I am using this space to put together my growing understanding of insulin resistance, cell biology of the gut, weight regulation, and nutrition. I am a scientist (PhD Cell Biology) so my discussion here will be very specific regarding the cell biology, genomics, metabolomics, and other matters. The material on this page will seem hodgepodge at first but will become more ordered but more complex over time.
There is an as yet to be understood relationship between the participation of the small intestine in the digestive process and the regulation of insulin as well as insulin receptivity of target cells. We know of this relationship because patients who have had their small intestines by-passed in the weight loss surgery called Roux-en-Y anastomosis have improved insulin utilization but patients who have had the Lap-Band (adjustable gastric band) do not experience the same dynamic. It is believed that GLP-1 (Glucagon-like peptide 1) is a critical molecule in this metabolic rescue. The following graphic (source) provides some pathway context for the GLP-1 molecule in this setting.
Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene.
GLP-1 secretion by L cells is dependent on the presence of nutrients in the lumen of the small intestine. There are many tissue types in the body and each has its special method of developing over the lifetime of an organism and its own unique metabolism. Today I’m going to discuss a revolutionary new method that has been scientifically proven (study performed by UK University team) to bring blood sugar level down to normal in only ONE week and CURE type 2 diabetes in 7 out of 10 people in 8 weeks. I’m sure lots of our readers are going to have a strong reaction to this article, so please read on and make your comment at the end.
Even if you believe this would be too tough for you to handle (true for 95% of us), read on to understand how this works and learn alternatives based on a similar philosophy, but a much easier approach. According to the scientists that did the study, the main benefit people received was to remove fat from glands in the pancreas that block insulin production. This method probably also removed fat that was blocking receptors on muscle cells that prevented them from accepting insulin messages, causing insulin resistance.
One of the major factors believed to trigger the inflammation reaction is a stimulate food such as sugar, which creates spikes in blood sugar in the body. This is a little similar to what Christian Goodman calls a “Focused-Break” in the high blood pressure program.
Indian gurus have encourages using fasting for centuries to improve and maintain good health. If you’re considering taking on the 600 calorie diet to cure your type 2 diabetes, there are several things you must keep in mind.


The participants also loaded up with healthy, non-starchy vegetables, which I think was the key for them to get the basic vitamins and minerals they needed. Finally, after the 8 weeks of the strict diet period was over, the study participants were given recommendations on a healthy diet. Although the study pushed the participants for eight weeks on this heavily restricted diet, there is nothing that indicates type 2 diabetes cannot be cured in a shorter period of time…or that only a few days of low calorie diet will drastically improve their health. But first, I’d really appreciate it if you click the Facebook button below and share this articles with your friends.
I may or may not be able to answer your question now but may be able to later, once I have learned it myself. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone.
The secretagogues (agents that cause or stimulate secretion) of this hormone include major nutrients like carbohydrate, protein and lipid.
You can calculate pretty much exactly how many calories you’re eating and subconscious cheating is almost impossible. Although genetics play some role, most experts agree that diet, obesity, lack of exercise, pollution (including smoking) and other lifestyle factors, in essence, created it.
Due to free-radicals and inflammation, your body attacks parts of itself (in this case the pancreas, muscle cells and the liver) seriously impacting their ability to release and use insulin. This is especially serious for type 2 diabetics since they have constant spikes in their blood sugar. So as we’ve forced down the blood sugar, we also cut off this inflammation circle … giving the body time to restore itself: “Time-Out”. The best thing to do is not to try to get into a bunch of different programs and settings and try to fix this and that.
If your doctor doesn’t want to go through with this with you, seek another one that’s more naturally focused. This vitamin is essential to fight inflammation and you won’t get it from the 600 calorie diet. Whereas 95% of people would give up on the 600 calorie diet before the end of eight weeks, almost everyone can stick to it for ONE week and then follow the easy plan in the 21-Day Guide to Beat Diabetes.
Once in the circulation, GLP-1 has a half life of less than 2 minutes, due to rapid degradation by the enzyme dipeptidyl peptidase-4.
Insulin functions through at least four mechanisms to promote adipocyte differentiation; two of these mechanisms are common to other regulatory pathways (activation of CREB by cAMP and regulation of GATA factors in the sonic hedgehog (SHH) pathway). Humoral factors like Wnt ligands, BMP and TGF- transmit their signals through cognate cell membrane receptors expressed by the differentiating cells.


Even if you have an extremely low insulin level in your blood, or many of your cells are insulin resistant, you’ll still use more glucose than you put into your system. That’s why one of the first things your body does when faced with starvation (600 calories would count for mild-starvation) is to draw energy from muscles. Therefore, eating is constantly triggering an inflammation reaction that attacks the pancreas and other cells.
His three exercises have worked for people who have tried everything else, no matter what they considered the cause of their high blood pressure to be. If you “cure” your diabetes in a few weeks and then go out and load up on a Big-Mac every day, the problem is going to raise its ugly face again. It is a potent antihyperglycemic hormone, inducing glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion.
Activation of -catenin signalling is used by both Wnt-family proteins and androgens to repress adipogenesis. Transcription factors often govern the final cell lineage decision during MSC differentiation, and their transcriptional activities are modulated through crosstalk with cell-membrane receptor-mediated signals.
When you develop type 2 diabetes, this process is interrupted so either not enough insulin is released or the cells in your body ignore the insulin message and refuse to take in the glucose from the blood. So there is no surprise or magic behind the fact that after one week, the participant’s blood sugar was down to normal. This is the reason why most very low calorie diets don’t work in the long-haul because the weight loss is rather muscle-loss than fat-loss. Such glucose-dependent action is particularly attractive because when the plasma glucose concentration is in the normal fasting range, GLP-1 no longer stimulates insulin to cause hypoglycemia.
In this case, however, it may be beneficial since this reduces the need for insulin and glucose delivery to the muscles, adding to the “Time-Out” effect that we mentioned before. The pain of the eight week, low calorie diet probably stuck with them as a reminder of never letting themselves go that far down again.
GLP-1 appears to restore the glucose sensitivity of pancreatic I?-cells , with the mechanism possibly involving the increased expression of GLUT2 and glucokinase. We have used + and – symbols to denote positive and negative effects on adipogenesis that are not understood mechanistically.
GLP-1 is also known to inhibit pancreatic I?-cell apoptosis and stimulate the proliferation and differentiation of insulin-secreting I?-cells.



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Comments

  1. 10.10.2015 at 16:52:57


    Hormone made by the pancreas young and middle-aged Pima Indians oral glucose.

    Author: KrIsTi
  2. 10.10.2015 at 10:57:30


    Have a very slight amount of either beta cell dysfunction or insulin resistance the liver.

    Author: KK_5_NIK
  3. 10.10.2015 at 17:55:10


    The time, a normal result for the.

    Author: Elnur_Guneshli