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The menstrual pain drug fenamate protects mice against Alzheimer’s disease, reversing brain inflammation and memory loss.
It is estimated that 1 in 14 people will suffer from Alzheimer’s-related dementia above the age of 65.
It was only recently when researchers found out that brain inflammation is a key component to understanding and trying to find a cure for Alzheimer’s. These plaques are a sticky toxic buildup that accumulates outside nerve cells. They can appear decades before the patient is diagnosed with the disease. As soon as inflammation and not amyloid plaques was determined as a key aspect to treat the disease, efforts went into finding some mechanism to deal with it. The Medical Research Council alongside the Alzheimer’s Society funded the study that resulted in a reduction of inflammation in the brains of mice.
Twenty transgenic mice that developed symptoms of Alzheimer’s were used in the study.
The research concluded that inflammation dictates the progression of Alzheimer’s disease and that the NLRP3-inflammasome is vital to this process, while the NLRP3-inflammasome was able to be inhibited with fenamate.
The final stages of Alzheimer’s render the patient bed-bound and unable of taking care of itself. It is the first time that researchers act upon the NLRP3 inflammatory pathway which causes damage to brain cells.
NSAIDs are known to cause adverse effects in people with irritable bowel syndrome and other gastrointestinal conditions.
So far, very few new Alzheimer’s disease therapies have been proven to be successful enough to be applied at a clinical level.
But determining that a common NSAID such as mefenamic acid is able to act upon one of the most severe and common diseases known to exist is very promising.
Customized genome editing a€“ the ability to edit desired DNA sequences to add, delete, activate or suppress specific genes a€“ has major potential for application in medicine, biotechnology, food and agriculture.
Understanding how various cell types differentiate themselves during development is one of the fundamental questions in developmental biology. Bacteria that cause tuberculosis, leprosy and other diseases, survive by switching between two different types of metabolism. In the first large-scale and comprehensive study on the impacts of transporting honey bees to pollinate various crops, research from North Carolina State University shows that travel can adversely affect bee health and lifespan. Early detection and treatment of hearing loss can mitigate the severity of deafness and could improve the condition of those suffering from the condition.
As aged people are more prone to develop hearing impairment, the sales of hearing aids are directly impacted by the current geriatric demographic dynamics in worldwide. Regionally, Europe has been exhibiting the most attractive opportunities for companies in the hearing aids market. However, the market in Asia Pacific is expected to grow at a fast pace during the forecast period. The market overview section of this report analyzes market dynamics such as drivers, restraints and opportunities that influence the hearing aids market in the current and future scenario. Based on product type, the hearing aids market has been segmented into behind the ear, receiver in the ear, in the ear, and canal hearing aids. Geographically, the hearing aids market has been differentiated into five major regions: North America, Europe, Asia Pacific, Latin America, and Rest of the World. The report provides market estimation of the hearing aids market in terms of revenue (US$ Mn) for all the segments and sub-segments, with CAGR % for the period from 2016 to 2024, considering 2015 as the base year.


The report concludes with the company profile section, which includes company overview, financial overview, product portfolio, business strategies, and recent developments for market players. Virtual microscopy may be defined as the process of placing microscopic images on computer networks that can be viewed by a large number of people across different locations. Traveler’s diarrhea refers to intestinal and stomach infection and occurs due to unsanitary conditions during handling of food. Orthotics is a medical field that deals with designing and construction of orthoses which is an external support to modify, control or immobilize movement. Cartilage is the tough, complex but flexible living tissue that covers the bony surface of joints. Use of images for any purpose including but not limited to research, commercial, personal, or non-commercial use is prohibited without prior written consent. David Brough from The University of Manchester, was published in the journal Nature Communications. Up until January, researchers were not able to find a successful treatment for Alzheimer’s.
Researchers could eventually conduct human trials to finally find a cure for Alzheimer’s disease, which is one of the most common types of dementia.
Non-Steroidal Anti Inflammatory Drugs (NSAID) have elevated researcher’s expectations. These drugs interact with diuretics and are known to cause hypocoagulability and hypertension. Blocking the NLRP3-inflammasome by applying mefenamic acid in mice paves the way for developing treatment procedures for humans. Its symptoms include language detriment, loss of problem-solving skills and other cognitive behaviors that are fundamental for a person to carry out daily activities. The main method of diagnosis consists in finding accumulated fragments of beta-amyloid in the form of plaques. They suggested that Alzheimer’s is able to be diagnosed way before episodes of memory loss become apparent. Further, accurate targeted insertion will improve the safety of gene therapy in human patients in the future. Subscribe to the mailing list and get a daily update with the most important news about General News! As per World Health Organization, in 2015 the hearing aid production globally, hardly met 10% of the total need and a meager 3% of demand across developing countries. Between 2016 and 2024, the global hearing aids market is thus expected to surge at a CAGR of 4.5%.
In the last of few years, the awareness level among patients and their families regarding hearing impairment has considerably increased. The prevalence of considerably high unmet medical needs and the rising investment in the health care infrastructure create immense opportunities for sale of hearing aids in Asia Pacific. The hearing aids market report comprises an elaborate executive summary, which includes a market snapshot that provides information about various segments of the market. The stakeholders for this report include companies involved in the manufacturing of hearing aids. Market share analysis among the market players is analyzed to signify percentage share of the major players operating in the hearing aids market. Furthermore, the report incorporates market attractiveness analysis, by geography, that depicts the most attractive and significant region in the global market in 2015.


Articular cartilage, fibro cartilage and elastic cartilage are the three different types of cartilage present in the body. It revealed that mefenamic acid, a very common anti-inflammatory drug used for treating menstrual pain, had a promising effect when applied in rodent models. Developing a dedicated Alzheimer’s drug based on mefenamic acid is now a very distinct possibility.
Although there is yet no evidence that this procedure will also work for people, expectations are high.
The disease is known to progress and affect more basic functions, such as swallowing, evacuating and walking. The new system can be also applied to other purposes such as production of livestock, fishes, plants, and microorganisms carrying useful traits.
This provides the global hearing aids market with substantial opportunities to gain from in the forthcoming years. This, combined with the recent advances in the hearing aid technology, is boosting sales of hearing aids worldwide. The presence of a large pool of aged people across Western Europe and the increasing willingness among consumers to spend on advanced medical devices have helped Europe attain the lead in the global hearing aids market.
Besides this, governments across emerging economies are making considerable efforts to educate people about conditions such as health impairments have fuelled demand for hearing aids in the region. However, in the forecast period growth exhibited by the pediatric segment is expected to be faster due to the rising prevalence of hearing loss among children. The report also includes key market dynamics, such as drivers, restraints, and opportunities, affecting the demand for hearing aids products globally. For providing a snapshot of this market to the stakeholders, executive summary section is included in this report, which summarizes the market size, trends, and competition in different regions. All these factors will help the market players to decide about the business strategies and plans to strengthen their positions in the global market. It is the first time a drug shows the capability of reducing the inflammatory symptoms of Alzheimer’s, which contribute to the development of the disease. Furthermore, the advent of rechargeable hearing aids with long lasting and quick charging features will also augment the market’s growth.
The fact that several of the prominent names in the industry are domiciled in the region has also augured well for the market. As per TMR, the regional market is expected to rise at a CAGR of 5.2% between 2016 and 2024. Comparative analysis has also been included in the executive summary that resembles the percentage market share of each regions in 2015 and 2024, respectively.
A detailed qualitative analysis of the factors responsible for driving and restraining the hearing aids market in various regions has been provided in this section. Much of previous research efforts have focused on detecting the disease as soon as possible.



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