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Correcting the altered permeability can have an immediate effect on relief of symptoms and a gradual improvement in the underlying condition.A  We just cannot overlook the important connection between the health of the human body and the integrity of the gut wall. So, the anti-gliadin tests can indicate a leaky gut and a positive anti-gliadin test DOES indicate that a person is mounting an immune response to gluten proteins in their blood stream.
Now, that may or may not lead to celiac disease, which by definition is a condition where the intestinal wall is damaged when a person eats gluten (but casein can also cause villous atrophy in and of itself). Thanks for sharing this information, I have just discovered I have been suffering from a Leaky Gut for years and suspect my children are too. I learned I had leaky gut when I tried Lyn-Genet Recitas’ The Plan which is supposed to eliminate inflammation in the body by seeing what foods you are reactive to. While the first step in this healing process is unquestionably to change your dietary habits in order to stop any further damage to your gut, taking the following eight supplements can be very beneficial in aiding in and speeding up the recovery process of healing of a leaky gut. Proteins and toxins from undigested food particles then leak through and make it into your bloodstream.
Certain foods that are harder to digest (grains, gluten, cow’s dairy) increase the likelihood of leaky gut, because they too cause inflammation (and remember, an inflamed gut means the tight junctions in the intestinal wall widen, letting particles leak through).
OTC meds, pharmaceutical drugs, antibiotics, antacids, painkillers: these irritate the gut lining and increase permeability. Grains that contain gluten damage your intestinal lining,A so while you are working to heal your system, stay away from all grains especially ones that contain gluten like wheat.A  Once your gut is healthy,A add grains back into your diet that have been fermented and sprouted. We come into contact with over 80,000 chemicals and toxins every single year but the worst offenders for causing leaky gut include antibiotics, pesticides, tap water, aspirin, and NSAIDS. One of the biggest warning signs that you may have leaky gut can be that youa€™re experiencing multiple food sensitivities.
One particular issue I want to touch on withA leaky gut, is how it can affect the brain.A  If youa€™ve ever seen a child with autism experience a mood swing, this can be caused by intestinal permeability.
Here's the good news, aA damaged gut responds well to certain foods, herbs and supplements, a clean diet and healthy lifestyle choices. These items contain both probiotics and SCFAa€™s that can help heal the gut.A  Pastured kefir, Greek yogurt, butter, and raw cheese are some of the best.
This amino acid has been shown to repair damaged tissue in the intestinal lining, as well as promoting tissue regrowth and regeneration in the gut.
Since leaky gut syndrome contributes to malabsorption of many nutrients, it's important to supplement the diet. Ron Hoggan has a GREAT explanation about celiac disease, non-celiac gluten sensitivity, leaky gut and autoimmune disease in Cereal Killers: Celiac Disease and Gluten-Free A to Z (Chapter 2). Glutamine is great for repairing damage to the gut, helping the gut lining to regrow and repair, undoing the damage caused by leaky gut, and reducing sugar cravings.
That of course varies from person to person and depends on how the gut became leaky in the first place.
You tend to harbor gut infections like parasites and pathogenic bacteria when you have any degree of intestinal inflammation because your gut is your first line of defense for the immune system. For many, this imbalance can begin at birth because of a C-section or because the mother didna€™t have a healthy gut herself. Autism, rheumatoid arthritis, periodontal disease, chronic fatigue syndrome, Crohn's disease and colitis stem from the inflammation triggered by a leaky gut. Minimizing stress, gentle exercise, adequate sleep and slowing down during mealtime supports this healing process. It eases the inflammation in the stomach lining, heals ulcers, and treats both diarrhea and constipation by creating a protective lining on the digestive tract.
Add back in one at a time after 30-60 days (except gluten, which activates inflammatory zonulin activity in the gut!) to see if you react. But I believe my gut issues stem from years ago when I had reocurring diarrhea and stomach aches.
OR, Candida (yeast) overgrowth may occur from poor diet or antibiotics, and candida causes the inflammation that leads to leaky gut. High cortisol changes the terrain in the gut, so it’s crucial to normalize stress hormone levels. Thinking maybe because my diet is so healthy I’m not getting the excessive symptoms as fas as someone would get if they were eating a lot of processed and toxic ingredients.
Ron Hoggan’s latest book Cereal Killers and am so excited to read all about his take on the relation of leaky gut and auto-immune diseases. Whatever else is in your small intestine (yeast, other toxins, bacteria) can leak into the bloodstream too, adding to your toxic load and making you feel crappy. And, when you compare this approach to the allopathic one of drugs with typically no healing and continued progression of symptoms, it’s clear which path makes the most sense. I feel I can attribute my issues to a leaky gut, because many with Inflammatory Bowel Disease (IBD) simply need more than diet modification + supplements to help them along.
Yeast infection may even be a condition known as vulvodynia until your remedy heal candida leaky gut is complete and infection is one that's. Wow!  I hope all of you got a chance to listen to some of the speakers from this online event which took place Nov. What happened was that I got a huge load of mercury when I was in China which triggered an immune inflammatory process, destroyed my gut, and led to severe symptoms and muscle damage and mitochondrial injury. Through my own journey I figured out how the body works, how it breaks down, what the causes of disease are—not just from a theoretical perspective, but from a cellular perspective.
So we looked at the causes, and we said, “Gee, it’s mercury and gluten, leaky gut…” she had tremendous overgrowth of yeast in her gut, so we had to kind of fix her gut. And I think the things we really think about are, “What are the toxins?” Like this woman I mentioned, she had high levels of mercury, there was this immunotoxin that caused inflammation.  We measured how her cells—her lymphocytes—were responding to mercury, and we saw that they were really upset that the mercury was around. We don’t really get the opportunity to appreciate the simple fact that inflammation underlies things like Alzheimer’s now affecting 5.4 million Americans and inflammatory disorders really for the most part, not a genetic disorder, not a genetic inheritance issue, but perhaps some genetic predisposition, but more importantly, absolutely, fundamentally related to our lifestyle choices that increase inflammation, and these are centered upon, for example, the very foods that we eat, leading to inflammation throughout the body, and clearly, being related to developing an incurable disease, at least, as you and I have this conversation, called “Alzheimer’s,” related to the foods that we eat.
Depression, for example, is now looked upon as a smoldering inflammatory event in the human brain brought on by leakiness of the gut.  So, how incredible it is, Dr.
There are obviously pathways that selectively allow things to get in that we need, but when those junctions have been traumatized by, in this case, glycation of proteins from having too high of a blood sugar, then things like proteins, and as I mentioned before, LPS (which is the covering of the gram-negative bacteria) get in to the systemic circulation and just beef up inflammation, and that basically sets the stage for things going on fire.
So, we’ve got to really start pay strict attention if we’re going to have leverage points in neurological conditions like ADHD and autism, Parkinson’s, multiple sclerosis, and Alzheimer’s.
Now, maybe this is a discussion that people might be uncomfortable with, but we’ve got to get over that because this is marking that child for the rest of his or her life.
Now, there is also research that indicates that you don’t undo the damage to the microbiome or the gut bacteria by breastfeeding. I think, more information remains (to be discovered) with the topic of this summit that is autoimmunity, and to be super clear, autoimmunity is a delicate balance between a malfunctioning immune system that’s either too active or one that is underactive, in which case we’re susceptible to all kinds of infection. The second component is an environmental trigger, something that is mismanaged by the immune system because of its genetic makeup. We start really to get more insights of what it takes to develop autoimmunity and that would allow us to learn the third pillar—loss of barrier function by the intestine—that becomes more permeable and therefore allows these enemies to more easily gain access in our body and therefore to be exposed to the immune system that can react in an inappropriate way. By the same token how can you permit that a molecule like gluten, for example, that’s much larger than what can come into our body, get access, and induce an immune response, unless something goes wrong in terms of gut permeability? The intestine being the largest interface with the environment is where most of this crosstalk occurs, and this long tube is covered by single-layer cells that represent this interface with the environment.
When they discovered zonulin, they discovered this could be the key of these doors if and when it’s in the picture, then we start to appreciate more and more the physiology of the mechanism.
Again, the reason why this (idea) has really been hard to accept, is because this completely revolutionized the concept of autoimmunity.
He’s a chiropractor and has a thriving practice in San Diego, helps train physicians and chiropractors around the world. What happens is the practitioners and insurance companies don’t really authorize or perform the thyroid antibodies, and the patient then leaves thinking they have a metabolic disease and not knowing they really have an autoimmune disease.
There’s less than nutritional things you can do specifically for some of these pathways, and just recently, in the laboratory, we’ve really discovered something really profound and we’re waiting to publish it, but we’ve been checking monoclonal antibodies to TSH receptor—TSH, T4, T3, 5’deionase—and we cross-reacted with 200 different foods.  So, we just got 40 new foods that we know cause molecular mimicry with thyroid, and we’re readying the manuscript to get it published. The point is that we’re doing some research now that’s really going to cause some breakthrough in our understanding, but we’ve also done monoclonal antibody testing now with various chemicals. So, we found that a lot of Hashimoto’s people, for example, can’t take a bioidentical source like Armour or Nature-Throid because they can’t handle the T3 in it. So, what we see for the most part is we see a lot of Hashimoto’s patients develop cerebellar degeneration, and what happens to them is the cerebellum starts to get degraded through this autoimmune process. By looking at antibodies in her blood, she had 10 times higher levels of antibodies against these two bacterial toxins, compared to any other individual who had the same age, and they were healthy at that time. Avoidance of wheat or becoming "gluten free" within the diet is becoming increasingly common - but what is the evidence saying about prevelance and reality of this issue beyond the hype and trendiness?
Gluten-related pathologies range from immune-mediated conditions, such as coeliac disease and wheat allergy, to non-coeliac gluten sensitivity. A recent review on intestinal microbiota and probiotics in coeliac disease (CD) revealed that research into CD and the effect of gluten on the intestinal-immune health in adults has only been studied since 2012; prior to that children were the cohort subjects. Probiotics modulate the immune response in children suffering from coeliac disease by reducing the pro- inflammatory cytokines according to a recent double-blind, placebo-controlled trial.
Eczema actually refers to a group of conditions that leave the skin red, itchy, and inflamed.  There are many different types of eczema but the most common form or eczema is Atopic Dermatitis or Atopic Eczema. The National Institutes of Health states that the prevalence of eczema is increasing from 9 – 30% of the population affected by it. Eczema is typically seen in young children and in infants and many children out grow the condition by the age of 2; however, some individuals continue to experience symptoms of eczema on and off through out there entire life.
Infants that are affected by eczema can have rashes that ooze or crush and this may be on the face or the scalp. The exact cause of eczema is unknown, but it is thought to be due to the body’s over active immune system responding to some sort of allergic trigger.
Depending on how we study this question you might have a different answer, in other words if we look only at the symptoms we would say Eczema is caused when the babies body does not  produce enough ceramides. The composition of a child’s bacterial flora is dependent on the mother’s microflora, since she is the primary source for the child’s bacteria at the outset.
Friendly bacteria that is needed by the intestinal tract and digestive system can be added to the childs diet through Probiotics. In 2007 The Journal of Clinical & Experimental Allergy reported that infants that started priobiotics after birth had less incidence of eczema at the age of 2 when compared to infants that didn’t supplement with probiotics.
Also The Lancet, conducted a study in 2001 were they gave probiotics to pregnant women who had at least one first degree relative with atopic eczema.  At 2 years of age the frequency of atopic eczema was 50% less than the mothers that did not consume probiotics during pregnancy.
When we have imbalances in bacteria we can see health conditions throughout our entire bodies.
Leaky gut syndrome occurs when the lining of the intestinal tract, which is typically tight and only allows a few selected small particles to pass through into the blood stream becomes “LEAKY” small holes.  This allows partially undigested food to enter into the blood stream. Leaky Gut Syndrome is often times caused by an imbalance between good and bad bacteria.  Overgrowth of bad bacteria and yeast can cause the cells of the intestinal tract to shrink leading to a LEAKY GUT. One Wellness Place Probiotics are pharmaceutical grade probiotics that provide 5 different strains of beneficial bacteria. Fish Oils and Omega 3 supplements are very helpful to treat Eczema and help to improve balance and help with symptoms. Eczema outbreaks can usually be avoided or the severity lessened by following these simple tips. Ultimately, healing the gut should be the primary focus of many autoimmune diseases today.A  This will go a long way in reducing the inflammatory and immune processes involved in such diseases.A  We need to ensure that we are treating the underlying cause and not just masking the symptoms!! I have just found out I have nutrient deficiencies, bad digestion, sluggish liver, severe candida and leaky gut to top it all off!!!
Our gut is full of a€?gooda€?and friendly bacteria that help us properly break down and digest our food. It’s a standard warning they have to put on every supplement, but it does not contain lead. The component of dairy that will harm your gut is the protein A1 Casein, as well asA the pasteurization process thatA will destroy vital enzymes making sugars like lactose very difficult to digest. Finally, one of the leading causes of leaky gut is a condition called dysbiosis,which means an imbalance between beneficial and harmful bacteria in theA gut. This allergic response doesna€™t mean youa€™ll break out in a rash, but it can lead to one of the symptoms Ia€™ve mentioned above.A  And, if left un-repaired can lead to more severe health issues like inflammatory bowel disease, IBS, arthritis, eczema,A psoriasis,A depression, anxiety, migraine headaches, muscle pain and chronic fatigue. This is also why leaky gut has been linked to other psychological disorders such as anxiety, depression and bipolar disorder. Probiotics are myA number one item on fighting Leaky GutA due to their proven health benefits in the intestines.
These foods contain organic acids that balance intestinal pH and probiotics to support the gut.A  Sauerkraut, Kimchi, and Kvass are excellent sources.
I have managed to heal my leaky gut through supplements and diet but I still have annoying thrush and a severe B12 deficiency, my GP is useless, I am currently saving up to see a Holistic Nutritionist. Myersa€™ method in diagnosing and treating gut infections in order to achieve optimal gut health.
Gluten &A Casein-Free Dieta€™s have proven effective for many children with autism because these proteins can leak through the gut and act on the brain similarly to an opioid drug.
I personally think the best can a patient do when suffering from leaky gut syndrome is to take a Vega Test (performed by alternative medicine practitioners) and see the underlying causes such as how bad is intestinal dysbiosis, the most damaged organs in terms of inflation, the accumulation of toxins and start a treatment accordingly. Caprylic acid is known for ita€™s antiviral and antifungal activity.A Candisol contains a combination of plant-based enzymes that break down the cell walls of Candida. YOUR PURCHASE HELPS SUPPORT MY WORK IN BRINGING YOU REAL INFORMATION ABOUT NUTRITION AND HEALTH.
Taking a highly concentrated dose (25-100 billion units a day) of probiotics on a daily basis can help you regain a healthy balance of bacteria in your gut. Remember that continuously eating foods you may have sensitivities to exacerbates leaky gut and causes continuous immune system firing. First, it works better than any other stomach product I tried but then I learned it can caused reproductive damage due to a lead content, which is why it is not for sale in CA. So either the inflammation contributes to gut infections, or the gut infections cause the inflammation. Oz Show, unless that’s a big secret I hope to not be spoiling…Editor of the Huffington Post, and the list goes on and on… Linus Pauling award winner, really the person who I believe has helped bring functional medicine to the mainstream and really is the pioneer leader of getting the message out. Mark Hyman: Well actually, in fact, I had a version of an autoimmune disease, an inflammatory condition where I had autoimmune antibodies and my body had broken down.
And so I had to literally figure out how to fix myself from the ground up, and no one had really mapped this out very well. My own body was the living experiment that I used to actually try all this stuff out, and see it work!  So many people suffer needlessly, and that’s what drives me.


Amy Myers: So, in your 15 plus years practicing functional medicine now…have you seen a rise in autoimmunity in your clinic? Amy Myers: So, based on the statistics you were just giving—and I’ve heard it’s the third leading chronic disease—but based on the statistics you just gave, it sounds like it’s actually the leading chronic disease. Mark Hyman: Well it’s not getting diagnosed because most doctors are not aggressively looking for it, and they often wait until the symptoms are dramatic or extreme. Amy Myers: Do you think part of that is also because they don’t really have effective treatments? And when she came to see me, she had severe rheumatoid arthritis, her auto-antibodies were like—her ANA was 1 to 1280, which is a very high number– she had severe joint pains and rheumatoid arthritis, she had migraines, she had irritable bowel syndrome, she had terrible fatigue, and she was really quite sick.
We had to get rid of the gluten, we had to get rid of the mercury, and over time, she has completely normalized. Mark Hyman: I think, Amy, it’s really important to think about the framework of functional medicine. When the gut is leaky, that is just like turning on gasoline to the flames of inflammation. Myers that you and I are having a conversation about things that go on in the brain and we are exploring the health of the gut as it relates to the brain. And unfortunately, our efforts to take care of these diseases don’t focus on the fire of inflammation. We’ve got to pay attention to what is going on in the gut, and that means we’ve got to pay attention to the overusage of antibiotics that damage the gut bacteria. Amy Myers: I don’t know if you’ve ever seen that movie, “The Business of Being Born,” but anybody watching this if they haven’t and they’re anticipating getting pregnant or are pregnant, I highly recommend it. These are real statistics from peer-reviewed medical literature that are really raising a red flag.
While breastfeeding is also clearly critically important in the development of the gut bacteria, it doesn’t fully offset those changes that are imparted by a cesarean section. Overactivity of the immune system to the extent that the body fails to differentiate between self and non-self—the cornerstone of autoimmunity—is really set by what goes on the gut bacteria.  So, these factors of early life exposure to antibiotics for every sniffle or sore ear that a child might have, the continued push for women to use formula when they’re given samples right when they get out of the delivery room before they leave the hospital, the continued overusage of antibiotics in the production of food, meat, and even as mentioned, this overusage of cesarean section is setting up a generation of newborns for conditions that are life-threatening and in my business, for conditions that threaten brain health, and it’s preventable by getting this information to the population in general. The immune system, in general, is all there to defend us against these enemies that can harm our body, but in people with genetic disposition to autoimmunity, the weapons of the immune system, rather to be directed against the enemy, is directed against your own body.
So again, this concept—others say unforeseen, not really generally accepted, or fully-formed thinking of concepts—was put out there, and the Scientific American article that was published roughly five years ago was indeed, the stone in the pond, and the waves started to move, and nevertheless there was mixed feeling in terms of accepting this concept mainly because this increased permeability, this leaky gut syndrome had been vilified according to the scientific establishment.  Complementary alternative medicine seems to claim that everything that goes wrong is due to the leaky gut, and people have a hard time believing that, and therefore, people had a really hard time to accept the concept. Amy Myers: And so, do you feel that gluten is a problem for all autoimmune diseases or only for celiac disease?
Alessio Fasano: Oh no, I don’t think that gluten is the culprit for all autoimmune diseases at all.
Amy Myers: But leaky gut, you would say, is something that does need to be present in other autoimmune diseases or not necessarily as well? Amy Myers: So, we’ve talked a ton about leaky gut in this summit and every time, your name comes up, but I would love to hear from the man himself, your explanation of what is leaky gut. Why we do that, how this works, how we really open these doors and then we close again, and what typically happens when the physiology’s pushed to the limit, you spin into pathology. In fact, I went to one of his seminars called “The Gut-Autoimmune-Gluten Connection,” and it was a fabulous seminar. Datis Kharrazian: Well, one of the most common autoimmune diseases worldwide is autoimmune thyroid. Amy Myers: One of the biggest things of why people love your book so much is you really talk about people that go on and get (thyroid) medicine, and they’re still not getting better, or their labs are totally normal, but they’re still having a lot of these hypothyroid symptoms. Datis Kharrazian: Well, there are lots of different triggers for autoimmunity, and gluten has become very popular.
In the near future, we’re going to have a very specific autoimmune Hashimoto’s diet because we’re able to identify multiple foods that cross-react.
Amy Myers: Many of the foods (that cross-react) are foods that people are eating on a Paleo diet? Now, we’re getting very specific which chemicals cross-react with which part of the thyroid, and we’re now identifying certain celiac markers versus the transglutaminase 2, 3 and 6 and what part of the thyroid they impact because they impact different parts of the circuit. Amy Myers: Can you tell us about why certain people might not do well with say, Synthroid which is just T4 versus Armour’s T4 and T3 or any particular medication and how conventional medicine is typically checking only the TSH or the TSH and the free T4, not all the other components of the thyroid? Amy Myers: So, you keep bringing up sort of this brain Hashimoto’s or brain thyroid autoimmune connection.
They start to get balance issues, they start to get maybe occasional vertigo, trivial types of movements in their background like things flashing really upset them, they get really sensitive to light, sound, they get all these different types of neurological impairment symptoms. Amy Myers: And what would some of the interventions be that would be specific to the brain?
Amy Myers: Before we get in to all that, I think you have a personal story about how you actually even got involved in autoimmunity and why that became an interest of yours? Amy Myers: Yes, and they are on the rise, so we definitely need to get people educated, so that they can help reverse what they have going on or prevent one from coming.
In either instance, symptoms can range from localised to systemic and may easily be misdiagnosed as seemingly unrelated to their underlying cause: gluten intolerance. In 2000 The Journal of Clinical & Experimental Allergy reported that infants given probiotic supplemented formulas had a significant improvement in atopic eczema skin conditions after 2 months when compared to those infants that were not supplemented with probiotics. I have yet to write a post on this because I am still in my learning phase but iron is so tricky. I know it is different for everybody, but I was wondering how long it takes (on average) to heal leaky gut syndrome. It might have kind of a strange name, but slippery elm has been used as an effective gut healer for centuries in the United States. ItA occurs when the intestinal lining of the gut begins to break down, thus allowing undigested food particles and other things to pass through the walls of the intestine and into the blood stream.
According to the Journal of Diabetes there is a strong body of evidence pointing to leaky gut as a major cause of autoimmune diseases including Type 1 Diabetes.
Candida is a fungus that attaches itself to the lining of the intestines, causing inflammation, irritation, and damage to the mucosal lining of the intestinal tract. Fiber protects the gut while sweeping fungus, harmful bacteria and other pathogens quickly out of the system. I just wanted to write and say thank you for providing such terrific information to those who are actively looking to heal themselves through dietary modification. If you have an inflamed gut or a leaky gut, you wont be absorbing all the nutrients from the foods you’re eating. Toxic waste can also leak from the inside of your intestinal wall into your blood stream causing an immune reaction. Essential fatty acids from fish, flax, or chia are also vital to healing the bowel and reducing inflammation. There is a vicious cycle involved with these internal factors since the leaky gut also causes them or contributes to their severity. Typically, I find that when one follows my 4R Program for healing a leaky gut and adds in the above supplements, it should be about a three-month process.
Physicians and natural medicine practitioners both agree, that the foundation of ourA health is located within the bowel, and combating disease involves healing a distressed and failing gut. For those who feel that you may be suffering from Candida or yeast overgrowth, these are safe, effective, and natural ways to treat Candida.
Amy Myers did an excellent job in gathering some of the leading experts, including researchers and clinicians from the fields of immunology, neurology, gastroenterology, and pioneers in the field of functional medicine for this free educational event.  Topics ranged from likely causes for this epidemic of autoimmune disease we are now seeing to genetics and environmental triggers of autoimmunity as well as diagnostic testing methods and management of these conditions through dietary and nutrient intervention.
Mark Hyman, who is effectively one of my most favorite people on the planet…and really probably does not need an introduction for the listeners out there, but I will give him one as it is.
And I had gone from being super healthy—I was a yoga teacher, I was a trainer for 10 years, I ran five miles a day, I’d ride my bike 100 miles a day.
And I sort of discovered a couple of pioneers in functional medicine: Sidney Baker, Leo Galland, Jeff Bland.
But there are also other toxins, all the chemicals and pesticides, the plastics we’re exposed to—they’re what we call autogens. If you think of what’s going on in the gut in terms of its genetic potential, in terms of what the gut bacteria can do in terms of human metabolism, obesity, inflammation, autoimmunity, that’s where it starts. It’s the same process of creating life-sustaining inflammatory chemicals—there’s a good side to inflammation.  It helps us deal with infection, it helps us immobilize a damaged part, but the downside is when it’s chronic, it increases free radicals, it damages our DNA, our fat, our protein, and leads to tissue destruction. Until recently, I think a lot of interest has been focused on what is called “glycation of proteins,” meaning that the higher your blood sugar is, the more your blood sugar will bind to proteins in a process called glycation. When the gut be­comes leaky—to be technical about it—what happens is there is a coating over what are called “gram-negative bacteria,” which are hugely represented in the gut.
So, it’s all about maintenance of the integrity of the gut lining, whether we’re talking about coronary artery disease, lupus, diabetes type 1, any autoimmune phenomenon, or any inflammatory condition in human physiology, we’ve got to pay very strict attention to all of the factors that play a role in maintaining the gut wall integrity. The explosive overusage of antibiotics in cattle that are then consumed by us—that’s where 70-80% of the antibiotics in America are used. It’s talking about the rise of C-sections in the United States now, and even if you’re not wanting it for just convenience, just how it got into somehow being in labor for 10 hours or 12 hours became unacceptable, and that was too long, or your baby wasn’t delivered right at 40 weeks and you’ve gone to 41 or 42 and suddenly, they have to induce and then when they do, giving that Pitocin then stimulates contractions, get the baby in distress and then it’s creating the C-section. In other countries, it may be as high as even—in one city in Rome, 80% of births are via C-section. These are the types of numbers that women need to understand before they get penciled in for a C-section next Thursday at noon. And even to take it further, the mother’s prenatal diet changes the bacteria in the birth canal, whether she is overweight or not has a dramatic effect on the bacteria in the birth canal, and therefore, that is passed on to the newborn baby. You know, you also have to appreciate that this has been very challenging to put this concept forward so we were really kind of current, and it was an uphill battle, starting with the concept to convince the colleagues in the scientific community in general that celiac disease is an autoimmune disease. With great frustration, we’ve focused lot of attention to find “the genes of autoimmunity,” just to find ourselves with empty hands because the more you search, the more genes come out. A different target organ can develop into a different disease, such as diabetes, MS (multiple sclerosis), or celiac disease. I am an expert in gut physiology and biology, and if you accept, and everybody does, that the main port of entry of this instigator of autoimmunity is the gut…if you don’t have a loss of this barrier function,  I just can’t see how molecules—that need to be large, these proteins, that are instigating the immune response—can get access and be seen by the immune system, because under normal circumstances, the gut has this formidable capability to keep at bay large molecules, potential enemies outside our body.  Therefore, I don’t see how you can instigate an immune response unless physically, the immune system that is within our body and these enemies that are outside are body, see each other, touch each other, and are physically interacting. So, I think that now this is not something that people will see as esoteric as before, so this is taking more and more ground in terms of key elements that you have to have in order to develop autoimmunity. Until the recent past, the space in between cells we thought was completely sealed by sort of cement and then in the mid-80s, the Japanese groups said that’s not the case, there are doors, but they are almost always closed.
That’s when we learned that when this system is out of control, one of the most frequent conditions that you can have is indeed autoimmunity.
Unfortunately, most people that have hypothyroidism never actually get diagnosed as being autoimmune because the standard of care is basically once you identify a high TSH, you’ll just be on thyroid replacement forever. That’s great because we’re already used to that, but there are other foods that cross-react to gluten, and things like rice, things like corn—they can also cause the entire gluten response because they have cross-reactive responses. Some cross-react with 5’deionase and now we have mechanisms for T3 conversion other than cortisol and selenium and inflammatory mechanisms, and then we’ve found specific foods that directly cross-react with T3, which would explain why some people don’t do well or don’t respond to the medications they’re taking from a molecular mimicry mechanism. So, in the near future or through the next year, we will have discovered multiple mechanisms that impact conversion patterns and then receptor pathways and then the use of hormones themselves as part of being available in getting the cross-reactivity from an immune response. When you look at the patients that suffer from thyroid disease, one of the key things is that at some point if their TSH gets tight, it’s really important for them to be on a replacement, and if they are not on replacement, they can accelerate brain degeneration and they can accelerate bone loss, they can develop gallstones. Some of them have such an underlying autoimmunity that as your autoimmunity destroy the thyroid gland, the tissue that’s broken down causes release of thyroid hormones and any additional T3 can make them have more anxiety and nervousness and insomnia.
One of the things that we see in my office, is we see most people that have Hashimoto’s have a pretty devastating decline in brain health, and part of it could be because I just love brain and I like to do brain evaluations on my patients. So, for the most part, what we’re seeing is we’re seeing a lot of thyroid patients end up with poor brain health. They tell us that autoimmunity is the process by which the immune system of an individual cannot differentiate between self and non-self, and thereby, produces antibodies against its own antigens. I was about six years old when my mother had severe infection in the gut, where she was going to so-called a dental technician without having any knowledge that we should not remove any teeth. So therefore, today, it’s very important to talk about the causes of autoimmune disease because when we learn about the causes of autoimmune disease, we can make huge difference in preventing autoimmune diseases.
In addition to being found in foods, probiotics are available as supplements in capsule, tablet, powder, and liquid form.
I now (selfishly) wish they wouldn’t fortify foods with iron and leave that one for the multivitamins. It weakens immune function, increases inflammation, jacks cortisol levels, and all these factors contribute to leaky gut.
Because a major contributing factor to LGS is inflammation in the intestines, reducing the amount of candida albicans which may be present in the gut can make a significant difference in healing. Malabsorption of nutrients, candida and parasitic infections along with food sensitivities and allergies are also connected with this syndrome. The more worksheets and checklists you complete, the more you will able to determine which protocol is best for you.A The focus of this 4-hour eCourse is to provide a detailed understanding of the importance of a healthy gut and the tools to achieve optimal gut health.
You have helped me personally and professionally, so absolutely one of my most favorite people.  So I know that you have a personal story, and most of us do in functional medicine of how we got here. And literally, from one day to the next, my body just fell apart, and I developed severe fatigue, cognitive dysfunction, muscle pain—my muscle enzymes went up, my autoimmune antibodies went up, my ANA went up. I began to learn from them and sit at their feet, go to their clinic, and try and ask for their help, and I slowly started to put myself back together like Humpty Dumpty.
So when you take it as a collective problem and you look at them together, there are 80 autoimmune diseases.
And this is common for these people, but they just treat everything separately, so they see a neurologist for the migraine, a G.I. Those are the key players in brain degenerative conditions like Parkinson’s and multiple sclerosis, Alzheimer’s, and even things like autism, and to some degree, even ADHD so prevalent in Western cultures, and we’re now really getting a handle on the notion that the gut has a huge influence on what goes on in the brain. We measure that, for example, with the playing old-fashioned HbA1c test –the diabetics use to measure their average blood sugar.
When that coating, that goes by the initials “LPS” makes its way to the systemic circulation, it just causes inflammation to go haywire.
And understand that this lining of the gut that is the focus of so much research that really mediates whether things get in or not is one cell thick. So, if you’re suffering from an inflammatory condition, you’re given an anti-inflammatory medication like, for example, a non-steroidal anti-inflammatory medicine, which are used by millions of Americans to treat inflammatory disorders like arthritis, and what these drugs do in the long run is they further damage the gut lining making the fire worse while people, moment to moment, feel a little bit better, but the problem worsens. We’ve got to understand that the very medication we are using to treat inflammation are damaging the gut lining, and we’ve even got to take this back to how you were born. You’ve got to understand that the process of being born, passing through the birth canal is probably one of the most fundamental events in developing a person’s immune system.
That said, we know that women who are overweight give birth to babies who have a higher tendency to become obese.


You’ve heard his name come up left and right in pretty much everybody’s talk about gluten and leaky gut. Again, there was very reluctant acceptance to the concept because the paradigm was, in autoimmunity, it’s something you cannot treat. Celiac disease is unique, because we know the enemy that we don’t know for any other autoimmune disease (that is gluten), and therefore we know that if there’s any way to stop this interplay between the genes and the environment, in this case, by eliminating one of the two ingredients, you can stop autoimmunity.
And again, the reason why, for example, there are a lot of medications that we cannot give by mouth is because they are too large, we have to give by injection like insulin. Only rarely they open to allow short time to make these molecules to go back and forth, and then would be immediately closed. And that’s how pretty much the field of leaky gut and its role in autoimmunity really stem into the new concept, this new mission, in which again, we have these three pillars to develop autoimmunity.  Because without inappropriate antigen trafficking, that continue to bombard your body, there isn’t physically, GI-wise, a way (to develop autoimmunity)—it’s an impossible task.
If there’s any way that you can stop this interplay between the genes and the environment, you can eventually stop and treat autoimmunity. Datis Kharrazian with us today, who many of you probably know if you’re suffering with thyroid disease. Since thyroid disease is really one of the biggest subsets of autoimmunity and given your background in writing the book that you did, I thought it’d be great if we talk specifically about thyroid.  Why don’t we just kind of go over autoimmune thyroid and how does that happen? They don’t really realize that when they have hypothyroidism, they’re actually suffering from one autoimmune disease, and it’s pretty likely that they have others and different variations of it, and things associated with autoimmunity like celiac disease or other variations. So, those people really don’t fall within what everyone wants them to really work which is like a bioidentical hormone with T3.
So, lack of oxygen to the brain is a mechanism, hypoxia of the brain is a mechanism, microglial activation is a mechanism, breach to the blood-brain barrier is a mechanism, impairments in dopamine, GABA, and acetylcholine—these are all various mechanisms. I normally don’t read somebody’s bio, but I think you all maybe a little more familiar with perhaps some of the other speakers, and I don’t want you all to miss out on all the goodness of this gentleman’s background. However, I’m going to add to that by saying that autoimmunity is a process by which the immune system of an individual, due to exposure to environmental triggers (this is the heart of the matter), cannot differentiate between self and non-self, and therefore produces antibodies against its own tissue.
During the infection, he was removing three or four each day.  And so, today, we know he exposed her to many bacterial toxins. However, if we look further we find that there are influences that cause the lack of production, specifically the imbalanced flora of intestinal bacteria health of the child, which is determined by a number of factors including the mother’s microflora. If the mother has a good flora of bacteria, the contact is an important help for the child to be able to be colonized by bacteria in the proper way. But if you have severe leaky gut, you may need to start out getting your fiber from steamed vegetables and fruit.
This can be crucial in helping the intestinal lining heal, as pathogens such as candida and parasites can wreak havoc on the intestinal lining. Now, every time you eat that food and it leaks into your bloodstream, your body recognizes the protein from that food as an invader, your immune system fires, and cytokines are released. Liver function tests went up, white count went down, and my digestion went completely upside down. It has the worst treatments, and we have the best outcomes, and it just drives me crazy that people don’t know about this. We often think, you know—and this is kind of weird in medicine, you have this sort of on-and-off diagnosis.
We say, “What is it that could be bugging you that’s triggering inflammation?” And we need to get rid of that. Microbes, bugs—not just bugs in your gut, abnormal gut flora, which we have like parasites, yeast, bad bugs—but also things like tick-borne diseases and other weird viruses and chronic viral infections.
He’s the author of “Grain Brain,” which I know has really kind of catapulted him into mainstream, which is awesome, and also the author of “The Grain Brain Cook­book” that I think will be out in two weeks?  And Grain Brain is now on its 17th publishing and is in 28 countries, and has been on the New York best seller list for 44 weeks.  Besides all that, he also actually has a very active practice in Florida. Well, it turns out that as a metric, HbA1c—a measurement of your average blood sugar (let’s just say “glycated protein”)—powerfully relates to the rate at which your brain shrinks.
Elevated levels of this LPS, which correlate to dramatic increased inflammation, are strongly correlated with Alzheimer’s, even Lou Gehrig’s disease for that matter. The method of fetal delivery is how we inoculate the gut bacteria from the get-go—that when that child passes through the mother’s birth canal, the bacteria are invested into the mouth to begin populating the gut and that sets the stage for inflammation for that child for the rest of his or her lifetime. These babies inherit, if you will—it’s not Mendelian inheritance, it’s not sperm-and-egg, gene-DNA inheritance—but they inherit the microbiome of mother that does tend to coat for weight gain, gives them bacteria that tend to be more thrifty, that hold on to calories, and that’s a heck of a thing to saddle a kid with.  Rewriting his or her destiny towards obesity just because of the changes that have happened to his or her gut bacteria—the microbiome.
We have some hints that gluten may have a role in type-1 diabetes, may have a role in multiple sclerosis, maybe that is a tangential and not the principal role like in celiac disease, but definitely, we don’t have the undisputable evidence that it can be really responsible for all of this. If you stretch the guts of an adult on the floor, you cover a double tennis court, 3,000 sq. He’s the author of, “Why Do I Still Have Thyroid Symptoms When My Labs Are Normal?” which is an incredible book. What we find is people that have hypothyroidism don’t really get their thyroid under control until they can actually address their autoimmunity.
I think we’ll have a whole new Hashimoto’s diet beyond just gluten because many of the foods that we found are within the Paleo diet. If someone has autoimmunity to their thyroid, at some point, the thyroid gland will be destroyed and they need to get on thyroid replacement; however, the question is, “Which type of replacement?” And you have kind of a spectrum where you have really orthodox conventional people only wanting things like levothyroxines, synthetic T4, and then we have the other side of the spectrum, we have alternative people really wanting natural bioidentical things like Nature-Throid or Armour and things like that.
There is actually molecular mimicry, and recently, we found similar things in our laboratory and through our research, and what we’re finding is that many people that have thyroid antibodies, those antibodies aren’t just attacking the thyroid, but they’re also attaching to the brain; they’re attaching to the cerebellum.
These three, plus stress, and some additional factors play a significant role in the development of autoimmunity.
It can be assumed that certain hygiene measures, such as antibiotics given in some countries in connection with deliveries, in normal cases may have a deleterious effect, since the mother then is at risk to get a skewed bacteria flora, which she passes on to the child,” says Goran Molin, professor of food hygiene at the Faculty of Engineering, Lund University, who co-directed the study with Siv Ahrne, also a professor of food hygiene.
We’re now partnering with the Cleveland Clinic, and we’re doing research in autoimmune disease, so we’re really taking this forward.
Whether it’s arthritis, lupus, inflammatory bowel, MS, Sjogren’s, or vitiligo, or all sorts of autoimmune things… psoriasis…it’s such a huge problem that people haven’t seen it as one problem. And the question then becomes not “How do I shut off inflammation?” but “How do I find the root cause of inflammation?
So we found out she in fact had very high anti-gliadin antibodies in her blood, which is a sign of gluten sensitivity. And you’re on the faculty of Institute of Functional Medicine and you are a board-certified neurologist. Higher A1c, even well below the levels that are qualified for diagnosing diabetes, directly correlate with the rate at which your brain shrinks, so that’s something you don’t want to have. That either sets the stage for an autoimmune condition like type-1 diabetes or celiac disease, or it sets the stage for that immune system to be perfectly balanced and adaptable and able to confront changes in the environment as that individual grows up.
The risk, for example, of becoming autistic doubles if an individual is born via cesarean section. With celiac disease being treatable with the diet—people, they really had a hard time to grasp the concept that this indeed was an autoimmune disease. The treatment is still: you’re going to go back every year and then get your replacement adjusted if your TSH is up.
When people have blood sugar spikes, they get IL-6 surge which stimulates the Th-17 pathway, whether they have a drop in blood sugar or have insulin surges from eating too much glucose. So, when you look at tuna, and we found some foods that are high in iodine and really cross-react with T3 and T4, but when they were cooked, there’s no cross-reactivity. A lot of times, what patients get is really what the practitioner likes, and it’s not really unique to the patient and this creates some problems. The filler of most of these is cornstarch, and many people that are gluten-sensitive cross-react with corn so they end up having filler issues, and there are some people that actually do better with just T4, even synthetic T4; they do better with it. We also know that many people that have Hashimoto’s have gluten sensitivity, and gluten itself—gluten antibodies have been shown to cross-react with the cerebellum as well.
That’s non-metabolic fatigue; it’s using your brain with no endurance for your brain and then getting exhausted. In the beginning of each chapter, I give lists of symptoms, and if the patient has those symptoms, that chapter’s really important for them, and then we try to get some strategies. He is currently a professor of neuroimmunology at the Carrick Institute for Graduate Studies.
Fifteen years later, she had full-blown rheumatoid arthritis, osteoarthritis, and then a couple of years after that, she needed total knee replacement.
Why is the immune system so pissed off?” That’s a question that most doctors don’t ask, so what we do in conventional care is we block, antagonize, suppress, and inhibit the immune system.
So there’s a process called molecular mimicry where our bodies start to react to these various triggers that are infectious.
The risk, for example, of developing an autoimmune celiac disease is increased by about 80%. He is the man who really has done the research behind leaky gut, zonulin, autoimmunity, celiac, and he has founded the Center for Celiac Research, which is now at Massachusetts General Hospital.
So, until the recent past, we thought that we need that to really maximize the capability to digest and sort foodstuff, but we overlooked these other key functions, one of being communicating with the environment. What people tend to forget is that the model for that type of therapy is that there is an assumption that since most people that have hypothyroidism have autoimmunity, there’s no reason to test the antibodies, and that the thyroid is going to get destroyed every year more.
Those are autoimmune-promoting mechanisms, so a lot of times when we see Hashimoto’s people, it’s not just about being gluten-free or avoiding foods, it’s about stabilizing blood sugar levels. People that have brain-based issues usually have everything blamed on their thyroid and they don’t do anything to support the brain health.
So at the end of the day, you’re trying to see which of these mechanisms there are and really understand why a person that has a thyroid issue—if you are a thyroid patient or if you work with thyroid patients as the practitioner—why are some of these people having such severe impairments in their function? There’s like all these different pieces that are treated and looked at by different people, and nobody’s looking at the problem as one whole continuing issue.
And she had super high levels of mercury like 120, and she also had immune response to mercury.
She’s full of energy and has no autoimmunity at all!  So most doctors don’t even think that that’s possible, and they don’t even bother checking the autoantibodies if they’ve been diagnosed initially, because they figure they’re just never going to go down. The bad stuff is a short list, and I think it’s really important to understand what those causes are, and they’re different for different people, so you can have 10 people with exactly the same autoimmune disease, and each one of those 10 people might have a different set of causes.
He’s also a visiting professor at Harvard, and recently, wrote a book called “Gluten Freedom,” which I have been reading.  So, you wrote in a very, sort of groundbreaking article that was the cover of Scientific American…I don’t know if that was five years or six years ago, but you kind of talked about this stool and having three legs of a stool in order to get celiac disease and then we can extrapolate that out to all autoimmune diseases about sort of genetics, the environment, and the gut.
But because this was a one of a kind autoimmune disease, we were able to really study in great detail what are the tools, what are the ingredients of this recipe, if you wish, and that’s how we learned that indeed, there are three pillars that you need to have in order to develop autoimmunity.
This is an extremely important function; it shapes who we are because you as an individual when you were born can be considered as a marble block that is the shape, and the size, and the color is determined by your genetic makeup. We found latex—it was one of the most devastating exposures to Hashimoto’s people—every path of the pathway: TSH, 5’deionase. So for me, when I wrote “Why Isn’t My Brain Working?”, it’s really part two of my thyroid explanation and some people haven’t really understood that. He has a PhD in microbiology and clinical immunology, with postdoctoral studies in tumor immunology at UCLA.
But we realize now there’s a continuum, and there’s even something called pre-autoimmune disease, which I think is a stupid name, because there’s no “pre” anything. We use steroids, we use drugs called TNF-alpha blockers which are called “disease modifying drugs” that suppress immunity and cause cancer, or an overwhelming infection.
But what comes out of this marble block depends on from the environment that is the sculptor that carves these blocks and whatever final product will be. These are usual things because you can package your food with latex and then you can get a reaction.
And for most people that have thyroid dysfunction, they’re still having depression and they’re still having fatigue, especially fatigue that’s induced by using their brain.
There needs to be, once the autoimmunity is somewhat managed with diet and lifestyle, an approach to really improve brain health for thyroid patients.
His research focuses on the predictive antibodies resulting in the development of numerous antibody assays. We’ll use chemo drugs—methotrexate, Imuran, cyclosporine—we’ve been using bone marrow transplants for some people. Even identical twins where they were split at birth and live in two different environments, they will look very differently, meaning that the environment does a great deal in terms of determining who we are, physically or socially and in terms of activities, and so on and so forth. There could be a brain component to it and doing strategies just for autoimmunity and leaky gut may not be enough.
So, a lot of people are talking about these Cyrex Labs as we’ve gone through this summit, and he is actually the chief scientific advisor, and also developing a lot of these arrays for the testing. One person might have an autoimmune disease from eating gluten, and another person might be from mercury, and another person might be from a parasite in their gut, and the list goes on and on. The risk of having a child with ADHD is tripled if that child doesn’t pass through the birth canal and becomes inoculated with mother’s vaginal bacteria. And the disease—whatever we call it, it sort of doesn’t matter—but maybe people would say it was chronic fatigue syndrome, it was whatever. I mean, listen, if you could take a pill like a vitamin or like a mild drug that didn’t really have all these side effects and it cured autoimmune disease, great! Other people with strongyloides, which is a weird worm that people get, causes autoimmunity.
Not everyone with Hashimoto’s will, let’s say, have a reaction, but if they have, let’s say, tuna antibodies that are elevated, those tuna antibodies can cross-react with T3 due to molecular mimicry. So there are a lot of things in your diet that can actually change the equation and push you toward autoimmunity.
So, some people would be very sensitive to some of those cross-reactive foods based on if they have antibodies to them, and some won’t. He’s published more than 140 articles, and he’s also the CEO and technical director of Immunoscience Labs.
So I really think it’s important to identify the trends in people’s bodies and see… I screen for that routinely. You have to treat that person with a worm pill, another person you have to do chelation, and for another person you have to change their diet.
So privileged to have you here with us.  You are definitely an expert in the world of autoimmunity. It’s really the third leading cause of morbidity and mortality after heart disease and cancer. Heart disease and cancer kill people and make people really sick, but autoimmune disease is right up there.




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