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Bacteria are classified under a distinct kingdom because of its peculiar cellular and morphological characteristics that makes it different and distinct from all other kingdoms like fungi, animal and virus. This article will discuss some major characteristics that are helpful in the determination of different types of bacteria. Streptococcus Pyogenes is the causative agent of mild sore throat and skin infections that may worsen in certain situations to lead to life threatening infections like toxic shock syndrome and septicemia (when bacteria gain access to the blood stream). E- Coli is a gram negative bacillis as discussed previously and is considered as a causative agent of travelera€™s diarrhea; however some pathogenic strains can also lead to bloody diarrhea and circulatory shock. Vibrio cholerae is the causative agent of cholera and is associated with intake of improperly cooked food or poor sanitary conditions. The most common causative agent of food poisoning throughout the world is Enteritis salmonella and can lead to serious and life threatening food poisoning, diarrhea, circulatory shock and dehydration in children. Lactobacillus acidophilus exists in different parts of human body like intestine, vagina and oral cavity. Due to its beneficial properties, it is used in a variety of dietary products like tempeh, yogurt, miso and probiotics supplements. Bacillus subtilis occurs independently in the environment around us and was first used by Nazi army to manage diarrheal illness. Bifidobacterium animalis is found in the intestine of animals and humans as a normal commensal that aid in digestive process.
Streptococcus thermophilus is classified under coccus and it has the ability to withstand a temperature of about 212 degrees Fahrenheit. Lactobacillus reuteri is one of the probiotics agents that are present in maternal breast milk and becomes a permanent part of gut flora. Since bacterial organisms are so minute, it is impossible to view the organisms without compound microscope. Gram staining is a special method that involves dying the outer covering of the bacterial cell wall that prevents it from physical and environmental trauma. There are a number of structural and functional variations in the bacteria of one group that helps in adapting these bacterial agents to survive in one environment where other bacteria cannot.
Rickettsia is considered unique bacteria since it is incapable of surviving outside living organisms. All bacteria are characterized by a cell wall outside cell-membrane; however, mycoplasma is unique as it lacks a cell wall that is also considered a protective mechanism that makes it easier for bacteria to evade antibiotic therapies. Mosquito and insect bites are one of the common thing which takes place in day to day life for mostly everybody.
Have a friend or family member take a look with a flashlight, or open wide and look in the mirror. The treatment for strep throat is penicillin, usually taken for 10 days (ask your provider about alternative antibiotics if you’re allergic to penicillin). You want to avoid common side effects of antibiotics such as upset stomach, diarrhea, and, if you’re female, yeast infections.
If you do start antibiotic treatment, remember to take every single dose of the medication all the way to the end, even if you start feeling better earlier, in order to prevent the bacteria from developing resistance to the antibiotics.
For sore throats, fever, headaches, and body aches: Take acetaminophen (Tylenol) or an anti-inflammatory pain reliever like ibuprofen (Advil, Motrin), naproxen (Aleve), or aspirin as directed.
One:Life is published by One Medical Group, an innovative primary care practice with offices in Boston, Chicago, Los Angeles, New York, Phoenix, the San Francisco Bay Area, and Washington, DC. You may delete cookies at any time but doing so may result in some parts of the site not working correctly. Noticeboard93% of Patients Would Recommend Broomfield to Friends and FamilyOf 204 patients surveyed in 2015  - 93% stated that they were extremely likely (74%) or likely (19%) to recommend Broomfield Park Medical Centre to their friends and family. Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. LIPITOR has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson Types I and V). In patients taking cyclosporine or the HIV protease inhibitors (tipranavir plus ritonavir) or the hepatitis C protease inhibitor (telaprevir), therapy with LIPITOR should be avoided. White, elliptical, film-coated tablets containing 10, 20, 40, and 80 mg atorvastatin calcium. Women who are pregnant or may become pregnant. LIPITOR may cause fetal harm when administered to a pregnant woman. It is not known whether atorvastatin is excreted into human milk; however a small amount of another drug in this class does pass into breast milk.
Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with LIPITOR and with other drugs in this class. A history of renal impairment may be a risk factor for the development of rhabdomyolysis.
Atorvastatin, like other statins, occasionally causes myopathy, defined as muscle aches or muscle weakness in conjunction with increases in creatine phosphokinase (CPK) values >10 times ULN.
There have been rare reports of immune-mediated necrotizing myopathy (IMNM), an autoimmune myopathy, associated with statin use. The risk of myopathy during treatment with drugs in this class is increased with concurrent administration of cyclosporine, fibric acid derivatives, erythromycin, clarithromycin, the hepatitis C protease inhibitor telaprevir, combinations of HIV protease inhibitors, including saquinavir plus ritonavir, lopinavir plus ritonavir, tipranavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, and fosamprenavir plus ritonavir, niacin, or azole antifungals.
Cases of myopathy, including rhabdomyolysis, have been reported with atorvastatin co-administered with colchicine, and caution should be exercised when prescribing atorvastatin with colchicine [see Drug Interactions (7.11)].
It is recommended that liver enzyme tests be obtained prior to initiating therapy with LIPITOR and repeated as clinically indicated. Increases in HbA1c and fasting serum glucose levels have been reported with HMG-CoA reductase inhibitors, including LIPITOR. CNS vascular lesions, characterized by perivascular hemorrhages, edema, and mononuclear cell infiltration of perivascular spaces, have been observed in dogs treated with other members of this class.
In a post-hoc analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study where LIPITOR 80 mg vs. Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. In the LIPITOR placebo-controlled clinical trial database of 16,066 patients (8755 LIPITOR vs. Table 2 summarizes the frequency of clinical adverse reactions, regardless of causality, reported in ? 2% and at a rate greater than placebo in patients treated with LIPITOR (n=8755), from seventeen placebo-controlled trials. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Diovan® (valsartan) is indicated for the treatment of hypertension, to lower blood pressure. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.
Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits.
Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. In clinically stable patients with left ventricular failure or left ventricular dysfunction following myocardial infarction, Diovan is indicated to reduce cardiovascular mortality [see Clinical Studies (14.3)]. The recommended starting dose of Diovan (valsartan) is 80 mg or 160 mg once daily when used as monotherapy in patients who are not volume-depleted.
The antihypertensive effect is substantially present within 2 weeks and maximal reduction is generally attained after 4 weeks.
No initial dosage adjustment is required for elderly patients, for patients with mild or moderate renal impairment, or for patients with mild or moderate liver insufficiency. No data are available in pediatric patients either undergoing dialysis or with a glomerular filtration rate [see Pediatric Use (8.4)].
Add 80 mL of Ora-Plus®* oral suspending vehicle to an amber glass bottle containing 8 Diovan 80 mg tablets, and shake for a minimum of 2 minutes. Do not coadminister aliskiren with Diovan in patients with diabetes [see Drug Interactions (7)]. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death.
Excessive hypotension was rarely seen (0.1%) in patients with uncomplicated hypertension treated with Diovan alone. Caution should be observed when initiating therapy in patients with heart failure or post-myocardial infarction patients.
If excessive hypotension occurs, the patient should be placed in the supine position and, if necessary, given an intravenous infusion of normal saline. Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin-angiotensin system and by diuretics.
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. Diovan (valsartan) has been evaluated for safety in more than 4,000 patients, including over 400 treated for over 6 months, and more than 160 for over 1 year.


The overall frequency of adverse reactions was neither dose-related nor related to gender, age, race, or regimen. The adverse reactions that occurred in placebo-controlled clinical trials in at least 1% of patients treated with Diovan and at a higher incidence in valsartan (n=2,316) than placebo (n=888) patients included viral infection (3% vs. Headache, dizziness, upper respiratory infection, cough, diarrhea, rhinitis, sinusitis, nausea, pharyngitis, edema, and arthralgia occurred at a more than 1% rate but at about the same incidence in placebo and valsartan patients. Diovan has been used concomitantly with hydrochlorothiazide without evidence of clinically important adverse interactions. Other adverse reactions that occurred in controlled clinical trials of patients treated with Diovan (>0.2% of valsartan patients) are listed below. Other reported events seen less frequently in clinical trials included chest pain, syncope, anorexia, vomiting, and angioedema. Diovan has been evaluated for safety in over 400 pediatric patients aged 6 to 17 years and more than 160 pediatric patients aged 6 months to 5 years.
The adverse experience profile of Diovan in heart failure patients was consistent with the pharmacology of the drug and the health status of the patients. The table shows adverse reactions in double-blind short-term heart failure trials, including the first 4 months of the Valsartan Heart Failure Trial, with an incidence of at least 2% that were more frequent in valsartan-treated patients than in placebo-treated patients. Other adverse reactions with an incidence greater than 1% and greater than placebo included headache NOS, nausea, renal impairment NOS, syncope, blurred vision, upper abdominal pain and vertigo. From the long-term data in the Valsartan Heart Failure Trial, there did not appear to be any significant adverse reactions not previously identified. The safety profile of Diovan was consistent with the pharmacology of the drug and the background diseases, cardiovascular risk factors, and clinical course of patients treated in the post-myocardial infarction setting. Rare cases of rhabdomyolysis have been reported in patients receiving angiotensin II receptor blockers. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. No clinically significant pharmacokinetic interactions were observed when Diovan (valsartan) was coadministered with amlodipine, atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin.
Coadministration of valsartan and warfarin did not change the pharmacokinetics of valsartan or the time-course of the anticoagulant properties of warfarin. Transporters: The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1 and the hepatic efflux transporter MRP2. Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including valsartan, may result in deterioration of renal function, including possible acute renal failure.
The antihypertensive effect of angiotensin II receptor antagonists, including valsartan may be attenuated by NSAIDs including selective COX-2 inhibitors. Dual Blockade of the Renin-Angiotensin System (RAS): Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Lithium: Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists, including Diovan.
In controlled clinical trials, clinically important changes in standard laboratory parameters were rarely associated with administration of Diovan. Liver Function Tests: Occasional elevations (greater than 150%) of liver chemistries occurred in Diovan-treated patients. In the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus. Colgate Total Is FDA-Approved, Even With Known Cancer-Causing Ingredient: Can We Really Trust Federal Health Safety Standards? What is the most important information I should know about sulfamethoxazole and trimethoprim? What should I discuss with my healthcare provider before taking sulfamethoxazole and trimethoprim? Bacteria are microscopic, unicellular (single celled) ancient organisms that are responsible for a number of lethal diseases.
Vibrio Cholerae is linked to hundreds and thousands of deaths worldwide (mostly in under- developed countries) due to cholera outbreak. Infection can be controlled by timely intake of proper antibiotics and circulatory support.
It is associated with a high mortality rate after initial infection and characterized by blood diarrhea, vomiting, dehydration, fever and may lead to death if proper treatment is not instituted at the right time.
Our body is loaded with hundreds and thousands of bacteria that serve to colonize our body in order to prevent overgrowth of pathogenic elements. It is responsible for slightly acidic pH of vagina that is helpful in preventing overgrowth of other microorganisms. In addition it can also be consumed in supplemental doses to improve the symptoms of constipation or irritable bowel syndrome.
In order to visualize the cellular components and to differentiate bacteria from other microbial agents, staining techniques are used by scientists to categorize different bacteria.
On the basis of gram staining, bacteria are widely classified as gram positive (bacteria with the cell wall) and gram negative (bacteria without cell- wall). These occurs abundantely in the environment and also as normal commensal on the human body (in nostrils, skin, oral cavity and genitals). Most popular species are salmonella (the causative agent of typhoid) and E- Col (causative agent for hemorrhagic diarrhea). Due to unstable morphological features, it is transmitted by different vector sources like ticks, fleas and mites to cause life threatening infectious diseases like Rocky mountain spotted fever and typhus. It is causative agent for life threatening pulmonary infections and some strains may cause pelvic disease. Strep throat, or Streptococcal pharyngitis, is a bacterial infection that can be treated with antibiotics to shorten the duration of symptoms and prevent complications, and it’s most common in young, school-age children.
It’s our quick-and-easy way to figure out the likelihood that someone with a sore throat has a bacterial infection that should be tested and treated. Take the quiz below, add up your points, and find out what your primary care provider would do next. They swell up and can become tender when they’re hard at work making white blood cells to fight infections. If you rest and drink plenty of fluids, your immune system can actually handle a strep infection on its own. Drug therapy is recommended as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily. In patients with HIV taking lopinavir plus ritonavir, caution should be used when prescribing LIPITOR and the lowest dose necessary employed.
Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Because statins have the potential for serious adverse reactions in nursing infants, women who require LIPITOR treatment should not breastfeed their infants [see Use in Specific Populations (8.3)]. Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever or if muscle signs and symptoms persist after discontinuing LIPITOR. Physicians considering combined therapy with LIPITOR and fibric acid derivatives, erythromycin, clarithromycin, a combination of saquinavir plus ritonavir, lopinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, or fosamprenavir plus ritonavir, azole antifungals, or lipid-modifying doses of niacin should carefully weigh the potential benefits and risks and should carefully monitor patients for any signs or symptoms of muscle pain, tenderness, or weakness, particularly during the initial months of therapy and during any periods of upward dosage titration of either drug.
Increases in liver function tests (LFT) in other patients were not associated with jaundice or other clinical signs or symptoms. There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including atorvastatin. Active liver disease or unexplained persistent transaminase elevations are contraindications to the use of LIPITOR [see Contraindications (4.1)]. Clinical studies have shown that LIPITOR does not reduce basal plasma cortisol concentration or impair adrenal reserve. A chemically similar drug in this class produced optic nerve degeneration (Wallerian degeneration of retinogeniculate fibers) in clinically normal dogs in a dose-dependent fashion at a dose that produced plasma drug levels about 30 times higher than the mean drug level in humans taking the highest recommended dose. Clinical adverse reactions occurring in ? 2% in patents treated with any dose of LIPITOR and at an incidence greater than placebo regardless of causality (% of patients). Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. In a controlled clinical trial, Diovan significantly reduced hospitalizations for heart failure.
If additional antihypertensive effect is required over the starting dose range, the dose may be increased to a maximum of 320 mg or a diuretic may be added.
Care should be exercised with dosing of Diovan in patients with hepatic or severe renal impairment.


Follow the suspension preparation instructions below (see Preparation of Suspension) to administer valsartan as a suspension. Uptitration to 80 mg and 160 mg twice daily should be done to the highest dose, as tolerated by the patient. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Patients with heart failure or post-myocardial infarction patients given Diovan commonly have some reduction in blood pressure, but discontinuation of therapy because of continuing symptomatic hypotension usually is not necessary when dosing instructions are followed. A transient hypotensive response is not a contraindication to further treatment, which usually can be continued without difficulty once the blood pressure has stabilized.
These effects are usually minor and transient, and they are more likely to occur in patients with pre-existing renal impairment. Adverse reactions have generally been mild and transient in nature and have only infrequently required discontinuation of therapy. An increase in the incidence of dizziness was observed in patients treated with Diovan 320 mg (8%) compared to 10 to 160 mg (2% to 4%).
No relevant differences were identified between the adverse experience profile for pediatric patients aged 6 to 16 years and that previously reported for adult patients.
In a study (n=90) of pediatric patients (1 to 5 years), two deaths and three cases of on-treatment transaminase elevations were seen in the one-year open-label extension phase. In the Valsartan Heart Failure Trial, comparing valsartan in total daily doses up to 320 mg (n=2,506) to placebo (n=2,494), 10% of valsartan patients discontinued for adverse reactions vs. All patients received standard drug therapy for heart failure, frequently as multiple medications, which could include diuretics, digitalis, beta-blockers. The table shows the percentage of patients discontinued in the valsartan and captopril-treated groups in the Valsartan in Acute Myocardial Infarction Trial (VALIANT) with a rate of at least 0.5% in either of the treatment groups.
Some of these patients previously experienced angioedema with other drugs including ACE inhibitors.
The valsartan-atenolol combination was more antihypertensive than either component, but it did not lower the heart rate more than atenolol alone. Coadministration of inhibitors of the uptake transporter (rifampin, cyclosporine) or efflux transporter (ritonavir) may increase the systemic exposure to valsartan. Closely monitor blood pressure, renal function and electrolytes in patients on Diovan and other agents that affect the RAS. There are different types of bacteria that shares classic morphological characteristics of the kingdom but are classified differently in 5 major groups on the basis of their habitat, laboratory characteristics, staining methods, requirement of certain nutrients for the generation of energy and presence of certain cytoplasmic extensions like flagella or cilia (that are helpful in the motility of bacteria). Gram negative as well as gram positive bacilli are well known causative agents for gastroenterological, pulmonary and cutaneous infections. This happens to your lymph nodes on either side of your Adam’s apple when you have an upper respiratory infection (URI). It also lowers your risk of developing a more serious throat infection or a very rare complication called rheumatic fever, which primarily affects the heart and joints. You’ll get through it more comfortably if you treat your symptoms with over-the-counter medications suggested below. In patients with CHD or multiple risk factors for CHD, LIPITOR can be started simultaneously with diet.
Atherosclerosis is a chronic process and discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. LIPITOR therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected.
Lower starting and maintenance doses of atorvastatin should be considered when taken concomitantly with the aforementioned drugs (see Drug Interactions (7)). Upon dose reduction, drug interruption, or discontinuation, transaminase levels returned to or near pretreatment levels without sequelae.
The effects of statins on male fertility have not been studied in adequate numbers of patients.
These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which valsartan principally belongs.
For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). There is no evidence that Diovan provides added benefits when it is used with an adequate dose of an ACE inhibitor [see Clinical Studies (14.2)].
When the suspension is replaced by a tablet, the dose of valsartan may have to be increased.
After the standing time, shake the suspension for a minimum of 1 additional minute. Add 80 mL of Ora-Sweet SF®* oral sweetening vehicle to the bottle and shake the suspension for at least 10 seconds to disperse the ingredients. Patients may be uptitrated within 7 days to 40 mg twice daily, with subsequent titrations to a target maintenance dose of 160 mg twice daily, as tolerated by the patient.
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. This condition should be corrected prior to administration of Diovan, or the treatment should start under close medical supervision.
The most common reasons for discontinuation of therapy with Diovan were headache and dizziness.
Headache and hyperkalemia were the most common adverse events suspected to be study drug-related in older children (6 to 17 years old) and younger children (6 months to 5 years old), respectively. These 5 events occurred in a study population in which patients frequently had significant co-morbidities. If oligohydramnios is observed, discontinue Diovan, unless it is considered lifesaving for the mother. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. There are no adequate and well-controlled studies of LIPITOR use during pregnancy; however in rare reports, congenital anomalies were observed following intrauterine exposure to statins.
Periodic creatine phosphokinase (CPK) determinations may be considered in such situations, but there is no assurance that such monitoring will prevent the occurrence of severe myopathy. Eighteen of 30 patients with persistent LFT elevations continued treatment with a reduced dose of LIPITOR. There are no controlled trials in hypertensive patients demonstrating risk reduction with Diovan. If symptomatic hypotension or renal dysfunction occurs, consideration should be given to a dosage reduction. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Diovan [see Drug Interactions (7)].
Sulfamethoxazole and trimethoprim will not treat a viral infection such as the common cold or flu.Antibiotic medicines can cause diarrhea, which may be a sign of a new infection.
The starting dose and maintenance doses of LIPITOR should be individualized according to patient characteristics such as goal of therapy and response (see current NCEP Guidelines). In rat and rabbit animal reproduction studies, atorvastatin revealed no evidence of teratogenicity.
Caution should be exercised if a statin is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones, such as ketoconazole, spironolactone, and cimetidine. Diovan may be given with other standard post-myocardial infarction treatment, including thrombolytics, aspirin, beta-blockers, and statins. Neurocognitive and developmental assessment of pediatric patients aged 6 to 16 years revealed no overall clinically relevant adverse impact after treatment with Diovan for up to 1 year.
In a second study in which 75 children aged 1 to 6 years were randomized, no deaths and one case of marked liver transaminase elevations occurred during a 1 year open-label extension. These adverse outcomes are usually associated with use of these drugs in the second and third trimesters of pregnancy.
LIPITOR SHOULD BE ADMINISTERED TO WOMEN OF CHILDBEARING AGE ONLY WHEN SUCH PATIENTS ARE HIGHLY UNLIKELY TO CONCEIVE AND HAVE BEEN INFORMED OF THE POTENTIAL HAZARDS. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents.
Do not use any medicine to stop the diarrhea unless your doctor has told you to.Avoid exposure to sunlight or tanning beds.
If the patient becomes pregnant while taking this drug, LIPITOR should be discontinued immediately and the patient apprised of the potential hazard to the fetus [see Use in Specific Populations (8.1)]. Some baseline characteristics, including hemorrhagic and lacunar stroke on study entry, were associated with a higher incidence of hemorrhagic stroke in the atorvastatin group [see Adverse Reactions (6.1)].
Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.



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