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The Vena8 Fluoro+™ biochip is ideal for rolling and adhesion assays on protein coatings or cell monolayers.
Disposable plastic biochips for cell analysis of cells under shear flow including rolling and adhesion assays on protein coatings or cell monolayers. Each biochip contains 8 capillaries in parallel which can be coated with different adhesion molecules for cell receptor-ligand (i.e. Recommended for platelet adhesion assays, thrombosis studies; biofilm studies and any requirements for tracking. I do research on methods and tools for the programming, compilation, modeling, simulation, physical design and control of microfluidic biochips. Microfluidic biochips (also known as lab-on-a-chip) are an alternative to conventional biochemical laboratories, and are revolutionizing many application, such as such as molecular biology procedures, DNA analysis, proteomics (the study of proteins) and clinical pathology (diagnostic of diseases).
Continuous-flow (see the videos on the page), based on the manipulation of continuous liquid through fabricated (video) micro-channels, using external pressure sources or integrated mechanical micro-pumps. Droplet-based, in which the liquid is manipulated as discrete droplets on a two-dimensional array of identical electrodes. PhD thesis: Wajid Hassan Minhass, System-Level Modeling and Synthesis Techniques for Flow-Based Microfluidic Large-Scale Integration Biochips, 2012. PhD thesis: Mirela Alistar, Compilation and Synthesis for Fault-Tolerant Digital Microfluidic Biochips, 2014. PhD thesis: Elena Maftei, Synthesis of Digital Microfluidic Biochips with Reconfigurable Operation Execution, 2011. Please contact Paul Pop if you are interested to obtain the software we developed as part of this research. The challenges facing biochips are similar to those faced by microelectronics some decades ago. Although biochips are becoming complex, with thousands of components, the current programming practice is to expose all of these components to the biochemist end-user, who has to control individually each component to implement the protocols. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.


Los biochips ofrecen la posibilidad de realizar un analisis mas detallado para el diagnostico del retraso mental en los ninos. Un equipo internacional de expertos acaba de dictaminar que ha llegado la hora de que se adopte como nuevo estandar el empleo de biochips de analisis cromosomico (CMA, sus siglas en ingles), dejando el procedimiento conocido como cariotipo para los casos en los que haya menos dudas de que existe una alteracion cromosomica y esta se pueda detectar facilmente (por ejemplo, el sindrome de Down). El cariotipo es una tecnica visual que permite ver, a traves del microscopio, los cromosomas y su morfologia.
Los autores de las recomendaciones de practica clinica que se publican en la ultima edicion de la revista The American Journal of Human Genetics han llegado a la conclusion de que los biochips no solo detectan un mayor numero de anomalias geneticas relacionadas con el retraso del desarrollo, el autismo u otros problemas, sino que su utilizacion es claramente mas rentable. Para llegar a esta conclusion analizaron un total de 33 estudios que incluyeron, en conjunto, a mas de 21.000 pacientes. La importancia de este tipo de pruebas geneticas radica en la alta incidencia de problemas de retraso mental y del desarrollo, que se situa en cerca del 3% de la poblacion general. El laboratorio de la Universidad Pompeu Fabra en el que trabaja el pediatra Luis Perez Jurado forma parte del consorcio que ha elaborado las nuevas recomendaciones. All biochips mimic human capillaries by working in tandem with the different instrumentation platforms. Our biochips are compatible with syringe pumps from Harvard Apparatus, World Precision Instruments, KD Scientific and many more. Vena8 Endothelial+ for culturing primary endothelial cells or coating with proteins and continuous flow. Vena8 Fluoro+ for coating with adhesion molecules or ligands and study interactions with cell surface receptor interactions. Applicable for cell rolling and adhesion studies to adhesion molecules or cell-cell interaction studies.
Suitable for a wide range of cell suspensions (primary and cell lines) including T-cells, monocytes, pbmcs, neutrophils, eosinophils, platelets and whole blood (heparanized). Vena8 Fluoro+:  Easy to coat microcapillaries with standard pipette with a range of different adhesion molecules including VCAM, ICAM, MAdCAM, fibronectin, vWF, collagen, fibrinogen etc. Vena8 Endothelial+: Easy to seed and culture a variety of endothelial cells (monolayers) including HUVEC, HMVEC, HCAECs etc.


They are becoming increasingly complex, with thousands of components, but are designed manually (called bottom-up full-custom design), which is extremely labor intensive and error prone.
Basic microfluidic operations, such as mixing and dilution, are performed on the array, by routing the corresponding droplets on a series of electrodes.
Cuando se tiene la posibilidad de utilizar las tecnologias mas punteras, parece logico preguntarse: ?Por que seguir siendo fiel a las viejas herramientas?
De estas investigaciones se desprende que el metodo mas nuevo presenta una tasa de deteccion de casi el 20%, frente al 3% del cariotipo.
Such a design complexity is possible because engineers are using Computer-Aided Design (CAD) tools, which, starting from a specification of the desired functionality, automatically build the best possible design (such a process is called top-down design). Los biochips ofrecen la posibilidad de realizar un analisis mucho mas detallado, con una resolucion 100 veces mayor, llegando a identificar alteraciones mucho mas pequenas. Con estas cifras, lo que suele ocurrir es que el uso de la herramienta tradicional en primer termino obliga, en buena parte de los casos, a hacer un segundo analisis con la tecnica mas novedosa. No obstante, anade que cada vez se emplean mas los biochips y el articulo que se acaba de publicar reforzara los argumentos de quienes defienden que se conviertan en la primera opcion en nuestro pais. As in the microelectronics area, CAD tools will reduce the development costs, increase the design productivity and yield, and are the key to the further growth and market penetration of biochips. A veces hay que hacer un cuidadoso analisis de la evidencia cientifica antes de decantarse por lo mas nuevo.
De hecho, la Asociacion Espanola de Genetica ha creado una comision, de la que Perez Jurado forma parte, que esta preparando un libro blanco en el que recomienda su generalizacion en el sistema sanitario publico.El especialista explica que los analisis geneticos en ninos con retraso mental son esenciales, sobre todo, para determinar el riesgo de sus progenitores de tener otros descendientes afectados.
My research vision in this area is to bring biochips to the same level of programmability as computers.



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