The pancreas detects the fall in the blood glucose level and releases another hormone, glucagon. The glucose curve is a great tool to differentiate between an insufficient insulin dose and the Somogyi effect. The procedure is as follows: shortly after the animal has been given its first meal (preferably at home), the first blood sample is taken just prior to the insulin injection in the morning. Collect a drop of capillary blood from the pinna and analyze it using a handheld glucometer. Glucometers should be calibrated specifically for dogs and cats because of the difference in the ratios of glucose in plasma and red blood cells from humans. Consider treatment successful when the clinical signs of diabetes mellitus improve without inducing hypoglycemia.
The aim of therapy is not to produce a series of blood glucose concentrations that are within the reference range, but to produce a blood glucose curve that approaches the reference range and avoids potentially fatal hypoglycemia. Important Safety InformationVetsulin should not be used in dogs or cats known to have a systemic allergy to pork or pork products.
Pregnant women who have never had diabetes before but who have high blood-glucose levels during pregnancy called gestational diabetes.
Almost all women have some degree of impaired glucose intolerance during pregnancy due to hormonal changes that occur during pregnancy. During pregnancy, increased levels of certain hormones made in the placenta help take nutrients from the mother to the developing fetus.


Gestational diabetes starts when your body is not able to make and use all the insulin it needs for pregnancy. When creating a glucose curve, remember that stress can affect the reliability of results, and the glucose curve is only one tool among others that can help diagnose and monitor diabetes mellitus. Thereafter, blood samples are collected every 2 hours throughout the day for 12 hours, if possible.
To achieve this goal, keep blood glucose concentrations below the renal threshold and avoid hypoglycemia. Plasma glucose concentrations are measured in the laboratory—the gold standard—or by an in-clinic analyzer. If a reading seems unusual or does not match the clinical signs, a second reading should be taken or another method used to confirm the blood glucose measurement. Careful monitoring and control during maintenance will help to limit the long-term complications. Therefore, it is necessary to diagnose; early diagnosis is always good for both mother and baby.
That means that their blood glucose is higher than normal, but not high enough to have diabetes. Take clinical signs (or lack thereof) into account when contemplating any change in the insulin therapy.
For twice-daily Vetsulin treatment to be effective, the duration of insulin activity following each injection needs to reach 10 to 12 hours.


The graph below demonstrates an ideal blood glucose curve for a cat receiving Vetsulin twice daily.
During the later part of pregnancy, these hormonal changes place a pregnant woman at risk for gestational diabetes.
However, these hormones also block the action of the mother's insulin in her body, called insulin resistance. The ultimate goal in regulating the diabetic cat is to control the clinical signs adequately so that the patient enjoys a good quality of life. Veterinarians can determine based on the nadir whether the dose needs to be increased or decreased (or remain as is). As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and prevent associated complications.
The safety and effectiveness of Vetsulin in puppies and kittens, breeding, pregnant, and lactating dogs and cats has not been evaluated.
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