement of her condition, several review articles have been written on the importance of using probiotics during and after taking antibiotics, as well as for the treatment of C. Results of a new study, just published this month (13 November 2012), bring a hint of good news for patients with C. Though Saccharomyces boulardii is the best studied of probiotics for the treatment of AAD, many common Lactobacillus strains are also effective. I typically prescribe a probiotic blend of Saccharomyces boulardii, Lactobacillus rhamnosus, Bifidobacterium bifidum, and Bifidobacterium breve. A probiotic is only functional if it can reach the intestines, establish itself and flourish. Medical and Site Disclaimer: The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Home About Live Cultures Live Cultures About Live Cultures Live Cultures What are Probiotics? Canadian researchers have discovered that using stool bacteria in capsules can treat patients suffering from Clostridium difficile (C.diff) infections, a method significantly less invasive than faecal transplants. Recent studies have demonstrated that faecal implants from healthy donors can restore the balance of good bacteria in the gut, but it involves expensive and invasive procedures and results have been variable. The less invasive and seemingly more effective method of using stool bacteria in a capsule was devised by Dr Thomas Louie, a specialist in infectious disease at the University of Calgary. The patients are firstly given antibiotics to kill the C.diff, followed by an enema so the bacteria are introduced to a ‘clean’ environment. The work of creating stool bacteria capsules has been praised by Dr Curtis Donskey of the Cleveland Veterans Affairs Medical Centre, who has carried out faecal transplants through colonoscopies.
These studies have shown the potential for stool bacteria pills to support those with severely imbalanced gut flora, such as those resistant to antibiotics. I can certainly advise you that OptiBac Probiotics does not yet offer this type of supplement!
I believe that faecal capsules are now commercially available, however, though I would not be able to recommend a particular brand. For over a decade, I have recommended a trial of probiotics to virtually all of my patients.
Probiotics are a vast group of living microbial organisms comprising normal gastrointestinal flora. Examples of probiotics include bacterial species  Lactobacillus and Bifidobacterium, as well as the Saccharomyces yeasts.
Prebiotics are nondigestible fibers and complex sugars that promote the growth and metabolic activity of the beneficial bacteria, primarily the Bifidobacterium, in the colon. Prebiotics were not defined until 1995.  One example of a prebiotic is inulin, found in Jerusalem artichokes and asparagus stems. Fermented milk products such as yogurt and kefir are considered synbiotic because they contain both the live probiotic bacteria and the prebiotic fuel working synergistically. For thousands of years, the food we ate was unrefrigerated, unpasteurized, and unprocessed.
The intestine is our first line of defense against harmful pathogens, chemicals, and preservatives that we do not want in our bodies. One leading scientific hypothesis proposes that dysbiosis allows tight junctions to loosen up, resulting in leaky gut syndrome or intestinal permeability. To maximize their effectiveness, probiotics must remain stable in the acidity of the stomach and the alkalinity of the duodenum.
If my client is taking probiotics to “promote good gut health,” I support exclusive use of food sources of probiotics. Probiotic supplements are formulated with a special coating to withstand stomach acid and bile before dissolving in the small intestine. The past decade has seen an increase in the number of scientific studies on the effectiveness of probiotic supplements.
It is challenging to provide detailed recommendations on which probiotic supplement to take and what dosage, due to variability in strength and viability. The International Scientific Association for Probiotics and Prebiotics (ISAPP), in The P’s and Q’s of Probiotics: A Consumer Guide for Making Smart Choices, recommends looking at these four criteria prior to choosing a probiotic. Probiotic Strain–  Try to match the particular strain with published scientific research. Do not take the probiotic with a hot beverage or cereal, as the heat might destroy some of the good bacteria. If taking prescription antibiotics, wait two hours before taking the probiotic so they do not cancel each other out. Occasionally, I will have a patient experience more severe symptoms when they first begin taking probiotic supplements. If you experience the Herx reaction, it is best to cut back on the dosage, while continuing to take probiotics until the toxins are eliminated from the body. Once the harmful bacteria have been eliminated, it is time for the probiotics to do their job. Last year I wrote a document entitled “The Vitamin C treatment of Whooping Cough” in order to meet the needs of parents who seek treatment that is safe and effective. Currently, the conventional approach to whooping cough(pertussis) is to vaccinate infants, and to give older children booster injections. The medical establishment’s own literature, as I outlined in my original document, admits that the vaccine is a failure. The other approach to active pertussis infection is to give antibiotics to those infected and to close contacts. Critics of vitamin C bring up the fact that there are only a handful of studies suggesting that vitamin C decreases cough severity and duration, and they are not modern studies.
OTANI in 1936, should be considered a pilot study as he did document improvement more rapidly than expected in the majority of his cases, though his dosing is far lower than what I would recommend. VERMILLION in 1938 published a study “In this small series of twenty-six cases of whooping cough, cevitamic acid seemed to be strikingly effective in relieving and checking the symptoms in all but two of the cases which apparently received little if any relief.
I agree with the critics that there are no randomized controlled trials(RCT) to demonstrate the effect of high-dose vitamin C on the duration and severity of pertussis. Now I have my own series of documented cases and testimonials where parents witnessed the rapid reduction in cough and improvement in symptoms.
At this point, while I recognize that RCT’s are thought to be the gold standard of proof in medical treatments, I would be reluctant to sign any child up for such a study since the half that is untreated would be knowingly deprived of a potentially life-saving intervention. As a nephrologist and internist, I am well aware that many decisions made by doctors every day not only have no RCT to support them, but that doctors are also using drugs off-label and attempting salvage with some hair-raising interventions, after their suppressive treatments have ended poorly.

As an example, consider the effect of antibiotics, which can and do lead to a superinfection named CLOSTRIDIUM DIFFICILE (c-diff) colitis. The procedure entails placing fresh fecal matter into an infected, inflamed and edematous colon (via the stomach, through the mouth) in attempt to reverse the problem caused by the doctor’s original intervention, the antibiotic. Can you imagine if a naturopath or any alternative practitioner ever attempted such a feat as fecal transplantation?
Another noteworthy medical intervention that allopaths commonly employ includes the placement of maggots into infected and gangrenous wounds when antibiotics are no longer useful or the bacteria have become resistant. Conventional medicine is rife with bizarre interventions that are well accepted, and usually involve an expensive drug, biological agent, and hefty fee for the doctor.
Vitamin C has been labeled dangerous, yet nobody seems to be able to produce the victims of its treatment. Currently there is a form of vitamin C called LIPOSPHERIC VITAMIN C or liposomal vitamin C that is taken orally and achieves tissue levels as high or higher than intravenous vitamin C. Kidney stones are a theoretical possibility yet have never been shown to be a true risk in the use of vitamin C. Hemolysis can occur in the rare disorder called glucose 6 phosphatase dehydrogenase deficiency (G6PD deficiency) if mega doses of vitamin C are given- yet there are cases of even those people tolerating vitamin C when they are deficient. It should be noted that when a person is in the midst of a toxin-mediated disease, the vitamin C is rapidly used up and has a low likelihood of existing in high enough concentration to cause problems.
While I do not mean to brush off the potential complication of G6PD in this small segment of the world’s population it is irrational to withhold vitamin C on this basis.
The follies among the allopaths would be entertaining were it not for the collateral damage they leave in their wake. However, we still need to establish the probiotic strains and doses that provide the best results, and determine the safety of probiotics in immunocompromised patients.”The issueAntibiotics treatment is known to disturb the beneficial bacteria that live in the gut, and it may allow other harmful bacteria like C.
Probiotics taken in conjunction with antibiotics reduced the number of people who suffered diarrhoea by 64%. As much as I’d wish to say otherwise, the efficacy data for probiotics in preventing C diff relapse are marginal at best. Rabbit vets have been treating rabbits in GI stasis with this method for at least a decade–my rabbit Mojo donated to the cause at one point. And BTW, if you understand the biology and the difference between tapering (makes no sense) and pulse dosing you can >99% of patients through this with those dreaded antibiotics. She went to the outpatient department in the local hospital for a routine endoscopy, for a problem she never had, and was infected by Clostridium difficile. They have been greatly overused in the treatment of minor infections, however, including viral infections, for which they are worthless. I was told that FloraStor was stocked in the hospital pharmacy, and was covered by Medicare, but rarely prescribed. They provide assistance through promoting cell receptor competition, encouraging healthy competition for nutrients, inhibiting the adherence of pathogens to the mucosal membrane, lowering colonic pH (a more acidic environment favoring the growth of nonpathogenic species), stimulating of immunity, and producing disease-reducing antimicrobial substances. Probiotic formulas using multiple strains are more than twice as effective as single strain products. To be effective, very high doses of at least 15 billion units are necessary several times daily.
This is true, which is why large dosages are necessary and why they are best taken with food.
Williams is a pioneer in integrative and functional medicine, the author of six books, and a practicing clinician with over 100,000 patient visits. C.diff is an infection that mainly affects the elderly, and causes severe digestive problems such as cramping, diarrhoea and nausea.
The procedure involves extracting bacteria from a health donor, usually a relative, which is then cleaned in a laboratory and packed into triple-gel coated capsules. The bacteria are contained in as many as 24-34 capsules, which the patients swallow and the pills then colonise the colon with a variety of bacteria. Doctors are now testing ways in which to store the bacteria without killing it, such as freezing to enable it to be stored and shipped to anywhere that a patient required it.
Dr Donskey summarised the exciting research by saying, “This approach, to me, has wide application in medicine.
We do not have these capsules in the OptiBac Probiotics range – and if they become available to the public it would most likely be through a hospital or university, as bespoke capsules taken from family donors are required for each individual. Back in November 2014 the capsules were still not available to the public, as you mentioned. There was not much published literature, but there were a lot of theories about how the body’s bacterial population influenced overall health. By the time my book was nearing completion in 2012, I had to re-write the whole chapter because of all the new scientific studies!
Put simply, probiotics are good bacteria that are supposed to live in your intestinal tract. In 1965, researchers coined the term “probiotics,” though the concept and use of beneficial bacteria to promote health had been around since the early 1900s.
They provide fuel for the probiotics already living in the intestine, favoring the good bacteria over the harmful ones.
Fructooligosaccharides (FOS), which occur naturally in garlic, onions, green bananas, zucchini, watermelon, and peaches, are another type of prebiotic. However, it is my experience that those who suffer from IBS-D (diarrhea predominant) or who are FODMAP-sensitive do not tolerate prebiotics; it exacerbates their diarrhea. In order to fight these invaders, the cells in the small intestine tightly line up next to each other, forming an impermeable barrier.  Probiotics assist the cells in maintaining these tight junctions.
Openings created between the cells may permit proteins or toxins cross the intestinal barrier. Further down the GI tract, they must adhere to the surface of the small intestine and effectively populate the colon. Yogurt is the most common and familiar form of probiotic, which contains primarily Bifidobacterium and Lactobacillus species.
However, if a patient is actively experiencing gastrointestinal symptoms from a known disease or disorder, I typically recommend they add an over-the-counter probiotic supplement to their daily regimen.
Once the probiotics are released, they can adhere to the intestinal wall and support immune system function. However, one difficulty in creating a clinical trial is the wide variety of yeasts and bacteria species available. When independent companies test products, they find wide variability in the quantity and potency of live bacteria in each capsule. I do not recommend one particular brand over another, primarily because information changes quickly, and specific probiotics may be better-suited for a particular medical condition.
Scientific studies have determined health benefits from 50 million to over 1 trillion colony forming units (CFUs) per day. Strain, quantity of CFUs, serving size, health benefits, proper storage conditions, expiration date, and additional corporate contact information should all be included.
It may take two to four weeks for those symptoms to subside while the good bacteria insert themselves into the intestine. Charcoal tablets taken about two hours after the probiotics can help bind and remove the toxins.
I have first hand experience of its effectiveness and there is old literature to suggest that even low doses of Vitamin C help reduce the severity and duration of the cough. Here is a very good BLOG regarding the failure of whooping cough vaccine that I wholeheartedly agree with. This is an intervention that carries its own risks, including alteration of bowel flora, drug reactions and possibly even worsen the cough. It is our opinion that it should be given further trial in all cases of whooping cough regardless of the age of the patient, or the length of time already elapsed since the original symptoms.” He also used very low doses of cevitamic acid.
Given that pertussis is a toxin-mediated disease, these low doses would not have reached anywhere near saturation. However, I have a friend who has been taking care of very young infants and children for thirty years using high dose vitamin C and they have not lost or damaged one of these children. If such a study was ever performed, it would have to be unblinded and open-label in order to minimize the risk to the untreated. C-diff colitis is caused by antibiotics, the same ones that can be used in pertussis, and it carries a 50 percent mortality rate.
No long-term follow up has been done to reveal any other complications of such a treatment. Women were taking it off-label for “idiopathic pulmonary fibrosis” years before any RCT was done. It seems very odd to me how viciously vitamin C has been attacked given that it is both safe and easily available. It works beautifully in infants and children for whooping cough with no side effect except the occasional greasy stool when the body becomes saturated. This potential risk is minimized by hydrating with lemon water to alkalize the urine so that oxalate cannot drop out of solution and crystallize.
Mind you, there are no drugs in the Physicians Desk Reference (PDR) without far more common risks and definitely more side effects than vitamin C. By relying on the comfort of fecal transplantation, it is no small wonder that they need to hammer away at one of nature’s cleanest and most effective medicines known. The 3 remaining patients received a second infusion with feces from a different donor, with resolution in 2 patients.

And remember, the people referred for these procedures were horribly weakened by recurrent C diff, and many had severe underlying medical conditions.
Our first referral was an 84-year-old man with two forms of cancer, diabetes, and 5 episodes of recurrent C diff, bad enough that he’d lost more than 15% of his baseline weight.
Just look at all the various euphemisms out there for this procedure — intestinal microbiota transplantation, fecal biotherapy, bacteriotherapy, human probiotic infusion. The first sign that some thing was wrong was fever, for which she was treated with antibiotics, which propelled the nasty bacteria into overproduction. Even when necessary, they dramatically alter gastrointestinal flora—the zoo of friendly and not-so-friendly bacteria that live in your gut.
It strikes about a half-million Americans each year, and hospital records indicate it causes more than 30,000 deaths a year in the United States. Based on my recommendation, her doctor ordered FloraStor, a yeast-based probiotic called Saccharomyces boulardii.
She was in and out of the hospital for two years before she finally succumbed to the consequences of the disease. The evidence the researchers found suggests that preventive treatment with probiotics greatly reduces C.
A tougher strain, Lactobacillus sporogenes, also called Bacillus coagulans, is somewhat antibiotic resistant and is also able to tolerate the acidity of the gastric environment, assuring that more probiotic bacteria reach the intestines. We encourage you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
It affects up to half a million Americans each year, of which around 14,000 cases will be fatal. The concept is not a million miles off our daily products – For every day and For every day EXTRA Strength, because they contain a variety of different types of friendly bacteria which have been shown to survive stomach acid when taken with a meal, and to colonise in the gut to give beneficial effects. Of all the strategies I discuss with clients, adding probiotics has resulted in the most significant decrease in chronic diarrhea. Beyond the benefits of carbohydrate, protein, fat, and calcium contained in the yogurt itself, it contains active cultures of L.
Once the foreign invaders are inside, antibodies are created as the immune system is activated.
However, fermented dairy beverages such as kefir actually contain a higher concentration of live cultures. In scientific studies, many probiotics are used individually or in combination with other bacteria or yeasts. The following table presents different conditions and the species of probiotic which has been scientifically studied and proven effective for that particular disease or disorder. One exception: you may continue to take a yeast probiotic (such as FloraStor®), with your antibiotic. It occurs when the bad bacteria are dying off and the body is unable to release the toxins quickly enough. It is my opinion, based on conventional information that this approach is unlikely to make much difference in the presence of pertussis. To me, it makes no sense that more vaccines are tossed to the world as a solution to the problem, simply because doctors and health officials have nothing else to offer.
Thus far it appears that the new vaccine will simply be added to the current vaccine schedule rather than used as a replacement. The reason most cited for using antibiotics in pertussis is not actually to treat the disease so much as to limit the spread, and data on that remains sketchy. There are thousands of happy mothers out there who know that vitamin C saved their children from suffering the feared ravages of pertussis- even in very young infants.
I believe that after just a few days the placebo half would quickly reveal the detriment of withholding vitamin C. This is a terrible and dreaded outcome of antibiotic use, though by far not the only dreaded outcome of antibiotics. The goal of this treatment is simply to snuff out the fire that the original treatment set.
However, if that same patient should die or develop worsening infection in the hands of an allopath, the judgment would be that every available treatment was offered.
HERE you will see that the majority of pulmonary fibrosis is idiopathic, but what is known is that doctors are causing most of what is not idiopathic. Could it be because vitamin C is not patented and because it leads to an improvement in overall health that FDA HAS COME DOWN SO HARD AGAINST ITS INTRAVENOUS USE? But there is a clear double standard regarding concern over G6PD when using vitamin C compared to many commonly used drugs, where use is never considered a risk, even though it is. If grandma develops protracted c-diff from the antibiotic she was given for being a contact of a pertussis case, even though the Cochrane database suggests it is not evidence based, her prescribing doctor need not worry. The occurrence of antibiotic-associated diarrhea (AAD) occurs in about one third of people who take antibiotics. This bacterium releases a powerful toxin that causes the lining of the colon to become inflamed and bleed.
This simple tropical strain of yeast, first isolated from lychee and mangosteen fruit in 1923 by French scientist Henri Boulard, saved my mother’s life.
Formerly from San Diego, he now resides in Sarasota, Florida and practices at the Florida Integrative Medical Center.
While this has prevented many types of dangerous illnesses, it has resulted in fewer beneficial bacteria living in our gut as well.
Many autoimmune and gastrointestinal disorders have been linked to leaky gut syndrome; these include Crohn’s disease, celiac disease, Type 1 diabetes, psoriasis, and eczema. In today’s marketplace, you can also find probiotics in soup, cheese, energy bars, even cereal. Studies have shown that some species are more effective in treating a particular disorder or disease.
In the short-term—days to a few weeks—these toxins can exacerbate the symptoms being treated and cause more gas, bloating, or diarrhea. Because both vaccinated and unvaccinated people get pertussis, we need a safe and effective treatment when the cough occurs. The CONSENSUS is that antibiotics may limit the period of infectivity but do not alter the clinical course and are not indicated in close contacts. Allopathic medicine is mainly concerned with getting rid of the problem at hand, rather than looking deeper and broader into the health of a person over the long term.
Or as you can see in the slide above, the death would be considered due to an “unrelated illness.” By the time a patient develops c-diff there are always “unrelated illnesses” that could be blamed.
As you can see from THIS ARTICLE many commonly used drugs today can pose a risk to the rare person with this disorder. The science bloggers and quackbusters will turn the blind eye as she is rescued by a homemade poop cocktail. A severe form of AAD is Pseudomembranous colitis, an infection of the large intestine associated with an overgrowth of Clostridium difficile antibiotic resistant bacteria.
This, in turn, leads to horrible watery, often bloody diarrhea, which results in dehydration. They may also create their own flu-like symptoms including headache, joint and muscle pain, body aches, sore throat, general malaise, sweating, chills, or nausea.
Most cases that come to treatment have already been coughing and spreading the disease, and antibiotics are of limited if any use. What seems most repulsive about this treatment is that it involves taking a fresh bowel movement from a donor, filtering out the large particles using a coffee filter, putting it in a household blender, adding saline and then dosing the raw fecal matter into the recipient through their mouth using a tube inserted into the stomach. I have yet to see a patient screened for G6PD disease prior to being given these commonly used drugs that include phenytoin(dilantin),antimalarials, sulfonamides including sulfamethoxazole used in Bactrim, nitrofurantoin a commonly used urine infection drug, quinine, salicylic acid, vitamin K and many more. This particular study was carried out on 27 patients and cured all 27 of them, despite strong antibiotics not being able to help. Yet we still see antibiotics being used rampantly in all contacts, and in infected children who have had the infection long enough that they have already passed the stage where antibiotics would render them non-infectious. Most patients think nothing of this treatment, because by the time the need it, they are very desperate. No matter, Pfizer’s income swelled nicely after this non-evidence based practice came about. You will also see on that table that ascorbic acid (vitamin C) is not among the most risky precipitants. If a child is admitted to a hospital with pertussis, the first intervention will be an antibiotic, even though there is no proof that the clinical course will change. Probiotics are not embraced by the conventional medical community, but in the case of c-diff, some doctors will bend and use them. Professor Thomas Borody, a pioneer in the field of fecal transplantation says “By the time I see them, they’ve often been sick for anywhere from six months to two years, so they’re quite desperate.
Vitamin C and edible clay are two very effective remedies that neutralize and absorb toxins. As you can see, this criticism needs to be viewed within the bigger picture, and in context. Most medical doctors would consider vit C and clay voodoo- but for some reason, fecal transplantation is considered an acceptable option.

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